Use of thyroid hormones in hypothyroid and euthyroid patients: a 2020 THESIS questionnaire survey of members of the Hellenic Endocrine ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-11-09

AUTHORS

Stavroula A. Paschou, Maria Alevizaki, Roberto Attanasio, Laszlo Hegedüs, Endre V. Nagy, Enrico Papini, Petros Perros, Andromachi Vryonidou

ABSTRACT

PurposeTo investigate current practices of specialists in the use of thyroid hormone preparations in Greece as part of an ongoing international survey, namely THESIS—Treatment of Hypothyroidism in Europe by Specialists: an International Survey.MethodsAn electronic link leading to an anonymized questionnaire was sent to all (n = 837) members of the Hellenic Endocrine Society.ResultsIn total, 501 respondents participated in the survey, though only part of the questionnaire was filled in by some participants. A total of 88.2% were endocrinologists and 57.9% worked in private practice. Levothyroxine (LT4) was the first-line choice (98.6%) for the treatment of hypothyroid patients. In total, 70.2% preferred LT4 soft-gel capsules for patients reporting intolerance to various foods. Soft-gel capsules were the preferred LT4 formulation for patients on generic LT4 and with unexplained poor biochemical control of hypothyroidism (66.3%) or inability to take LT4 fasted and separate from food/drink (68.3%). It was found that 48.4% would never use combined LT4 + LT3. However, 25% would use combination therapy for a short period in patients recovering from protracted hypothyroidism or in patients with normal serum TSH but persistent symptoms. Concerning euthyroid individuals, 31.9% considered treatment with thyroid hormones in infertile females with positive thyroid antibodies and 24.4% in patients with growing goiter. Selenium or iodine supplementation was used occasionally, mostly in patients with coexisting autoimmune thyroiditis.ConclusionsLT4 tablets are the treatment of choice for hypothyroidism in Greece. Several conditions may lead to various other practices, some of which deviate from current evidence-based guidelines and need more scrutiny. More... »

PAGES

103-111

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s42000-021-00335-w

DOI

http://dx.doi.org/10.1007/s42000-021-00335-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1142483947

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34755283


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