Sustained Antidepressant Effect of Sleep Deprivation Combined with Pindolol in Bipolar Depression: A Placebo-Controlled Trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-04

AUTHORS

Enrico Smeraldi, Francesco Benedetti, Barbara Barbini, Euridice Campori, Cristina Colombo

ABSTRACT

Total sleep deprivation (TSD) shows powerful but transient clinical effects in patients affected by bipolar depression. Pindolol blocks the serotonergic 5-HT1A autoreceptor, thus improving the antidepressant effect of selective serotonin reuptake inhibitors. We evaluated the interaction of TSD and pindolol in the treatment of acute episodes of bipolar depression. Forty bipolar depressed inpatients were randomized to receive pindolol 7.5 mg/day or placebo for nine days in combination with three consecutive TSD cycles. Pindolol significantly improved the antidepressant effect of TSD, and prevented the short-term relapse after treatment. The response rate (HDRS scores < 8) at the end of treatment was 15/20 for pindolol, and 3/20 for placebo. Coadministration of pindolol and TSD resulted in a complete response, which could be sustained for six months with lithium salts alone, in 65% of cases. This results suggest a major role for serotonergic transmission in the mechanism of action of TSD, and makes TSD treatment more effective in the treatment of bipolar depression. More... »

PAGES

1395312

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/s0893-133x(98)00129-8

DOI

http://dx.doi.org/10.1016/s0893-133x(98)00129-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023013827

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10088139


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1016/s0893-133x(98)00129-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1016/s0893-133x(98)00129-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1016/s0893-133x(98)00129-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1016/s0893-133x(98)00129-8'


 

This table displays all metadata directly associated to this object as RDF triples.

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