Rapid Tryptophan Depletion Plus a Serotonin 1A Agonist: Competing Effects on Sleep in Healthy Men View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-11

AUTHORS

Polly Moore, Erich Seifritz, Arlene Schlosser, Debbie Greenfield, Steven Stahl, Mark Rapaport, John Kelsoe

ABSTRACT

In the present study, we hypothesized that the REM-suppressing effects of 5-HT(1A) receptor stimulation would counteract the REM-disinhibiting effects of rapid tryptophan depletion (RTD), and vice versa. We administered RTD plus ipsapirone (10 mg, p.o.) or RTD plus placebo to 10 healthy men. In contrast to our previous findings but partially consistent with other studies, RTD in combination with placebo did not produce a significant enhancement of any REM sleep measure. The combination of RTD and ipsapirone produced a significant suppression of REM sleep that was remarkably similar to the effect of ipsapirone alone. These data appear to deepen the mystery of variable and inconsistent RTD-induced responses in healthy subjects. In the case of REM sleep measures, this differs markedly from the consistent RTD-induced REM-disinhibiting effect seen in medicated depressed patients. More... »

PAGES

s40

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/s0893-133x(01)00326-8

DOI

http://dx.doi.org/10.1016/s0893-133x(01)00326-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003667159

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11682272


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