The Alpha-2A-Adrenoceptor Agonist, Guanfacine, Increases Regional Cerebral Blood Flow in Dorsolateral Prefrontal Cortex of Monkeys Performing a Spatial Working Memory ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-09-01

AUTHORS

Robert A Avery, Jenna S Franowicz, Colin Studholme, Christopher H van Dyck, Amy FT Arnsten

ABSTRACT

Research indicates that norepinephrine enhances the working memory functions of the prefrontal cortex (PFC) through actions at post-synaptic, alpha-2A adrenoceptors. The current study examined the effects of the alpha-2A adrenoreceptor agonist, guanfacine (0.7 mg/kg, i.m.), compared to saline on SPECT measures of regional cerebral blood flow (rCBF) in monkeys performing a spatial working memory task. Animals were infused with the SPECT blood flow tracer, Tcm-99m ECD, through an indwelling intravenous catheter while performing the working memory task. Guanfacine treatment significantly improved cognitive performance of the working memory task, and significantly increased rCBF values in the dorsolateral PFC, the brain region most tightly associated with performance of spatial working memory tasks. In contrast, guanfacine had no significant effect on rCBF in the superior temporal cortex, an auditory association area unrelated to task performance. These data are consistent with the hypothesis that alpha-2A adrenoceptor stimulation preferentially enhances functioning of the PFC. More... »

PAGES

1395519

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/s0893-133x(00)00111-1

DOI

http://dx.doi.org/10.1016/s0893-133x(00)00111-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033181767

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10942848


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1701", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Psychology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/17", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Psychology and Cognitive Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adrenergic alpha-2 Receptor Agonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adrenergic alpha-Agonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebrovascular Circulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cognition", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guanfacine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Image Processing, Computer-Assisted", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macaca mulatta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Memory", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prefrontal Cortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Space Perception", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stimulation, Chemical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, Emission-Computed, Single-Photon", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Diagnostic Radiology, Yale Medical School, New Haven, CT USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Avery", 
        "givenName": "Robert A", 
        "id": "sg:person.01144562316.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144562316.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Section of Neurobiology, Yale Medical School, New Haven, CT USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Franowicz", 
        "givenName": "Jenna S", 
        "id": "sg:person.01024423747.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024423747.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Diagnostic Radiology, Yale Medical School, New Haven, CT USA", 
            "Department of Electrical Engineering, Yale Medical School, New Haven, CT USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Studholme", 
        "givenName": "Colin", 
        "id": "sg:person.0610515701.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610515701.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Psychiatry, Yale Medical School, New Haven, CT USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Dyck", 
        "givenName": "Christopher H", 
        "id": "sg:person.010314560137.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010314560137.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Section of Neurobiology, Yale Medical School, New Haven, CT USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arnsten", 
        "givenName": "Amy FT", 
        "id": "sg:person.014130671777.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014130671777.04"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0163-1047(05)80034-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000208800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.1997.tb01635.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002187171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0893-133x(98)00127-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003785366", 
          "https://doi.org/10.1016/s0893-133x(98)00127-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(99)00139-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007408457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.902820302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007745435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002130050533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011583097", 
          "https://doi.org/10.1007/s002130050533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1118/1.598130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013313254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1117/12.237936", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013721382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1117/12.237936", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013721382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1460-9568.1999.00464.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014053694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02311179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014222582", 
          "https://doi.org/10.1007/bf02311179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02311179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014222582", 
          "https://doi.org/10.1007/bf02311179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0031-3203(98)00091-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015765380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004583-199501000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015887160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004583-199501000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015887160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4886(70)90222-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022770558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0893-133x(98)00093-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024965277", 
          "https://doi.org/10.1016/s0893-133x(98)00093-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(93)91034-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025091367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(93)91034-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025091367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-2236(90)90146-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025676326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-2236(90)90146-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025676326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(91)90299-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029085569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(91)90299-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029085569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0893-133x(99)00070-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034010103", 
          "https://doi.org/10.1016/s0893-133x(99)00070-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0920-9964(88)90024-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034396956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(88)92668-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037750474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpsyc.1996.01830050084013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038327209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0893-133x(99)00060-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038890206", 
          "https://doi.org/10.1016/s0893-133x(99)00060-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004583-199509000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042649637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004583-199509000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042649637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0163-1047(92)90327-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047074388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-7138(09)60065-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047499644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1364-6613(98)01240-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048645815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00180841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051901673", 
          "https://doi.org/10.1007/bf00180841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0361-9230(96)00026-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053481448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0033291700026829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053983389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0033291700026829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053983389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/cap.1995.5.215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059240611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/42.730402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061170674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2999977", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062580099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079394574", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.08-11-04287.1988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079446869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1989.61.2.331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079453831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.14-05-02775.1994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082690149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1998.80.4.2200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083329738"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-09-01", 
    "datePublishedReg": "2000-09-01", 
    "description": "Research indicates that norepinephrine enhances the working memory functions of the prefrontal cortex (PFC) through actions at post-synaptic, alpha-2A adrenoceptors. The current study examined the effects of the alpha-2A adrenoreceptor agonist, guanfacine (0.7 mg/kg, i.m.), compared to saline on SPECT measures of regional cerebral blood flow (rCBF) in monkeys performing a spatial working memory task. Animals were infused with the SPECT blood flow tracer, Tcm-99m ECD, through an indwelling intravenous catheter while performing the working memory task. Guanfacine treatment significantly improved cognitive performance of the working memory task, and significantly increased rCBF values in the dorsolateral PFC, the brain region most tightly associated with performance of spatial working memory tasks. In contrast, guanfacine had no significant effect on rCBF in the superior temporal cortex, an auditory association area unrelated to task performance. These data are consistent with the hypothesis that alpha-2A adrenoceptor stimulation preferentially enhances functioning of the PFC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1016/s0893-133x(00)00111-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1099176", 
        "issn": [
          "0893-133X", 
          "1740-634X"
        ], 
        "name": "Neuropsychopharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "name": "The Alpha-2A-Adrenoceptor Agonist, Guanfacine, Increases Regional Cerebral Blood Flow in Dorsolateral Prefrontal Cortex of Monkeys Performing a Spatial Working Memory Task", 
    "pagination": "1395519", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9e127a52044fd29cc69794714491b503a2fd21d02c1470756dff9ddf42ac0574"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10942848"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8904907"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1016/s0893-133x(00)00111-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033181767"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1016/s0893-133x(00)00111-1", 
      "https://app.dimensions.ai/details/publication/pub.1033181767"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1395519"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1016/s0893-133x(00)00111-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1016/s0893-133x(00)00111-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1016/s0893-133x(00)00111-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1016/s0893-133x(00)00111-1'


 

This table displays all metadata directly associated to this object as RDF triples.

277 TRIPLES      21 PREDICATES      80 URIs      35 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1016/s0893-133x(00)00111-1 schema:about N32589ddde73a4e1e87481c91ad21c753
2 N389162f3899c41858f49429fbfe231f7
3 N4ed09a7db95b495897bc22c8c74c5b12
4 N7039cb3f3da2404abccb92ed2de7f768
5 N7e2ab23e14b84c89bb5057d2221a50aa
6 N969270bb00ce4842a916c5b3ee016201
7 Na5e1153a052848e58fc77ee47cf9bc5d
8 Na9b080a21b29462386b75e94e8e7a4fd
9 Nab9dc56c900444abb7c862ce9f4375c1
10 Nb1cede3de71247a2944848c0f41eb6a6
11 Nc131cb473dea487899b2d9f87a746015
12 Nc52c34dd23e94938a494076a30f4d9b1
13 Ncc09433a4b5e4d598f4cc671853f0856
14 Neea8fa815132449798f53af163e57ec3
15 Nf86e972b33214a9abee7d572e0708a1d
16 anzsrc-for:17
17 anzsrc-for:1701
18 schema:author Nb7989cb938dd41c2b21b92266270297b
19 schema:citation sg:pub.10.1007/bf00180841
20 sg:pub.10.1007/bf02311179
21 sg:pub.10.1007/s002130050533
22 sg:pub.10.1016/s0893-133x(98)00093-1
23 sg:pub.10.1016/s0893-133x(98)00127-4
24 sg:pub.10.1016/s0893-133x(99)00060-3
25 sg:pub.10.1016/s0893-133x(99)00070-6
26 https://app.dimensions.ai/details/publication/pub.1079394574
27 https://doi.org/10.1001/archpsyc.1996.01830050084013
28 https://doi.org/10.1002/cne.902820302
29 https://doi.org/10.1016/0006-8993(93)91034-p
30 https://doi.org/10.1016/0014-2999(91)90299-6
31 https://doi.org/10.1016/0014-4886(70)90222-0
32 https://doi.org/10.1016/0163-1047(92)90327-z
33 https://doi.org/10.1016/0166-2236(90)90146-2
34 https://doi.org/10.1016/0361-9230(96)00026-3
35 https://doi.org/10.1016/0920-9964(88)90024-2
36 https://doi.org/10.1016/s0002-7138(09)60065-0
37 https://doi.org/10.1016/s0006-3223(99)00139-0
38 https://doi.org/10.1016/s0031-3203(98)00091-0
39 https://doi.org/10.1016/s0140-6736(88)92668-2
40 https://doi.org/10.1016/s0163-1047(05)80034-2
41 https://doi.org/10.1016/s1364-6613(98)01240-6
42 https://doi.org/10.1017/s0033291700026829
43 https://doi.org/10.1046/j.1460-9568.1999.00464.x
44 https://doi.org/10.1089/cap.1995.5.215
45 https://doi.org/10.1097/00004583-199501000-00013
46 https://doi.org/10.1097/00004583-199509000-00010
47 https://doi.org/10.1109/42.730402
48 https://doi.org/10.1111/j.1460-9568.1997.tb01635.x
49 https://doi.org/10.1117/12.237936
50 https://doi.org/10.1118/1.598130
51 https://doi.org/10.1126/science.2999977
52 https://doi.org/10.1152/jn.1989.61.2.331
53 https://doi.org/10.1152/jn.1998.80.4.2200
54 https://doi.org/10.1523/jneurosci.08-11-04287.1988
55 https://doi.org/10.1523/jneurosci.14-05-02775.1994
56 schema:datePublished 2000-09-01
57 schema:datePublishedReg 2000-09-01
58 schema:description Research indicates that norepinephrine enhances the working memory functions of the prefrontal cortex (PFC) through actions at post-synaptic, alpha-2A adrenoceptors. The current study examined the effects of the alpha-2A adrenoreceptor agonist, guanfacine (0.7 mg/kg, i.m.), compared to saline on SPECT measures of regional cerebral blood flow (rCBF) in monkeys performing a spatial working memory task. Animals were infused with the SPECT blood flow tracer, Tcm-99m ECD, through an indwelling intravenous catheter while performing the working memory task. Guanfacine treatment significantly improved cognitive performance of the working memory task, and significantly increased rCBF values in the dorsolateral PFC, the brain region most tightly associated with performance of spatial working memory tasks. In contrast, guanfacine had no significant effect on rCBF in the superior temporal cortex, an auditory association area unrelated to task performance. These data are consistent with the hypothesis that alpha-2A adrenoceptor stimulation preferentially enhances functioning of the PFC.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree true
62 schema:isPartOf N4dd9de19616f4d6b8f274dbccdf9e906
63 N7dd13c7d3851444a9911b4527ad0157f
64 sg:journal.1099176
65 schema:name The Alpha-2A-Adrenoceptor Agonist, Guanfacine, Increases Regional Cerebral Blood Flow in Dorsolateral Prefrontal Cortex of Monkeys Performing a Spatial Working Memory Task
66 schema:pagination 1395519
67 schema:productId N33993be073b74e6fbba16f8f14246be4
68 N4aee293b3b3a44a581bf07bc6efdf2a5
69 N8d58b39867684bc383e8c2ad647880bc
70 N8d8a4e76a416461ea63face26f800580
71 N99a87ce11001491bad9503f100c78ab1
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033181767
73 https://doi.org/10.1016/s0893-133x(00)00111-1
74 schema:sdDatePublished 2019-04-10T18:08
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher N64afb699219a4c4f91e203a5e6bdc340
77 schema:url http://www.nature.com/articles/1395519
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N22c7da0859c54d2882a2f69f4b7c1ef0 rdf:first sg:person.014130671777.04
82 rdf:rest rdf:nil
83 N32589ddde73a4e1e87481c91ad21c753 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Stimulation, Chemical
85 rdf:type schema:DefinedTerm
86 N33993be073b74e6fbba16f8f14246be4 schema:name dimensions_id
87 schema:value pub.1033181767
88 rdf:type schema:PropertyValue
89 N389162f3899c41858f49429fbfe231f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Memory
91 rdf:type schema:DefinedTerm
92 N4aee293b3b3a44a581bf07bc6efdf2a5 schema:name readcube_id
93 schema:value 9e127a52044fd29cc69794714491b503a2fd21d02c1470756dff9ddf42ac0574
94 rdf:type schema:PropertyValue
95 N4dd9de19616f4d6b8f274dbccdf9e906 schema:volumeNumber 23
96 rdf:type schema:PublicationVolume
97 N4ed09a7db95b495897bc22c8c74c5b12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Prefrontal Cortex
99 rdf:type schema:DefinedTerm
100 N51b1efc56ee746819f1e16523879f819 rdf:first sg:person.010314560137.05
101 rdf:rest N22c7da0859c54d2882a2f69f4b7c1ef0
102 N64afb699219a4c4f91e203a5e6bdc340 schema:name Springer Nature - SN SciGraph project
103 rdf:type schema:Organization
104 N7039cb3f3da2404abccb92ed2de7f768 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Macaca mulatta
106 rdf:type schema:DefinedTerm
107 N7dd13c7d3851444a9911b4527ad0157f schema:issueNumber 3
108 rdf:type schema:PublicationIssue
109 N7e2ab23e14b84c89bb5057d2221a50aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Tomography, Emission-Computed, Single-Photon
111 rdf:type schema:DefinedTerm
112 N8d58b39867684bc383e8c2ad647880bc schema:name doi
113 schema:value 10.1016/s0893-133x(00)00111-1
114 rdf:type schema:PropertyValue
115 N8d8a4e76a416461ea63face26f800580 schema:name nlm_unique_id
116 schema:value 8904907
117 rdf:type schema:PropertyValue
118 N9288e868fe734a6788cd559c2648073f rdf:first sg:person.0610515701.03
119 rdf:rest N51b1efc56ee746819f1e16523879f819
120 N969270bb00ce4842a916c5b3ee016201 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Cerebrovascular Circulation
122 rdf:type schema:DefinedTerm
123 N99a87ce11001491bad9503f100c78ab1 schema:name pubmed_id
124 schema:value 10942848
125 rdf:type schema:PropertyValue
126 Na5e1153a052848e58fc77ee47cf9bc5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Image Processing, Computer-Assisted
128 rdf:type schema:DefinedTerm
129 Na9b080a21b29462386b75e94e8e7a4fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Guanfacine
131 rdf:type schema:DefinedTerm
132 Nab9dc56c900444abb7c862ce9f4375c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Cognition
134 rdf:type schema:DefinedTerm
135 Nb1cede3de71247a2944848c0f41eb6a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Adrenergic alpha-2 Receptor Agonists
137 rdf:type schema:DefinedTerm
138 Nb7989cb938dd41c2b21b92266270297b rdf:first sg:person.01144562316.13
139 rdf:rest Ne842547a4ab944828a35e03e75952430
140 Nc131cb473dea487899b2d9f87a746015 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Animals
142 rdf:type schema:DefinedTerm
143 Nc52c34dd23e94938a494076a30f4d9b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Magnetic Resonance Imaging
145 rdf:type schema:DefinedTerm
146 Ncc09433a4b5e4d598f4cc671853f0856 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Space Perception
148 rdf:type schema:DefinedTerm
149 Ne842547a4ab944828a35e03e75952430 rdf:first sg:person.01024423747.64
150 rdf:rest N9288e868fe734a6788cd559c2648073f
151 Neea8fa815132449798f53af163e57ec3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Adrenergic alpha-Agonists
153 rdf:type schema:DefinedTerm
154 Nf86e972b33214a9abee7d572e0708a1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Female
156 rdf:type schema:DefinedTerm
157 anzsrc-for:17 schema:inDefinedTermSet anzsrc-for:
158 schema:name Psychology and Cognitive Sciences
159 rdf:type schema:DefinedTerm
160 anzsrc-for:1701 schema:inDefinedTermSet anzsrc-for:
161 schema:name Psychology
162 rdf:type schema:DefinedTerm
163 sg:journal.1099176 schema:issn 0893-133X
164 1740-634X
165 schema:name Neuropsychopharmacology
166 rdf:type schema:Periodical
167 sg:person.01024423747.64 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
168 schema:familyName Franowicz
169 schema:givenName Jenna S
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024423747.64
171 rdf:type schema:Person
172 sg:person.010314560137.05 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
173 schema:familyName van Dyck
174 schema:givenName Christopher H
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010314560137.05
176 rdf:type schema:Person
177 sg:person.01144562316.13 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
178 schema:familyName Avery
179 schema:givenName Robert A
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144562316.13
181 rdf:type schema:Person
182 sg:person.014130671777.04 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
183 schema:familyName Arnsten
184 schema:givenName Amy FT
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014130671777.04
186 rdf:type schema:Person
187 sg:person.0610515701.03 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
188 schema:familyName Studholme
189 schema:givenName Colin
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610515701.03
191 rdf:type schema:Person
192 sg:pub.10.1007/bf00180841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051901673
193 https://doi.org/10.1007/bf00180841
194 rdf:type schema:CreativeWork
195 sg:pub.10.1007/bf02311179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014222582
196 https://doi.org/10.1007/bf02311179
197 rdf:type schema:CreativeWork
198 sg:pub.10.1007/s002130050533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011583097
199 https://doi.org/10.1007/s002130050533
200 rdf:type schema:CreativeWork
201 sg:pub.10.1016/s0893-133x(98)00093-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024965277
202 https://doi.org/10.1016/s0893-133x(98)00093-1
203 rdf:type schema:CreativeWork
204 sg:pub.10.1016/s0893-133x(98)00127-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003785366
205 https://doi.org/10.1016/s0893-133x(98)00127-4
206 rdf:type schema:CreativeWork
207 sg:pub.10.1016/s0893-133x(99)00060-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038890206
208 https://doi.org/10.1016/s0893-133x(99)00060-3
209 rdf:type schema:CreativeWork
210 sg:pub.10.1016/s0893-133x(99)00070-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034010103
211 https://doi.org/10.1016/s0893-133x(99)00070-6
212 rdf:type schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1079394574 schema:CreativeWork
214 https://doi.org/10.1001/archpsyc.1996.01830050084013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038327209
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1002/cne.902820302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007745435
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/0006-8993(93)91034-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1025091367
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/0014-2999(91)90299-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029085569
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/0014-4886(70)90222-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022770558
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/0163-1047(92)90327-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1047074388
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/0166-2236(90)90146-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025676326
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/0361-9230(96)00026-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053481448
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/0920-9964(88)90024-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034396956
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0002-7138(09)60065-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047499644
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0006-3223(99)00139-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007408457
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/s0031-3203(98)00091-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015765380
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/s0140-6736(88)92668-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037750474
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0163-1047(05)80034-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000208800
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/s1364-6613(98)01240-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048645815
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1017/s0033291700026829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053983389
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1046/j.1460-9568.1999.00464.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014053694
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1089/cap.1995.5.215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059240611
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1097/00004583-199501000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015887160
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1097/00004583-199509000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042649637
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1109/42.730402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061170674
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1111/j.1460-9568.1997.tb01635.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002187171
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1117/12.237936 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013721382
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1118/1.598130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013313254
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1126/science.2999977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062580099
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1152/jn.1989.61.2.331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079453831
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1152/jn.1998.80.4.2200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083329738
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1523/jneurosci.08-11-04287.1988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079446869
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1523/jneurosci.14-05-02775.1994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082690149
271 rdf:type schema:CreativeWork
272 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
273 schema:name Department of Diagnostic Radiology, Yale Medical School, New Haven, CT USA
274 Department of Electrical Engineering, Yale Medical School, New Haven, CT USA
275 Department of Psychiatry, Yale Medical School, New Haven, CT USA
276 Section of Neurobiology, Yale Medical School, New Haven, CT USA
277 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...