Association of corticotropin releasing factor receptor‐2 variants with response to inhaled glucocorticoids in asthma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-02

AUTHORS

E. S. Silverman, S. L. Lake, K. G. Tantisira, B. G. Richter, A. A. Litonjua, R. Lazarus, J. Valone, S. A. Shore, S. T. Weiss

ABSTRACT

CRFR2 is a G-protein-coupled receptor that regulates glucocorticoid levels and smooth muscle tone. CRFR2 may have anti-inflammatory and bronchodilator effects in the airways of asthmatics. Because genetic variants in the homologous receptor CRFR1 have been associated with altered glucocorticoid response, we hypothesized that there exist variants in CRFR2 that are associated with altered response. We genotyped 16 polymorphisms in CRFR2 in two clinical trial populations: 311 childhood asthmatics treated with glucocorticoids for 8 weeks and 336 adult asthmatics treated with glucocorticoids for 8 weeks. The association of single SNPs and haplotypes with response at 8 weeks was explored with response measured as a change in the forced expiratory volume at one second (FEV1) as a continuous trait. FEV1 was adjusted for age, height, and sex as covariates. Only Caucasians were included in the analysis to minimize the effects of population stratification. Two CRFR2 SNPs were significantly associated (p < 0.05) with glucocorticoid response in the childhood asthma study and one of these SNPs was also associated with response in the adult study. CRFR2 variants may be associated with response to inhaled glucocorticoids in asthmatics. These findings suggest that the CRF pathway may be an important genetic source of therapeutic heterogeneity that is relevant to the many inflammatory diseases treated with exogenous glucocorticoids. Clinical Pharmacology & Therapeutics (2005) 77, P97–P97; doi: 10.1016/j.clpt.2004.12.264 More... »

PAGES

p97-p97

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/j.clpt.2004.12.264

DOI

http://dx.doi.org/10.1016/j.clpt.2004.12.264

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020618534


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