The effects of acarbose on chemokine and cytokine production in human monocytic THP-1 cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-02

AUTHORS

Yi-Ching Lin, Yen-Chun Chen, Hui-Pin Hsiao, Chang-Hung Kuo, Bai-Hsiun Chen, Yi-Ting Chen, Shih-Ling Wang, Mei-Lan Tsai, Chih-Hsing Hung

ABSTRACT

BACKGROUND AND OBJECTIVES: Chronic inflammation induced by proinflammatory cytokines and chemokines is postulated to be involved in insulin resistance and β-cell dysfunction in type 2 diabetes mellitus (T2DM). Acarbose, the α-glucosidase inhibitor, is an oral antidiabetic drug for T2DM. Acarbose suppresses inflammatory cytokine production in patients with T2DM, though the underlying mechanisms are unclear. In the present study, we aimed to investigate the anti-inflammatory effects and the exact mechanisms of acarbose in human monocytic THP-1 cells. METHODS: THP-1 cells were pretreated with acarbose and then stimulated with lipopolysaccharide (LPS). The levels of Th1-related chemokines, including interferon-γ-inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1), Th2-related chemokine macrophage-derived chemokine (MDC), and proinflammatory cytokine tumor necrosis factor-α (TNF-α), were determined by enzyme-linked immunosorbent assay. Intracellular signaling pathways were explored by Western blot analysis and using a chromatin immunoprecipitation assay. RESULTS: Acarbose suppressed the levels of IP-10, MCP-1, MDC, and TNF-α and downregulated phosphorylation of p38, c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and nuclear factor-kappa B-p65 (NF-κB-p65) in LPS-stimulated THP-1 cells. Acarbose suppressed LPS-induced acetylation of histones H3 (H3) and H4 in the IP-10 and MCP-1 promoter regions. These findings revealed the suppressive effects of acarbose on IP-10, MCP-1, MDC, and TNF-α production in THP-1 cells via, at least partially, the p38, JNK, ERK, and NF-κB-p65 pathways, as well as through epigenetic regulation via histone H3 and H4 acetylation. CONCLUSION: Our study points to the therapeutic anti-inflammatory potential of acarbose. More... »

PAGES

1-9

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s42000-019-00101-z

DOI

http://dx.doi.org/10.1007/s42000-019-00101-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112504915

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30827017


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kaohsiung Medical University", 
          "id": "https://www.grid.ac/institutes/grid.412019.f", 
          "name": [
            "Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China", 
            "Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China", 
            "Department of Laboratory Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, No.100, Shihchuan 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China", 
            "Research Center for Environmental Medicine, Kaohsiung Medical University, No.100, Shihchuan 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Yi-Ching", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kaohsiung Municipal Hsiao-Kang Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415003.3", 
          "name": [
            "Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China", 
            "Department of Pediatrics, Kaohsiung Municipal Hsiao-Kang Hospital, No.482, Shanming Road, Siaogang District, 812, Kaohsiung City, Taiwan, Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Yen-Chun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hsiao", 
        "givenName": "Hui-Pin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kaohsiung Municipal Ta-Tung Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415007.7", 
          "name": [
            "Ta-Kuo Clinic, No.69, Ziqiang 2nd Road, Cianjin District, 144, Kaohsiung City, Taiwan, Republic of China", 
            "Department of Pediatrics, Kaohsiung Municipal Ta-Tung Hospital, No.68, Jhonghua 3rd Road, Cianjin District, 145, Kaohsiung City, Taiwan, Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuo", 
        "givenName": "Chang-Hung", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kaohsiung Medical University", 
          "id": "https://www.grid.ac/institutes/grid.412019.f", 
          "name": [
            "Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China", 
            "Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China", 
            "Research Center for Environmental Medicine, Kaohsiung Medical University, No.100, Shihchuan 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China", 
            "Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, No.100, Shihchuan 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Bai-Hsiun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Yi-Ting", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Shih-Ling", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsai", 
        "givenName": "Mei-Lan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kaohsiung Medical University", 
          "id": "https://www.grid.ac/institutes/grid.412019.f", 
          "name": [
            "Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China", 
            "Research Center for Environmental Medicine, Kaohsiung Medical University, No.100, Shihchuan 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China", 
            "Department of Pediatrics, Kaohsiung Municipal Hsiao-Kang Hospital, No.482, Shanming Road, Siaogang District, 812, Kaohsiung City, Taiwan, Republic of China", 
            "Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, No.100, Shihchuan 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hung", 
        "givenName": "Chih-Hsing", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1155/2013/635284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001265637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-010-0694-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006659310", 
          "https://doi.org/10.1007/s00109-010-0694-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-010-0694-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006659310", 
          "https://doi.org/10.1007/s00109-010-0694-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/147323000603400510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008372665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/147323000603400510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008372665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/84205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010268186", 
          "https://doi.org/10.1038/84205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/84205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010268186", 
          "https://doi.org/10.1038/84205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-006-0190-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014150258", 
          "https://doi.org/10.1007/s00125-006-0190-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-006-0190-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014150258", 
          "https://doi.org/10.1007/s00125-006-0190-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-006-0190-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014150258", 
          "https://doi.org/10.1007/s00125-006-0190-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1681.2011.05497.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015971632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje-15-1065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016155271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2005.09.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018084868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2222.2006.02606.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018295089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0962-8924(00)01856-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022449886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/openhrt-2014-000205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024337950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/openhrt-2014-000205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024337950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.0710402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024882678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.1202618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025784073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.00200.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033052147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.metabol.2009.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038839840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cyto.2012.06.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039398092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/1753-0407.12232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039491916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2010.12.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040279191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jep.2015.01.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041339816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m311786200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041648024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/jme-15-0146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043482321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2014/181450", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045494074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jdiacomp.2015.12.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047785791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.52.5.1256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048215562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dmrr.559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050566633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dmrr.559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050566633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00445.2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051999262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00445.2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051999262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molimm.2017.01.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053846711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2005-0920", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064247630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.44.7.830", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070737603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/br.2016.744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071502746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.68.3.400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074698009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075341047", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4239/wjd.v6.i4.598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079089251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079109254", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082854670", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03-02", 
    "datePublishedReg": "2019-03-02", 
    "description": "BACKGROUND AND OBJECTIVES: Chronic inflammation induced by proinflammatory cytokines and chemokines is postulated to be involved in insulin resistance and \u03b2-cell dysfunction in type 2 diabetes mellitus (T2DM). Acarbose, the \u03b1-glucosidase inhibitor, is an oral antidiabetic drug for T2DM. Acarbose suppresses inflammatory cytokine production in patients with T2DM, though the underlying mechanisms are unclear. In the present study, we aimed to investigate the anti-inflammatory effects and the exact mechanisms of acarbose in human monocytic THP-1 cells.\nMETHODS: THP-1 cells were pretreated with acarbose and then stimulated with lipopolysaccharide (LPS). The levels of Th1-related chemokines, including interferon-\u03b3-inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1), Th2-related chemokine macrophage-derived chemokine (MDC), and proinflammatory cytokine tumor necrosis factor-\u03b1 (TNF-\u03b1), were determined by enzyme-linked immunosorbent assay. Intracellular signaling pathways were explored by Western blot analysis and using a chromatin immunoprecipitation assay.\nRESULTS: Acarbose suppressed the levels of IP-10, MCP-1, MDC, and TNF-\u03b1 and downregulated phosphorylation of p38, c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and nuclear factor-kappa B-p65 (NF-\u03baB-p65) in LPS-stimulated THP-1 cells. Acarbose suppressed LPS-induced acetylation of histones H3 (H3) and H4 in the IP-10 and MCP-1 promoter regions. These findings revealed the suppressive effects of acarbose on IP-10, MCP-1, MDC, and TNF-\u03b1 production in THP-1 cells via, at least partially, the p38, JNK, ERK, and NF-\u03baB-p65 pathways, as well as through epigenetic regulation via histone H3 and H4 acetylation.\nCONCLUSION: Our study points to the therapeutic anti-inflammatory potential of acarbose.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s42000-019-00101-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1030758", 
        "issn": [
          "1109-3099", 
          "2520-8721"
        ], 
        "name": "Hormones", 
        "type": "Periodical"
      }
    ], 
    "name": "The effects of acarbose on chemokine and cytokine production in human monocytic THP-1 cells", 
    "pagination": "1-9", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b1444b7447ddbea30e1e52d5e4a98bfb4abf05d47f9fc8817286560634720eb8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30827017"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101142469"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s42000-019-00101-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112504915"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s42000-019-00101-z", 
      "https://app.dimensions.ai/details/publication/pub.1112504915"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000350_0000000350/records_77564_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs42000-019-00101-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s42000-019-00101-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s42000-019-00101-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s42000-019-00101-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s42000-019-00101-z'


 

This table displays all metadata directly associated to this object as RDF triples.

237 TRIPLES      21 PREDICATES      61 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s42000-019-00101-z schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N552891810802416d9af87d0efe69f618
4 schema:citation sg:pub.10.1007/s00109-010-0694-2
5 sg:pub.10.1007/s00125-006-0190-y
6 sg:pub.10.1038/84205
7 https://app.dimensions.ai/details/publication/pub.1075341047
8 https://app.dimensions.ai/details/publication/pub.1079109254
9 https://app.dimensions.ai/details/publication/pub.1082854670
10 https://doi.org/10.1002/dmrr.559
11 https://doi.org/10.1016/j.cmet.2010.12.008
12 https://doi.org/10.1016/j.cyto.2012.06.018
13 https://doi.org/10.1016/j.jaci.2005.09.035
14 https://doi.org/10.1016/j.jdiacomp.2015.12.018
15 https://doi.org/10.1016/j.jep.2015.01.015
16 https://doi.org/10.1016/j.metabol.2009.02.003
17 https://doi.org/10.1016/j.molimm.2017.01.009
18 https://doi.org/10.1016/s0962-8924(00)01856-0
19 https://doi.org/10.1074/jbc.m311786200
20 https://doi.org/10.1111/1753-0407.12232
21 https://doi.org/10.1111/j.1365-2222.2006.02606.x
22 https://doi.org/10.1111/j.1440-1681.2011.05497.x
23 https://doi.org/10.1136/openhrt-2014-000205
24 https://doi.org/10.1152/ajpendo.00445.2015
25 https://doi.org/10.1152/ajprenal.00200.2010
26 https://doi.org/10.1155/2013/635284
27 https://doi.org/10.1155/2014/181450
28 https://doi.org/10.1177/147323000603400510
29 https://doi.org/10.1189/jlb.0710402
30 https://doi.org/10.1189/jlb.1202618
31 https://doi.org/10.1189/jlb.68.3.400
32 https://doi.org/10.1210/en.2005-0920
33 https://doi.org/10.1530/eje-15-1065
34 https://doi.org/10.1530/jme-15-0146
35 https://doi.org/10.2337/diab.44.7.830
36 https://doi.org/10.2337/diabetes.52.5.1256
37 https://doi.org/10.3892/br.2016.744
38 https://doi.org/10.4239/wjd.v6.i4.598
39 schema:datePublished 2019-03-02
40 schema:datePublishedReg 2019-03-02
41 schema:description BACKGROUND AND OBJECTIVES: Chronic inflammation induced by proinflammatory cytokines and chemokines is postulated to be involved in insulin resistance and β-cell dysfunction in type 2 diabetes mellitus (T2DM). Acarbose, the α-glucosidase inhibitor, is an oral antidiabetic drug for T2DM. Acarbose suppresses inflammatory cytokine production in patients with T2DM, though the underlying mechanisms are unclear. In the present study, we aimed to investigate the anti-inflammatory effects and the exact mechanisms of acarbose in human monocytic THP-1 cells. METHODS: THP-1 cells were pretreated with acarbose and then stimulated with lipopolysaccharide (LPS). The levels of Th1-related chemokines, including interferon-γ-inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1), Th2-related chemokine macrophage-derived chemokine (MDC), and proinflammatory cytokine tumor necrosis factor-α (TNF-α), were determined by enzyme-linked immunosorbent assay. Intracellular signaling pathways were explored by Western blot analysis and using a chromatin immunoprecipitation assay. RESULTS: Acarbose suppressed the levels of IP-10, MCP-1, MDC, and TNF-α and downregulated phosphorylation of p38, c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and nuclear factor-kappa B-p65 (NF-κB-p65) in LPS-stimulated THP-1 cells. Acarbose suppressed LPS-induced acetylation of histones H3 (H3) and H4 in the IP-10 and MCP-1 promoter regions. These findings revealed the suppressive effects of acarbose on IP-10, MCP-1, MDC, and TNF-α production in THP-1 cells via, at least partially, the p38, JNK, ERK, and NF-κB-p65 pathways, as well as through epigenetic regulation via histone H3 and H4 acetylation. CONCLUSION: Our study points to the therapeutic anti-inflammatory potential of acarbose.
42 schema:genre research_article
43 schema:inLanguage en
44 schema:isAccessibleForFree false
45 schema:isPartOf sg:journal.1030758
46 schema:name The effects of acarbose on chemokine and cytokine production in human monocytic THP-1 cells
47 schema:pagination 1-9
48 schema:productId N1475aee0a27b4a389c160960b0effc94
49 N2b1d9c70b97644e3869382b2d8476fe0
50 Nb12b7b2bf14e44aea4b0f3df2fcf01ba
51 Nf13674c48a874a5dba9a07349d098d9f
52 Nfbca59c590ff494f8573745684f71771
53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112504915
54 https://doi.org/10.1007/s42000-019-00101-z
55 schema:sdDatePublished 2019-04-11T10:49
56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
57 schema:sdPublisher Na0524d83da5e4566bf919b58a014b7f3
58 schema:url https://link.springer.com/10.1007%2Fs42000-019-00101-z
59 sgo:license sg:explorer/license/
60 sgo:sdDataset articles
61 rdf:type schema:ScholarlyArticle
62 N1475aee0a27b4a389c160960b0effc94 schema:name pubmed_id
63 schema:value 30827017
64 rdf:type schema:PropertyValue
65 N1a965fdf143a48a19dd373d8c37cde6a rdf:first Nefc572b9af044af786e42c0064e02229
66 rdf:rest Nf31196fe5f944cfb87c6a4e8d36dcf0f
67 N2b1d9c70b97644e3869382b2d8476fe0 schema:name doi
68 schema:value 10.1007/s42000-019-00101-z
69 rdf:type schema:PropertyValue
70 N44690d8a246648de978be05d7e3e4144 schema:affiliation https://www.grid.ac/institutes/grid.412019.f
71 schema:familyName Hung
72 schema:givenName Chih-Hsing
73 rdf:type schema:Person
74 N513d6bdbf3194676941214e8cc8a1abe rdf:first N81bab0bd08b84c5ebf866ad4a214cab3
75 rdf:rest N7ab922a51e844599b7a23d3f1c9668af
76 N552891810802416d9af87d0efe69f618 rdf:first Ndce9e5ac20dd4f6d853bbf8ed8e2e49c
77 rdf:rest N1a965fdf143a48a19dd373d8c37cde6a
78 N55fbfc2ed2e34c80af71dc794acdcb9f schema:affiliation N7583630a3d3e498f888b237763e72c91
79 schema:familyName Chen
80 schema:givenName Yi-Ting
81 rdf:type schema:Person
82 N5b756a5d523e42aa95512d36597f8e15 schema:affiliation Nae1aa8a45bac44fcb2707faf214a862e
83 schema:familyName Tsai
84 schema:givenName Mei-Lan
85 rdf:type schema:Person
86 N5c720c34419546d7adf89e37f7fa9240 schema:affiliation https://www.grid.ac/institutes/grid.415007.7
87 schema:familyName Kuo
88 schema:givenName Chang-Hung
89 rdf:type schema:Person
90 N5ff9ba496572412c8c9afbe03c89ee27 schema:name Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China
91 rdf:type schema:Organization
92 N67d7a9714a2941c09009567055622bce schema:affiliation N5ff9ba496572412c8c9afbe03c89ee27
93 schema:familyName Hsiao
94 schema:givenName Hui-Pin
95 rdf:type schema:Person
96 N711d71fe15b84fb7a4133dab0af3008d schema:name Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China
97 rdf:type schema:Organization
98 N7583630a3d3e498f888b237763e72c91 schema:name Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China
99 rdf:type schema:Organization
100 N7ab922a51e844599b7a23d3f1c9668af rdf:first N55fbfc2ed2e34c80af71dc794acdcb9f
101 rdf:rest Nb0fd6a0acd364193aac6f6ab89d47208
102 N81bab0bd08b84c5ebf866ad4a214cab3 schema:affiliation https://www.grid.ac/institutes/grid.412019.f
103 schema:familyName Chen
104 schema:givenName Bai-Hsiun
105 rdf:type schema:Person
106 N98aa66f937ee4f3a918214aeca32621c schema:affiliation N711d71fe15b84fb7a4133dab0af3008d
107 schema:familyName Wang
108 schema:givenName Shih-Ling
109 rdf:type schema:Person
110 Na0524d83da5e4566bf919b58a014b7f3 schema:name Springer Nature - SN SciGraph project
111 rdf:type schema:Organization
112 Nae1aa8a45bac44fcb2707faf214a862e schema:name Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China
113 rdf:type schema:Organization
114 Nb0fd6a0acd364193aac6f6ab89d47208 rdf:first N98aa66f937ee4f3a918214aeca32621c
115 rdf:rest Nfca778ebdd8f46829d86e3c6b042c781
116 Nb12b7b2bf14e44aea4b0f3df2fcf01ba schema:name readcube_id
117 schema:value b1444b7447ddbea30e1e52d5e4a98bfb4abf05d47f9fc8817286560634720eb8
118 rdf:type schema:PropertyValue
119 Nbb4f40bdd1e1469c8f47fe980a39debd rdf:first N5c720c34419546d7adf89e37f7fa9240
120 rdf:rest N513d6bdbf3194676941214e8cc8a1abe
121 Nbcb0097a18fc4bdc99d5eb8e2b08276c rdf:first N44690d8a246648de978be05d7e3e4144
122 rdf:rest rdf:nil
123 Ndce9e5ac20dd4f6d853bbf8ed8e2e49c schema:affiliation https://www.grid.ac/institutes/grid.412019.f
124 schema:familyName Lin
125 schema:givenName Yi-Ching
126 rdf:type schema:Person
127 Nefc572b9af044af786e42c0064e02229 schema:affiliation https://www.grid.ac/institutes/grid.415003.3
128 schema:familyName Chen
129 schema:givenName Yen-Chun
130 rdf:type schema:Person
131 Nf13674c48a874a5dba9a07349d098d9f schema:name dimensions_id
132 schema:value pub.1112504915
133 rdf:type schema:PropertyValue
134 Nf31196fe5f944cfb87c6a4e8d36dcf0f rdf:first N67d7a9714a2941c09009567055622bce
135 rdf:rest Nbb4f40bdd1e1469c8f47fe980a39debd
136 Nfbca59c590ff494f8573745684f71771 schema:name nlm_unique_id
137 schema:value 101142469
138 rdf:type schema:PropertyValue
139 Nfca778ebdd8f46829d86e3c6b042c781 rdf:first N5b756a5d523e42aa95512d36597f8e15
140 rdf:rest Nbcb0097a18fc4bdc99d5eb8e2b08276c
141 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
142 schema:name Biological Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
145 schema:name Biochemistry and Cell Biology
146 rdf:type schema:DefinedTerm
147 sg:journal.1030758 schema:issn 1109-3099
148 2520-8721
149 schema:name Hormones
150 rdf:type schema:Periodical
151 sg:pub.10.1007/s00109-010-0694-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006659310
152 https://doi.org/10.1007/s00109-010-0694-2
153 rdf:type schema:CreativeWork
154 sg:pub.10.1007/s00125-006-0190-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1014150258
155 https://doi.org/10.1007/s00125-006-0190-y
156 rdf:type schema:CreativeWork
157 sg:pub.10.1038/84205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010268186
158 https://doi.org/10.1038/84205
159 rdf:type schema:CreativeWork
160 https://app.dimensions.ai/details/publication/pub.1075341047 schema:CreativeWork
161 https://app.dimensions.ai/details/publication/pub.1079109254 schema:CreativeWork
162 https://app.dimensions.ai/details/publication/pub.1082854670 schema:CreativeWork
163 https://doi.org/10.1002/dmrr.559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050566633
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1016/j.cmet.2010.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040279191
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1016/j.cyto.2012.06.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039398092
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1016/j.jaci.2005.09.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018084868
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/j.jdiacomp.2015.12.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047785791
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/j.jep.2015.01.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041339816
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/j.metabol.2009.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038839840
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/j.molimm.2017.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053846711
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/s0962-8924(00)01856-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022449886
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1074/jbc.m311786200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041648024
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1111/1753-0407.12232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039491916
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1111/j.1365-2222.2006.02606.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018295089
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1111/j.1440-1681.2011.05497.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015971632
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1136/openhrt-2014-000205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024337950
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1152/ajpendo.00445.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051999262
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1152/ajprenal.00200.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033052147
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1155/2013/635284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001265637
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1155/2014/181450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045494074
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1177/147323000603400510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008372665
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1189/jlb.0710402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024882678
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1189/jlb.1202618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025784073
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1189/jlb.68.3.400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074698009
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1210/en.2005-0920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064247630
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1530/eje-15-1065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016155271
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1530/jme-15-0146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043482321
212 rdf:type schema:CreativeWork
213 https://doi.org/10.2337/diab.44.7.830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070737603
214 rdf:type schema:CreativeWork
215 https://doi.org/10.2337/diabetes.52.5.1256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048215562
216 rdf:type schema:CreativeWork
217 https://doi.org/10.3892/br.2016.744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071502746
218 rdf:type schema:CreativeWork
219 https://doi.org/10.4239/wjd.v6.i4.598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079089251
220 rdf:type schema:CreativeWork
221 https://www.grid.ac/institutes/grid.412019.f schema:alternateName Kaohsiung Medical University
222 schema:name Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China
223 Department of Laboratory Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, No.100, Shihchuan 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China
224 Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China
225 Department of Pediatrics, Kaohsiung Municipal Hsiao-Kang Hospital, No.482, Shanming Road, Siaogang District, 812, Kaohsiung City, Taiwan, Republic of China
226 Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, No.100, Shihchuan 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China
227 Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, No.100, Shihchuan 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China
228 Research Center for Environmental Medicine, Kaohsiung Medical University, No.100, Shihchuan 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China
229 rdf:type schema:Organization
230 https://www.grid.ac/institutes/grid.415003.3 schema:alternateName Kaohsiung Municipal Hsiao-Kang Hospital
231 schema:name Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Sanmin District, 807, Kaohsiung City, Taiwan, Republic of China
232 Department of Pediatrics, Kaohsiung Municipal Hsiao-Kang Hospital, No.482, Shanming Road, Siaogang District, 812, Kaohsiung City, Taiwan, Republic of China
233 rdf:type schema:Organization
234 https://www.grid.ac/institutes/grid.415007.7 schema:alternateName Kaohsiung Municipal Ta-Tung Hospital
235 schema:name Department of Pediatrics, Kaohsiung Municipal Ta-Tung Hospital, No.68, Jhonghua 3rd Road, Cianjin District, 145, Kaohsiung City, Taiwan, Republic of China
236 Ta-Kuo Clinic, No.69, Ziqiang 2nd Road, Cianjin District, 144, Kaohsiung City, Taiwan, Republic of China
237 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...