Myocardial efficiency during calcium sensitization with levosimendan: A noninvasive study with positron emission tomography and echocardiography in healthy volunteers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-05

AUTHORS

Heikki Ukkonen, Markku Saraste, Juha Akkila, M. Juhani Knuuti, Pertti Lehikoinen, Kjell Någren, Lasse Lehtonen, Liisa‐Maria Voipio‐Pulkki

ABSTRACT

Dynamic positron emission tomography (PET) with [11C]acetate allows noninvasive assessment of myocardial oxygen consumption. In combination with echocardiography, PET enables determination of cardiac efficiency (defined as useful cardiac work per unit of oxygen consumption). We used this approach to compare the effects of levosimendan, a Ca(2+)-dependent calcium sensitizer, with dobutamine and sodium nitroprusside in healthy male volunteers. The effects of levosimendan on k(mono), an index of oxygen consumption, and cardiac efficiency were neutral, whereas the hemodynamic profile was consistent with balanced inotropism and vasodilatation. Dobutamine enhanced cardiac efficiency at the expense of increased oxygen requirement, but the effects of nitroprusside on k(mono) and cardiac efficiency were neutral. This study shows the feasibility of PET in phase 1 pharmacodynamic studies and suggests potential energetical advantages of calcium sensitization with levosimendan. More... »

PAGES

596-607

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/s0009-9236(97)90139-9

DOI

http://dx.doi.org/10.1016/s0009-9236(97)90139-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042474398

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9164421


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