A nonlinear three-compartment model for the administration of 2',3'-dideoxycytidine by using red blood cells as bioreactors. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990

AUTHORS

F Solimano, G I Bischi, M Bianchi, L Rossi, M Magnani

ABSTRACT

A non-linear three-compartment model is proposed to describe a new strategy for the administration of 2',3'-dideoxycytidine (ddCyd) in the treatment of HIV infections. The drug is injected after having been encapsulated in a non-diffusible form (ddCMP) into erythrocytes. Numerical solutions show that by this treatment the highest ddCyd blood concentration is strongly reduced and in turn its toxicity, while long-lasting therapeutic effect is assured. The model is compared with experimental data in vitro. More... »

PAGES

785-96

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/s0092-8240(05)80385-4

DOI

http://dx.doi.org/10.1016/s0092-8240(05)80385-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1054613854

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2177675


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