A Simple Method to Measure Baseline Occupancy of Neostriatal Dopamine D2 Receptors by Dopamine In Vivo in Healthy Subjects View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-08

AUTHORS

NPLG Verhoeff, S Kapur, D Hussey, M Lee, B Christensen, C Psych, G Papatheodorou, RB Zipursky

ABSTRACT

The effect of endogenous dopamine (DA) on measurement of neostriatal DA D(2) receptor binding potential (D(2)RBP) in vivo was evaluated with positron emission tomography (PET) and the radiotracer [11C]raclopride by comparing the D(2)RBP before and after acute DA depletion. DA depletion was achieved by per-oral administration of 4.5 g alpha-methyl-para-tyrosine (AMPT) given in 25 h. Six healthy subjects completed the protocol. The AMPT treatment increased D(2)RBP significantly from 3.11 +/- 0.25 to 3.68 +/- 0.23 and decreased plasma levels of the DA metabolite homovanillic acid by 71 +/- 11% and levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenethyleneglycol by 53 +/- 7%. Increase in D(2)RBP correlated with decrease in attentiveness and with increase in errors of commission from Conners' Continuous Performance Test. On AMPT, a significant decrease in subjective happiness scores was observed. The results imply that a noninvasive [11C]raclopride PET protocol coupled with relatively brief administration of a rather low total dose of AMPT resulted in measurable acute DA depletion that might provide estimates of synaptic neostriatal DA concentration. More... »

PAGES

1395674

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/s0893-133x(01)00231-7

DOI

http://dx.doi.org/10.1016/s0893-133x(01)00231-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022536927

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11425505


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Analysis of Variance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cognition", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dopamine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dopamine Antagonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homovanillic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methoxyhydroxyphenylglycol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neostriatum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Outcome Assessment (Health Care)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prolactin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Raclopride", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Dopamine D2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Statistics, Nonparametric", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, Emission-Computed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "alpha-Methyltyrosine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "PET Centre and Schizophrenia and Continuing Care Division, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verhoeff", 
        "givenName": "NPLG", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "PET Centre and Schizophrenia and Continuing Care Division, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kapur", 
        "givenName": "S", 
        "id": "sg:person.01112127345.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112127345.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "PET Centre and Schizophrenia and Continuing Care Division, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hussey", 
        "givenName": "D", 
        "id": "sg:person.01351126744.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351126744.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "PET Centre and Schizophrenia and Continuing Care Division, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "M", 
        "id": "sg:person.01372154037.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372154037.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "PET Centre and Schizophrenia and Continuing Care Division, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Christensen", 
        "givenName": "B", 
        "id": "sg:person.0723242563.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723242563.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "PET Centre and Schizophrenia and Continuing Care Division, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Psych", 
        "givenName": "C", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "PET Centre and Schizophrenia and Continuing Care Division, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Papatheodorou", 
        "givenName": "G", 
        "id": "sg:person.01063477271.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063477271.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "PET Centre and Schizophrenia and Continuing Care Division, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zipursky", 
        "givenName": "RB", 
        "id": "sg:person.0661456670.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661456670.53"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/(sici)1098-2396(199704)25:4<321::aid-syn2>3.0.co;2-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001176004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/nimg.1996.0066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002690366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.14.8104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002918415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(87)42068-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003490110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/syn.890210107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005378084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-1327.1999.00125.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007172337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0891-0618(95)00064-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011167831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(97)00449-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012969540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(96)00262-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013916538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-4347(84)80095-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015778470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/nimg.1999.0431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015941235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(77)90010-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018510399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(77)90010-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018510399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.1993.34", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020371024", 
          "https://doi.org/10.1038/npp.1993.34"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.1993.34", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020371024", 
          "https://doi.org/10.1038/npp.1993.34"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00833017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020557763", 
          "https://doi.org/10.1007/bf00833017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/nimg.1997.0303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021838870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004714-199008000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021977209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004714-199008000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021977209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(86)90013-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021987226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(86)90013-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021987226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0969-8051(98)00048-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023918415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(89)90179-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023981737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(89)90179-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023981737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1985.tb07223.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024194977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0893-133x(97)00043-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024594849", 
          "https://doi.org/10.1016/s0893-133x(97)00043-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(93)90267-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028212396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(93)90267-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028212396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci105753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031732354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-3223(92)90153-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034211235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-3223(92)90153-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034211235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/syn.890150311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034722127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hbm.460030104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035601133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hbm.460030104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035601133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.6.2569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036506224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(98)00293-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036844977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4530(95)00049-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038354533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hbm.460020402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041201593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hbm.460020402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041201593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/00004647-199809000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042584915", 
          "https://doi.org/10.1097/00004647-199809000-00003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199809000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042584915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199809000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042584915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002130051163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045712585", 
          "https://doi.org/10.1007/s002130051163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/syn.890160402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045982865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-2999(99)00817-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046662970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/00004647-199709000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047381051", 
          "https://doi.org/10.1097/00004647-199709000-00003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199709000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047381051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199709000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047381051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9861(19981221)402:3<353::aid-cne5>3.0.co;2-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047711079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0091-3057(92)90033-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047851705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0091-3057(92)90033-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047851705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00841408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049454244", 
          "https://doi.org/10.1007/bf00841408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00169199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049859814", 
          "https://doi.org/10.1007/bf00169199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00169199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049859814", 
          "https://doi.org/10.1007/bf00169199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/00004647-199601000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050730737", 
          "https://doi.org/10.1097/00004647-199601000-00005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199601000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050730737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199601000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050730737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/00004647-200003000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052956062", 
          "https://doi.org/10.1097/00004647-200003000-00001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-200003000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052956062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-200003000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052956062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-199605000-00020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060189018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.177.4055.1205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062505787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3838821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062621976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/ajp.155.10.1325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063485293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/ajp.155.11.1550", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063485353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080336433", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081604254", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083174109", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-08", 
    "datePublishedReg": "2001-08-01", 
    "description": "The effect of endogenous dopamine (DA) on measurement of neostriatal DA D(2) receptor binding potential (D(2)RBP) in vivo was evaluated with positron emission tomography (PET) and the radiotracer [11C]raclopride by comparing the D(2)RBP before and after acute DA depletion. DA depletion was achieved by per-oral administration of 4.5 g alpha-methyl-para-tyrosine (AMPT) given in 25 h. Six healthy subjects completed the protocol. The AMPT treatment increased D(2)RBP significantly from 3.11 +/- 0.25 to 3.68 +/- 0.23 and decreased plasma levels of the DA metabolite homovanillic acid by 71 +/- 11% and levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenethyleneglycol by 53 +/- 7%. Increase in D(2)RBP correlated with decrease in attentiveness and with increase in errors of commission from Conners' Continuous Performance Test. On AMPT, a significant decrease in subjective happiness scores was observed. The results imply that a noninvasive [11C]raclopride PET protocol coupled with relatively brief administration of a rather low total dose of AMPT resulted in measurable acute DA depletion that might provide estimates of synaptic neostriatal DA concentration.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1016/s0893-133x(01)00231-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1099176", 
        "issn": [
          "0893-133X", 
          "1740-634X"
        ], 
        "name": "Neuropsychopharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "25"
      }
    ], 
    "name": "A Simple Method to Measure Baseline Occupancy of Neostriatal Dopamine D2 Receptors by Dopamine In Vivo in Healthy Subjects", 
    "pagination": "1395674", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6b5eed564166f48e23f620b9522c345ae08035e8e3db72e5776b36030d5ab31a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11425505"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8904907"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1016/s0893-133x(01)00231-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022536927"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1016/s0893-133x(01)00231-7", 
      "https://app.dimensions.ai/details/publication/pub.1022536927"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1395674"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1016/s0893-133x(01)00231-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1016/s0893-133x(01)00231-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1016/s0893-133x(01)00231-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1016/s0893-133x(01)00231-7'


 

This table displays all metadata directly associated to this object as RDF triples.

358 TRIPLES      21 PREDICATES      101 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1016/s0893-133x(01)00231-7 schema:about N1d85408ce1914b799a415c10e7451ade
2 N24bf024f5985469f8b82254d38234f03
3 N45e2a4a7de8e4895b5e7971b2b938aab
4 N5bd51a00ee234c9da61adf669fc5eaf9
5 N5f8435ae75e645a58d3036fb214144ad
6 N681506c47a644b52970dc587fb341f5e
7 N7154c9a707ca4ff7b37b3244c4849c0b
8 N78bca6a40a104e1cb993444b2358ac9f
9 N7c9c5fe662764114abbabece8fcb69f4
10 Na2a6a85d98e247a29524fb6d3a1c553a
11 Naaf6f9ba680a435e9cc2c82ee71467a4
12 Nb14b516946634477a5f0a6ba84447b77
13 Nb926c04bad744279881cc50b8a5bb167
14 Nba2fcef2b1394749a0fee6fb42fd03ec
15 Nc01883b7792248708eddd3083561d26e
16 Nc2259d7f8d8c46d7b98597b82fe63884
17 Nc6395d9512224ed7af0a4672b2bca2a6
18 Ne06da5c4979349139606d64b5956bf80
19 Nf4bfaf3c319b4b1aae79d54a0aa02c1b
20 anzsrc-for:11
21 anzsrc-for:1103
22 schema:author N663892640ad14dc0ba886eee076b69ba
23 schema:citation sg:pub.10.1007/bf00169199
24 sg:pub.10.1007/bf00833017
25 sg:pub.10.1007/bf00841408
26 sg:pub.10.1007/s002130051163
27 sg:pub.10.1016/s0893-133x(97)00043-2
28 sg:pub.10.1038/npp.1993.34
29 sg:pub.10.1097/00004647-199601000-00005
30 sg:pub.10.1097/00004647-199709000-00003
31 sg:pub.10.1097/00004647-199809000-00003
32 sg:pub.10.1097/00004647-200003000-00001
33 https://app.dimensions.ai/details/publication/pub.1080336433
34 https://app.dimensions.ai/details/publication/pub.1081604254
35 https://app.dimensions.ai/details/publication/pub.1083174109
36 https://doi.org/10.1002/(sici)1096-9861(19981221)402:3<353::aid-cne5>3.0.co;2-4
37 https://doi.org/10.1002/(sici)1098-2396(199704)25:4<321::aid-syn2>3.0.co;2-c
38 https://doi.org/10.1002/hbm.460020402
39 https://doi.org/10.1002/hbm.460030104
40 https://doi.org/10.1002/syn.890150311
41 https://doi.org/10.1002/syn.890160402
42 https://doi.org/10.1002/syn.890210107
43 https://doi.org/10.1006/nimg.1996.0066
44 https://doi.org/10.1006/nimg.1997.0303
45 https://doi.org/10.1006/nimg.1999.0431
46 https://doi.org/10.1016/0006-3223(92)90153-q
47 https://doi.org/10.1016/0006-8993(86)90013-2
48 https://doi.org/10.1016/0009-8981(77)90010-9
49 https://doi.org/10.1016/0024-3205(96)00262-7
50 https://doi.org/10.1016/0091-3057(92)90033-c
51 https://doi.org/10.1016/0306-4522(89)90179-6
52 https://doi.org/10.1016/0306-4522(93)90267-j
53 https://doi.org/10.1016/0306-4530(95)00049-6
54 https://doi.org/10.1016/0378-4347(84)80095-x
55 https://doi.org/10.1016/0891-0618(95)00064-e
56 https://doi.org/10.1016/s0006-3223(97)00449-6
57 https://doi.org/10.1016/s0006-3223(98)00293-5
58 https://doi.org/10.1016/s0014-2999(99)00817-1
59 https://doi.org/10.1016/s0076-6879(87)42068-5
60 https://doi.org/10.1016/s0969-8051(98)00048-1
61 https://doi.org/10.1046/j.1432-1327.1999.00125.x
62 https://doi.org/10.1073/pnas.94.6.2569
63 https://doi.org/10.1073/pnas.97.14.8104
64 https://doi.org/10.1097/00004647-199601000-00005
65 https://doi.org/10.1097/00004647-199709000-00003
66 https://doi.org/10.1097/00004647-199809000-00003
67 https://doi.org/10.1097/00004647-200003000-00001
68 https://doi.org/10.1097/00004714-199008000-00003
69 https://doi.org/10.1097/00004728-199605000-00020
70 https://doi.org/10.1111/j.1471-4159.1985.tb07223.x
71 https://doi.org/10.1126/science.177.4055.1205
72 https://doi.org/10.1126/science.3838821
73 https://doi.org/10.1172/jci105753
74 https://doi.org/10.1176/ajp.155.10.1325
75 https://doi.org/10.1176/ajp.155.11.1550
76 schema:datePublished 2001-08
77 schema:datePublishedReg 2001-08-01
78 schema:description The effect of endogenous dopamine (DA) on measurement of neostriatal DA D(2) receptor binding potential (D(2)RBP) in vivo was evaluated with positron emission tomography (PET) and the radiotracer [11C]raclopride by comparing the D(2)RBP before and after acute DA depletion. DA depletion was achieved by per-oral administration of 4.5 g alpha-methyl-para-tyrosine (AMPT) given in 25 h. Six healthy subjects completed the protocol. The AMPT treatment increased D(2)RBP significantly from 3.11 +/- 0.25 to 3.68 +/- 0.23 and decreased plasma levels of the DA metabolite homovanillic acid by 71 +/- 11% and levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenethyleneglycol by 53 +/- 7%. Increase in D(2)RBP correlated with decrease in attentiveness and with increase in errors of commission from Conners' Continuous Performance Test. On AMPT, a significant decrease in subjective happiness scores was observed. The results imply that a noninvasive [11C]raclopride PET protocol coupled with relatively brief administration of a rather low total dose of AMPT resulted in measurable acute DA depletion that might provide estimates of synaptic neostriatal DA concentration.
79 schema:genre research_article
80 schema:inLanguage en
81 schema:isAccessibleForFree true
82 schema:isPartOf N7c62674f67844a18b8d70e6ba02b2bb0
83 Nab070ae75a954ea397ab790c580a5acb
84 sg:journal.1099176
85 schema:name A Simple Method to Measure Baseline Occupancy of Neostriatal Dopamine D2 Receptors by Dopamine In Vivo in Healthy Subjects
86 schema:pagination 1395674
87 schema:productId N367f2de7693f4cd3a9bc3f86a9d7a756
88 N9786cb70243c469496a61c1ed49cb072
89 N9a072637760040c681fa0f1f79c0125f
90 Ne48d0c52b25a4cc6a169fbd20ed55fd7
91 Nf74619aa38c34529877cdf5217aaf1d5
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022536927
93 https://doi.org/10.1016/s0893-133x(01)00231-7
94 schema:sdDatePublished 2019-04-10T23:11
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher N41150db4ab004673affe362d82629645
97 schema:url http://www.nature.com/articles/1395674
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N078cd9bac76f462fae36d01a6ee3194f schema:affiliation https://www.grid.ac/institutes/grid.17063.33
102 schema:familyName Psych
103 schema:givenName C
104 rdf:type schema:Person
105 N1d85408ce1914b799a415c10e7451ade schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name alpha-Methyltyrosine
107 rdf:type schema:DefinedTerm
108 N23be5cee4903474cb758389b2815bab0 rdf:first sg:person.0723242563.72
109 rdf:rest Neba0e86130b0456b9af4e85a3c81b814
110 N24bf024f5985469f8b82254d38234f03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Humans
112 rdf:type schema:DefinedTerm
113 N2ccae796828d4996bf859169596eae5d rdf:first sg:person.01112127345.25
114 rdf:rest Nebcdada736d442c6b87b589398d4e428
115 N367f2de7693f4cd3a9bc3f86a9d7a756 schema:name dimensions_id
116 schema:value pub.1022536927
117 rdf:type schema:PropertyValue
118 N41150db4ab004673affe362d82629645 schema:name Springer Nature - SN SciGraph project
119 rdf:type schema:Organization
120 N45e2a4a7de8e4895b5e7971b2b938aab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Enzyme Inhibitors
122 rdf:type schema:DefinedTerm
123 N5bd51a00ee234c9da61adf669fc5eaf9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Analysis of Variance
125 rdf:type schema:DefinedTerm
126 N5f8435ae75e645a58d3036fb214144ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Receptors, Dopamine D2
128 rdf:type schema:DefinedTerm
129 N663892640ad14dc0ba886eee076b69ba rdf:first N970abd92d052470cb10060f0d2302096
130 rdf:rest N2ccae796828d4996bf859169596eae5d
131 N681506c47a644b52970dc587fb341f5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Adult
133 rdf:type schema:DefinedTerm
134 N7154c9a707ca4ff7b37b3244c4849c0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Dopamine
136 rdf:type schema:DefinedTerm
137 N724e04a3f6f94558824e075ccdb2804e rdf:first sg:person.01372154037.30
138 rdf:rest N23be5cee4903474cb758389b2815bab0
139 N78bca6a40a104e1cb993444b2358ac9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Outcome Assessment (Health Care)
141 rdf:type schema:DefinedTerm
142 N7c62674f67844a18b8d70e6ba02b2bb0 schema:volumeNumber 25
143 rdf:type schema:PublicationVolume
144 N7c9c5fe662764114abbabece8fcb69f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Prolactin
146 rdf:type schema:DefinedTerm
147 N9525dfa788e943c182bd17b2b87f7551 rdf:first sg:person.0661456670.53
148 rdf:rest rdf:nil
149 N970abd92d052470cb10060f0d2302096 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
150 schema:familyName Verhoeff
151 schema:givenName NPLG
152 rdf:type schema:Person
153 N9786cb70243c469496a61c1ed49cb072 schema:name nlm_unique_id
154 schema:value 8904907
155 rdf:type schema:PropertyValue
156 N9a072637760040c681fa0f1f79c0125f schema:name doi
157 schema:value 10.1016/s0893-133x(01)00231-7
158 rdf:type schema:PropertyValue
159 Na2a6a85d98e247a29524fb6d3a1c553a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Tomography, Emission-Computed
161 rdf:type schema:DefinedTerm
162 Naaf6f9ba680a435e9cc2c82ee71467a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Homovanillic Acid
164 rdf:type schema:DefinedTerm
165 Nab070ae75a954ea397ab790c580a5acb schema:issueNumber 2
166 rdf:type schema:PublicationIssue
167 Nb14b516946634477a5f0a6ba84447b77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Dopamine Antagonists
169 rdf:type schema:DefinedTerm
170 Nb926c04bad744279881cc50b8a5bb167 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Methoxyhydroxyphenylglycol
172 rdf:type schema:DefinedTerm
173 Nba2fcef2b1394749a0fee6fb42fd03ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Female
175 rdf:type schema:DefinedTerm
176 Nbea7a956295a447ea4a99a3c799baf2a rdf:first sg:person.01063477271.12
177 rdf:rest N9525dfa788e943c182bd17b2b87f7551
178 Nc01883b7792248708eddd3083561d26e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Raclopride
180 rdf:type schema:DefinedTerm
181 Nc2259d7f8d8c46d7b98597b82fe63884 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Statistics, Nonparametric
183 rdf:type schema:DefinedTerm
184 Nc6395d9512224ed7af0a4672b2bca2a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Cognition
186 rdf:type schema:DefinedTerm
187 Ne06da5c4979349139606d64b5956bf80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Male
189 rdf:type schema:DefinedTerm
190 Ne48d0c52b25a4cc6a169fbd20ed55fd7 schema:name pubmed_id
191 schema:value 11425505
192 rdf:type schema:PropertyValue
193 Neba0e86130b0456b9af4e85a3c81b814 rdf:first N078cd9bac76f462fae36d01a6ee3194f
194 rdf:rest Nbea7a956295a447ea4a99a3c799baf2a
195 Nebcdada736d442c6b87b589398d4e428 rdf:first sg:person.01351126744.89
196 rdf:rest N724e04a3f6f94558824e075ccdb2804e
197 Nf4bfaf3c319b4b1aae79d54a0aa02c1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Neostriatum
199 rdf:type schema:DefinedTerm
200 Nf74619aa38c34529877cdf5217aaf1d5 schema:name readcube_id
201 schema:value 6b5eed564166f48e23f620b9522c345ae08035e8e3db72e5776b36030d5ab31a
202 rdf:type schema:PropertyValue
203 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
204 schema:name Medical and Health Sciences
205 rdf:type schema:DefinedTerm
206 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
207 schema:name Clinical Sciences
208 rdf:type schema:DefinedTerm
209 sg:journal.1099176 schema:issn 0893-133X
210 1740-634X
211 schema:name Neuropsychopharmacology
212 rdf:type schema:Periodical
213 sg:person.01063477271.12 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
214 schema:familyName Papatheodorou
215 schema:givenName G
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063477271.12
217 rdf:type schema:Person
218 sg:person.01112127345.25 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
219 schema:familyName Kapur
220 schema:givenName S
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112127345.25
222 rdf:type schema:Person
223 sg:person.01351126744.89 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
224 schema:familyName Hussey
225 schema:givenName D
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351126744.89
227 rdf:type schema:Person
228 sg:person.01372154037.30 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
229 schema:familyName Lee
230 schema:givenName M
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372154037.30
232 rdf:type schema:Person
233 sg:person.0661456670.53 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
234 schema:familyName Zipursky
235 schema:givenName RB
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661456670.53
237 rdf:type schema:Person
238 sg:person.0723242563.72 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
239 schema:familyName Christensen
240 schema:givenName B
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723242563.72
242 rdf:type schema:Person
243 sg:pub.10.1007/bf00169199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049859814
244 https://doi.org/10.1007/bf00169199
245 rdf:type schema:CreativeWork
246 sg:pub.10.1007/bf00833017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020557763
247 https://doi.org/10.1007/bf00833017
248 rdf:type schema:CreativeWork
249 sg:pub.10.1007/bf00841408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049454244
250 https://doi.org/10.1007/bf00841408
251 rdf:type schema:CreativeWork
252 sg:pub.10.1007/s002130051163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045712585
253 https://doi.org/10.1007/s002130051163
254 rdf:type schema:CreativeWork
255 sg:pub.10.1016/s0893-133x(97)00043-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024594849
256 https://doi.org/10.1016/s0893-133x(97)00043-2
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/npp.1993.34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020371024
259 https://doi.org/10.1038/npp.1993.34
260 rdf:type schema:CreativeWork
261 sg:pub.10.1097/00004647-199601000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050730737
262 https://doi.org/10.1097/00004647-199601000-00005
263 rdf:type schema:CreativeWork
264 sg:pub.10.1097/00004647-199709000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047381051
265 https://doi.org/10.1097/00004647-199709000-00003
266 rdf:type schema:CreativeWork
267 sg:pub.10.1097/00004647-199809000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042584915
268 https://doi.org/10.1097/00004647-199809000-00003
269 rdf:type schema:CreativeWork
270 sg:pub.10.1097/00004647-200003000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052956062
271 https://doi.org/10.1097/00004647-200003000-00001
272 rdf:type schema:CreativeWork
273 https://app.dimensions.ai/details/publication/pub.1080336433 schema:CreativeWork
274 https://app.dimensions.ai/details/publication/pub.1081604254 schema:CreativeWork
275 https://app.dimensions.ai/details/publication/pub.1083174109 schema:CreativeWork
276 https://doi.org/10.1002/(sici)1096-9861(19981221)402:3<353::aid-cne5>3.0.co;2-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047711079
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1002/(sici)1098-2396(199704)25:4<321::aid-syn2>3.0.co;2-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1001176004
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1002/hbm.460020402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041201593
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1002/hbm.460030104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035601133
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1002/syn.890150311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034722127
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1002/syn.890160402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045982865
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1002/syn.890210107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005378084
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1006/nimg.1996.0066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002690366
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1006/nimg.1997.0303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021838870
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1006/nimg.1999.0431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015941235
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/0006-3223(92)90153-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1034211235
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/0006-8993(86)90013-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021987226
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/0009-8981(77)90010-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018510399
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/0024-3205(96)00262-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013916538
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/0091-3057(92)90033-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1047851705
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/0306-4522(89)90179-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023981737
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/0306-4522(93)90267-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1028212396
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/0306-4530(95)00049-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038354533
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/0378-4347(84)80095-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015778470
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/0891-0618(95)00064-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1011167831
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/s0006-3223(97)00449-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012969540
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/s0006-3223(98)00293-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036844977
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/s0014-2999(99)00817-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046662970
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/s0076-6879(87)42068-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003490110
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/s0969-8051(98)00048-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023918415
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1046/j.1432-1327.1999.00125.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007172337
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1073/pnas.94.6.2569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036506224
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1073/pnas.97.14.8104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002918415
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1097/00004647-199601000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050730737
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1097/00004647-199709000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047381051
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1097/00004647-199809000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042584915
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1097/00004647-200003000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052956062
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1097/00004714-199008000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021977209
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1097/00004728-199605000-00020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060189018
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1111/j.1471-4159.1985.tb07223.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024194977
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1126/science.177.4055.1205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062505787
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1126/science.3838821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062621976
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1172/jci105753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031732354
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1176/ajp.155.10.1325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063485293
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1176/ajp.155.11.1550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063485353
355 rdf:type schema:CreativeWork
356 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
357 schema:name PET Centre and Schizophrenia and Continuing Care Division, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
358 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...