Regression and regrowth of tumour cords following single-dose anticancer treatment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-09

AUTHORS

Alessandro Bertuzzi, Alberto D’Onofrio, Antonio Fasano, Alberto Gandolfi

ABSTRACT

In this paper, the evolution of a tumour cord after treatment is investigated by extensive numerical simulations on the basis of a mathematical model developed by Bertuzzi et al. (submitted). The model is formulated in cylindrical symmetry adopting the continuum approach, and takes into account the influence of oxygen level on the proliferation and death rate of cells, the volume reduction due to disgregation of dead cells, and the cell killing effects of radiation and drugs. Some extensions of the model are proposed to represent more accurately the radioresistance of hypoxic cells and the cytotoxic action of anticancer drugs. The steady state of the cord, and the cord evolution from the steady state after the delivery of a single dose of an anticancer agent, are computed for various combinations of model parameters and for different choices of the functions describing the effects of treatments. The results of the numerical computations show that, in spite of its many simplifications, the model behaviour appears to be reasonable in view of the available experimental observations. The model allows having a better insight into some complex treatment-related events, such as cell reoxygenation and repopulation. More... »

PAGES

903-931

References to SciGraph publications

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  • 2001-03. Tumor Physiology and Drug Resistance in CANCER AND METASTASIS REVIEWS
  • 1984-09. Tumour-cord parameters in two rat hepatomas that differ in their radiobiological oxygenation status in RADIATION AND ENVIRONMENTAL BIOPHYSICS
  • 1999-03. Measurement of delivery and metabolism of tirapazamine to tumour tissue using the multilayered cell culture model in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 1995-01. Angiogenesis in cancer, vascular, rheumatoid and other disease in NATURE MEDICINE
  • 1968-06. The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour in BRITISH JOURNAL OF CANCER
  • 1991-07. Changes in tumour morphology with alterations in oxygen availability: further evidence for oxygen as a limiting substrate in BRITISH JOURNAL OF CANCER
  • 2002-08. The role of cell-cell interactions in a two-phase model for avascular tumour growth in JOURNAL OF MATHEMATICAL BIOLOGY
  • 1995-02. Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression in NATURE MEDICINE
  • 1985-03. Tumour cords in 52 human bronchial and cervical squamous cell carcinomas: Inferences for their cellular kinetics and radiobiology in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1016/s0092-8240(03)00054-5

    DOI

    http://dx.doi.org/10.1016/s0092-8240(03)00054-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1033177391

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12909255


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