A Simple Method to Measure Baseline Occupancy of Neostriatal Dopamine D2 Receptors by Dopamine In Vivo in Healthy Subjects View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-08

AUTHORS

NPLG Verhoeff, S Kapur, D Hussey, M Lee, B Christensen, C Psych, G Papatheodorou, RB Zipursky

ABSTRACT

The effect of endogenous dopamine (DA) on measurement of neostriatal DA D(2) receptor binding potential (D(2)RBP) in vivo was evaluated with positron emission tomography (PET) and the radiotracer [11C]raclopride by comparing the D(2)RBP before and after acute DA depletion. DA depletion was achieved by per-oral administration of 4.5 g alpha-methyl-para-tyrosine (AMPT) given in 25 h. Six healthy subjects completed the protocol. The AMPT treatment increased D(2)RBP significantly from 3.11 +/- 0.25 to 3.68 +/- 0.23 and decreased plasma levels of the DA metabolite homovanillic acid by 71 +/- 11% and levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenethyleneglycol by 53 +/- 7%. Increase in D(2)RBP correlated with decrease in attentiveness and with increase in errors of commission from Conners' Continuous Performance Test. On AMPT, a significant decrease in subjective happiness scores was observed. The results imply that a noninvasive [11C]raclopride PET protocol coupled with relatively brief administration of a rather low total dose of AMPT resulted in measurable acute DA depletion that might provide estimates of synaptic neostriatal DA concentration. More... »

PAGES

1395674

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/s0893-133x(01)00231-7

DOI

http://dx.doi.org/10.1016/s0893-133x(01)00231-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022536927

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11425505


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