Allergy Evaluation During Hospitalized Asthma Improves Disease Management Outcomes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02-14

AUTHORS

James P. Brock, Eliezer Nussbaum, Tricia L. Morphew, Veerpal S. Sandhu, Nathan L. Marsteller, Brian S. Yang, Inderpal S. Randhawa

ABSTRACT

Hospitalization for asthma exacerbation is significantly related to overall poor asthma control. The study aimed to contrast post-hospitalization outcomes of those asthmatics who underwent serologic specific IgE (sIgE) testing for regional environmental allergens to an untested cohort. Of 8061 asthma encounters, 273 subjects who met the criteria were included in this retrospective cohort study. Those asthmatics identified with persistent disease were hospitalized at Miller Children’s Hospital during the period June 2008–October 2015. A total of 207 patients underwent sIgE testing during initial hospitalization for asthma and 66 were not tested. The Cox regression analysis assessed time from discharge to first emergency room (ER) visit, required systemic steroids, and next hospitalization in sIgE vs. non-tested groups, stratified by severity (mild or moderate-severe) and adjusted for age (≥ 12 or < 12), gender, and race. Serum allergy evaluation by sIgE testing reduced the hazard of an ER visit and systemic corticosteroids requirement by half in mild asthmatics (p < 0.05). The average time to next ER visit was almost 1 year in the allergy-tested group compared to < 6 months in the no-test group. Blood-based allergy evaluation as part of inpatient asthma treatment was shown to improve disease management specifically in time to next ER and/or exacerbation and systemic corticosteroids requirement in patients with mild disease. In more severe adolescent asthmatics, sIgE testing appeared protective against future hospitalization. Inpatient serologic testing may be beneficial in raising alertness in the asthma population, deploying early comprehensive care and lowering the rate of hospitalization. More... »

PAGES

1-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s42399-019-0044-9

DOI

http://dx.doi.org/10.1007/s42399-019-0044-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112142069


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "MemorialCare Health System", 
          "id": "https://www.grid.ac/institutes/grid.429311.c", 
          "name": [
            "Pediatric Pulmonology Division, Miller Children\u2019s Hospital \u2013 PEDS Pulmonary, 2801 Atlantic Ave, 90806, Long Beach, CA, USA", 
            "Irvine School of Medicine, University of California, Irvine, CA, USA", 
            "MemorialCare Health System, Long Beach, CA, USA", 
            "The Translational Pulmonary and Immunology Research Center, Long Beach, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brock", 
        "givenName": "James P.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MemorialCare Health System", 
          "id": "https://www.grid.ac/institutes/grid.429311.c", 
          "name": [
            "Pediatric Pulmonology Division, Miller Children\u2019s Hospital \u2013 PEDS Pulmonary, 2801 Atlantic Ave, 90806, Long Beach, CA, USA", 
            "Irvine School of Medicine, University of California, Irvine, CA, USA", 
            "MemorialCare Health System, Long Beach, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nussbaum", 
        "givenName": "Eliezer", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MemorialCare Health System", 
          "id": "https://www.grid.ac/institutes/grid.429311.c", 
          "name": [
            "MemorialCare Health System, Long Beach, CA, USA", 
            "Morphew Consulting, LLC, Bothell, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morphew", 
        "givenName": "Tricia L.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "The Translational Pulmonary and Immunology Research Center, Long Beach, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sandhu", 
        "givenName": "Veerpal S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MemorialCare Health System", 
          "id": "https://www.grid.ac/institutes/grid.429311.c", 
          "name": [
            "MemorialCare Health System, Long Beach, CA, USA", 
            "The Translational Pulmonary and Immunology Research Center, Long Beach, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marsteller", 
        "givenName": "Nathan L.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Thermo Fisher Scientific (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418190.5", 
          "name": [
            "Thermo Fisher Scientific, Waltham, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Brian S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MemorialCare Health System", 
          "id": "https://www.grid.ac/institutes/grid.429311.c", 
          "name": [
            "Pediatric Pulmonology Division, Miller Children\u2019s Hospital \u2013 PEDS Pulmonary, 2801 Atlantic Ave, 90806, Long Beach, CA, USA", 
            "Irvine School of Medicine, University of California, Irvine, CA, USA", 
            "MemorialCare Health System, Long Beach, CA, USA", 
            "The Translational Pulmonary and Immunology Research Center, Long Beach, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Randhawa", 
        "givenName": "Inderpal S.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1378/chest.12-2773", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008269586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.130.1_suppl.4s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017388677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thoraxjnl-2012-202093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018596624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thoraxjnl-2012-202093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018596624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.scitotenv.2012.02.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019465883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.2012-0913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024473470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1278", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030285678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.acap.2012.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040874229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2105/ajph.2012.300806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068845987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077503121", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02-14", 
    "datePublishedReg": "2019-02-14", 
    "description": "Hospitalization for asthma exacerbation is significantly related to overall poor asthma control. The study aimed to contrast post-hospitalization outcomes of those asthmatics who underwent serologic specific IgE (sIgE) testing for regional environmental allergens to an untested cohort. Of 8061 asthma encounters, 273 subjects who met the criteria were included in this retrospective cohort study. Those asthmatics identified with persistent disease were hospitalized at Miller Children\u2019s Hospital during the period June 2008\u2013October 2015. A total of 207 patients underwent sIgE testing during initial hospitalization for asthma and 66 were not tested. The Cox regression analysis assessed time from discharge to first emergency room (ER) visit, required systemic steroids, and next hospitalization in sIgE vs. non-tested groups, stratified by severity (mild or moderate-severe) and adjusted for age (\u2265 12 or < 12), gender, and race. Serum allergy evaluation by sIgE testing reduced the hazard of an ER visit and systemic corticosteroids requirement by half in mild asthmatics (p < 0.05). The average time to next ER visit was almost 1 year in the allergy-tested group compared to < 6 months in the no-test group. Blood-based allergy evaluation as part of inpatient asthma treatment was shown to improve disease management specifically in time to next ER and/or exacerbation and systemic corticosteroids requirement in patients with mild disease. In more severe adolescent asthmatics, sIgE testing appeared protective against future hospitalization. Inpatient serologic testing may be beneficial in raising alertness in the asthma population, deploying early comprehensive care and lowering the rate of hospitalization.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s42399-019-0044-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1336306", 
        "issn": [
          "2523-8973"
        ], 
        "name": "SN Comprehensive Clinical Medicine", 
        "type": "Periodical"
      }
    ], 
    "name": "Allergy Evaluation During Hospitalized Asthma Improves Disease Management Outcomes", 
    "pagination": "1-6", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3a75a0597b08872101d58fbc1bd361fb8c58ba8986f4aa876b5ee362a89f3949"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s42399-019-0044-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112142069"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s42399-019-0044-9", 
      "https://app.dimensions.ai/details/publication/pub.1112142069"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000337_0000000337/records_37575_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs42399-019-0044-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s42399-019-0044-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s42399-019-0044-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s42399-019-0044-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s42399-019-0044-9'


 

This table displays all metadata directly associated to this object as RDF triples.

124 TRIPLES      21 PREDICATES      33 URIs      16 LITERALS      5 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s42399-019-0044-9 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author N2c24be19c1594c1fb85e21ae0ae2ccda
4 schema:citation https://app.dimensions.ai/details/publication/pub.1077503121
5 https://doi.org/10.1016/j.acap.2012.04.004
6 https://doi.org/10.1016/j.scitotenv.2012.02.015
7 https://doi.org/10.1136/thoraxjnl-2012-202093
8 https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1278
9 https://doi.org/10.1378/chest.12-2773
10 https://doi.org/10.1378/chest.130.1_suppl.4s
11 https://doi.org/10.1542/peds.2012-0913
12 https://doi.org/10.2105/ajph.2012.300806
13 schema:datePublished 2019-02-14
14 schema:datePublishedReg 2019-02-14
15 schema:description Hospitalization for asthma exacerbation is significantly related to overall poor asthma control. The study aimed to contrast post-hospitalization outcomes of those asthmatics who underwent serologic specific IgE (sIgE) testing for regional environmental allergens to an untested cohort. Of 8061 asthma encounters, 273 subjects who met the criteria were included in this retrospective cohort study. Those asthmatics identified with persistent disease were hospitalized at Miller Children’s Hospital during the period June 2008–October 2015. A total of 207 patients underwent sIgE testing during initial hospitalization for asthma and 66 were not tested. The Cox regression analysis assessed time from discharge to first emergency room (ER) visit, required systemic steroids, and next hospitalization in sIgE vs. non-tested groups, stratified by severity (mild or moderate-severe) and adjusted for age (≥ 12 or < 12), gender, and race. Serum allergy evaluation by sIgE testing reduced the hazard of an ER visit and systemic corticosteroids requirement by half in mild asthmatics (p < 0.05). The average time to next ER visit was almost 1 year in the allergy-tested group compared to < 6 months in the no-test group. Blood-based allergy evaluation as part of inpatient asthma treatment was shown to improve disease management specifically in time to next ER and/or exacerbation and systemic corticosteroids requirement in patients with mild disease. In more severe adolescent asthmatics, sIgE testing appeared protective against future hospitalization. Inpatient serologic testing may be beneficial in raising alertness in the asthma population, deploying early comprehensive care and lowering the rate of hospitalization.
16 schema:genre research_article
17 schema:inLanguage en
18 schema:isAccessibleForFree false
19 schema:isPartOf sg:journal.1336306
20 schema:name Allergy Evaluation During Hospitalized Asthma Improves Disease Management Outcomes
21 schema:pagination 1-6
22 schema:productId N286e45ed11a046bc80d5d72676a07203
23 Ne9ca2565799746a78113925962ce4f0f
24 Nf6be420ac4014eb59ae51e717a15c74a
25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112142069
26 https://doi.org/10.1007/s42399-019-0044-9
27 schema:sdDatePublished 2019-04-11T09:07
28 schema:sdLicense https://scigraph.springernature.com/explorer/license/
29 schema:sdPublisher Nc7aae489295c4672a5f58e79a3ec2f05
30 schema:url https://link.springer.com/10.1007%2Fs42399-019-0044-9
31 sgo:license sg:explorer/license/
32 sgo:sdDataset articles
33 rdf:type schema:ScholarlyArticle
34 N25b2a9a7b2a74c8791464f33b4fa7a5a schema:affiliation https://www.grid.ac/institutes/grid.429311.c
35 schema:familyName Randhawa
36 schema:givenName Inderpal S.
37 rdf:type schema:Person
38 N286e45ed11a046bc80d5d72676a07203 schema:name readcube_id
39 schema:value 3a75a0597b08872101d58fbc1bd361fb8c58ba8986f4aa876b5ee362a89f3949
40 rdf:type schema:PropertyValue
41 N2c24be19c1594c1fb85e21ae0ae2ccda rdf:first N6d5fe52f05a748bfa602f9e50e9ec766
42 rdf:rest N74197593c91f4c0eb1e5e2d51a5027c5
43 N31d6c03867814477b85e23d4868ab48c rdf:first Nd33d0d85bfa9430ab331dab8ba6463fc
44 rdf:rest N46bcf6c7c1674b7bb6e6f9229de2dace
45 N3464db3f757f4a1ba6d58d5ce238f93e rdf:first N25b2a9a7b2a74c8791464f33b4fa7a5a
46 rdf:rest rdf:nil
47 N46bcf6c7c1674b7bb6e6f9229de2dace rdf:first Nb90688a02c944682b42266499d5d26a7
48 rdf:rest N8bcabb2601b7404e926d6d8de1f929b6
49 N46d76db4a0e245f8bec72c1d1f6f8907 schema:affiliation https://www.grid.ac/institutes/grid.418190.5
50 schema:familyName Yang
51 schema:givenName Brian S.
52 rdf:type schema:Person
53 N6d5fe52f05a748bfa602f9e50e9ec766 schema:affiliation https://www.grid.ac/institutes/grid.429311.c
54 schema:familyName Brock
55 schema:givenName James P.
56 rdf:type schema:Person
57 N74197593c91f4c0eb1e5e2d51a5027c5 rdf:first Nb015869c08c842aca739faf6b507bfdc
58 rdf:rest Ne0d0ee58694d4b2996a96c0e131b3f01
59 N8bcabb2601b7404e926d6d8de1f929b6 rdf:first N46d76db4a0e245f8bec72c1d1f6f8907
60 rdf:rest N3464db3f757f4a1ba6d58d5ce238f93e
61 Nb015869c08c842aca739faf6b507bfdc schema:affiliation https://www.grid.ac/institutes/grid.429311.c
62 schema:familyName Nussbaum
63 schema:givenName Eliezer
64 rdf:type schema:Person
65 Nb90688a02c944682b42266499d5d26a7 schema:affiliation https://www.grid.ac/institutes/grid.429311.c
66 schema:familyName Marsteller
67 schema:givenName Nathan L.
68 rdf:type schema:Person
69 Nbe69d7b94bb24399b5f85faa41a81025 schema:affiliation https://www.grid.ac/institutes/grid.429311.c
70 schema:familyName Morphew
71 schema:givenName Tricia L.
72 rdf:type schema:Person
73 Nc7aae489295c4672a5f58e79a3ec2f05 schema:name Springer Nature - SN SciGraph project
74 rdf:type schema:Organization
75 Nd33d0d85bfa9430ab331dab8ba6463fc schema:affiliation Nf4a454e80b8d4c38941cd033790863a6
76 schema:familyName Sandhu
77 schema:givenName Veerpal S.
78 rdf:type schema:Person
79 Ne0d0ee58694d4b2996a96c0e131b3f01 rdf:first Nbe69d7b94bb24399b5f85faa41a81025
80 rdf:rest N31d6c03867814477b85e23d4868ab48c
81 Ne9ca2565799746a78113925962ce4f0f schema:name doi
82 schema:value 10.1007/s42399-019-0044-9
83 rdf:type schema:PropertyValue
84 Nf4a454e80b8d4c38941cd033790863a6 schema:name The Translational Pulmonary and Immunology Research Center, Long Beach, CA, USA
85 rdf:type schema:Organization
86 Nf6be420ac4014eb59ae51e717a15c74a schema:name dimensions_id
87 schema:value pub.1112142069
88 rdf:type schema:PropertyValue
89 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
90 schema:name Medical and Health Sciences
91 rdf:type schema:DefinedTerm
92 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
93 schema:name Cardiorespiratory Medicine and Haematology
94 rdf:type schema:DefinedTerm
95 sg:journal.1336306 schema:issn 2523-8973
96 schema:name SN Comprehensive Clinical Medicine
97 rdf:type schema:Periodical
98 https://app.dimensions.ai/details/publication/pub.1077503121 schema:CreativeWork
99 https://doi.org/10.1016/j.acap.2012.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040874229
100 rdf:type schema:CreativeWork
101 https://doi.org/10.1016/j.scitotenv.2012.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019465883
102 rdf:type schema:CreativeWork
103 https://doi.org/10.1136/thoraxjnl-2012-202093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018596624
104 rdf:type schema:CreativeWork
105 https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030285678
106 rdf:type schema:CreativeWork
107 https://doi.org/10.1378/chest.12-2773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008269586
108 rdf:type schema:CreativeWork
109 https://doi.org/10.1378/chest.130.1_suppl.4s schema:sameAs https://app.dimensions.ai/details/publication/pub.1017388677
110 rdf:type schema:CreativeWork
111 https://doi.org/10.1542/peds.2012-0913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024473470
112 rdf:type schema:CreativeWork
113 https://doi.org/10.2105/ajph.2012.300806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068845987
114 rdf:type schema:CreativeWork
115 https://www.grid.ac/institutes/grid.418190.5 schema:alternateName Thermo Fisher Scientific (United States)
116 schema:name Thermo Fisher Scientific, Waltham, MA, USA
117 rdf:type schema:Organization
118 https://www.grid.ac/institutes/grid.429311.c schema:alternateName MemorialCare Health System
119 schema:name Irvine School of Medicine, University of California, Irvine, CA, USA
120 MemorialCare Health System, Long Beach, CA, USA
121 Morphew Consulting, LLC, Bothell, WA, USA
122 Pediatric Pulmonology Division, Miller Children’s Hospital – PEDS Pulmonary, 2801 Atlantic Ave, 90806, Long Beach, CA, USA
123 The Translational Pulmonary and Immunology Research Center, Long Beach, CA, USA
124 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...