Reversal of Phencyclidine-Induced Hyperactivity by Glycine and the Glycine Uptake Inhibitor Glycyldodecylamide View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-09

AUTHORS

Daniel C Javitt, Henry Sershen, Audrey Hashim, Abel Lajtha

ABSTRACT

Phencyclidine (PCP) induces a psychotic state that closely resembles schizophrenia. In preclinical studies, PCP has been shown to induce its unique behavioral effects by blocking excitatory neurotransmission mediated at the N-methyl-D-aspartate (NMDA) receptors, suggesting that agents which potentiate NMDA receptor-mediated neurotransmission might have clinically beneficial effects. The present study demonstrates that the NMDA co-agonist glycine inhibits rodent hyperactivity induced by PCP, but not amphetamine. Glycyldodecylamide, a compound that blocks neuronal glycine uptake and which may therefore increase intrasynaptic glycine levels, inhibits PCP-induced hyperactivity more potently than glycine. These results complement recent clinical studies with glycine and suggest that glycine-uptake inhibitors, as well as glycine, may be beneficial in the treatment of PCP-induced psychosis and schizophrenia. More... »

PAGES

1395028

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/s0893-133x(97)00047-x

DOI

http://dx.doi.org/10.1016/s0893-133x(97)00047-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008126225

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9272487


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