Underestimation of extent of ischemia by gated SPECT myocardial perfusion imaging in patients with left main coronary artery disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-07

AUTHORS

Daniel S. Berman, Xingping Kang, Piotr J. Slomka, James Gerlach, Ling de Yang, Sean W. Hayes, John D. Friedman, Louise E. J. Thomson, Guido Germano

ABSTRACT

BackgroundThere have been limited data regarding the value of gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) for the detection of left main coronary artery disease (CAD).Methods and ResultsWe studied 101 patients with angiographic left main CAD (≥50% stenosis) and no prior myocardial infarction or coronary revascularization who underwent gated exercise or adenosine stress technetium 99m sestamibi SPECT MPI. By perfusion assessment alone, high-risk disease with moderate to severe defects (>10% myocardium at stress) was identified in only 56% of patients visually and 59% quantitatively. Absence of significant perfusion defect (≥5% myocardium) was seen in 13% of patients visually and 15% quantitatively. However, by combining visual perfusion data and nonperfusion variables, especially transient ischemic dilation, 83% of patients were identified as high risk.ConclusionsThe findings of this study demonstrate that assessment of perfusion data alone by visual or quantitative SPECT MPI analysis underestimates the magnitude of left main CAD. The combination of perfusion and nonperfusion abnormalities on gated MPI identifies high risk in most patients with left main CAD. More... »

PAGES

521-528

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/j.nuclcard.2007.05.008

DOI

http://dx.doi.org/10.1016/j.nuclcard.2007.05.008

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031384775

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17679060


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