Studies on the mechanism of multidrug resistance of Acinetobacter baumannii by proteomic analysis of the outer membrane vesicles of the ... View Full Text


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Article Info

DATE

2019-03

AUTHORS

Bina Agarwal, Raman Karthikeyan, P. Gayathri, B. RameshBabu, G. Ahmed, M. V. Jagannadham

ABSTRACT

Acinetobacter baumannii, an opportunistic pathogen is responsible for pneumonia, meningitis and a wide range of other infections. It is typically involved in nosocomial infections. Outer membrane vesicles (OMVs) released from the bacteria play an important role in the bacterial physiology including pathogenesis. In this study, OMVs were isolated and characterized form sensitive and multidrug-resistant clinical strains of A. baumannii. A comparative proteomics analysis of the OMVs from the A. baumannii sensitive and MDR strain revealed the increased content of carbapenemase and a host of other related antibiotic resistant enzymes in the OMVs of the A. baumannii MDR strain. The OMVs of antibiotic-sensitive strain contained only 8 antibiotic resistance-conferring proteins, whereas the OMVs of multidrug resistance contained 24 proteins. Growth studies on the sensitive and MDR strain in the presence of polymyxin B and OMVs prepared from the respective strains revealed that the OMVs protected the bacteria against the antibiotic. Bacteria were grown in the presence of antibiotic and an indole derivative has shown that the minimum inhibitory concentration was reduced in the presence of derivative indicating that the derivative regulated the production of OMVs. Interestingly, it was also found that the degradosome complex involved in RNA processing was associated with the OMVs. These studies reveal that OMVs may play an important role in antibiotic resistance/persistence. More... »

PAGES

1-15

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s42485-018-0001-4

DOI

http://dx.doi.org/10.1007/s42485-018-0001-4

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52 schema:description Acinetobacter baumannii, an opportunistic pathogen is responsible for pneumonia, meningitis and a wide range of other infections. It is typically involved in nosocomial infections. Outer membrane vesicles (OMVs) released from the bacteria play an important role in the bacterial physiology including pathogenesis. In this study, OMVs were isolated and characterized form sensitive and multidrug-resistant clinical strains of A. baumannii. A comparative proteomics analysis of the OMVs from the A. baumannii sensitive and MDR strain revealed the increased content of carbapenemase and a host of other related antibiotic resistant enzymes in the OMVs of the A. baumannii MDR strain. The OMVs of antibiotic-sensitive strain contained only 8 antibiotic resistance-conferring proteins, whereas the OMVs of multidrug resistance contained 24 proteins. Growth studies on the sensitive and MDR strain in the presence of polymyxin B and OMVs prepared from the respective strains revealed that the OMVs protected the bacteria against the antibiotic. Bacteria were grown in the presence of antibiotic and an indole derivative has shown that the minimum inhibitory concentration was reduced in the presence of derivative indicating that the derivative regulated the production of OMVs. Interestingly, it was also found that the degradosome complex involved in RNA processing was associated with the OMVs. These studies reveal that OMVs may play an important role in antibiotic resistance/persistence.
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