Metabolism and action of urodilatin infusion in healthy volunteers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-07-11

AUTHORS

Jan Carstens, Kaare T. Jensen, Erling B. Pedersen

ABSTRACT

OBJECTIVES: The objective of this investigation was to study both the pharmacokinetics and renal pharmacodynamic properties of intravenously infused urodilatin in human beings. METHODS: Twelve healthy subjects received a short-term infusion (90 minutes) of urodilatin and placebo with a graded infusion rate (from 7.5 to 15 to 30 ng.kg body weight-1.min-1) in a randomized, double-blind, crossover study design. The renal parameters were evaluated by clearance technique with the use of 51Cr-ethylenediaminetetraacetic acid, 125I-hippuran, and lithium. Urodilatin concentrations were determined by a radioimmunoassay with a urodilatin-specific antibody. RESULTS: Kinetics were characterized by a high apparent volume of distribution (43.7 +/- 11.2 L), a high total body clearance (5383 +/- 581 ml/min), and a short plasma half-life (5.57 +/- 0.8 minutes). The maximal plasma urodilatin level was 177.2 +/- 25.8 pmol/L. Less than 1% of total infused urodilatin was recovered in urine. Urodilatin significantly increased glomerular filtration rate (urodilatin, 7.0%, versus placebo, -1.9%; p < 0.05), reduced effective renal plasma flow (urodilatin, -17%, versus placebo, -3%; p < 0.01), increased fractional excretion of sodium (urodilatin, 137%, versus placebo, 27%; p < 0.05), and increased urine flow rate (urodilatin, 46%, versus placebo, -15%; p < 0.01). Fractional excretion of lithium did not change. Mean blood pressure decreased and vasoactive hormone levels remained unchanged or increased. CONCLUSION: The natriuretic and diuretic effects of urodilatin closely followed the profile of urodilatin concentration in plasma. A major part of the synthetic urodilatin was removed from circulation by a route other than filtration through the glomeruli. More... »

PAGES

73-86

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/s0009-9236(98)90025-x

DOI

http://dx.doi.org/10.1016/s0009-9236(98)90025-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031759984

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9695722


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aldosterone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiotensin II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arginine Vasopressin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Atrial Natriuretic Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Over Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic GMP", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diuretics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Double-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematocrit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infusions, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lithium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metabolic Clearance Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Natriuretic Peptide, Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Tissue Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Fragments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sodium", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Research Laboratory of Nephrology and Hypertension Aarhus University Hospital Aarhus Denmark", 
          "id": "http://www.grid.ac/institutes/grid.154185.c", 
          "name": [
            "Research Laboratory of Nephrology and Hypertension Aarhus University Hospital Aarhus Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carstens", 
        "givenName": "Jan", 
        "id": "sg:person.01044156633.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044156633.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Laboratory of Nephrology and Hypertension Aarhus University Hospital Aarhus Denmark", 
          "id": "http://www.grid.ac/institutes/grid.154185.c", 
          "name": [
            "Research Laboratory of Nephrology and Hypertension Aarhus University Hospital Aarhus Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jensen", 
        "givenName": "Kaare T.", 
        "id": "sg:person.01061663771.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061663771.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Laboratory of Nephrology and Hypertension Aarhus University Hospital Aarhus Denmark", 
          "id": "http://www.grid.ac/institutes/grid.154185.c", 
          "name": [
            "Research Laboratory of Nephrology and Hypertension Aarhus University Hospital Aarhus Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pedersen", 
        "givenName": "Erling B.", 
        "id": "sg:person.011776301422.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011776301422.62"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf01726570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028609592", 
          "https://doi.org/10.1007/bf01726570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/324473a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020188762", 
          "https://doi.org/10.1038/324473a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00374863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008732762", 
          "https://doi.org/10.1007/bf00374863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-199324010-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016172365", 
          "https://doi.org/10.2165/00003088-199324010-00003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/344336a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007166174", 
          "https://doi.org/10.1038/344336a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00543482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009463155", 
          "https://doi.org/10.1007/bf00543482"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998-07-11", 
    "datePublishedReg": "1998-07-11", 
    "description": "OBJECTIVES: The objective of this investigation was to study both the pharmacokinetics and renal pharmacodynamic properties of intravenously infused urodilatin in human beings.\nMETHODS: Twelve healthy subjects received a short-term infusion (90 minutes) of urodilatin and placebo with a graded infusion rate (from 7.5 to 15 to 30 ng.kg body weight-1.min-1) in a randomized, double-blind, crossover study design. The renal parameters were evaluated by clearance technique with the use of 51Cr-ethylenediaminetetraacetic acid, 125I-hippuran, and lithium. Urodilatin concentrations were determined by a radioimmunoassay with a urodilatin-specific antibody.\nRESULTS: Kinetics were characterized by a high apparent volume of distribution (43.7 +/- 11.2 L), a high total body clearance (5383 +/- 581 ml/min), and a short plasma half-life (5.57 +/- 0.8 minutes). The maximal plasma urodilatin level was 177.2 +/- 25.8 pmol/L. Less than 1% of total infused urodilatin was recovered in urine. Urodilatin significantly increased glomerular filtration rate (urodilatin, 7.0%, versus placebo, -1.9%; p < 0.05), reduced effective renal plasma flow (urodilatin, -17%, versus placebo, -3%; p < 0.01), increased fractional excretion of sodium (urodilatin, 137%, versus placebo, 27%; p < 0.05), and increased urine flow rate (urodilatin, 46%, versus placebo, -15%; p < 0.01). Fractional excretion of lithium did not change. Mean blood pressure decreased and vasoactive hormone levels remained unchanged or increased.\nCONCLUSION: The natriuretic and diuretic effects of urodilatin closely followed the profile of urodilatin concentration in plasma. A major part of the synthetic urodilatin was removed from circulation by a route other than filtration through the glomeruli.", 
    "genre": "article", 
    "id": "sg:pub.10.1016/s0009-9236(98)90025-x", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017409", 
        "issn": [
          "0009-9236", 
          "1532-6535"
        ], 
        "name": "Clinical Pharmacology & Therapeutics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "64"
      }
    ], 
    "keywords": [
      "fractional excretion", 
      "high total body clearance", 
      "effective renal plasma flow", 
      "vasoactive hormone levels", 
      "mean blood pressure", 
      "glomerular filtration rate", 
      "renal plasma flow", 
      "total body clearance", 
      "short-term infusion", 
      "crossover study design", 
      "urine flow rate", 
      "high apparent volume", 
      "pmol/L.", 
      "synthetic urodilatin", 
      "urodilatin infusion", 
      "renal parameters", 
      "blood pressure", 
      "body clearance", 
      "clearance technique", 
      "filtration rate", 
      "diuretic effect", 
      "hormone levels", 
      "healthy subjects", 
      "infusion rate", 
      "healthy volunteers", 
      "pharmacodynamic properties", 
      "urodilatin", 
      "apparent volume", 
      "short plasma", 
      "study design", 
      "infusion", 
      "excretion", 
      "plasma flow", 
      "placebo", 
      "pharmacokinetics", 
      "glomeruli", 
      "radioimmunoassay", 
      "antibodies", 
      "clearance", 
      "volunteers", 
      "urine", 
      "rate", 
      "levels", 
      "plasma", 
      "metabolism", 
      "subjects", 
      "concentration", 
      "sodium", 
      "circulation", 
      "action", 
      "effect", 
      "volume", 
      "profile", 
      "objective", 
      "acid", 
      "pressure", 
      "use", 
      "lithium", 
      "major part", 
      "human beings", 
      "investigation", 
      "route", 
      "being", 
      "flow rate", 
      "part", 
      "filtration", 
      "L.", 
      "technique", 
      "parameters", 
      "flow", 
      "distribution", 
      "kinetics", 
      "design", 
      "properties"
    ], 
    "name": "Metabolism and action of urodilatin infusion in healthy volunteers", 
    "pagination": "73-86", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031759984"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1016/s0009-9236(98)90025-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9695722"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1016/s0009-9236(98)90025-x", 
      "https://app.dimensions.ai/details/publication/pub.1031759984"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_306.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1016/s0009-9236(98)90025-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1016/s0009-9236(98)90025-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1016/s0009-9236(98)90025-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1016/s0009-9236(98)90025-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1016/s0009-9236(98)90025-x'


 

This table displays all metadata directly associated to this object as RDF triples.

269 TRIPLES      21 PREDICATES      129 URIs      115 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1016/s0009-9236(98)90025-x schema:about N195166387bc345e89c7cd1da8f573940
2 N1fd4bebf2da143a596a1aa69e96f861d
3 N270bddad3bbf4cf29ebea8525c72c683
4 N29a24df6a0d54f068d18644005e775a0
5 N2bb119e509a84c4fb0d22818d30eb700
6 N39b0cacec5054262a614b07868fd7dfa
7 N3b749caa7ef54ecbb59e11fcfbe7adeb
8 N40f77b6c2d374e20b00584dddcc9b1de
9 N50e060631b6c4c66b912c82f12674f92
10 N5af461c6f173483480080fa2502a4008
11 N5bab0f4db4a345309aca72fd803d1471
12 N76c28acd208f47189daee9f79dfca95a
13 N7ba2aeb42ba947a6b478dc8272b8b906
14 N9b7df4cc123444d9a3a2508cd92349b0
15 Na96ddf6099c04f62af15557e4f957083
16 Nac70d767e928458ebded16b7fe6e75b2
17 Naf208359754c480d96e99fdd84083753
18 Nb13cb69a937148a0b139d522f4274880
19 Nbf673d5334ad4e76b714ec71cb08268b
20 Nc62fd0b96ab14a6598cb381e71efde2e
21 Nccab21d56be7436dae395a3843e28f7f
22 Need485381dcb4f6ca6b38b9f4c1edde6
23 Nf05a092fcc8743fbbc68e9a744c70949
24 Nfeaf87bd22ab4186803e9463b099d526
25 anzsrc-for:11
26 anzsrc-for:1103
27 schema:author Nbaf5374789ec44778e64439ae7c501cb
28 schema:citation sg:pub.10.1007/bf00374863
29 sg:pub.10.1007/bf00543482
30 sg:pub.10.1007/bf01726570
31 sg:pub.10.1038/324473a0
32 sg:pub.10.1038/344336a0
33 sg:pub.10.2165/00003088-199324010-00003
34 schema:datePublished 1998-07-11
35 schema:datePublishedReg 1998-07-11
36 schema:description OBJECTIVES: The objective of this investigation was to study both the pharmacokinetics and renal pharmacodynamic properties of intravenously infused urodilatin in human beings. METHODS: Twelve healthy subjects received a short-term infusion (90 minutes) of urodilatin and placebo with a graded infusion rate (from 7.5 to 15 to 30 ng.kg body weight-1.min-1) in a randomized, double-blind, crossover study design. The renal parameters were evaluated by clearance technique with the use of 51Cr-ethylenediaminetetraacetic acid, 125I-hippuran, and lithium. Urodilatin concentrations were determined by a radioimmunoassay with a urodilatin-specific antibody. RESULTS: Kinetics were characterized by a high apparent volume of distribution (43.7 +/- 11.2 L), a high total body clearance (5383 +/- 581 ml/min), and a short plasma half-life (5.57 +/- 0.8 minutes). The maximal plasma urodilatin level was 177.2 +/- 25.8 pmol/L. Less than 1% of total infused urodilatin was recovered in urine. Urodilatin significantly increased glomerular filtration rate (urodilatin, 7.0%, versus placebo, -1.9%; p < 0.05), reduced effective renal plasma flow (urodilatin, -17%, versus placebo, -3%; p < 0.01), increased fractional excretion of sodium (urodilatin, 137%, versus placebo, 27%; p < 0.05), and increased urine flow rate (urodilatin, 46%, versus placebo, -15%; p < 0.01). Fractional excretion of lithium did not change. Mean blood pressure decreased and vasoactive hormone levels remained unchanged or increased. CONCLUSION: The natriuretic and diuretic effects of urodilatin closely followed the profile of urodilatin concentration in plasma. A major part of the synthetic urodilatin was removed from circulation by a route other than filtration through the glomeruli.
37 schema:genre article
38 schema:isAccessibleForFree false
39 schema:isPartOf N1efd2988c0d542b0a6d1ee7a1acf47a9
40 N895c386dc4854a81b253b6972fab82fd
41 sg:journal.1017409
42 schema:keywords L.
43 acid
44 action
45 antibodies
46 apparent volume
47 being
48 blood pressure
49 body clearance
50 circulation
51 clearance
52 clearance technique
53 concentration
54 crossover study design
55 design
56 distribution
57 diuretic effect
58 effect
59 effective renal plasma flow
60 excretion
61 filtration
62 filtration rate
63 flow
64 flow rate
65 fractional excretion
66 glomerular filtration rate
67 glomeruli
68 healthy subjects
69 healthy volunteers
70 high apparent volume
71 high total body clearance
72 hormone levels
73 human beings
74 infusion
75 infusion rate
76 investigation
77 kinetics
78 levels
79 lithium
80 major part
81 mean blood pressure
82 metabolism
83 objective
84 parameters
85 part
86 pharmacodynamic properties
87 pharmacokinetics
88 placebo
89 plasma
90 plasma flow
91 pmol/L.
92 pressure
93 profile
94 properties
95 radioimmunoassay
96 rate
97 renal parameters
98 renal plasma flow
99 route
100 short plasma
101 short-term infusion
102 sodium
103 study design
104 subjects
105 synthetic urodilatin
106 technique
107 total body clearance
108 urine
109 urine flow rate
110 urodilatin
111 urodilatin infusion
112 use
113 vasoactive hormone levels
114 volume
115 volunteers
116 schema:name Metabolism and action of urodilatin infusion in healthy volunteers
117 schema:pagination 73-86
118 schema:productId N002a7632294f4a5d9ef7c7a5959fa6bc
119 N88425cbb99e74da39f6081203bc862d7
120 Nd69390c0e858412aa9c22249d739a7c4
121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031759984
122 https://doi.org/10.1016/s0009-9236(98)90025-x
123 schema:sdDatePublished 2022-09-02T15:49
124 schema:sdLicense https://scigraph.springernature.com/explorer/license/
125 schema:sdPublisher N7fffd4eaba7c4d75945131412625c936
126 schema:url https://doi.org/10.1016/s0009-9236(98)90025-x
127 sgo:license sg:explorer/license/
128 sgo:sdDataset articles
129 rdf:type schema:ScholarlyArticle
130 N002a7632294f4a5d9ef7c7a5959fa6bc schema:name dimensions_id
131 schema:value pub.1031759984
132 rdf:type schema:PropertyValue
133 N0feb72b569f34652b10e5d8491cbc084 rdf:first sg:person.011776301422.62
134 rdf:rest rdf:nil
135 N195166387bc345e89c7cd1da8f573940 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Nerve Tissue Proteins
137 rdf:type schema:DefinedTerm
138 N1efd2988c0d542b0a6d1ee7a1acf47a9 schema:issueNumber 1
139 rdf:type schema:PublicationIssue
140 N1fd4bebf2da143a596a1aa69e96f861d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Metabolic Clearance Rate
142 rdf:type schema:DefinedTerm
143 N270bddad3bbf4cf29ebea8525c72c683 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Sodium
145 rdf:type schema:DefinedTerm
146 N29a24df6a0d54f068d18644005e775a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Hematocrit
148 rdf:type schema:DefinedTerm
149 N2bb119e509a84c4fb0d22818d30eb700 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Peptide Fragments
151 rdf:type schema:DefinedTerm
152 N39b0cacec5054262a614b07868fd7dfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Natriuretic Peptide, Brain
154 rdf:type schema:DefinedTerm
155 N3b749caa7ef54ecbb59e11fcfbe7adeb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Diuretics
157 rdf:type schema:DefinedTerm
158 N40f77b6c2d374e20b00584dddcc9b1de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Humans
160 rdf:type schema:DefinedTerm
161 N50e060631b6c4c66b912c82f12674f92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Double-Blind Method
163 rdf:type schema:DefinedTerm
164 N5af461c6f173483480080fa2502a4008 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Aldosterone
166 rdf:type schema:DefinedTerm
167 N5bab0f4db4a345309aca72fd803d1471 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Cyclic GMP
169 rdf:type schema:DefinedTerm
170 N76c28acd208f47189daee9f79dfca95a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Infusions, Intravenous
172 rdf:type schema:DefinedTerm
173 N7ba2aeb42ba947a6b478dc8272b8b906 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Renin
175 rdf:type schema:DefinedTerm
176 N7fffd4eaba7c4d75945131412625c936 schema:name Springer Nature - SN SciGraph project
177 rdf:type schema:Organization
178 N88425cbb99e74da39f6081203bc862d7 schema:name doi
179 schema:value 10.1016/s0009-9236(98)90025-x
180 rdf:type schema:PropertyValue
181 N895c386dc4854a81b253b6972fab82fd schema:volumeNumber 64
182 rdf:type schema:PublicationVolume
183 N9b7df4cc123444d9a3a2508cd92349b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Cross-Over Studies
185 rdf:type schema:DefinedTerm
186 Na96ddf6099c04f62af15557e4f957083 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Atrial Natriuretic Factor
188 rdf:type schema:DefinedTerm
189 Nac70d767e928458ebded16b7fe6e75b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Male
191 rdf:type schema:DefinedTerm
192 Naf208359754c480d96e99fdd84083753 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Arginine Vasopressin
194 rdf:type schema:DefinedTerm
195 Nb13cb69a937148a0b139d522f4274880 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Adult
197 rdf:type schema:DefinedTerm
198 Nbaf5374789ec44778e64439ae7c501cb rdf:first sg:person.01044156633.92
199 rdf:rest Ne97e343c20b64ca78fdd1485a6e90aa8
200 Nbf673d5334ad4e76b714ec71cb08268b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Heart Rate
202 rdf:type schema:DefinedTerm
203 Nc62fd0b96ab14a6598cb381e71efde2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Lithium
205 rdf:type schema:DefinedTerm
206 Nccab21d56be7436dae395a3843e28f7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Body Weight
208 rdf:type schema:DefinedTerm
209 Nd69390c0e858412aa9c22249d739a7c4 schema:name pubmed_id
210 schema:value 9695722
211 rdf:type schema:PropertyValue
212 Ne97e343c20b64ca78fdd1485a6e90aa8 rdf:first sg:person.01061663771.62
213 rdf:rest N0feb72b569f34652b10e5d8491cbc084
214 Need485381dcb4f6ca6b38b9f4c1edde6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Angiotensin II
216 rdf:type schema:DefinedTerm
217 Nf05a092fcc8743fbbc68e9a744c70949 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Kidney
219 rdf:type schema:DefinedTerm
220 Nfeaf87bd22ab4186803e9463b099d526 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
221 schema:name Blood Pressure
222 rdf:type schema:DefinedTerm
223 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
224 schema:name Medical and Health Sciences
225 rdf:type schema:DefinedTerm
226 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
227 schema:name Clinical Sciences
228 rdf:type schema:DefinedTerm
229 sg:journal.1017409 schema:issn 0009-9236
230 1532-6535
231 schema:name Clinical Pharmacology & Therapeutics
232 schema:publisher Springer Nature
233 rdf:type schema:Periodical
234 sg:person.01044156633.92 schema:affiliation grid-institutes:grid.154185.c
235 schema:familyName Carstens
236 schema:givenName Jan
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044156633.92
238 rdf:type schema:Person
239 sg:person.01061663771.62 schema:affiliation grid-institutes:grid.154185.c
240 schema:familyName Jensen
241 schema:givenName Kaare T.
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061663771.62
243 rdf:type schema:Person
244 sg:person.011776301422.62 schema:affiliation grid-institutes:grid.154185.c
245 schema:familyName Pedersen
246 schema:givenName Erling B.
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011776301422.62
248 rdf:type schema:Person
249 sg:pub.10.1007/bf00374863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008732762
250 https://doi.org/10.1007/bf00374863
251 rdf:type schema:CreativeWork
252 sg:pub.10.1007/bf00543482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009463155
253 https://doi.org/10.1007/bf00543482
254 rdf:type schema:CreativeWork
255 sg:pub.10.1007/bf01726570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028609592
256 https://doi.org/10.1007/bf01726570
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/324473a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020188762
259 https://doi.org/10.1038/324473a0
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/344336a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007166174
262 https://doi.org/10.1038/344336a0
263 rdf:type schema:CreativeWork
264 sg:pub.10.2165/00003088-199324010-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016172365
265 https://doi.org/10.2165/00003088-199324010-00003
266 rdf:type schema:CreativeWork
267 grid-institutes:grid.154185.c schema:alternateName Research Laboratory of Nephrology and Hypertension Aarhus University Hospital Aarhus Denmark
268 schema:name Research Laboratory of Nephrology and Hypertension Aarhus University Hospital Aarhus Denmark
269 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...