Quantitative proteomic analysis of chromatin-associated factors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-07-01

AUTHORS

Yuzuru Shiio, Robert N. Eisenman, Eugene C. Yi, Sam Donohoe, David R. Goodlett, Ruedi Aebersold

ABSTRACT

A method to identify and quantify chromatin-associated proteins has been developed and applied to the analysis of changes in chromatin-associated proteins induced by Myc oncoprotein expression in human B lymphocytes. Chromatin-enriched fractions were isolated by differential detergent/salt extraction and analyzed by ICAT reagent labeling, multi-dimensional chromatography and tandem mass spectrometry. Many known chromatin-associated regulatory factors were identified and quantified. The method will be widely applicable to various biological systems and reveal changes in chromatin-associated regulatory factors that underlie biological phenomena. More... »

PAGES

696-703

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/s1044-0305(03)00204-6

DOI

http://dx.doi.org/10.1016/s1044-0305(03)00204-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020708456

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12837591


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