Effects of Peritoneal Dialysis Solution on Experimental Necrotizing Enterocolitis in Newborn Rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-05-31

AUTHORS

Hatice Sonay Yalcin Comert, Haluk Sarihan, Ismail Saygin, Mustafa Imamoglu, Dilek Basar, Gamze Can

ABSTRACT

Necrotizing enterocolitis (NEC) is one of the most urgent gastrointestinal diseases in premature newborns. We utilized a newborn model of hypoxia and hypothermia that resembles human NEC to investigate the effects of irrigation with peritoneal dialysis solution (PDS) on the treatment of NEC. For the NEC model, 1-day-old rats were stressed with 100% CO2 for 5 min by placing them in an airtight perfused box; then, they were exposed to cold stress in 4 °C for 10 min twice daily for the next 4 days. The newborn rats (n = 24) were divided into four equal groups: group 1 (control), group 2 (NEC), group 3 (NEC + irrigated with saline), and group 4 (NEC + irrigated with PDS). The animals in group 3 were irrigated with intraperitoneal saline, and the animals in group 4 were irrigated with PDS twice daily for the next 2 days. Then, all animals were sacrificed on day 7, and intestinal specimens were harvested. Histopathologic damage of the intestine was evaluated, and there was a highly significant difference between the control group and groups 2 and 3. In group 4, values were significantly less than in the other groups (2 and 3), except the control group. Also, significant differences were found when group 4 was compared with groups 2 and 3 (P < 0.0001). We believe peritoneal irrigation with PDS may be efficacious in NEC patients to obtain better results. More... »

PAGES

547-551

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s42399-019-00079-0

DOI

http://dx.doi.org/10.1007/s42399-019-00079-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1116178734


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