Intestinal hypoperfusion contributes to gut barrier failure in severe acute pancreatitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-02

AUTHORS

Sakhawat H. Rahman, Basil J. Ammori, John Holmfield, Michael Larvin, Michael J. McMahon

ABSTRACT

Intestinal barrier failure and subsequent bacterial translocation have been implicated in the development of organ dysfunction and septic complications associated with severe acute pancreatitis. Splanchnic hypoperfusion and ischemia/reperfusion injury have been postulated as a cause of increased intestinal permeability. The urinary concentration of intestinal fatty acid binding protein (IFABP) has been shown to be a sensitive marker of intestinal ischemia, with increased levels being associated with ischemia/reperfusion. The aim of the current study was to assess the relationship between excretion of IFABP in urine, gut mucosal barrier failure (intestinal hyperpermeability and systemic exposure to endotoxemia), and clinical severity. Patients with a clinical and biochemical diagnosis of acute pancreatitis were studied within 72 hours of onset of pain. Polyethylene glycol probes of 3350 kDa and 400 kDa were administered enterally, and the ratio of the percentage of retrieval of each probe after renal excretion was used as a measure of intestinal macromolecular permeability. Collected urine was also used to determine the IFABP concentration (IFABP-c) and total IFABP (IFABP-t) excreted over the 24-hour period, using an enzyme-linked immunosorbent assay technique. The systemic inflammatory response was estimated from peak 0 to 72-hour plasma C-reactive protein levels, and systemic exposure to endotoxins was measured using serum IgM endotoxin cytoplasmic antibody (EndoCAb) levels. The severity of the attack was assessed on the basis of the Atlanta criteria. Sixty-one patients with acute pancreatitis (severe in 19) and 12 healthy control subjects were studied. Compared to mild attacks, severe attacks were associated with significantly higher urinary IFABP-c (median 1092 pg/ml vs. 84 pg/ml; P < 0.001) and IFABP-t (median 1.14 microg vs. 0.21 microg; P = 0.003). Furthermore, the control group had significantly lower IFABP-c (median 37 pg/ml; P = 0.029) and IFABP-t (median 0.06 microg; P = 0.005) than patients with mild attacks. IFABP correlated positively with the polyethylene glycol 3350 percentage retrieval (r = 0.50; P < 0.001), CRP (r = 0.51; P < 0.001), and inversely with serum IgM EndoCAb levels (r = -0.32; P = 0.02). The results of this study support the hypothesis that splanchnic hypoperfusion contributes to the loss of intestinal mucosal integrity associated with a severe attack of pancreatitis. More... »

PAGES

26-36

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/s1091-255x(02)00090-2

DOI

http://dx.doi.org/10.1016/s1091-255x(02)00090-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017205490

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12559182


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "C-Reactive Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endotoxins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme-Linked Immunosorbent Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acid-Binding Protein 7", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acid-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin M", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ischemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multiple Organ Failure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatitis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Permeability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyethylene Glycols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Leeds General Infirmary", 
          "id": "https://www.grid.ac/institutes/grid.418161.b", 
          "name": [
            "Academic Department of Surgery, The General Infirmary at Leeds, Leeds"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rahman", 
        "givenName": "Sakhawat H.", 
        "id": "sg:person.01225073042.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225073042.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leeds General Infirmary", 
          "id": "https://www.grid.ac/institutes/grid.418161.b", 
          "name": [
            "Academic Department of Surgery, The General Infirmary at Leeds, Leeds"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ammori", 
        "givenName": "Basil J.", 
        "id": "sg:person.01162024754.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162024754.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leeds General Infirmary", 
          "id": "https://www.grid.ac/institutes/grid.418161.b", 
          "name": [
            "Academic Department of Surgery, The General Infirmary at Leeds, Leeds"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holmfield", 
        "givenName": "John", 
        "id": "sg:person.01105610541.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105610541.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nottingham", 
          "id": "https://www.grid.ac/institutes/grid.4563.4", 
          "name": [
            "Postgraduate Medical School, University of Nottingham, Derby, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Larvin", 
        "givenName": "Michael", 
        "id": "sg:person.01172416415.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172416415.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leeds General Infirmary", 
          "id": "https://www.grid.ac/institutes/grid.418161.b", 
          "name": [
            "Academic Department of Surgery, The General Infirmary at Leeds, Leeds"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McMahon", 
        "givenName": "Michael J.", 
        "id": "sg:person.016016267262.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016016267262.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1016/s1091-255x(99)80067-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000200535", 
          "https://doi.org/10.1016/s1091-255x(99)80067-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(92)91450-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000565714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.23.8.656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001801723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci107768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004011413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004630-198708060-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004146643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004630-198708060-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004146643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800800840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007273870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/ijgc:27:3:209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007493942", 
          "https://doi.org/10.1385/ijgc:27:3:209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198606000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008654558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198606000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008654558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9610(92)90260-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008786338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01658676", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010708233", 
          "https://doi.org/10.1007/bf01658676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01658676", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010708233", 
          "https://doi.org/10.1007/bf01658676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9610(83)90288-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010931385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198002000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012922470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198002000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012922470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jps.2600810412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013071734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198804000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013763691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198804000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013763691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198804000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013763691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800831113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014104306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1993.01420170122019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015767287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.48.1.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017547594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0039-6109(16)40337-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017652406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9610(64)90274-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017889186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-198807000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017891788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-198807000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017891788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-198505000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018013926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-198505000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018013926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.25.10.1065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020370047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01296004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021212834", 
          "https://doi.org/10.1007/bf01296004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01296004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021212834", 
          "https://doi.org/10.1007/bf01296004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1988.01400360029003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022351389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01577729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022448609", 
          "https://doi.org/10.1007/bf01577729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01577729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022448609", 
          "https://doi.org/10.1007/bf01577729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-198108000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024196548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-198108000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024196548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-198108000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024196548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(87)90261-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024819556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199507000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025681273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199507000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025681273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800810632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025796318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s1091-255x(01)80063-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026401271", 
          "https://doi.org/10.1016/s1091-255x(01)80063-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01070880", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028955789", 
          "https://doi.org/10.1007/bf01070880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01070880", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028955789", 
          "https://doi.org/10.1007/bf01070880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.70.12.3301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029015788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9610(05)80611-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029813044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198710000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029834093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198710000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029834093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-199511000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031700659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-199511000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031700659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9610(79)90276-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031805154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.1996.v110.pm8566578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033192182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.1996.v110.pm8566607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033306757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(95)92280-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035314475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(95)92280-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035314475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9610(88)80691-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036070141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1987.01400140067008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036932167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11605-006-0008-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037843012", 
          "https://doi.org/10.1007/s11605-006-0008-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9610(91)90355-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042030031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002689900065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043369051", 
          "https://doi.org/10.1007/s002689900065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01308298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043418464", 
          "https://doi.org/10.1007/bf01308298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01308298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043418464", 
          "https://doi.org/10.1007/bf01308298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(93)91027-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043579742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800801031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043639582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.33.8.1126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043873612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000018801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044638636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(86)90078-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044931845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199208000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046709697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199208000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046709697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-4804(91)90064-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046741284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199308000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048546245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199308000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048546245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1996.01430130059010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048712609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198806093182301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049053386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-200110000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049801290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-200110000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049801290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.13.10.784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050230086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(89)90381-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051675045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(89)90381-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051675045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/110241500750008772", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051698492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(86)90579-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051723515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2776(08)60802-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052472232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1986.01400020082010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053320352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/152.1.99", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059699503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-199811000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060209770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-199811000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060209770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-199811000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060209770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076270321", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02925994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077039410", 
          "https://doi.org/10.1007/bf02925994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077059368", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078434739", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079064344", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02924421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079091470", 
          "https://doi.org/10.1007/bf02924421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079455788", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.1988.254.5.g768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079588449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079677181", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079827456", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080685378", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081688580", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081750805", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081881199", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082018111", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082072842", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082369754", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0749-0704(18)30068-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082508038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082650403", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082773089", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.1993.265.1.g189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082788031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082800340", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.1993.264.1.g143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082803928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082824961", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082828516", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0749-0704(18)30196-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082829326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.1993.74.4.1515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082839821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.1993.74.4.1521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082839822"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-02", 
    "datePublishedReg": "2003-02-01", 
    "description": "Intestinal barrier failure and subsequent bacterial translocation have been implicated in the development of organ dysfunction and septic complications associated with severe acute pancreatitis. Splanchnic hypoperfusion and ischemia/reperfusion injury have been postulated as a cause of increased intestinal permeability. The urinary concentration of intestinal fatty acid binding protein (IFABP) has been shown to be a sensitive marker of intestinal ischemia, with increased levels being associated with ischemia/reperfusion. The aim of the current study was to assess the relationship between excretion of IFABP in urine, gut mucosal barrier failure (intestinal hyperpermeability and systemic exposure to endotoxemia), and clinical severity. Patients with a clinical and biochemical diagnosis of acute pancreatitis were studied within 72 hours of onset of pain. Polyethylene glycol probes of 3350 kDa and 400 kDa were administered enterally, and the ratio of the percentage of retrieval of each probe after renal excretion was used as a measure of intestinal macromolecular permeability. Collected urine was also used to determine the IFABP concentration (IFABP-c) and total IFABP (IFABP-t) excreted over the 24-hour period, using an enzyme-linked immunosorbent assay technique. The systemic inflammatory response was estimated from peak 0 to 72-hour plasma C-reactive protein levels, and systemic exposure to endotoxins was measured using serum IgM endotoxin cytoplasmic antibody (EndoCAb) levels. The severity of the attack was assessed on the basis of the Atlanta criteria. Sixty-one patients with acute pancreatitis (severe in 19) and 12 healthy control subjects were studied. Compared to mild attacks, severe attacks were associated with significantly higher urinary IFABP-c (median 1092 pg/ml vs. 84 pg/ml; P < 0.001) and IFABP-t (median 1.14 microg vs. 0.21 microg; P = 0.003). Furthermore, the control group had significantly lower IFABP-c (median 37 pg/ml; P = 0.029) and IFABP-t (median 0.06 microg; P = 0.005) than patients with mild attacks. IFABP correlated positively with the polyethylene glycol 3350 percentage retrieval (r = 0.50; P < 0.001), CRP (r = 0.51; P < 0.001), and inversely with serum IgM EndoCAb levels (r = -0.32; P = 0.02). The results of this study support the hypothesis that splanchnic hypoperfusion contributes to the loss of intestinal mucosal integrity associated with a severe attack of pancreatitis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1016/s1091-255x(02)00090-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1116755", 
        "issn": [
          "1091-255X", 
          "1873-4626"
        ], 
        "name": "Journal of Gastrointestinal Surgery", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Intestinal hypoperfusion contributes to gut barrier failure in severe acute pancreatitis", 
    "pagination": "26-36", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "51f9915b9c5c4d34a323fefc2b07684d54b37d024f6a70d626892e700eaaf241"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12559182"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9706084"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1016/s1091-255x(02)00090-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017205490"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1016/s1091-255x(02)00090-2", 
      "https://app.dimensions.ai/details/publication/pub.1017205490"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000369_0000000369/records_68984_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1016%2FS1091-255X%2802%2900090-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1016/s1091-255x(02)00090-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1016/s1091-255x(02)00090-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1016/s1091-255x(02)00090-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1016/s1091-255x(02)00090-2'


 

This table displays all metadata directly associated to this object as RDF triples.

465 TRIPLES      21 PREDICATES      145 URIs      45 LITERALS      33 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1016/s1091-255x(02)00090-2 schema:about N09c54f7023b04a47bc29291f7e435205
2 N1300044c724e4aba8cfe32a44b8bf1bf
3 N133698c65a724ed78cb97e1a6353c82f
4 N1d943cae8acb4812ac52ba8e786ada25
5 N207eb296b28c4136b41125f81d853448
6 N36b5d49b52cf4257b71c9228715c80d0
7 N38e4219e6488493c826e3642be1f9b86
8 N3a3eda0b966c467681d5ce9522253c94
9 N3a721e1e2b844657aa32afcb73dfeb5e
10 N429b1ddc63af485e838574e1ac5cdd55
11 N4c753311b5ab4d07b014136c9aa6f77b
12 N55c0de22d7d540ccae8799bba9542851
13 N7c68efcc9ada4f01a1398536bf6b0e70
14 N7daa63880f054cae9d2097dd4d76bac7
15 N8178291390094ca8bb79a8c176b2f3dc
16 N89114afd027c468dbeb60b19e2435888
17 N8cb92191204e45a6b0b5180700c4d712
18 N99862c275c754629a8a31e3f991ac944
19 Na039f87958a74a09b712c4b0118d2a6f
20 Na0b3eead1336430b9d5d3c135647314e
21 Nb400ec239a294e74a1dd2e0286f8f930
22 Nc839c8188ce84f56a450065987038af3
23 Nf83075a7f1bc4c55b54a10c49d71bb40
24 Nfd65063f2c4b4f7cb433e3d8072d8951
25 anzsrc-for:11
26 anzsrc-for:1103
27 schema:author Nf4521310a14f4abcbb79a29ab67a404c
28 schema:citation sg:pub.10.1007/bf01070880
29 sg:pub.10.1007/bf01296004
30 sg:pub.10.1007/bf01308298
31 sg:pub.10.1007/bf01577729
32 sg:pub.10.1007/bf01658676
33 sg:pub.10.1007/bf02924421
34 sg:pub.10.1007/bf02925994
35 sg:pub.10.1007/s002689900065
36 sg:pub.10.1007/s11605-006-0008-8
37 sg:pub.10.1016/s1091-255x(01)80063-9
38 sg:pub.10.1016/s1091-255x(99)80067-5
39 sg:pub.10.1385/ijgc:27:3:209
40 https://app.dimensions.ai/details/publication/pub.1076270321
41 https://app.dimensions.ai/details/publication/pub.1077059368
42 https://app.dimensions.ai/details/publication/pub.1078434739
43 https://app.dimensions.ai/details/publication/pub.1079064344
44 https://app.dimensions.ai/details/publication/pub.1079455788
45 https://app.dimensions.ai/details/publication/pub.1079677181
46 https://app.dimensions.ai/details/publication/pub.1079827456
47 https://app.dimensions.ai/details/publication/pub.1080685378
48 https://app.dimensions.ai/details/publication/pub.1081688580
49 https://app.dimensions.ai/details/publication/pub.1081750805
50 https://app.dimensions.ai/details/publication/pub.1081881199
51 https://app.dimensions.ai/details/publication/pub.1082018111
52 https://app.dimensions.ai/details/publication/pub.1082072842
53 https://app.dimensions.ai/details/publication/pub.1082369754
54 https://app.dimensions.ai/details/publication/pub.1082650403
55 https://app.dimensions.ai/details/publication/pub.1082773089
56 https://app.dimensions.ai/details/publication/pub.1082800340
57 https://app.dimensions.ai/details/publication/pub.1082824961
58 https://app.dimensions.ai/details/publication/pub.1082828516
59 https://doi.org/10.1001/archsurg.1986.01400020082010
60 https://doi.org/10.1001/archsurg.1987.01400140067008
61 https://doi.org/10.1001/archsurg.1988.01400360029003
62 https://doi.org/10.1001/archsurg.1993.01420170122019
63 https://doi.org/10.1001/archsurg.1996.01430130059010
64 https://doi.org/10.1002/bjs.1800800840
65 https://doi.org/10.1002/bjs.1800801031
66 https://doi.org/10.1002/bjs.1800810632
67 https://doi.org/10.1002/bjs.1800831113
68 https://doi.org/10.1002/jps.2600810412
69 https://doi.org/10.1016/0002-9610(64)90274-0
70 https://doi.org/10.1016/0002-9610(79)90276-9
71 https://doi.org/10.1016/0002-9610(83)90288-x
72 https://doi.org/10.1016/0002-9610(91)90355-h
73 https://doi.org/10.1016/0002-9610(92)90260-x
74 https://doi.org/10.1016/0016-5085(86)90078-8
75 https://doi.org/10.1016/0016-5085(86)90579-2
76 https://doi.org/10.1016/0016-5085(87)90261-7
77 https://doi.org/10.1016/0016-5085(92)91450-i
78 https://doi.org/10.1016/0016-5085(93)91027-f
79 https://doi.org/10.1016/0022-4804(91)90064-s
80 https://doi.org/10.1016/s0002-9610(05)80611-7
81 https://doi.org/10.1016/s0002-9610(88)80691-3
82 https://doi.org/10.1016/s0039-6109(16)40337-3
83 https://doi.org/10.1016/s0065-2776(08)60802-0
84 https://doi.org/10.1016/s0140-6736(89)90381-4
85 https://doi.org/10.1016/s0140-6736(95)92280-6
86 https://doi.org/10.1016/s0749-0704(18)30068-x
87 https://doi.org/10.1016/s0749-0704(18)30196-9
88 https://doi.org/10.1053/gast.1996.v110.pm8566578
89 https://doi.org/10.1053/gast.1996.v110.pm8566607
90 https://doi.org/10.1056/nejm198806093182301
91 https://doi.org/10.1073/pnas.70.12.3301
92 https://doi.org/10.1080/110241500750008772
93 https://doi.org/10.1093/infdis/152.1.99
94 https://doi.org/10.1097/00000658-198002000-00010
95 https://doi.org/10.1097/00000658-198606000-00004
96 https://doi.org/10.1097/00000658-198710000-00004
97 https://doi.org/10.1097/00000658-198804000-00004
98 https://doi.org/10.1097/00000658-199208000-00002
99 https://doi.org/10.1097/00000658-199308000-00001
100 https://doi.org/10.1097/00000658-199507000-00010
101 https://doi.org/10.1097/00003246-198108000-00008
102 https://doi.org/10.1097/00004630-198708060-00005
103 https://doi.org/10.1097/00005373-198505000-00002
104 https://doi.org/10.1097/00005373-198807000-00002
105 https://doi.org/10.1097/00005373-199811000-00011
106 https://doi.org/10.1097/00006676-199511000-00008
107 https://doi.org/10.1097/00006676-200110000-00011
108 https://doi.org/10.1136/gut.13.10.784
109 https://doi.org/10.1136/gut.23.8.656
110 https://doi.org/10.1136/gut.25.10.1065
111 https://doi.org/10.1136/gut.33.8.1126
112 https://doi.org/10.1136/gut.48.1.62
113 https://doi.org/10.1152/ajpgi.1988.254.5.g768
114 https://doi.org/10.1152/ajpgi.1993.264.1.g143
115 https://doi.org/10.1152/ajpgi.1993.265.1.g189
116 https://doi.org/10.1152/jappl.1993.74.4.1515
117 https://doi.org/10.1152/jappl.1993.74.4.1521
118 https://doi.org/10.1159/000018801
119 https://doi.org/10.1172/jci107768
120 schema:datePublished 2003-02
121 schema:datePublishedReg 2003-02-01
122 schema:description Intestinal barrier failure and subsequent bacterial translocation have been implicated in the development of organ dysfunction and septic complications associated with severe acute pancreatitis. Splanchnic hypoperfusion and ischemia/reperfusion injury have been postulated as a cause of increased intestinal permeability. The urinary concentration of intestinal fatty acid binding protein (IFABP) has been shown to be a sensitive marker of intestinal ischemia, with increased levels being associated with ischemia/reperfusion. The aim of the current study was to assess the relationship between excretion of IFABP in urine, gut mucosal barrier failure (intestinal hyperpermeability and systemic exposure to endotoxemia), and clinical severity. Patients with a clinical and biochemical diagnosis of acute pancreatitis were studied within 72 hours of onset of pain. Polyethylene glycol probes of 3350 kDa and 400 kDa were administered enterally, and the ratio of the percentage of retrieval of each probe after renal excretion was used as a measure of intestinal macromolecular permeability. Collected urine was also used to determine the IFABP concentration (IFABP-c) and total IFABP (IFABP-t) excreted over the 24-hour period, using an enzyme-linked immunosorbent assay technique. The systemic inflammatory response was estimated from peak 0 to 72-hour plasma C-reactive protein levels, and systemic exposure to endotoxins was measured using serum IgM endotoxin cytoplasmic antibody (EndoCAb) levels. The severity of the attack was assessed on the basis of the Atlanta criteria. Sixty-one patients with acute pancreatitis (severe in 19) and 12 healthy control subjects were studied. Compared to mild attacks, severe attacks were associated with significantly higher urinary IFABP-c (median 1092 pg/ml vs. 84 pg/ml; P < 0.001) and IFABP-t (median 1.14 microg vs. 0.21 microg; P = 0.003). Furthermore, the control group had significantly lower IFABP-c (median 37 pg/ml; P = 0.029) and IFABP-t (median 0.06 microg; P = 0.005) than patients with mild attacks. IFABP correlated positively with the polyethylene glycol 3350 percentage retrieval (r = 0.50; P < 0.001), CRP (r = 0.51; P < 0.001), and inversely with serum IgM EndoCAb levels (r = -0.32; P = 0.02). The results of this study support the hypothesis that splanchnic hypoperfusion contributes to the loss of intestinal mucosal integrity associated with a severe attack of pancreatitis.
123 schema:genre research_article
124 schema:inLanguage en
125 schema:isAccessibleForFree false
126 schema:isPartOf N4c8436220c2e49d5bf034c4f1a910bda
127 N790398671b2e48199a9c29ad9630f9fd
128 sg:journal.1116755
129 schema:name Intestinal hypoperfusion contributes to gut barrier failure in severe acute pancreatitis
130 schema:pagination 26-36
131 schema:productId N104634b4a0a94964b022f4a7f49c4d5f
132 N163dc45baba64d3a9f456f551b79c548
133 N3cd7c5f8191a405ab0a5e3d78366a9a4
134 N46e55a60e5c5403abddfadc4a858d99b
135 N9f344d7198744889b519c66b98c60ed5
136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017205490
137 https://doi.org/10.1016/s1091-255x(02)00090-2
138 schema:sdDatePublished 2019-04-11T13:25
139 schema:sdLicense https://scigraph.springernature.com/explorer/license/
140 schema:sdPublisher Na425b2828c1840d5b733e4a739f90967
141 schema:url https://link.springer.com/10.1016%2FS1091-255X%2802%2900090-2
142 sgo:license sg:explorer/license/
143 sgo:sdDataset articles
144 rdf:type schema:ScholarlyArticle
145 N09c54f7023b04a47bc29291f7e435205 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Carrier Proteins
147 rdf:type schema:DefinedTerm
148 N104634b4a0a94964b022f4a7f49c4d5f schema:name readcube_id
149 schema:value 51f9915b9c5c4d34a323fefc2b07684d54b37d024f6a70d626892e700eaaf241
150 rdf:type schema:PropertyValue
151 N1300044c724e4aba8cfe32a44b8bf1bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Tumor Suppressor Proteins
153 rdf:type schema:DefinedTerm
154 N133698c65a724ed78cb97e1a6353c82f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Aged
156 rdf:type schema:DefinedTerm
157 N163dc45baba64d3a9f456f551b79c548 schema:name doi
158 schema:value 10.1016/s1091-255x(02)00090-2
159 rdf:type schema:PropertyValue
160 N1756a8ca03724f6eaef9d3f44b8674ad rdf:first sg:person.01105610541.00
161 rdf:rest Na1a7c614105a420f8d0cd1a92546aab5
162 N1d943cae8acb4812ac52ba8e786ada25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Fatty Acid-Binding Proteins
164 rdf:type schema:DefinedTerm
165 N207eb296b28c4136b41125f81d853448 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Male
167 rdf:type schema:DefinedTerm
168 N36b5d49b52cf4257b71c9228715c80d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Endotoxins
170 rdf:type schema:DefinedTerm
171 N38e4219e6488493c826e3642be1f9b86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Biomarkers
173 rdf:type schema:DefinedTerm
174 N3a3eda0b966c467681d5ce9522253c94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Middle Aged
176 rdf:type schema:DefinedTerm
177 N3a721e1e2b844657aa32afcb73dfeb5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Multiple Organ Failure
179 rdf:type schema:DefinedTerm
180 N3cd7c5f8191a405ab0a5e3d78366a9a4 schema:name pubmed_id
181 schema:value 12559182
182 rdf:type schema:PropertyValue
183 N429b1ddc63af485e838574e1ac5cdd55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Adult
185 rdf:type schema:DefinedTerm
186 N46e55a60e5c5403abddfadc4a858d99b schema:name dimensions_id
187 schema:value pub.1017205490
188 rdf:type schema:PropertyValue
189 N4c753311b5ab4d07b014136c9aa6f77b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Fatty Acids
191 rdf:type schema:DefinedTerm
192 N4c8436220c2e49d5bf034c4f1a910bda schema:volumeNumber 7
193 rdf:type schema:PublicationVolume
194 N55c0de22d7d540ccae8799bba9542851 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Permeability
196 rdf:type schema:DefinedTerm
197 N790398671b2e48199a9c29ad9630f9fd schema:issueNumber 1
198 rdf:type schema:PublicationIssue
199 N7c68efcc9ada4f01a1398536bf6b0e70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Immunoglobulin M
201 rdf:type schema:DefinedTerm
202 N7daa63880f054cae9d2097dd4d76bac7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Pancreatitis
204 rdf:type schema:DefinedTerm
205 N8178291390094ca8bb79a8c176b2f3dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Acute Disease
207 rdf:type schema:DefinedTerm
208 N87ec98fce97a41a9b5c4710bfb3575b3 rdf:first sg:person.01162024754.63
209 rdf:rest N1756a8ca03724f6eaef9d3f44b8674ad
210 N89114afd027c468dbeb60b19e2435888 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Polyethylene Glycols
212 rdf:type schema:DefinedTerm
213 N8cb92191204e45a6b0b5180700c4d712 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Fatty Acid-Binding Protein 7
215 rdf:type schema:DefinedTerm
216 N99862c275c754629a8a31e3f991ac944 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Ischemia
218 rdf:type schema:DefinedTerm
219 N9f344d7198744889b519c66b98c60ed5 schema:name nlm_unique_id
220 schema:value 9706084
221 rdf:type schema:PropertyValue
222 Na039f87958a74a09b712c4b0118d2a6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Female
224 rdf:type schema:DefinedTerm
225 Na0b3eead1336430b9d5d3c135647314e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name C-Reactive Protein
227 rdf:type schema:DefinedTerm
228 Na1a7c614105a420f8d0cd1a92546aab5 rdf:first sg:person.01172416415.09
229 rdf:rest Na819bc8585ce471bb47226829967ab5d
230 Na425b2828c1840d5b733e4a739f90967 schema:name Springer Nature - SN SciGraph project
231 rdf:type schema:Organization
232 Na819bc8585ce471bb47226829967ab5d rdf:first sg:person.016016267262.02
233 rdf:rest rdf:nil
234 Nb400ec239a294e74a1dd2e0286f8f930 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
235 schema:name Enzyme-Linked Immunosorbent Assay
236 rdf:type schema:DefinedTerm
237 Nc839c8188ce84f56a450065987038af3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
238 schema:name Humans
239 rdf:type schema:DefinedTerm
240 Nf4521310a14f4abcbb79a29ab67a404c rdf:first sg:person.01225073042.22
241 rdf:rest N87ec98fce97a41a9b5c4710bfb3575b3
242 Nf83075a7f1bc4c55b54a10c49d71bb40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
243 schema:name Neoplasm Proteins
244 rdf:type schema:DefinedTerm
245 Nfd65063f2c4b4f7cb433e3d8072d8951 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
246 schema:name Intestines
247 rdf:type schema:DefinedTerm
248 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
249 schema:name Medical and Health Sciences
250 rdf:type schema:DefinedTerm
251 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
252 schema:name Clinical Sciences
253 rdf:type schema:DefinedTerm
254 sg:journal.1116755 schema:issn 1091-255X
255 1873-4626
256 schema:name Journal of Gastrointestinal Surgery
257 rdf:type schema:Periodical
258 sg:person.01105610541.00 schema:affiliation https://www.grid.ac/institutes/grid.418161.b
259 schema:familyName Holmfield
260 schema:givenName John
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105610541.00
262 rdf:type schema:Person
263 sg:person.01162024754.63 schema:affiliation https://www.grid.ac/institutes/grid.418161.b
264 schema:familyName Ammori
265 schema:givenName Basil J.
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162024754.63
267 rdf:type schema:Person
268 sg:person.01172416415.09 schema:affiliation https://www.grid.ac/institutes/grid.4563.4
269 schema:familyName Larvin
270 schema:givenName Michael
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172416415.09
272 rdf:type schema:Person
273 sg:person.01225073042.22 schema:affiliation https://www.grid.ac/institutes/grid.418161.b
274 schema:familyName Rahman
275 schema:givenName Sakhawat H.
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225073042.22
277 rdf:type schema:Person
278 sg:person.016016267262.02 schema:affiliation https://www.grid.ac/institutes/grid.418161.b
279 schema:familyName McMahon
280 schema:givenName Michael J.
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016016267262.02
282 rdf:type schema:Person
283 sg:pub.10.1007/bf01070880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028955789
284 https://doi.org/10.1007/bf01070880
285 rdf:type schema:CreativeWork
286 sg:pub.10.1007/bf01296004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021212834
287 https://doi.org/10.1007/bf01296004
288 rdf:type schema:CreativeWork
289 sg:pub.10.1007/bf01308298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043418464
290 https://doi.org/10.1007/bf01308298
291 rdf:type schema:CreativeWork
292 sg:pub.10.1007/bf01577729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022448609
293 https://doi.org/10.1007/bf01577729
294 rdf:type schema:CreativeWork
295 sg:pub.10.1007/bf01658676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010708233
296 https://doi.org/10.1007/bf01658676
297 rdf:type schema:CreativeWork
298 sg:pub.10.1007/bf02924421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079091470
299 https://doi.org/10.1007/bf02924421
300 rdf:type schema:CreativeWork
301 sg:pub.10.1007/bf02925994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077039410
302 https://doi.org/10.1007/bf02925994
303 rdf:type schema:CreativeWork
304 sg:pub.10.1007/s002689900065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043369051
305 https://doi.org/10.1007/s002689900065
306 rdf:type schema:CreativeWork
307 sg:pub.10.1007/s11605-006-0008-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037843012
308 https://doi.org/10.1007/s11605-006-0008-8
309 rdf:type schema:CreativeWork
310 sg:pub.10.1016/s1091-255x(01)80063-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026401271
311 https://doi.org/10.1016/s1091-255x(01)80063-9
312 rdf:type schema:CreativeWork
313 sg:pub.10.1016/s1091-255x(99)80067-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000200535
314 https://doi.org/10.1016/s1091-255x(99)80067-5
315 rdf:type schema:CreativeWork
316 sg:pub.10.1385/ijgc:27:3:209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007493942
317 https://doi.org/10.1385/ijgc:27:3:209
318 rdf:type schema:CreativeWork
319 https://app.dimensions.ai/details/publication/pub.1076270321 schema:CreativeWork
320 https://app.dimensions.ai/details/publication/pub.1077059368 schema:CreativeWork
321 https://app.dimensions.ai/details/publication/pub.1078434739 schema:CreativeWork
322 https://app.dimensions.ai/details/publication/pub.1079064344 schema:CreativeWork
323 https://app.dimensions.ai/details/publication/pub.1079455788 schema:CreativeWork
324 https://app.dimensions.ai/details/publication/pub.1079677181 schema:CreativeWork
325 https://app.dimensions.ai/details/publication/pub.1079827456 schema:CreativeWork
326 https://app.dimensions.ai/details/publication/pub.1080685378 schema:CreativeWork
327 https://app.dimensions.ai/details/publication/pub.1081688580 schema:CreativeWork
328 https://app.dimensions.ai/details/publication/pub.1081750805 schema:CreativeWork
329 https://app.dimensions.ai/details/publication/pub.1081881199 schema:CreativeWork
330 https://app.dimensions.ai/details/publication/pub.1082018111 schema:CreativeWork
331 https://app.dimensions.ai/details/publication/pub.1082072842 schema:CreativeWork
332 https://app.dimensions.ai/details/publication/pub.1082369754 schema:CreativeWork
333 https://app.dimensions.ai/details/publication/pub.1082650403 schema:CreativeWork
334 https://app.dimensions.ai/details/publication/pub.1082773089 schema:CreativeWork
335 https://app.dimensions.ai/details/publication/pub.1082800340 schema:CreativeWork
336 https://app.dimensions.ai/details/publication/pub.1082824961 schema:CreativeWork
337 https://app.dimensions.ai/details/publication/pub.1082828516 schema:CreativeWork
338 https://doi.org/10.1001/archsurg.1986.01400020082010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053320352
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1001/archsurg.1987.01400140067008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036932167
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1001/archsurg.1988.01400360029003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022351389
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1001/archsurg.1993.01420170122019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015767287
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1001/archsurg.1996.01430130059010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048712609
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1002/bjs.1800800840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007273870
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1002/bjs.1800801031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043639582
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1002/bjs.1800810632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025796318
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1002/bjs.1800831113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014104306
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1002/jps.2600810412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013071734
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1016/0002-9610(64)90274-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017889186
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1016/0002-9610(79)90276-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031805154
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1016/0002-9610(83)90288-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010931385
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1016/0002-9610(91)90355-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1042030031
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1016/0002-9610(92)90260-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008786338
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1016/0016-5085(86)90078-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044931845
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1016/0016-5085(86)90579-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051723515
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1016/0016-5085(87)90261-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024819556
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1016/0016-5085(92)91450-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1000565714
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1016/0016-5085(93)91027-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1043579742
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1016/0022-4804(91)90064-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1046741284
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1016/s0002-9610(05)80611-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029813044
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1016/s0002-9610(88)80691-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036070141
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1016/s0039-6109(16)40337-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017652406
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1016/s0065-2776(08)60802-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052472232
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1016/s0140-6736(89)90381-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051675045
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1016/s0140-6736(95)92280-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035314475
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1016/s0749-0704(18)30068-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082508038
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1016/s0749-0704(18)30196-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082829326
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1053/gast.1996.v110.pm8566578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033192182
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1053/gast.1996.v110.pm8566607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033306757
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1056/nejm198806093182301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049053386
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1073/pnas.70.12.3301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029015788
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1080/110241500750008772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051698492
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1093/infdis/152.1.99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059699503
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1097/00000658-198002000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012922470
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1097/00000658-198606000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008654558
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1097/00000658-198710000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029834093
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1097/00000658-198804000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013763691
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1097/00000658-199208000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046709697
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1097/00000658-199308000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048546245
419 rdf:type schema:CreativeWork
420 https://doi.org/10.1097/00000658-199507000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025681273
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1097/00003246-198108000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024196548
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1097/00004630-198708060-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004146643
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1097/00005373-198505000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018013926
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1097/00005373-198807000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017891788
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1097/00005373-199811000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060209770
431 rdf:type schema:CreativeWork
432 https://doi.org/10.1097/00006676-199511000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031700659
433 rdf:type schema:CreativeWork
434 https://doi.org/10.1097/00006676-200110000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049801290
435 rdf:type schema:CreativeWork
436 https://doi.org/10.1136/gut.13.10.784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050230086
437 rdf:type schema:CreativeWork
438 https://doi.org/10.1136/gut.23.8.656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001801723
439 rdf:type schema:CreativeWork
440 https://doi.org/10.1136/gut.25.10.1065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020370047
441 rdf:type schema:CreativeWork
442 https://doi.org/10.1136/gut.33.8.1126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043873612
443 rdf:type schema:CreativeWork
444 https://doi.org/10.1136/gut.48.1.62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017547594
445 rdf:type schema:CreativeWork
446 https://doi.org/10.1152/ajpgi.1988.254.5.g768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079588449
447 rdf:type schema:CreativeWork
448 https://doi.org/10.1152/ajpgi.1993.264.1.g143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082803928
449 rdf:type schema:CreativeWork
450 https://doi.org/10.1152/ajpgi.1993.265.1.g189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082788031
451 rdf:type schema:CreativeWork
452 https://doi.org/10.1152/jappl.1993.74.4.1515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082839821
453 rdf:type schema:CreativeWork
454 https://doi.org/10.1152/jappl.1993.74.4.1521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082839822
455 rdf:type schema:CreativeWork
456 https://doi.org/10.1159/000018801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044638636
457 rdf:type schema:CreativeWork
458 https://doi.org/10.1172/jci107768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004011413
459 rdf:type schema:CreativeWork
460 https://www.grid.ac/institutes/grid.418161.b schema:alternateName Leeds General Infirmary
461 schema:name Academic Department of Surgery, The General Infirmary at Leeds, Leeds
462 rdf:type schema:Organization
463 https://www.grid.ac/institutes/grid.4563.4 schema:alternateName University of Nottingham
464 schema:name Postgraduate Medical School, University of Nottingham, Derby, UK
465 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...