Ontology type: schema:ScholarlyArticle
2021-10-13
AUTHORSBeatriz Ugalde-Abiega, Cristina Lamas Oliveira, José Joaquín Alfaro Martínez, Olalla Meizoso-Pita, Cristina Sevillano Collantes, Inés Gomez García, Ana Perez Rodríguez, Isabel Huguet
ABSTRACTIntroduction Hypoparathyroidism is considered a rare endocrine disease. Despite being a deficiency of parathyroid hormone, the standard therapy is based on oral calcium and active vitamin D supplementation. This approach provides satisfactory management in most cases but may be inadequate for patients in the most complex spectrum of the disease. Other therapies are being explored, and among them, the use of recombinant human parathyroid hormone (PTH) has proved to decrease the requirements of calcium and active vitamin D to reach adequate therapeutic goals.ObjectiveWe aimed to provide information on the effectiveness of the current recombinant parathyroid hormone analogs in the clinical management of difficult to control cases of hypoparathyroidism.Method and materialsWe report our experience using teriparatide and PTH (1–84) through five complex cases of hypoparathyroidism of diverse etiologies. We describe each case and report the effectiveness of treatment in clinical practice.ResultsFour patients with postsurgical hypoparathyroidism and one patient with autoimmune hypoparathyroidism, all of them with suboptimal control under the standard treatment with calcium and calcitriol supplements or calcium gluconate infusion, are presented. They were all started on teriparatide or PTH (1–84), and all of them showed a diminishment of symptoms and were able to maintain normocalcemia without parenteral calcium despite a reduction of oral treatment.ConclusionThis article highlights the effectiveness and safety of hormonal replacement treatment in difficult to manage hypoparathyroidism and provides evidence which justifies its off-label prescription in the case of teriparatide. We consider that this treatment should be considered in cases in which standard treatment fails to reach adequate therapeutic goals. More... »
PAGES71-77
http://scigraph.springernature.com/pub.10.1007/s42000-021-00326-x
DOIhttp://dx.doi.org/10.1007/s42000-021-00326-x
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1141850350
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/34647284
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Calcium",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dietary Supplements",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hypoparathyroidism",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Parathyroid Hormone",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Teriparatide",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Vitamin D",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Hospital Universitario Infanta Leonor, Avda Gran V\u00eda del Este, 80. 28031, Madrid, Spain",
"id": "http://www.grid.ac/institutes/grid.414761.1",
"name": [
"Hospital Universitario Infanta Leonor, Avda Gran V\u00eda del Este, 80. 28031, Madrid, Spain"
],
"type": "Organization"
},
"familyName": "Ugalde-Abiega",
"givenName": "Beatriz",
"id": "sg:person.012036104533.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012036104533.70"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Complejo Hospitalario Universitario Albacete, Albacete, Spain",
"id": "http://www.grid.ac/institutes/grid.411839.6",
"name": [
"Complejo Hospitalario Universitario Albacete, Albacete, Spain"
],
"type": "Organization"
},
"familyName": "Lamas Oliveira",
"givenName": "Cristina",
"id": "sg:person.01144773672.96",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144773672.96"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Complejo Hospitalario Universitario Albacete, Albacete, Spain",
"id": "http://www.grid.ac/institutes/grid.411839.6",
"name": [
"Complejo Hospitalario Universitario Albacete, Albacete, Spain"
],
"type": "Organization"
},
"familyName": "Alfaro Mart\u00ednez",
"givenName": "Jos\u00e9 Joaqu\u00edn",
"id": "sg:person.01364374343.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364374343.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hospital Universitario Infanta Leonor, Avda Gran V\u00eda del Este, 80. 28031, Madrid, Spain",
"id": "http://www.grid.ac/institutes/grid.414761.1",
"name": [
"Hospital Universitario Infanta Leonor, Avda Gran V\u00eda del Este, 80. 28031, Madrid, Spain"
],
"type": "Organization"
},
"familyName": "Meizoso-Pita",
"givenName": "Olalla",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hospital Universitario Infanta Leonor, Avda Gran V\u00eda del Este, 80. 28031, Madrid, Spain",
"id": "http://www.grid.ac/institutes/grid.414761.1",
"name": [
"Hospital Universitario Infanta Leonor, Avda Gran V\u00eda del Este, 80. 28031, Madrid, Spain"
],
"type": "Organization"
},
"familyName": "Sevillano Collantes",
"givenName": "Cristina",
"id": "sg:person.0720767140.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720767140.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hospital Mancha Centro de Alc\u00e1zar de San Juan, Alc\u00e1zar de San Juan, Spain",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Hospital Mancha Centro de Alc\u00e1zar de San Juan, Alc\u00e1zar de San Juan, Spain"
],
"type": "Organization"
},
"familyName": "Gomez Garc\u00eda",
"givenName": "In\u00e9s",
"id": "sg:person.010404200472.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010404200472.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Complejo Hospitalario Universitario Albacete, Albacete, Spain",
"id": "http://www.grid.ac/institutes/grid.411839.6",
"name": [
"Complejo Hospitalario Universitario Albacete, Albacete, Spain"
],
"type": "Organization"
},
"familyName": "Perez Rodr\u00edguez",
"givenName": "Ana",
"id": "sg:person.01262222113.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262222113.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hospital Universitario Infanta Leonor, Avda Gran V\u00eda del Este, 80. 28031, Madrid, Spain",
"id": "http://www.grid.ac/institutes/grid.414761.1",
"name": [
"Hospital Universitario Infanta Leonor, Avda Gran V\u00eda del Este, 80. 28031, Madrid, Spain"
],
"type": "Organization"
},
"familyName": "Huguet",
"givenName": "Isabel",
"id": "sg:person.010443143533.61",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010443143533.61"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s12020-019-02128-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1122412025",
"https://doi.org/10.1007/s12020-019-02128-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s002689900459",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046664105",
"https://doi.org/10.1007/s002689900459"
],
"type": "CreativeWork"
}
],
"datePublished": "2021-10-13",
"datePublishedReg": "2021-10-13",
"description": "Abstract\nIntroduction\nHypoparathyroidism is considered a rare endocrine disease. Despite being a deficiency of parathyroid hormone, the standard therapy is based on oral calcium and active vitamin D supplementation. This approach provides satisfactory management in most cases but may be inadequate for patients in the most complex spectrum of the disease. Other therapies are being explored, and among them, the use of recombinant human parathyroid hormone (PTH) has proved to decrease the requirements of calcium and active vitamin D to reach adequate therapeutic goals.ObjectiveWe aimed to provide information on the effectiveness of the current recombinant parathyroid hormone analogs in the clinical management of difficult to control cases of hypoparathyroidism.Method and materialsWe report our experience using teriparatide and PTH (1\u201384) through five complex cases of hypoparathyroidism of diverse etiologies. We describe each case and report the effectiveness of treatment in clinical practice.ResultsFour patients with postsurgical hypoparathyroidism and one patient with autoimmune hypoparathyroidism, all of them with suboptimal control under the standard treatment with calcium and calcitriol supplements or calcium gluconate infusion, are presented. They were all started on teriparatide or PTH (1\u201384), and all of them showed a diminishment of symptoms and were able to maintain normocalcemia without parenteral calcium despite a reduction of oral treatment.ConclusionThis article highlights the effectiveness and safety of hormonal replacement treatment in difficult to manage hypoparathyroidism and provides evidence which justifies its off-label prescription in the case of teriparatide. We consider that this treatment should be considered in cases in which standard treatment fails to reach adequate therapeutic goals.",
"genre": "article",
"id": "sg:pub.10.1007/s42000-021-00326-x",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1030758",
"issn": [
"1109-3099",
"2520-8721"
],
"name": "Hormones",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "21"
}
],
"keywords": [
"parathyroid hormone",
"standard treatment",
"therapeutic goals",
"active vitamin D supplementation",
"recombinant human parathyroid hormone",
"calcium gluconate infusion",
"hormonal replacement treatment",
"vitamin D supplementation",
"active vitamin D",
"cases of hypoparathyroidism",
"rare endocrine disease",
"parathyroid hormone analogues",
"off-label prescriptions",
"effectiveness of treatment",
"human parathyroid hormone",
"requirement of calcium",
"oral calcium",
"D supplementation",
"ResultsFour patients",
"autoimmune hypoparathyroidism",
"calcitriol supplements",
"parenteral calcium",
"postsurgical hypoparathyroidism",
"standard therapy",
"oral treatment",
"case series",
"vitamin D",
"severe hypoparathyroidism",
"endocrine diseases",
"clinical management",
"replacement treatment",
"diverse etiologies",
"hypoparathyroidism",
"clinical practice",
"hormone analogue",
"patients",
"satisfactory management",
"ConclusionThis article",
"treatment",
"therapy",
"disease",
"hormone",
"calcium",
"complex cases",
"most cases",
"Teriparatide",
"normocalcemia",
"infusion",
"cases",
"etiology",
"symptoms",
"management",
"MaterialsWe",
"ObjectiveWe",
"supplementation",
"suboptimal control",
"prescription",
"supplements",
"deficiency",
"safety",
"evidence",
"effectiveness",
"control",
"reduction",
"experience",
"use",
"practice",
"goal",
"analogues",
"diminishment",
"series",
"information",
"introduction",
"method",
"article",
"complex spectra",
"approach",
"requirements",
"spectra"
],
"name": "Improving management of severe hypoparathyroidism: a case series",
"pagination": "71-77",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1141850350"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s42000-021-00326-x"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"34647284"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s42000-021-00326-x",
"https://app.dimensions.ai/details/publication/pub.1141850350"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:39",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_918.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s42000-021-00326-x"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s42000-021-00326-x'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s42000-021-00326-x'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s42000-021-00326-x'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s42000-021-00326-x'
This table displays all metadata directly associated to this object as RDF triples.
231 TRIPLES
22 PREDICATES
113 URIs
103 LITERALS
14 BLANK NODES