Role of insulin resistance in heart and skeletal muscle F-18 fluorodeoxyglucose uptake in patients with noninsulin-dependent diabetes mellitus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-05

AUTHORS

Ikuo Yokoyama, Katsunori Yonekura, Tohru Ohtake, Hidehiro Kawamura, Akihiro Matsumoto, Yusuke Inoue, Teruhiko Aoyagi, Seiryo Sugiura, Masao Omata, Kuni Ohtomo, Ryozo Nagai

ABSTRACT

BackgroundAltered heart and skeletal glucose usage has been reported in patients with non-insulin-dependent diabetes mellitus (NIDDM). Although elevations in plasma free fatty acid (FFA) concentrations have been implicated in reduced myocardial 18fluorine-fluoro-2-deoxy-d-glucose uptake (MFU), the specific role of whole-body insulin resistance in MFU in patients with NIDDM compared with skeletal muscle metabolism remains controversial.PurposeMFU and skeletal muscle 18fluorine-fluoro-2-deoxy-d-glucose uptake (SMFU) were compared with positron emission tomography and the whole-body glucose disposal rate (GDR) during hyperinsulinemic euglycemic clamping in 26 normotensive asymptomatic patients with NIDDM who were not taking medication. These factors were also compared in 12 age-matched control subjects to increase the knowledge of the influence of whole-body insulin resistance on MFU. In addition, independent factors for both SMFU and MFU were investigated.ResultsGDR in control subjects (10.0±2.97 mg/min per kilogram) was significantly higher than in patients with NIDDM (4.05±2.37 mg/min per kilogram, P<.01). SMFU in patients with NIDDM (0.826 +-0.604 mg/min per 100g) was significantly lower than that in control subjects (1.86±1.06 mg/min per 100g, P<.01). MFU in patients with NIDDM (5.35±2.10 mg/min per 100 g) was also significantly lower than that of control subjects (7.05±1.66 mg/min per 100 g, P =.0182). SMFU significantly correlated with GDR (r=.727, P<.01) and FFA (r=-.52, P <.01) in patients with NIDDM. MFU also correlated with GDR (r=.778, P<.01) and FFA (r=-.72, P<.01) in patients with NIDDM. Multivariate stepwise regression analysis showed that GDR (F=36.8) was independently related to MFU (r=.85, P<.01) whereas FFA was not (F=1.763), where F is the value for statistical analysis of multivariate stepwise regression analysis.ConclusionInsulin resistance is the most essential factor for both heart and skeletal muscle FDG uptake in patients with NIDDM. More... »

PAGES

242-248

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/s1071-3581(00)70013-4

DOI

http://dx.doi.org/10.1016/s1071-3581(00)70013-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050735883

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10888395


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acids, Nonesterified", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorodeoxyglucose F18", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Skeletal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, Emission-Computed", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yokoyama", 
        "givenName": "Ikuo", 
        "id": "sg:person.01355412055.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355412055.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yonekura", 
        "givenName": "Katsunori", 
        "id": "sg:person.0746234355.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746234355.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Radiology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohtake", 
        "givenName": "Tohru", 
        "id": "sg:person.01253520654.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253520654.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawamura", 
        "givenName": "Hidehiro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsumoto", 
        "givenName": "Akihiro", 
        "id": "sg:person.01235416167.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235416167.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Radiology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inoue", 
        "givenName": "Yusuke", 
        "id": "sg:person.010476276272.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010476276272.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aoyagi", 
        "givenName": "Teruhiko", 
        "id": "sg:person.010646460075.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010646460075.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugiura", 
        "givenName": "Seiryo", 
        "id": "sg:person.01277502614.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277502614.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Gastroenterology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Omata", 
        "givenName": "Masao", 
        "id": "sg:person.0775700471.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775700471.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Radiology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohtomo", 
        "givenName": "Kuni", 
        "id": "sg:person.01152022531.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152022531.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagai", 
        "givenName": "Ryozo", 
        "id": "sg:person.0772176333.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772176333.38"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00275270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033854319", 
          "https://doi.org/10.1007/bf00275270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s1071-3581(97)90061-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023219716", 
          "https://doi.org/10.1016/s1071-3581(97)90061-1"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-05", 
    "datePublishedReg": "2000-05-01", 
    "description": "BackgroundAltered heart and skeletal glucose usage has been reported in patients with non-insulin-dependent diabetes mellitus (NIDDM). Although elevations in plasma free fatty acid (FFA) concentrations have been implicated in reduced myocardial 18fluorine-fluoro-2-deoxy-d-glucose uptake (MFU), the specific role of whole-body insulin resistance in MFU in patients with NIDDM compared with skeletal muscle metabolism remains controversial.PurposeMFU and skeletal muscle 18fluorine-fluoro-2-deoxy-d-glucose uptake (SMFU) were compared with positron emission tomography and the whole-body glucose disposal rate (GDR) during hyperinsulinemic euglycemic clamping in 26 normotensive asymptomatic patients with NIDDM who were not taking medication. These factors were also compared in 12 age-matched control subjects to increase the knowledge of the influence of whole-body insulin resistance on MFU. In addition, independent factors for both SMFU and MFU were investigated.ResultsGDR in control subjects (10.0\u00b12.97 mg/min per kilogram) was significantly higher than in patients with NIDDM (4.05\u00b12.37 mg/min per kilogram, P<.01). SMFU in patients with NIDDM (0.826 +-0.604 mg/min per 100g) was significantly lower than that in control subjects (1.86\u00b11.06 mg/min per 100g, P<.01). MFU in patients with NIDDM (5.35\u00b12.10 mg/min per 100 g) was also significantly lower than that of control subjects (7.05\u00b11.66 mg/min per 100 g, P =.0182). SMFU significantly correlated with GDR (r=.727, P<.01) and FFA (r=-.52, P <.01) in patients with NIDDM. MFU also correlated with GDR (r=.778, P<.01) and FFA (r=-.72, P<.01) in patients with NIDDM. Multivariate stepwise regression analysis showed that GDR (F=36.8) was independently related to MFU (r=.85, P<.01) whereas FFA was not (F=1.763), where F is the value for statistical analysis of multivariate stepwise regression analysis.ConclusionInsulin resistance is the most essential factor for both heart and skeletal muscle FDG uptake in patients with NIDDM.", 
    "genre": "article", 
    "id": "sg:pub.10.1016/s1071-3581(00)70013-4", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1106202", 
        "issn": [
          "1071-3581", 
          "1532-6551"
        ], 
        "name": "Journal of Nuclear Cardiology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "keywords": [
      "glucose disposal rate", 
      "whole-body insulin resistance", 
      "multivariate stepwise regression analysis", 
      "control subjects", 
      "insulin resistance", 
      "diabetes mellitus", 
      "noninsulin-dependent diabetes mellitus", 
      "age-matched control subjects", 
      "skeletal muscle FDG uptake", 
      "whole-body glucose disposal rate", 
      "stepwise regression analysis", 
      "plasma free fatty acid concentrations", 
      "glucose uptake", 
      "muscle FDG uptake", 
      "dependent diabetes mellitus", 
      "free fatty acid concentrations", 
      "skeletal muscle metabolism", 
      "regression analysis", 
      "positron emission tomography", 
      "hyperinsulinemic euglycemic", 
      "ConclusionInsulin resistance", 
      "asymptomatic patients", 
      "FDG uptake", 
      "NIDDM", 
      "independent factors", 
      "patients", 
      "disposal rate", 
      "muscle metabolism", 
      "emission tomography", 
      "glucose usage", 
      "fatty acid concentrations", 
      "mellitus", 
      "MFU", 
      "heart", 
      "subjects", 
      "FFA", 
      "specific role", 
      "uptake", 
      "medications", 
      "euglycemic", 
      "factors", 
      "statistical analysis", 
      "acid concentration", 
      "F-18", 
      "tomography", 
      "resistance", 
      "role", 
      "elevation", 
      "metabolism", 
      "essential factor", 
      "analysis", 
      "rate", 
      "concentration", 
      "addition", 
      "knowledge", 
      "values", 
      "influence", 
      "usage", 
      "BackgroundAltered heart", 
      "skeletal glucose usage", 
      "PurposeMFU", 
      "skeletal muscle 18fluorine", 
      "muscle 18fluorine", 
      "normotensive asymptomatic patients", 
      "SMFU", 
      "ResultsGDR", 
      "skeletal muscle F-18", 
      "muscle F-18"
    ], 
    "name": "Role of insulin resistance in heart and skeletal muscle F-18 fluorodeoxyglucose uptake in patients with noninsulin-dependent diabetes mellitus", 
    "pagination": "242-248", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1050735883"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1016/s1071-3581(00)70013-4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10888395"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1016/s1071-3581(00)70013-4", 
      "https://app.dimensions.ai/details/publication/pub.1050735883"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:13", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_335.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1016/s1071-3581(00)70013-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1016/s1071-3581(00)70013-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1016/s1071-3581(00)70013-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1016/s1071-3581(00)70013-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1016/s1071-3581(00)70013-4'


 

This table displays all metadata directly associated to this object as RDF triples.

267 TRIPLES      22 PREDICATES      111 URIs      101 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1016/s1071-3581(00)70013-4 schema:about N058ddcafa0ab4817b7be508b9fa4472b
2 N1d8e108900dd49308d968592b287bca0
3 N20bb1a72b48a46a7bba5e318f39cc7b6
4 N2c29ebfee29f4083a86abf1fbd89029b
5 N2d60c87e5ad847eeb1a644735e94a257
6 N2eba4f67c5fc47f8b553d68bc02a87ec
7 N9675f8417c0447c9baaeade5ca2bcc7a
8 Na4af6c4057ef4cec905954e2324af300
9 Nb455a57eb38744e8a9d7344a855c3748
10 Nc1d6ba88be784d77b1a565231b78bf9b
11 Ncf18d177521547cf94d44feefbb2fd10
12 Nebbbe0fe5d14487d80c83c75158f0a41
13 Neced02d6937b476b8407bf9bd782385e
14 Nf894c493cff44ccaa8397d48411afd29
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N240403599600464eaae4ca10a968a374
18 schema:citation sg:pub.10.1007/bf00275270
19 sg:pub.10.1016/s1071-3581(97)90061-1
20 schema:datePublished 2000-05
21 schema:datePublishedReg 2000-05-01
22 schema:description BackgroundAltered heart and skeletal glucose usage has been reported in patients with non-insulin-dependent diabetes mellitus (NIDDM). Although elevations in plasma free fatty acid (FFA) concentrations have been implicated in reduced myocardial 18fluorine-fluoro-2-deoxy-d-glucose uptake (MFU), the specific role of whole-body insulin resistance in MFU in patients with NIDDM compared with skeletal muscle metabolism remains controversial.PurposeMFU and skeletal muscle 18fluorine-fluoro-2-deoxy-d-glucose uptake (SMFU) were compared with positron emission tomography and the whole-body glucose disposal rate (GDR) during hyperinsulinemic euglycemic clamping in 26 normotensive asymptomatic patients with NIDDM who were not taking medication. These factors were also compared in 12 age-matched control subjects to increase the knowledge of the influence of whole-body insulin resistance on MFU. In addition, independent factors for both SMFU and MFU were investigated.ResultsGDR in control subjects (10.0±2.97 mg/min per kilogram) was significantly higher than in patients with NIDDM (4.05±2.37 mg/min per kilogram, P<.01). SMFU in patients with NIDDM (0.826 +-0.604 mg/min per 100g) was significantly lower than that in control subjects (1.86±1.06 mg/min per 100g, P<.01). MFU in patients with NIDDM (5.35±2.10 mg/min per 100 g) was also significantly lower than that of control subjects (7.05±1.66 mg/min per 100 g, P =.0182). SMFU significantly correlated with GDR (r=.727, P<.01) and FFA (r=-.52, P <.01) in patients with NIDDM. MFU also correlated with GDR (r=.778, P<.01) and FFA (r=-.72, P<.01) in patients with NIDDM. Multivariate stepwise regression analysis showed that GDR (F=36.8) was independently related to MFU (r=.85, P<.01) whereas FFA was not (F=1.763), where F is the value for statistical analysis of multivariate stepwise regression analysis.ConclusionInsulin resistance is the most essential factor for both heart and skeletal muscle FDG uptake in patients with NIDDM.
23 schema:genre article
24 schema:inLanguage en
25 schema:isAccessibleForFree false
26 schema:isPartOf N996e6ceac7fa41fc919896880777998d
27 Nd8e6ee85d9fa4b0788edd83f15caedbe
28 sg:journal.1106202
29 schema:keywords BackgroundAltered heart
30 ConclusionInsulin resistance
31 F-18
32 FDG uptake
33 FFA
34 MFU
35 NIDDM
36 PurposeMFU
37 ResultsGDR
38 SMFU
39 acid concentration
40 addition
41 age-matched control subjects
42 analysis
43 asymptomatic patients
44 concentration
45 control subjects
46 dependent diabetes mellitus
47 diabetes mellitus
48 disposal rate
49 elevation
50 emission tomography
51 essential factor
52 euglycemic
53 factors
54 fatty acid concentrations
55 free fatty acid concentrations
56 glucose disposal rate
57 glucose uptake
58 glucose usage
59 heart
60 hyperinsulinemic euglycemic
61 independent factors
62 influence
63 insulin resistance
64 knowledge
65 medications
66 mellitus
67 metabolism
68 multivariate stepwise regression analysis
69 muscle 18fluorine
70 muscle F-18
71 muscle FDG uptake
72 muscle metabolism
73 noninsulin-dependent diabetes mellitus
74 normotensive asymptomatic patients
75 patients
76 plasma free fatty acid concentrations
77 positron emission tomography
78 rate
79 regression analysis
80 resistance
81 role
82 skeletal glucose usage
83 skeletal muscle 18fluorine
84 skeletal muscle F-18
85 skeletal muscle FDG uptake
86 skeletal muscle metabolism
87 specific role
88 statistical analysis
89 stepwise regression analysis
90 subjects
91 tomography
92 uptake
93 usage
94 values
95 whole-body glucose disposal rate
96 whole-body insulin resistance
97 schema:name Role of insulin resistance in heart and skeletal muscle F-18 fluorodeoxyglucose uptake in patients with noninsulin-dependent diabetes mellitus
98 schema:pagination 242-248
99 schema:productId N5d2f8e1c8ec54ddaa10302e68e419e21
100 N7d9f462195064c89b60fa4e0354c0573
101 Nb07f180d706d44fb8f61e0b744ef61f5
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050735883
103 https://doi.org/10.1016/s1071-3581(00)70013-4
104 schema:sdDatePublished 2021-12-01T19:13
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher N469a3bdd97654992b83d6eb8a8fff02d
107 schema:url https://doi.org/10.1016/s1071-3581(00)70013-4
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N003e9b996b7d46699bfe8a3275330be6 rdf:first sg:person.01253520654.94
112 rdf:rest N5d24856c01bd4d2e82810837333ceb15
113 N058ddcafa0ab4817b7be508b9fa4472b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Adult
115 rdf:type schema:DefinedTerm
116 N1d8e108900dd49308d968592b287bca0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Aged
118 rdf:type schema:DefinedTerm
119 N20bb1a72b48a46a7bba5e318f39cc7b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Fatty Acids, Nonesterified
121 rdf:type schema:DefinedTerm
122 N240403599600464eaae4ca10a968a374 rdf:first sg:person.01355412055.69
123 rdf:rest Ne96a82a843d94ce3be4cc6864d0f994a
124 N2c29ebfee29f4083a86abf1fbd89029b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Muscle, Skeletal
126 rdf:type schema:DefinedTerm
127 N2d60c87e5ad847eeb1a644735e94a257 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Female
129 rdf:type schema:DefinedTerm
130 N2eba4f67c5fc47f8b553d68bc02a87ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Insulin Resistance
132 rdf:type schema:DefinedTerm
133 N3d134ee09daf441394e352d8a7b59b75 rdf:first sg:person.01152022531.08
134 rdf:rest Ne31f5f1ac9274447846bc1b9924f41c9
135 N469a3bdd97654992b83d6eb8a8fff02d schema:name Springer Nature - SN SciGraph project
136 rdf:type schema:Organization
137 N5062ad76f08d496d947b8f0161d19487 rdf:first sg:person.0775700471.08
138 rdf:rest N3d134ee09daf441394e352d8a7b59b75
139 N5d24856c01bd4d2e82810837333ceb15 rdf:first Nf2a8c002bb7f438b83f7973e9dc73ce8
140 rdf:rest N65a8f37e7c724c4e9f94c81800282cc4
141 N5d2f8e1c8ec54ddaa10302e68e419e21 schema:name pubmed_id
142 schema:value 10888395
143 rdf:type schema:PropertyValue
144 N65a8f37e7c724c4e9f94c81800282cc4 rdf:first sg:person.01235416167.92
145 rdf:rest Nf0dcb7d0f0b34fc8a8cb83a2f41a3175
146 N6c55e83f040246c9b5f3d202c129dcc8 rdf:first sg:person.01277502614.69
147 rdf:rest N5062ad76f08d496d947b8f0161d19487
148 N7d9f462195064c89b60fa4e0354c0573 schema:name dimensions_id
149 schema:value pub.1050735883
150 rdf:type schema:PropertyValue
151 N9675f8417c0447c9baaeade5ca2bcc7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Diabetes Mellitus, Type 2
153 rdf:type schema:DefinedTerm
154 N996e6ceac7fa41fc919896880777998d schema:volumeNumber 7
155 rdf:type schema:PublicationVolume
156 Na4af6c4057ef4cec905954e2324af300 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Male
158 rdf:type schema:DefinedTerm
159 Na790fd3219504e5a933baab00806321c rdf:first sg:person.010646460075.48
160 rdf:rest N6c55e83f040246c9b5f3d202c129dcc8
161 Nb07f180d706d44fb8f61e0b744ef61f5 schema:name doi
162 schema:value 10.1016/s1071-3581(00)70013-4
163 rdf:type schema:PropertyValue
164 Nb455a57eb38744e8a9d7344a855c3748 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Insulin
166 rdf:type schema:DefinedTerm
167 Nc1d6ba88be784d77b1a565231b78bf9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Humans
169 rdf:type schema:DefinedTerm
170 Ncf18d177521547cf94d44feefbb2fd10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Fluorodeoxyglucose F18
172 rdf:type schema:DefinedTerm
173 Nd8e6ee85d9fa4b0788edd83f15caedbe schema:issueNumber 3
174 rdf:type schema:PublicationIssue
175 Ne31f5f1ac9274447846bc1b9924f41c9 rdf:first sg:person.0772176333.38
176 rdf:rest rdf:nil
177 Ne96a82a843d94ce3be4cc6864d0f994a rdf:first sg:person.0746234355.31
178 rdf:rest N003e9b996b7d46699bfe8a3275330be6
179 Nebbbe0fe5d14487d80c83c75158f0a41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Tomography, Emission-Computed
181 rdf:type schema:DefinedTerm
182 Neced02d6937b476b8407bf9bd782385e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Myocardium
184 rdf:type schema:DefinedTerm
185 Nf0dcb7d0f0b34fc8a8cb83a2f41a3175 rdf:first sg:person.010476276272.43
186 rdf:rest Na790fd3219504e5a933baab00806321c
187 Nf2a8c002bb7f438b83f7973e9dc73ce8 schema:affiliation grid-institutes:grid.26999.3d
188 schema:familyName Kawamura
189 schema:givenName Hidehiro
190 rdf:type schema:Person
191 Nf894c493cff44ccaa8397d48411afd29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Middle Aged
193 rdf:type schema:DefinedTerm
194 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
195 schema:name Medical and Health Sciences
196 rdf:type schema:DefinedTerm
197 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
198 schema:name Clinical Sciences
199 rdf:type schema:DefinedTerm
200 sg:journal.1106202 schema:issn 1071-3581
201 1532-6551
202 schema:name Journal of Nuclear Cardiology
203 schema:publisher Springer Nature
204 rdf:type schema:Periodical
205 sg:person.010476276272.43 schema:affiliation grid-institutes:grid.26999.3d
206 schema:familyName Inoue
207 schema:givenName Yusuke
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010476276272.43
209 rdf:type schema:Person
210 sg:person.010646460075.48 schema:affiliation grid-institutes:grid.26999.3d
211 schema:familyName Aoyagi
212 schema:givenName Teruhiko
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010646460075.48
214 rdf:type schema:Person
215 sg:person.01152022531.08 schema:affiliation grid-institutes:grid.26999.3d
216 schema:familyName Ohtomo
217 schema:givenName Kuni
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152022531.08
219 rdf:type schema:Person
220 sg:person.01235416167.92 schema:affiliation grid-institutes:grid.26999.3d
221 schema:familyName Matsumoto
222 schema:givenName Akihiro
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235416167.92
224 rdf:type schema:Person
225 sg:person.01253520654.94 schema:affiliation grid-institutes:grid.26999.3d
226 schema:familyName Ohtake
227 schema:givenName Tohru
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253520654.94
229 rdf:type schema:Person
230 sg:person.01277502614.69 schema:affiliation grid-institutes:grid.26999.3d
231 schema:familyName Sugiura
232 schema:givenName Seiryo
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277502614.69
234 rdf:type schema:Person
235 sg:person.01355412055.69 schema:affiliation grid-institutes:grid.26999.3d
236 schema:familyName Yokoyama
237 schema:givenName Ikuo
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355412055.69
239 rdf:type schema:Person
240 sg:person.0746234355.31 schema:affiliation grid-institutes:grid.26999.3d
241 schema:familyName Yonekura
242 schema:givenName Katsunori
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746234355.31
244 rdf:type schema:Person
245 sg:person.0772176333.38 schema:affiliation grid-institutes:grid.26999.3d
246 schema:familyName Nagai
247 schema:givenName Ryozo
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772176333.38
249 rdf:type schema:Person
250 sg:person.0775700471.08 schema:affiliation grid-institutes:grid.26999.3d
251 schema:familyName Omata
252 schema:givenName Masao
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775700471.08
254 rdf:type schema:Person
255 sg:pub.10.1007/bf00275270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033854319
256 https://doi.org/10.1007/bf00275270
257 rdf:type schema:CreativeWork
258 sg:pub.10.1016/s1071-3581(97)90061-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023219716
259 https://doi.org/10.1016/s1071-3581(97)90061-1
260 rdf:type schema:CreativeWork
261 grid-institutes:grid.26999.3d schema:alternateName Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan
262 Department of Gastroenterology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan
263 Department of Radiology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan
264 schema:name Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan
265 Department of Gastroenterology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan
266 Department of Radiology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongoh Bunkyo-ku, 113-8655, Tokyo, Japan
267 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...