Philadelphia chromosome-negative cells with trisomy 8 after busulfan and interferon treatment of Ph1-positive chronic myelogenous leukemia. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996

AUTHORS

T Izumi, S Imagawa, K Hatake, Y Miura, T Ariyama, J Inazawa, T Abe

ABSTRACT

A 48-year-old Japanese man with Philadelphia chromosome (Ph1)-positive chronic myelogenous leukemia (CML) was treated with busulfan followed by interferon-alpha (IFN-alpha). Ten months after IFN-alpha treatment, Ph1(-) cells with trisomy 8 were detected by the conventional banding technique and fluorescence in situ hybridization (FISH) analysis. Add(Y)(q12) was also found in Ph1(-) cells with trisomy 8. Although Ph1(+) cells disappeared after the treatment with IFN-alpha, Ph1(-) cells with trisomy 8 did not. We summarize four previous case reports of Ph1(+) CML developing Ph1(-) cells with trisomy 8. All four patients had received busulfan and IFN-alpha. These drugs may be related to the ontogenesis of Ph1(-) cells with trisomy 8, but the significance of Ph1(-) cells with trisomy 8 is not known, and further observation is needed. More... »

PAGES

73-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1016/0925-5710(96)00469-0

DOI

http://dx.doi.org/10.1016/0925-5710(96)00469-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1054563958

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8757971


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