Mutational analysis of the N-ras gene in acute lymphoblastic leukemia: a study of 125 Japanese pediatric cases. View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998

AUTHORS

S Yokota, M Nakao, S Horiike, T Seriu, T Iwai, H Kaneko, H Azuma, T Oka, T Takeda, A Watanabe, A Kikuta, K Asami, I Sekine, T Matsushita, T Tsuhciya, J Mimaya, S Koizumi, M Miyake, K Nishikawa, Y Takaue, Y Kawano, A Iwai, Y Ishida, K Matsumoto, T Fujimoto

ABSTRACT

A point mutation of the N-ras gene is one of the known genetic alterations identified in patients with acute lymphoblastic leukemia (ALL), but its clinical importance is still controversial. Using polymerase chain reactions, we examined codons 12, 13 and 61 of this gene in 125 Japanese childhood ALL patients (64 common-ALL, 22 pre-B-ALL, 33 T-ALL, 2 B-ALL, 3 undifferentiated ALL, and 1 unclassified ALL) including 9 relapsed patients. An N-ras point mutation was observed in 14 (11%) patients (9 common-ALL, 3 T-ALL, and 2 undifferentiated ALL; 13 patients at diagnosis and 1 at relapse). The patients with undifferentiated ALL harbored an N-ras mutation at a significantly higher rate. However, no correlation was found between the presence of an N-ras mutation and sex, age, or white blood count. There was no significant difference in the event-free survival rate between 13 fresh patients with an N-ras mutation and 103 patients with a wild-type configuration. The N-ras mutation was present in about 10% of childhood ALL cases but it did not have a prognostic impact. The sequence analyses revealed that the majority of the patients (13/14) had an N-ras mutation of a G to A transition. This finding was consistent with previous reports on N-ras mutations in acute leukemias in which the incidence of a G to A mutation was significantly higher in ALL than in myeloid malignancies. More... »

PAGES

379-87

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/s0925-5710(98)00015-2

DOI

http://dx.doi.org/10.1016/s0925-5710(98)00015-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1054664140

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9695411


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