Hemodynamic effects of continuous urodilatin infusion: A dose‐finding study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-09-11

AUTHORS

Guido T. Dorner, Nicole Selenko, Thomas Kral, Leopold Schmetterer, Hans‐Georg Eichler, Michael Wolzt

ABSTRACT

OBJECTIVE: To evaluate the effects of urodilatin (INN, ularitide) on systemic and renal hemodynamic parameters. METHODS: Twenty healthy male subjects were included in this double-blind, randomized placebo-controlled trial and assigned to receive either continuous intravenous infusion of different doses of 7.5, 15, or 22.5 ng/kg body weight/min urodilatin or placebo over 300 minutes. Cardiac performance, systolic time intervals, and airway function were measured noninvasively. The effects on renal hemodynamic values were assessed with para-aminohippurate and inulin clearance techniques. RESULTS: Urodilatin was well tolerated by all subjects at doses of 7.5 and 15 ng/kg/min. Infusion was stopped prematurely for the group that received 22.5 ng/kg/min urodilatin group because of systemic hypotensive responses with nausea and dizziness. Infusion of 15 ng/kg/min urodilatin significantly increased urine flow by a maximum of 165%, filtration fraction by 46%, renal resistance by 49%, and systemic vascular resistance by 45%. It decreased renal plasma flow by a maximum of 31% from baseline value. No change in cardiac inotropic function was detectable, but cardiac output decreased in all dose groups. Effects on glomerular filtration rate, forced expiratory volume, blood pressure, and pulse were not different from those with placebo. CONCLUSION: Continuous infusion of 7.5 ng/kg/min and 15 ng/kg/min urodilatin exerts a significant increase in systemic and renal vascular resistance. Results of our experiments suggested that the therapeutic window for continuous urodilatin infusion is small and that doses higher than approximately 20 ng/kg/min urodilatin carry high risk for adverse drug reactions. More... »

PAGES

322-330

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/s0009-9236(98)90181-3

DOI

http://dx.doi.org/10.1016/s0009-9236(98)90181-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052818063

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9757156


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Atrial Natriuretic Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diuretics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Double-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Administration Schedule", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemodynamics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infusions, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Fragments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renal Circulation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Clinical Pharmacology and Institute of Medical Physics Vienna University Vienna Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Clinical Pharmacology and Institute of Medical Physics Vienna University Vienna Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dorner", 
        "givenName": "Guido T.", 
        "id": "sg:person.01353176734.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353176734.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Pharmacology and Institute of Medical Physics Vienna University Vienna Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Clinical Pharmacology and Institute of Medical Physics Vienna University Vienna Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Selenko", 
        "givenName": "Nicole", 
        "id": "sg:person.01212503046.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212503046.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Pharmacology and Institute of Medical Physics Vienna University Vienna Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Clinical Pharmacology and Institute of Medical Physics Vienna University Vienna Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kral", 
        "givenName": "Thomas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Pharmacology and Institute of Medical Physics Vienna University Vienna Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Clinical Pharmacology and Institute of Medical Physics Vienna University Vienna Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmetterer", 
        "givenName": "Leopold", 
        "id": "sg:person.01200335373.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200335373.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Pharmacology and Institute of Medical Physics Vienna University Vienna Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Clinical Pharmacology and Institute of Medical Physics Vienna University Vienna Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eichler", 
        "givenName": "Hans\u2010Georg", 
        "id": "sg:person.014224752232.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014224752232.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Pharmacology and Institute of Medical Physics Vienna University Vienna Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Clinical Pharmacology and Institute of Medical Physics Vienna University Vienna Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wolzt", 
        "givenName": "Michael", 
        "id": "sg:person.01071421740.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071421740.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00180284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010236877", 
          "https://doi.org/10.1007/bf00180284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01726570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028609592", 
          "https://doi.org/10.1007/bf01726570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00180055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033442648", 
          "https://doi.org/10.1007/bf00180055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/clpt.1992.199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039035481", 
          "https://doi.org/10.1038/clpt.1992.199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001010050271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054510475", 
          "https://doi.org/10.1007/s001010050271"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998-09-11", 
    "datePublishedReg": "1998-09-11", 
    "description": "OBJECTIVE: To evaluate the effects of urodilatin (INN, ularitide) on systemic and renal hemodynamic parameters.\nMETHODS: Twenty healthy male subjects were included in this double-blind, randomized placebo-controlled trial and assigned to receive either continuous intravenous infusion of different doses of 7.5, 15, or 22.5 ng/kg body weight/min urodilatin or placebo over 300 minutes. Cardiac performance, systolic time intervals, and airway function were measured noninvasively. The effects on renal hemodynamic values were assessed with para-aminohippurate and inulin clearance techniques.\nRESULTS: Urodilatin was well tolerated by all subjects at doses of 7.5 and 15 ng/kg/min. Infusion was stopped prematurely for the group that received 22.5 ng/kg/min urodilatin group because of systemic hypotensive responses with nausea and dizziness. Infusion of 15 ng/kg/min urodilatin significantly increased urine flow by a maximum of 165%, filtration fraction by 46%, renal resistance by 49%, and systemic vascular resistance by 45%. It decreased renal plasma flow by a maximum of 31% from baseline value. No change in cardiac inotropic function was detectable, but cardiac output decreased in all dose groups. Effects on glomerular filtration rate, forced expiratory volume, blood pressure, and pulse were not different from those with placebo.\nCONCLUSION: Continuous infusion of 7.5 ng/kg/min and 15 ng/kg/min urodilatin exerts a significant increase in systemic and renal vascular resistance. Results of our experiments suggested that the therapeutic window for continuous urodilatin infusion is small and that doses higher than approximately 20 ng/kg/min urodilatin carry high risk for adverse drug reactions.", 
    "genre": "article", 
    "id": "sg:pub.10.1016/s0009-9236(98)90181-3", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017409", 
        "issn": [
          "0009-9236", 
          "1532-6535"
        ], 
        "name": "Clinical Pharmacology & Therapeutics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "64"
      }
    ], 
    "keywords": [
      "urodilatin infusion", 
      "vascular resistance", 
      "randomized placebo-controlled trial", 
      "effects of urodilatin", 
      "systemic hypotensive responses", 
      "cardiac inotropic function", 
      "placebo-controlled trial", 
      "systemic vascular resistance", 
      "renal vascular resistance", 
      "renal hemodynamic parameters", 
      "glomerular filtration rate", 
      "continuous intravenous infusion", 
      "renal plasma flow", 
      "dose-finding study", 
      "adverse drug reactions", 
      "inulin clearance technique", 
      "healthy male subjects", 
      "systolic time intervals", 
      "hypotensive response", 
      "airway function", 
      "expiratory volume", 
      "hemodynamic effects", 
      "hemodynamic values", 
      "blood pressure", 
      "renal resistance", 
      "inotropic function", 
      "dose group", 
      "intravenous infusion", 
      "cardiac output", 
      "continuous infusion", 
      "filtration rate", 
      "drug reactions", 
      "clearance technique", 
      "urine flow", 
      "hemodynamic parameters", 
      "cardiac performance", 
      "filtration fraction", 
      "baseline values", 
      "therapeutic window", 
      "high risk", 
      "urodilatin", 
      "para-aminohippurate", 
      "male subjects", 
      "infusion", 
      "different doses", 
      "significant increase", 
      "doses", 
      "group", 
      "subjects", 
      "plasma flow", 
      "nausea", 
      "placebo", 
      "dizziness", 
      "min", 
      "trials", 
      "time interval", 
      "effect", 
      "risk", 
      "resistance", 
      "minutes", 
      "response", 
      "interval", 
      "function", 
      "study", 
      "rate", 
      "increase", 
      "volume", 
      "changes", 
      "pressure", 
      "values", 
      "fraction", 
      "results", 
      "flow", 
      "reaction", 
      "technique", 
      "maximum", 
      "window", 
      "output", 
      "parameters", 
      "experiments", 
      "pulses", 
      "performance"
    ], 
    "name": "Hemodynamic effects of continuous urodilatin infusion: A dose\u2010finding study", 
    "pagination": "322-330", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1052818063"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1016/s0009-9236(98)90181-3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9757156"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1016/s0009-9236(98)90181-3", 
      "https://app.dimensions.ai/details/publication/pub.1052818063"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_283.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1016/s0009-9236(98)90181-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1016/s0009-9236(98)90181-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1016/s0009-9236(98)90181-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1016/s0009-9236(98)90181-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1016/s0009-9236(98)90181-3'


 

This table displays all metadata directly associated to this object as RDF triples.

245 TRIPLES      21 PREDICATES      124 URIs      111 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1016/s0009-9236(98)90181-3 schema:about N0e998ec04c5e47e5842acdb7ddd395e7
2 N2a13103812534feea59958e48b5adf3f
3 N466f97e1a24840f4a0bf2550a79d4aaf
4 N5b5cbd34e24240cf89aa11583b4882bf
5 N630303945c1a43739ccc8e7430de83ca
6 N735894d6380d4184892412ba9524d308
7 N76698a24e7c74d6695cb87e346571394
8 N7afcd7fd7bac4e2984c83640bfd4aece
9 N912c2cd3ce9a40628f6c545bae11122e
10 Nb2347427901f47f8b397f09b1f9962b1
11 Nde6a75b6b64841dcbef83abd55d29a82
12 Ne58c57a8b0ea4c209c553a61ea8d700a
13 anzsrc-for:11
14 anzsrc-for:1102
15 schema:author N16021939b62b4c898c5fa7f1164c537d
16 schema:citation sg:pub.10.1007/bf00180055
17 sg:pub.10.1007/bf00180284
18 sg:pub.10.1007/bf01726570
19 sg:pub.10.1007/s001010050271
20 sg:pub.10.1038/clpt.1992.199
21 schema:datePublished 1998-09-11
22 schema:datePublishedReg 1998-09-11
23 schema:description OBJECTIVE: To evaluate the effects of urodilatin (INN, ularitide) on systemic and renal hemodynamic parameters. METHODS: Twenty healthy male subjects were included in this double-blind, randomized placebo-controlled trial and assigned to receive either continuous intravenous infusion of different doses of 7.5, 15, or 22.5 ng/kg body weight/min urodilatin or placebo over 300 minutes. Cardiac performance, systolic time intervals, and airway function were measured noninvasively. The effects on renal hemodynamic values were assessed with para-aminohippurate and inulin clearance techniques. RESULTS: Urodilatin was well tolerated by all subjects at doses of 7.5 and 15 ng/kg/min. Infusion was stopped prematurely for the group that received 22.5 ng/kg/min urodilatin group because of systemic hypotensive responses with nausea and dizziness. Infusion of 15 ng/kg/min urodilatin significantly increased urine flow by a maximum of 165%, filtration fraction by 46%, renal resistance by 49%, and systemic vascular resistance by 45%. It decreased renal plasma flow by a maximum of 31% from baseline value. No change in cardiac inotropic function was detectable, but cardiac output decreased in all dose groups. Effects on glomerular filtration rate, forced expiratory volume, blood pressure, and pulse were not different from those with placebo. CONCLUSION: Continuous infusion of 7.5 ng/kg/min and 15 ng/kg/min urodilatin exerts a significant increase in systemic and renal vascular resistance. Results of our experiments suggested that the therapeutic window for continuous urodilatin infusion is small and that doses higher than approximately 20 ng/kg/min urodilatin carry high risk for adverse drug reactions.
24 schema:genre article
25 schema:isAccessibleForFree false
26 schema:isPartOf N97b7945fe32249adbf58bd88d991c046
27 Nc44327b43f11430a96b64c03a273cb9a
28 sg:journal.1017409
29 schema:keywords adverse drug reactions
30 airway function
31 baseline values
32 blood pressure
33 cardiac inotropic function
34 cardiac output
35 cardiac performance
36 changes
37 clearance technique
38 continuous infusion
39 continuous intravenous infusion
40 different doses
41 dizziness
42 dose group
43 dose-finding study
44 doses
45 drug reactions
46 effect
47 effects of urodilatin
48 experiments
49 expiratory volume
50 filtration fraction
51 filtration rate
52 flow
53 fraction
54 function
55 glomerular filtration rate
56 group
57 healthy male subjects
58 hemodynamic effects
59 hemodynamic parameters
60 hemodynamic values
61 high risk
62 hypotensive response
63 increase
64 infusion
65 inotropic function
66 interval
67 intravenous infusion
68 inulin clearance technique
69 male subjects
70 maximum
71 min
72 minutes
73 nausea
74 output
75 para-aminohippurate
76 parameters
77 performance
78 placebo
79 placebo-controlled trial
80 plasma flow
81 pressure
82 pulses
83 randomized placebo-controlled trial
84 rate
85 reaction
86 renal hemodynamic parameters
87 renal plasma flow
88 renal resistance
89 renal vascular resistance
90 resistance
91 response
92 results
93 risk
94 significant increase
95 study
96 subjects
97 systemic hypotensive responses
98 systemic vascular resistance
99 systolic time intervals
100 technique
101 therapeutic window
102 time interval
103 trials
104 urine flow
105 urodilatin
106 urodilatin infusion
107 values
108 vascular resistance
109 volume
110 window
111 schema:name Hemodynamic effects of continuous urodilatin infusion: A dose‐finding study
112 schema:pagination 322-330
113 schema:productId N21c5cc6fd2944191a0a0245c91b5e2c9
114 N556bb382f0c14d848102d75df3edf130
115 N6981b92e5fb540c9af70dc6003fe752e
116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052818063
117 https://doi.org/10.1016/s0009-9236(98)90181-3
118 schema:sdDatePublished 2022-09-02T15:48
119 schema:sdLicense https://scigraph.springernature.com/explorer/license/
120 schema:sdPublisher Nc9500f21caed453ab46f17a50f06777a
121 schema:url https://doi.org/10.1016/s0009-9236(98)90181-3
122 sgo:license sg:explorer/license/
123 sgo:sdDataset articles
124 rdf:type schema:ScholarlyArticle
125 N0534b7ca693f4f7eb0ec7938d6ab979b rdf:first sg:person.014224752232.33
126 rdf:rest Na2360da9eeb9412095d6734ef39f8055
127 N0e998ec04c5e47e5842acdb7ddd395e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Male
129 rdf:type schema:DefinedTerm
130 N16021939b62b4c898c5fa7f1164c537d rdf:first sg:person.01353176734.61
131 rdf:rest Ne31b162ef1424453aaf95c44f58085aa
132 N21c5cc6fd2944191a0a0245c91b5e2c9 schema:name dimensions_id
133 schema:value pub.1052818063
134 rdf:type schema:PropertyValue
135 N2a13103812534feea59958e48b5adf3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Adult
137 rdf:type schema:DefinedTerm
138 N466f97e1a24840f4a0bf2550a79d4aaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Peptide Fragments
140 rdf:type schema:DefinedTerm
141 N49756a87a65b4b218a7c01e362018fe5 rdf:first sg:person.01200335373.31
142 rdf:rest N0534b7ca693f4f7eb0ec7938d6ab979b
143 N556bb382f0c14d848102d75df3edf130 schema:name pubmed_id
144 schema:value 9757156
145 rdf:type schema:PropertyValue
146 N5b5cbd34e24240cf89aa11583b4882bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Atrial Natriuretic Factor
148 rdf:type schema:DefinedTerm
149 N630303945c1a43739ccc8e7430de83ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Infusions, Intravenous
151 rdf:type schema:DefinedTerm
152 N6981b92e5fb540c9af70dc6003fe752e schema:name doi
153 schema:value 10.1016/s0009-9236(98)90181-3
154 rdf:type schema:PropertyValue
155 N735894d6380d4184892412ba9524d308 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Hemodynamics
157 rdf:type schema:DefinedTerm
158 N76698a24e7c74d6695cb87e346571394 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Drug Administration Schedule
160 rdf:type schema:DefinedTerm
161 N7afcd7fd7bac4e2984c83640bfd4aece schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Dose-Response Relationship, Drug
163 rdf:type schema:DefinedTerm
164 N7e1dba662dca4d3fa24292ae5a583d99 schema:affiliation grid-institutes:grid.22937.3d
165 schema:familyName Kral
166 schema:givenName Thomas
167 rdf:type schema:Person
168 N912c2cd3ce9a40628f6c545bae11122e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Renal Circulation
170 rdf:type schema:DefinedTerm
171 N97b7945fe32249adbf58bd88d991c046 schema:issueNumber 3
172 rdf:type schema:PublicationIssue
173 Na2360da9eeb9412095d6734ef39f8055 rdf:first sg:person.01071421740.29
174 rdf:rest rdf:nil
175 Nb2347427901f47f8b397f09b1f9962b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Diuretics
177 rdf:type schema:DefinedTerm
178 Nc44327b43f11430a96b64c03a273cb9a schema:volumeNumber 64
179 rdf:type schema:PublicationVolume
180 Nc9500f21caed453ab46f17a50f06777a schema:name Springer Nature - SN SciGraph project
181 rdf:type schema:Organization
182 Nde6a75b6b64841dcbef83abd55d29a82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Humans
184 rdf:type schema:DefinedTerm
185 Ne31b162ef1424453aaf95c44f58085aa rdf:first sg:person.01212503046.46
186 rdf:rest Nfa2c890951cc44fcbc2fdabd9e8195df
187 Ne58c57a8b0ea4c209c553a61ea8d700a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Double-Blind Method
189 rdf:type schema:DefinedTerm
190 Nfa2c890951cc44fcbc2fdabd9e8195df rdf:first N7e1dba662dca4d3fa24292ae5a583d99
191 rdf:rest N49756a87a65b4b218a7c01e362018fe5
192 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
193 schema:name Medical and Health Sciences
194 rdf:type schema:DefinedTerm
195 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
196 schema:name Cardiorespiratory Medicine and Haematology
197 rdf:type schema:DefinedTerm
198 sg:journal.1017409 schema:issn 0009-9236
199 1532-6535
200 schema:name Clinical Pharmacology & Therapeutics
201 schema:publisher Springer Nature
202 rdf:type schema:Periodical
203 sg:person.01071421740.29 schema:affiliation grid-institutes:grid.22937.3d
204 schema:familyName Wolzt
205 schema:givenName Michael
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071421740.29
207 rdf:type schema:Person
208 sg:person.01200335373.31 schema:affiliation grid-institutes:grid.22937.3d
209 schema:familyName Schmetterer
210 schema:givenName Leopold
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200335373.31
212 rdf:type schema:Person
213 sg:person.01212503046.46 schema:affiliation grid-institutes:grid.22937.3d
214 schema:familyName Selenko
215 schema:givenName Nicole
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212503046.46
217 rdf:type schema:Person
218 sg:person.01353176734.61 schema:affiliation grid-institutes:grid.22937.3d
219 schema:familyName Dorner
220 schema:givenName Guido T.
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353176734.61
222 rdf:type schema:Person
223 sg:person.014224752232.33 schema:affiliation grid-institutes:grid.22937.3d
224 schema:familyName Eichler
225 schema:givenName Hans‐Georg
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014224752232.33
227 rdf:type schema:Person
228 sg:pub.10.1007/bf00180055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033442648
229 https://doi.org/10.1007/bf00180055
230 rdf:type schema:CreativeWork
231 sg:pub.10.1007/bf00180284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010236877
232 https://doi.org/10.1007/bf00180284
233 rdf:type schema:CreativeWork
234 sg:pub.10.1007/bf01726570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028609592
235 https://doi.org/10.1007/bf01726570
236 rdf:type schema:CreativeWork
237 sg:pub.10.1007/s001010050271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054510475
238 https://doi.org/10.1007/s001010050271
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/clpt.1992.199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039035481
241 https://doi.org/10.1038/clpt.1992.199
242 rdf:type schema:CreativeWork
243 grid-institutes:grid.22937.3d schema:alternateName Department of Clinical Pharmacology and Institute of Medical Physics Vienna University Vienna Austria
244 schema:name Department of Clinical Pharmacology and Institute of Medical Physics Vienna University Vienna Austria
245 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...