Continuous Phencyclidine Treatment Induces Schizophrenia-Like Hyperreactivity of Striatal Dopamine Release View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-08

AUTHORS

Andrea Balla, Rajeth Koneru, John Smiley, Henry Sershen, Daniel C Javitt

ABSTRACT

Functional dopaminergic hyperactivity is a key feature of schizophrenia. Recent in vivo imaging studies have demonstrated greater striatal dopamine release in response to amphetamine challenge in schizophrenia subjects than in normal controls. N-methyl-D-aspartate (NMDA) receptors are known to play a prominent role in regulation of striatal dopamine release. In humans, NMDA antagonists induce a psychotic state that closely resembles schizophrenia. The present study investigates the degree to which chronic continuous administration of the NMDA antagonist phencyclidine (PCP) induces schizophrenia-like hyperreactivity of striatal dopamine release to amphetamine in rodents. Rats were treated with 10 or 15 mg/kg/d PCP for two weeks by osmotic minipump, and striatal dopamine release to amphetamine challenge (1 mg/kg) was monitored by microdialysis. PCP-treated rats showed significant enhancement in amphetamine-induced dopamine release, along with significantly enhanced locomotor activity. These findings support the concept that NMDA receptor dysfunction may contribute to dopaminergic dysfunction in schizophrenia. More... »

PAGES

1395673

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/s0893-133x(01)00230-5

DOI

http://dx.doi.org/10.1016/s0893-133x(01)00230-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014402796

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11425499


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