Regression of low-grade gastric mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori: possible association with p16 hypermethylation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-01

AUTHORS

You Sun Kim, Joo Sung Kim, Hyun Chae Jung, Chang Hee Lee, Chul Woo Kim, In Sung Song, Chung Yong Kim

ABSTRACT

BACKGROUND: Many reports have stated that the cure of Helicobacter pylori infection can induce a complete remission of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Although p16 hypermethylation was frequently found in MALT lymphoma, the association between this finding and the remission of MALT lymphoma has not been clarified. We performed a prospective study to evaluate the outcome of patients with low-grade gastric MALT lymphoma and the expression of p16 hypermethylation. METHODS: We prospectively enrolled 20 patients with H. pylori-positive low-grade gastric MALT lymphoma (stage I E1). After the eradication of H. pylori, the patients were regularly followed-up with endoscopic and histological assessment. The methylation-specific polymerase chain reaction (PCR) (MSP) method was used for the serial detection of p16 hypermethylation. RESULTS: Eighteen patients (90%) achieved complete remission, with a median duration of 15.7 months. The initial detection rate of p16 hypermethylation was 58% (7 of the 12 patients in whom p16 hypermethylation was evaluated successfully). In a serial investigation, 3 patients who were followed-up for a median 28 months showed that the p16 hypermethylation had disappeared. CONCLUSIONS: Complete remission of low-grade gastric MALT lymphoma after the eradication of H. pylori infection can be maintained for more than 1 year. Further studies are warranted to investigate the role of p16 hypermethylation in the pathogenesis of gastric MALT lymphoma. More... »

PAGES

17-22

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s535-002-8127-8

DOI

http://dx.doi.org/10.1007/s535-002-8127-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042612204

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11824795


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amoxicillin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Bacterial Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Ulcer Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clarithromycin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Therapy, Combination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, p16", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Helicobacter Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Helicobacter pylori", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma, B-Cell, Marginal Zone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Omeprazole", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Remission Induction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungon-dong, Chongno-gu 110-744, Seoul, Korea, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "You Sun", 
        "id": "sg:person.01165177162.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165177162.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungon-dong, Chongno-gu 110-744, Seoul, Korea, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Joo Sung", 
        "id": "sg:person.07514633567.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07514633567.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungon-dong, Chongno-gu 110-744, Seoul, Korea, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jung", 
        "givenName": "Hyun Chae", 
        "id": "sg:person.01230372236.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230372236.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungon-dong, Chongno-gu 110-744, Seoul, Korea, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Chang Hee", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Pathology, Seoul National University College of Medicine, Seoul, Korea, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Chul Woo", 
        "id": "sg:person.01152623257.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152623257.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungon-dong, Chongno-gu 110-744, Seoul, Korea, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "In Sung", 
        "id": "sg:person.01001342362.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001342362.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungon-dong, Chongno-gu 110-744, Seoul, Korea, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Chung Yong", 
        "id": "sg:person.0714777622.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714777622.22"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0140-6736(91)92035-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000117383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(91)92035-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000117383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0046-8177(93)90214-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001996774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0046-8177(93)90235-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008628740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00365529709000208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011355801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199405053301803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011656502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0046-8177(96)90071-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012558647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9896(199609)180:1<26::aid-path681>3.0.co;2-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013413092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9896(199609)180:1<26::aid-path681>3.0.co;2-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013413092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(95)90113-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021687626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(95)90113-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021687626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65630-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029361101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00365529709011193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030253083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2400579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030812017", 
          "https://doi.org/10.1038/sj.leu.2400579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2400579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030812017", 
          "https://doi.org/10.1038/sj.leu.2400579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.48.5.395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035501711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/25.12.2532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036662191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(94)90828-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041588390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(92)90280-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044989379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(92)90280-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044989379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(93)91409-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048146190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(93)91409-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048146190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199610000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060122155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8153634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062652972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-122-10-199505150-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073699196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.12.3822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083360509"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-01", 
    "datePublishedReg": "2002-01-01", 
    "description": "BACKGROUND: Many reports have stated that the cure of Helicobacter pylori infection can induce a complete remission of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Although p16 hypermethylation was frequently found in MALT lymphoma, the association between this finding and the remission of MALT lymphoma has not been clarified. We performed a prospective study to evaluate the outcome of patients with low-grade gastric MALT lymphoma and the expression of p16 hypermethylation.\nMETHODS: We prospectively enrolled 20 patients with H. pylori-positive low-grade gastric MALT lymphoma (stage I E1). After the eradication of H. pylori, the patients were regularly followed-up with endoscopic and histological assessment. The methylation-specific polymerase chain reaction (PCR) (MSP) method was used for the serial detection of p16 hypermethylation.\nRESULTS: Eighteen patients (90%) achieved complete remission, with a median duration of 15.7 months. The initial detection rate of p16 hypermethylation was 58% (7 of the 12 patients in whom p16 hypermethylation was evaluated successfully). In a serial investigation, 3 patients who were followed-up for a median 28 months showed that the p16 hypermethylation had disappeared.\nCONCLUSIONS: Complete remission of low-grade gastric MALT lymphoma after the eradication of H. pylori infection can be maintained for more than 1 year. Further studies are warranted to investigate the role of p16 hypermethylation in the pathogenesis of gastric MALT lymphoma.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s535-002-8127-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1009747", 
        "issn": [
          "0944-1174", 
          "1435-5922"
        ], 
        "name": "Journal of Gastroenterology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "37"
      }
    ], 
    "name": "Regression of low-grade gastric mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori: possible association with p16 hypermethylation", 
    "pagination": "17-22", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cafad8b59b244c2595d559ccaec76b9ded47c5739b641935856dba25cd43ff74"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11824795"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9430794"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s535-002-8127-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042612204"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s535-002-8127-8", 
      "https://app.dimensions.ai/details/publication/pub.1042612204"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000523.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs535-002-8127-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s535-002-8127-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s535-002-8127-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s535-002-8127-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s535-002-8127-8'


 

This table displays all metadata directly associated to this object as RDF triples.

264 TRIPLES      21 PREDICATES      72 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s535-002-8127-8 schema:about N05d6d457ef654d248d246072e6d56531
2 N27a6bce76fcb44f38a86ed16af862a75
3 N2dc87013416b4e45b0c78aeeceea0cdc
4 N3062cbefd83f479281c8981d48716e69
5 N32f089b89d174156b32259d31382c636
6 N357ca77a12674862b2a7a2a6b217c210
7 N35edbf7ef2a9415b8c26148adaac114b
8 N465223b50a7a4a52a1d8a1c5f8de3fd3
9 N488cbde757fa45b39e1785f1ff97fd85
10 N48d2c00ab61d441b9e4947a08bf17bf3
11 N4aa35c299f3149eeaf0fd02ff1bf3583
12 N5c41740e251e47b198f176c75d285131
13 N5cf46500b7b44c10ab13a4a47d8efc2e
14 N5d0c72cba97946e58f919a1919d64934
15 N760f7f29fc3f455f88daee65d9a3e4a1
16 N822d72335cde4159974e9de61e1d5008
17 N9b90380d91c14a41a77764eb345c1eb7
18 Nba7dcd590bfa4e9b853e7333114e12e9
19 Nbdaf7b85ab8445febad8b23f43748c61
20 Nbf1cf44a1ac8484b9019a7b1a9423ac9
21 Nc55100ab55ee4d4592785244561bae3f
22 Ncb48242ea10a4a8894684ab74c6f0a3d
23 Ne9d72f8efae747548687e01a53f354dd
24 anzsrc-for:11
25 anzsrc-for:1103
26 schema:author N2d57006cb9e64f489bbce8677973e1dc
27 schema:citation sg:pub.10.1038/sj.leu.2400579
28 https://doi.org/10.1002/(sici)1096-9896(199609)180:1<26::aid-path681>3.0.co;2-x
29 https://doi.org/10.1016/0016-5085(94)90828-1
30 https://doi.org/10.1016/0046-8177(93)90214-2
31 https://doi.org/10.1016/0046-8177(93)90235-9
32 https://doi.org/10.1016/0140-6736(91)92035-z
33 https://doi.org/10.1016/0140-6736(92)90280-g
34 https://doi.org/10.1016/0140-6736(93)91409-f
35 https://doi.org/10.1016/s0002-9440(10)65630-1
36 https://doi.org/10.1016/s0046-8177(96)90071-4
37 https://doi.org/10.1016/s0140-6736(95)90113-2
38 https://doi.org/10.1056/nejm199405053301803
39 https://doi.org/10.1093/nar/25.12.2532
40 https://doi.org/10.1097/00000478-199610000-00001
41 https://doi.org/10.1126/science.8153634
42 https://doi.org/10.1136/jcp.48.5.395
43 https://doi.org/10.1200/jco.1998.16.12.3822
44 https://doi.org/10.3109/00365529709000208
45 https://doi.org/10.3109/00365529709011193
46 https://doi.org/10.7326/0003-4819-122-10-199505150-00006
47 schema:datePublished 2002-01
48 schema:datePublishedReg 2002-01-01
49 schema:description BACKGROUND: Many reports have stated that the cure of Helicobacter pylori infection can induce a complete remission of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Although p16 hypermethylation was frequently found in MALT lymphoma, the association between this finding and the remission of MALT lymphoma has not been clarified. We performed a prospective study to evaluate the outcome of patients with low-grade gastric MALT lymphoma and the expression of p16 hypermethylation. METHODS: We prospectively enrolled 20 patients with H. pylori-positive low-grade gastric MALT lymphoma (stage I E1). After the eradication of H. pylori, the patients were regularly followed-up with endoscopic and histological assessment. The methylation-specific polymerase chain reaction (PCR) (MSP) method was used for the serial detection of p16 hypermethylation. RESULTS: Eighteen patients (90%) achieved complete remission, with a median duration of 15.7 months. The initial detection rate of p16 hypermethylation was 58% (7 of the 12 patients in whom p16 hypermethylation was evaluated successfully). In a serial investigation, 3 patients who were followed-up for a median 28 months showed that the p16 hypermethylation had disappeared. CONCLUSIONS: Complete remission of low-grade gastric MALT lymphoma after the eradication of H. pylori infection can be maintained for more than 1 year. Further studies are warranted to investigate the role of p16 hypermethylation in the pathogenesis of gastric MALT lymphoma.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree false
53 schema:isPartOf N5157d153a26c4e49922d4719ab3ab27f
54 Nc36a7c7bd3114f4c993dbbafdcc5f309
55 sg:journal.1009747
56 schema:name Regression of low-grade gastric mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori: possible association with p16 hypermethylation
57 schema:pagination 17-22
58 schema:productId N0b0d6218a739457f8ff8a1480837b897
59 N132ef1dfdb7a410d996b613460d7b946
60 N80c226e276994bd09412a18912495778
61 N91527528887a473fb42b48aa1845906c
62 N944d3bf416df44c580e9686bb35a8dce
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042612204
64 https://doi.org/10.1007/s535-002-8127-8
65 schema:sdDatePublished 2019-04-10T21:39
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N3472c9a95f504a9ea9e02ba0bf963cf5
68 schema:url http://link.springer.com/10.1007%2Fs535-002-8127-8
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N05d6d457ef654d248d246072e6d56531 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Stomach Neoplasms
74 rdf:type schema:DefinedTerm
75 N0b0d6218a739457f8ff8a1480837b897 schema:name dimensions_id
76 schema:value pub.1042612204
77 rdf:type schema:PropertyValue
78 N132ef1dfdb7a410d996b613460d7b946 schema:name readcube_id
79 schema:value cafad8b59b244c2595d559ccaec76b9ded47c5739b641935856dba25cd43ff74
80 rdf:type schema:PropertyValue
81 N27a6bce76fcb44f38a86ed16af862a75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Omeprazole
83 rdf:type schema:DefinedTerm
84 N2d57006cb9e64f489bbce8677973e1dc rdf:first sg:person.01165177162.38
85 rdf:rest Nac976ce3299749f6836a0735b205dee1
86 N2dc87013416b4e45b0c78aeeceea0cdc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Drug Therapy, Combination
88 rdf:type schema:DefinedTerm
89 N2dcb805a232548789864debedd40c01c rdf:first sg:person.01001342362.12
90 rdf:rest Ncc056556859c4dd89d2fb652e5c4020f
91 N3062cbefd83f479281c8981d48716e69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Prospective Studies
93 rdf:type schema:DefinedTerm
94 N32f089b89d174156b32259d31382c636 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Helicobacter Infections
96 rdf:type schema:DefinedTerm
97 N3472c9a95f504a9ea9e02ba0bf963cf5 schema:name Springer Nature - SN SciGraph project
98 rdf:type schema:Organization
99 N357ca77a12674862b2a7a2a6b217c210 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Treatment Outcome
101 rdf:type schema:DefinedTerm
102 N35edbf7ef2a9415b8c26148adaac114b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Female
104 rdf:type schema:DefinedTerm
105 N465223b50a7a4a52a1d8a1c5f8de3fd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Adult
107 rdf:type schema:DefinedTerm
108 N488cbde757fa45b39e1785f1ff97fd85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Aged
110 rdf:type schema:DefinedTerm
111 N48d2c00ab61d441b9e4947a08bf17bf3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Clarithromycin
113 rdf:type schema:DefinedTerm
114 N4aa35c299f3149eeaf0fd02ff1bf3583 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Male
116 rdf:type schema:DefinedTerm
117 N5157d153a26c4e49922d4719ab3ab27f schema:issueNumber 1
118 rdf:type schema:PublicationIssue
119 N591cfa0d309e404183abcbbb6d5a256d schema:affiliation https://www.grid.ac/institutes/grid.31501.36
120 schema:familyName Lee
121 schema:givenName Chang Hee
122 rdf:type schema:Person
123 N5c41740e251e47b198f176c75d285131 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Anti-Ulcer Agents
125 rdf:type schema:DefinedTerm
126 N5cf46500b7b44c10ab13a4a47d8efc2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Helicobacter pylori
128 rdf:type schema:DefinedTerm
129 N5d0c72cba97946e58f919a1919d64934 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Genes, p16
131 rdf:type schema:DefinedTerm
132 N760f7f29fc3f455f88daee65d9a3e4a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name DNA Methylation
134 rdf:type schema:DefinedTerm
135 N80c226e276994bd09412a18912495778 schema:name doi
136 schema:value 10.1007/s535-002-8127-8
137 rdf:type schema:PropertyValue
138 N822d72335cde4159974e9de61e1d5008 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Amoxicillin
140 rdf:type schema:DefinedTerm
141 N8d9ca8c0efa34871884efc26d584ecc5 rdf:first N591cfa0d309e404183abcbbb6d5a256d
142 rdf:rest Ne5cae29d10db416ab1115499f97727d1
143 N91527528887a473fb42b48aa1845906c schema:name pubmed_id
144 schema:value 11824795
145 rdf:type schema:PropertyValue
146 N944d3bf416df44c580e9686bb35a8dce schema:name nlm_unique_id
147 schema:value 9430794
148 rdf:type schema:PropertyValue
149 N9b90380d91c14a41a77764eb345c1eb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Humans
151 rdf:type schema:DefinedTerm
152 Nabe7cd3b338f425ba9efb944c693cc9a rdf:first sg:person.01230372236.08
153 rdf:rest N8d9ca8c0efa34871884efc26d584ecc5
154 Nac976ce3299749f6836a0735b205dee1 rdf:first sg:person.07514633567.21
155 rdf:rest Nabe7cd3b338f425ba9efb944c693cc9a
156 Nba7dcd590bfa4e9b853e7333114e12e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Lymphoma, B-Cell, Marginal Zone
158 rdf:type schema:DefinedTerm
159 Nbdaf7b85ab8445febad8b23f43748c61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Polymerase Chain Reaction
161 rdf:type schema:DefinedTerm
162 Nbf1cf44a1ac8484b9019a7b1a9423ac9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Gene Expression
164 rdf:type schema:DefinedTerm
165 Nc36a7c7bd3114f4c993dbbafdcc5f309 schema:volumeNumber 37
166 rdf:type schema:PublicationVolume
167 Nc55100ab55ee4d4592785244561bae3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Remission Induction
169 rdf:type schema:DefinedTerm
170 Ncb48242ea10a4a8894684ab74c6f0a3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Anti-Bacterial Agents
172 rdf:type schema:DefinedTerm
173 Ncc056556859c4dd89d2fb652e5c4020f rdf:first sg:person.0714777622.22
174 rdf:rest rdf:nil
175 Ne5cae29d10db416ab1115499f97727d1 rdf:first sg:person.01152623257.56
176 rdf:rest N2dcb805a232548789864debedd40c01c
177 Ne9d72f8efae747548687e01a53f354dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Middle Aged
179 rdf:type schema:DefinedTerm
180 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
181 schema:name Medical and Health Sciences
182 rdf:type schema:DefinedTerm
183 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
184 schema:name Clinical Sciences
185 rdf:type schema:DefinedTerm
186 sg:journal.1009747 schema:issn 0944-1174
187 1435-5922
188 schema:name Journal of Gastroenterology
189 rdf:type schema:Periodical
190 sg:person.01001342362.12 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
191 schema:familyName Song
192 schema:givenName In Sung
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001342362.12
194 rdf:type schema:Person
195 sg:person.01152623257.56 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
196 schema:familyName Kim
197 schema:givenName Chul Woo
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152623257.56
199 rdf:type schema:Person
200 sg:person.01165177162.38 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
201 schema:familyName Kim
202 schema:givenName You Sun
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165177162.38
204 rdf:type schema:Person
205 sg:person.01230372236.08 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
206 schema:familyName Jung
207 schema:givenName Hyun Chae
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230372236.08
209 rdf:type schema:Person
210 sg:person.0714777622.22 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
211 schema:familyName Kim
212 schema:givenName Chung Yong
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714777622.22
214 rdf:type schema:Person
215 sg:person.07514633567.21 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
216 schema:familyName Kim
217 schema:givenName Joo Sung
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07514633567.21
219 rdf:type schema:Person
220 sg:pub.10.1038/sj.leu.2400579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030812017
221 https://doi.org/10.1038/sj.leu.2400579
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1002/(sici)1096-9896(199609)180:1<26::aid-path681>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013413092
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/0016-5085(94)90828-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041588390
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/0046-8177(93)90214-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001996774
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/0046-8177(93)90235-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008628740
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/0140-6736(91)92035-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1000117383
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/0140-6736(92)90280-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1044989379
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/0140-6736(93)91409-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1048146190
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/s0002-9440(10)65630-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029361101
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s0046-8177(96)90071-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012558647
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s0140-6736(95)90113-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021687626
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1056/nejm199405053301803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011656502
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1093/nar/25.12.2532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036662191
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1097/00000478-199610000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060122155
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1126/science.8153634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062652972
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1136/jcp.48.5.395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035501711
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1200/jco.1998.16.12.3822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083360509
254 rdf:type schema:CreativeWork
255 https://doi.org/10.3109/00365529709000208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011355801
256 rdf:type schema:CreativeWork
257 https://doi.org/10.3109/00365529709011193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030253083
258 rdf:type schema:CreativeWork
259 https://doi.org/10.7326/0003-4819-122-10-199505150-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073699196
260 rdf:type schema:CreativeWork
261 https://www.grid.ac/institutes/grid.31501.36 schema:alternateName Seoul National University
262 schema:name Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungon-dong, Chongno-gu 110-744, Seoul, Korea, KR
263 Department of Pathology, Seoul National University College of Medicine, Seoul, Korea, KR
264 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...