Ontology type: schema:ScholarlyArticle
2002-06
AUTHORSChristopher D. Roman, Jason Morrow, Robert Whitehead, R. Daniel Beauchamp
ABSTRACTCyclooxygenase-2 (COX-2) expression appears to be important in colorectal carcinogenesis. Elevated COX-2 expression and activity have been observed in several different transformed cell types. Prior studies implicating involvement of the Ras oncogene and growth factors on COX-2 expression were largely derived from rat small intestinal cell lines. We have investigated whether mouse colonocyte COX-2 levels are regulated by oncogenic Ras or transforming growth factor-beta(1) (TGF-beta(1)), and whether these factors also serve to regulate cellular invasiveness. Young adult mouse colonocyte cells are colonocytes derived from the "Immortomouse" and immortalized by the SV40 large T antigen. Young adult mouse colonocyte Ras cells were derived by transfection of young adult mouse colonocyte cells with oncogenic Ha-Ras and are known to be tumorigenic. We found that the induction of COX-2 and eicosanoid release were augmented in the presence of activated Ras and that TGF-beta(1) caused a further increase in COX-2 in the Ras-transformed mouse colonocytes. Increased COX-2 expression was correlated with increased release of prostaglandins E(2) and I(2). Activated Ras and TGF-beta increased the invasiveness of the young adult mouse colonocyte cells, but treatment with a COX-2 inhibitor did not inhibit invasiveness. Thus we found that transforming growth factor-beta collaborates to increase COX-2 expression, protaglandin release, and invasiveness in mouse colonocytes, but the increased COX-2 activity does not appear to contribute to the invasive response. More... »
PAGES304-309
http://scigraph.springernature.com/pub.10.1016/s1091-255x(01)00041-5
DOIhttp://dx.doi.org/10.1016/s1091-255x(01)00041-5
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1012897162
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/12022979
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cells, Cultured",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Colon",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Colorectal Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cyclooxygenase 2",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Regulation, Neoplastic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Isoenzymes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oncogene Protein p21(ras)",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prostaglandin-Endoperoxide Synthases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transforming Growth Factor beta",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transforming Growth Factor beta1",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Vanderbilt University Medical Center",
"id": "https://www.grid.ac/institutes/grid.412807.8",
"name": [
"Department of Surgery, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee"
],
"type": "Organization"
},
"familyName": "Roman",
"givenName": "Christopher D.",
"id": "sg:person.0730045433.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730045433.11"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vanderbilt University Medical Center",
"id": "https://www.grid.ac/institutes/grid.412807.8",
"name": [
"Department of Medicine, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee"
],
"type": "Organization"
},
"familyName": "Morrow",
"givenName": "Jason",
"id": "sg:person.01276263512.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276263512.00"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vanderbilt University Medical Center",
"id": "https://www.grid.ac/institutes/grid.412807.8",
"name": [
"Department of Medicine, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee"
],
"type": "Organization"
},
"familyName": "Whitehead",
"givenName": "Robert",
"id": "sg:person.01321265157.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321265157.11"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vanderbilt University Medical Center",
"id": "https://www.grid.ac/institutes/grid.412807.8",
"name": [
"Department of Surgery, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee",
"Department of Cell Biology, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee"
],
"type": "Organization"
},
"familyName": "Beauchamp",
"givenName": "R. Daniel",
"id": "sg:person.01355254152.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355254152.34"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1101/gad.10.19.2462",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001793958"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.273.16.9921",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002914814"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj3210677",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006410757"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj3210677",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006410757"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0016-5085(91)90519-q",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006519488"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0092-8674(95)90127-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007200098"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.273.34.22120",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009897151"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.biochem.67.1.753",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011423022"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.274.41.29138",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011684068"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1202397",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011970400",
"https://doi.org/10.1038/sj.onc.1202397"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1202397",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011970400",
"https://doi.org/10.1038/sj.onc.1202397"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.90.2.587",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013548465"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00006676-199007000-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016198823"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00006676-199007000-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016198823"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.270.46.27622",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019132773"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm199305063281805",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020972146"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.275.9.6628",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020980550"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci119400",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023711478"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0014-4827(89)90101-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024450034"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/sj.neo.7900051",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025399328"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/327298a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026973030",
"https://doi.org/10.1038/327298a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00001574-199612010-00004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033822085"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00001574-199612010-00004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033822085"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0092-8674(00)81433-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034592591"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-9822(07)00533-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035083502"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/327293a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035638144",
"https://doi.org/10.1038/327293a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.270.30.18123",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036826615"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.272.23.14501",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037067236"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcp.1041590110",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037654970"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm199112053252301",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038254600"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.94.7.3336",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038658027"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.273.49.32943",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039257107"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm199509073331001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041145010"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.271.49.31742",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041904327"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/bjs.1800801244",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042686895"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/carcin/17.5.989",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043278531"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archinte.159.2.161",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043564508"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.129.3.853",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047833392"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0092-8674(00)81988-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048354178"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1357-4310(98)01247-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050710871"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.7291992",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062645247"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1096/fasebj.13.15.2186",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074561292"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075479334",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082212741",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082408642",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082507705",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082569670",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082818381",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082853952",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082886166",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083070925",
"type": "CreativeWork"
}
],
"datePublished": "2002-06",
"datePublishedReg": "2002-06-01",
"description": "Cyclooxygenase-2 (COX-2) expression appears to be important in colorectal carcinogenesis. Elevated COX-2 expression and activity have been observed in several different transformed cell types. Prior studies implicating involvement of the Ras oncogene and growth factors on COX-2 expression were largely derived from rat small intestinal cell lines. We have investigated whether mouse colonocyte COX-2 levels are regulated by oncogenic Ras or transforming growth factor-beta(1) (TGF-beta(1)), and whether these factors also serve to regulate cellular invasiveness. Young adult mouse colonocyte cells are colonocytes derived from the \"Immortomouse\" and immortalized by the SV40 large T antigen. Young adult mouse colonocyte Ras cells were derived by transfection of young adult mouse colonocyte cells with oncogenic Ha-Ras and are known to be tumorigenic. We found that the induction of COX-2 and eicosanoid release were augmented in the presence of activated Ras and that TGF-beta(1) caused a further increase in COX-2 in the Ras-transformed mouse colonocytes. Increased COX-2 expression was correlated with increased release of prostaglandins E(2) and I(2). Activated Ras and TGF-beta increased the invasiveness of the young adult mouse colonocyte cells, but treatment with a COX-2 inhibitor did not inhibit invasiveness. Thus we found that transforming growth factor-beta collaborates to increase COX-2 expression, protaglandin release, and invasiveness in mouse colonocytes, but the increased COX-2 activity does not appear to contribute to the invasive response.",
"genre": "research_article",
"id": "sg:pub.10.1016/s1091-255x(01)00041-5",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.2472568",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2435709",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2495856",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1116755",
"issn": [
"1091-255X",
"1873-4626"
],
"name": "Journal of Gastrointestinal Surgery",
"type": "Periodical"
},
{
"issueNumber": "3",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "6"
}
],
"name": "Induction of cyclooxygenase-2 and invasiveness by transforming growth factor-\u03b21 in immortalized mouse colonocytes expressing oncogenic ras",
"pagination": "304-309",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"3d70e9cb582bc00f80d1e005b1036e063704cdbfe5e68bf372118113c369ef5d"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"12022979"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9706084"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1016/s1091-255x(01)00041-5"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1012897162"
]
}
],
"sameAs": [
"https://doi.org/10.1016/s1091-255x(01)00041-5",
"https://app.dimensions.ai/details/publication/pub.1012897162"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T14:57",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000499.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1016/S1091-255X(01)00041-5"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1016/s1091-255x(01)00041-5'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1016/s1091-255x(01)00041-5'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1016/s1091-255x(01)00041-5'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1016/s1091-255x(01)00041-5'
This table displays all metadata directly associated to this object as RDF triples.
281 TRIPLES
21 PREDICATES
88 URIs
33 LITERALS
21 BLANK NODES