Rare but important adverse effects of all-trans retinoic acid in acute promyelocytic leukemia and their management. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997

AUTHORS

K Hatake, M Uwai, T Ohtsuki, H Tomizuka, T Izumi, M Yoshida, Y Miura

ABSTRACT

Several adverse effects have been reported to occur after clinical application of all-trans retinoic acid (RA) in acute promyelocytic leukemia (APL). Except for severe side effects including retinoic acid syndrome, the mechanism of action of RA on adverse effects remains unclear. Here we describe some rare adverse effects and their management. We reviewed the English literature, and we added our cases of endocrine and metabolic adverse effects, such as hypercalcemia, male infertility, bone marrow necrosis, fibrosis and acute pancreatitis. We also described our cases of thromboembolic events, RA-dependent growth of pathologic cells including Sweet's syndrome, erythema nodosum, hyperhistaminemia, granulomatous proliferation, and mild cases of pulmonary complications. In addition, we reviewed the efficacy of RA administration for other types of leukemia or myelodysplastic syndrome. RA and chemotherapeutic agents might induce complete remission, but we obtained a response in only one case of M2 in the third relapse. During RA administration the patient should be monitored for these adverse effects, and early diagnosis and appropriate treatment are important. More... »

PAGES

13-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/s0925-5710(96)00578-6

DOI

http://dx.doi.org/10.1016/s0925-5710(96)00578-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1054664018

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9220656


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Promyelocytic, Acute", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tretinoin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Jichi Medical School, Tochigi, Japan.", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Medicine, Jichi Medical School, Tochigi, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hatake", 
        "givenName": "K", 
        "id": "sg:person.01252161657.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252161657.78"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Uwai", 
        "givenName": "M", 
        "id": "sg:person.0611422410.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611422410.38"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ohtsuki", 
        "givenName": "T", 
        "id": "sg:person.01346111724.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346111724.08"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Tomizuka", 
        "givenName": "H", 
        "id": "sg:person.01057753710.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057753710.77"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Izumi", 
        "givenName": "T", 
        "id": "sg:person.016006612452.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016006612452.12"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Yoshida", 
        "givenName": "M", 
        "id": "sg:person.013016502302.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013016502302.00"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Miura", 
        "givenName": "Y", 
        "id": "sg:person.01301423302.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301423302.39"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1997", 
    "datePublishedReg": "1997-01-01", 
    "description": "Several adverse effects have been reported to occur after clinical application of all-trans retinoic acid (RA) in acute promyelocytic leukemia (APL). Except for severe side effects including retinoic acid syndrome, the mechanism of action of RA on adverse effects remains unclear. Here we describe some rare adverse effects and their management. We reviewed the English literature, and we added our cases of endocrine and metabolic adverse effects, such as hypercalcemia, male infertility, bone marrow necrosis, fibrosis and acute pancreatitis. We also described our cases of thromboembolic events, RA-dependent growth of pathologic cells including Sweet's syndrome, erythema nodosum, hyperhistaminemia, granulomatous proliferation, and mild cases of pulmonary complications. In addition, we reviewed the efficacy of RA administration for other types of leukemia or myelodysplastic syndrome. RA and chemotherapeutic agents might induce complete remission, but we obtained a response in only one case of M2 in the third relapse. During RA administration the patient should be monitored for these adverse effects, and early diagnosis and appropriate treatment are important.", 
    "genre": "article", 
    "id": "sg:pub.10.1016/s0925-5710(96)00578-6", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1076985", 
        "issn": [
          "0925-5710", 
          "1865-3774"
        ], 
        "name": "International Journal of Hematology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "66"
      }
    ], 
    "keywords": [
      "acute promyelocytic leukemia", 
      "trans retinoic acid", 
      "adverse effects", 
      "retinoic acid", 
      "RA administration", 
      "promyelocytic leukemia", 
      "metabolic adverse effects", 
      "rare adverse effect", 
      "retinoic acid syndrome", 
      "bone marrow necrosis", 
      "important adverse effects", 
      "severe side effects", 
      "types of leukemia", 
      "mechanism of action", 
      "pulmonary complications", 
      "thromboembolic events", 
      "Sweet's syndrome", 
      "complete remission", 
      "third relapse", 
      "erythema nodosum", 
      "marrow necrosis", 
      "acute pancreatitis", 
      "myelodysplastic syndrome", 
      "mild cases", 
      "appropriate treatment", 
      "early diagnosis", 
      "side effects", 
      "male infertility", 
      "granulomatous proliferation", 
      "chemotherapeutic agents", 
      "syndrome", 
      "pathologic cells", 
      "leukemia", 
      "English literature", 
      "case of M2", 
      "clinical application", 
      "administration", 
      "hyperhistaminemia", 
      "hypercalcemia", 
      "remission", 
      "pancreatitis", 
      "complications", 
      "relapse", 
      "patients", 
      "fibrosis", 
      "infertility", 
      "necrosis", 
      "cases", 
      "diagnosis", 
      "efficacy", 
      "effect", 
      "management", 
      "Ras-dependent growth", 
      "treatment", 
      "nodosum", 
      "proliferation", 
      "cells", 
      "acid", 
      "agents", 
      "response", 
      "action", 
      "events", 
      "m2", 
      "mechanism", 
      "literature", 
      "addition", 
      "types", 
      "growth", 
      "applications"
    ], 
    "name": "Rare but important adverse effects of all-trans retinoic acid in acute promyelocytic leukemia and their management.", 
    "pagination": "13-9", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1054664018"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1016/s0925-5710(96)00578-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9220656"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1016/s0925-5710(96)00578-6", 
      "https://app.dimensions.ai/details/publication/pub.1054664018"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_266.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1016/s0925-5710(96)00578-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1016/s0925-5710(96)00578-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1016/s0925-5710(96)00578-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1016/s0925-5710(96)00578-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1016/s0925-5710(96)00578-6'


 

This table displays all metadata directly associated to this object as RDF triples.

186 TRIPLES      20 PREDICATES      100 URIs      92 LITERALS      12 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1016/s0925-5710(96)00578-6 schema:about N13bc9aa933f04baea6427515daad993f
2 N722da527631e4413bf0166e0cdc2a396
3 N9a0f104207294667aa48c01f9d0f01f6
4 Nb76167dfdede451b9ac93ef0808d4318
5 Nc6fd46806fc94f5e822844b70181d01b
6 anzsrc-for:11
7 anzsrc-for:1103
8 schema:author N5e06b87476d2406ea541d8a2aeb944c7
9 schema:datePublished 1997
10 schema:datePublishedReg 1997-01-01
11 schema:description Several adverse effects have been reported to occur after clinical application of all-trans retinoic acid (RA) in acute promyelocytic leukemia (APL). Except for severe side effects including retinoic acid syndrome, the mechanism of action of RA on adverse effects remains unclear. Here we describe some rare adverse effects and their management. We reviewed the English literature, and we added our cases of endocrine and metabolic adverse effects, such as hypercalcemia, male infertility, bone marrow necrosis, fibrosis and acute pancreatitis. We also described our cases of thromboembolic events, RA-dependent growth of pathologic cells including Sweet's syndrome, erythema nodosum, hyperhistaminemia, granulomatous proliferation, and mild cases of pulmonary complications. In addition, we reviewed the efficacy of RA administration for other types of leukemia or myelodysplastic syndrome. RA and chemotherapeutic agents might induce complete remission, but we obtained a response in only one case of M2 in the third relapse. During RA administration the patient should be monitored for these adverse effects, and early diagnosis and appropriate treatment are important.
12 schema:genre article
13 schema:isAccessibleForFree false
14 schema:isPartOf N38402f8c7df14a8bb32f87350b4afb06
15 Nf656834fb3554cfe8bb2e23ca30fa5c8
16 sg:journal.1076985
17 schema:keywords English literature
18 RA administration
19 Ras-dependent growth
20 Sweet's syndrome
21 acid
22 action
23 acute pancreatitis
24 acute promyelocytic leukemia
25 addition
26 administration
27 adverse effects
28 agents
29 applications
30 appropriate treatment
31 bone marrow necrosis
32 case of M2
33 cases
34 cells
35 chemotherapeutic agents
36 clinical application
37 complete remission
38 complications
39 diagnosis
40 early diagnosis
41 effect
42 efficacy
43 erythema nodosum
44 events
45 fibrosis
46 granulomatous proliferation
47 growth
48 hypercalcemia
49 hyperhistaminemia
50 important adverse effects
51 infertility
52 leukemia
53 literature
54 m2
55 male infertility
56 management
57 marrow necrosis
58 mechanism
59 mechanism of action
60 metabolic adverse effects
61 mild cases
62 myelodysplastic syndrome
63 necrosis
64 nodosum
65 pancreatitis
66 pathologic cells
67 patients
68 proliferation
69 promyelocytic leukemia
70 pulmonary complications
71 rare adverse effect
72 relapse
73 remission
74 response
75 retinoic acid
76 retinoic acid syndrome
77 severe side effects
78 side effects
79 syndrome
80 third relapse
81 thromboembolic events
82 trans retinoic acid
83 treatment
84 types
85 types of leukemia
86 schema:name Rare but important adverse effects of all-trans retinoic acid in acute promyelocytic leukemia and their management.
87 schema:pagination 13-9
88 schema:productId N27ffd2493e0b4b0db2f9909994952c8d
89 N9fbb246f220146e6bc972801a82fa8f2
90 Ne3bd44d6c8854982bac2af893264a807
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054664018
92 https://doi.org/10.1016/s0925-5710(96)00578-6
93 schema:sdDatePublished 2022-09-02T15:47
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher N45ab20d93e7c47509ee1e03590c3c724
96 schema:url https://doi.org/10.1016/s0925-5710(96)00578-6
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N13bc9aa933f04baea6427515daad993f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Leukemia, Promyelocytic, Acute
102 rdf:type schema:DefinedTerm
103 N14af96f096ab44828e5a0a58e2e0c288 rdf:first sg:person.016006612452.12
104 rdf:rest N4b07189cbd4d4705aeedc22b312667bd
105 N1a5a6c7d553d4a68a8d1e313165fee72 rdf:first sg:person.01346111724.08
106 rdf:rest N60155d5c100840d487ecd05977806b4e
107 N27ffd2493e0b4b0db2f9909994952c8d schema:name dimensions_id
108 schema:value pub.1054664018
109 rdf:type schema:PropertyValue
110 N38402f8c7df14a8bb32f87350b4afb06 schema:issueNumber 1
111 rdf:type schema:PublicationIssue
112 N45ab20d93e7c47509ee1e03590c3c724 schema:name Springer Nature - SN SciGraph project
113 rdf:type schema:Organization
114 N4b07189cbd4d4705aeedc22b312667bd rdf:first sg:person.013016502302.00
115 rdf:rest N55703f641f4049d9a34d996a4cf26459
116 N55703f641f4049d9a34d996a4cf26459 rdf:first sg:person.01301423302.39
117 rdf:rest rdf:nil
118 N5e06b87476d2406ea541d8a2aeb944c7 rdf:first sg:person.01252161657.78
119 rdf:rest Nbef29be8e61c4461a70f262b9a8a8f11
120 N60155d5c100840d487ecd05977806b4e rdf:first sg:person.01057753710.77
121 rdf:rest N14af96f096ab44828e5a0a58e2e0c288
122 N722da527631e4413bf0166e0cdc2a396 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Tretinoin
124 rdf:type schema:DefinedTerm
125 N9a0f104207294667aa48c01f9d0f01f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Antineoplastic Agents
127 rdf:type schema:DefinedTerm
128 N9fbb246f220146e6bc972801a82fa8f2 schema:name pubmed_id
129 schema:value 9220656
130 rdf:type schema:PropertyValue
131 Nb76167dfdede451b9ac93ef0808d4318 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Male
133 rdf:type schema:DefinedTerm
134 Nbef29be8e61c4461a70f262b9a8a8f11 rdf:first sg:person.0611422410.38
135 rdf:rest N1a5a6c7d553d4a68a8d1e313165fee72
136 Nc6fd46806fc94f5e822844b70181d01b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Humans
138 rdf:type schema:DefinedTerm
139 Ne3bd44d6c8854982bac2af893264a807 schema:name doi
140 schema:value 10.1016/s0925-5710(96)00578-6
141 rdf:type schema:PropertyValue
142 Nf656834fb3554cfe8bb2e23ca30fa5c8 schema:volumeNumber 66
143 rdf:type schema:PublicationVolume
144 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
145 schema:name Medical and Health Sciences
146 rdf:type schema:DefinedTerm
147 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
148 schema:name Clinical Sciences
149 rdf:type schema:DefinedTerm
150 sg:journal.1076985 schema:issn 0925-5710
151 1865-3774
152 schema:name International Journal of Hematology
153 schema:publisher Springer Nature
154 rdf:type schema:Periodical
155 sg:person.01057753710.77 schema:familyName Tomizuka
156 schema:givenName H
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057753710.77
158 rdf:type schema:Person
159 sg:person.01252161657.78 schema:affiliation grid-institutes:grid.410804.9
160 schema:familyName Hatake
161 schema:givenName K
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252161657.78
163 rdf:type schema:Person
164 sg:person.01301423302.39 schema:familyName Miura
165 schema:givenName Y
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301423302.39
167 rdf:type schema:Person
168 sg:person.013016502302.00 schema:familyName Yoshida
169 schema:givenName M
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013016502302.00
171 rdf:type schema:Person
172 sg:person.01346111724.08 schema:familyName Ohtsuki
173 schema:givenName T
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346111724.08
175 rdf:type schema:Person
176 sg:person.016006612452.12 schema:familyName Izumi
177 schema:givenName T
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016006612452.12
179 rdf:type schema:Person
180 sg:person.0611422410.38 schema:familyName Uwai
181 schema:givenName M
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611422410.38
183 rdf:type schema:Person
184 grid-institutes:grid.410804.9 schema:alternateName Department of Medicine, Jichi Medical School, Tochigi, Japan.
185 schema:name Department of Medicine, Jichi Medical School, Tochigi, Japan.
186 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...