Epigallocatechin gallate accelerates healing of indomethacin-induced stomach ulcers in mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-03

AUTHORS

Biplab Adhikary, Sudhir K. Yadav, Sandip K. Bandyopadhyay, Subrata Chattopadhyay

ABSTRACT

Management of the gastric toxicity of non-steroidal anti-inflammatory drugs (NSAIDs) remains a crucial problem because the commercially available drugs have side effects and are often expensive. Therefore, we examined the potential of the green tea-derived polyphenol epigallocatechin gallate (EGCG) to treat indomethacin-induced stomach ulcers in mice. Administration of indomethacin (18 mg/kg, po) to mice induced ulceration in the glandular portion of the gastric mucosa, accompanied by increased lipid peroxidation (LPO) and protein oxidation and reductions in thiol defense, mucin, cyclooxygenase (COX) expression and prostaglandin (PG) synthesis in the gastric tissues. Daily oral administration of EGCG (2 mg/kg) or omeprazole (3 mg/kg) for 3 days produced similar (≈ 72-75%, p < 0.001) beneficial effects on the acute gastric ulceration. Treatment with the test samples partially reversed all the adverse oxidative effects of indomethacin. In addition, EGCG, but not omeprazole, enhanced expression of the COX isoforms and PG synthesis. The results suggest that the non-toxic and inexpensive tea polyphenol EGCG may be an excellent candidate for further evaluation as a potent anti-ulcer drug. More... »

PAGES

527-536

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/s1734-1140(11)70519-9

DOI

http://dx.doi.org/10.1016/s1734-1140(11)70519-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036213136

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21602608


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