Molecular basis of vitamin D action in neurodegeneration: the story of a team perspective View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Duygu Gezen-Ak, Erdinç Dursun

ABSTRACT

Vitamin D, a secosteroid hormone, has, over the years, mainly been known for its classic role in the maintenance of calcium homeostasis of the human body. However, there is increasing understanding that vitamin D contributes to the regulation of Ca2+ homeostasis, especially via voltage-gated calcium channels, in another major organ that uses calcium, the brain. Almost 30 years ago, the role of dysregulation in the aging brain and in Alzheimer's disease (AD) gave rise to the Ca2+ hypothesis of brain aging and dementia. We thus made calcium homeostasis the starting point of our studies, proposing the notion that the consequences of long-term deficiency and/or inefficient utilization of vitamin D may cause the disruption of calcium homeostasis in neurons, this creating a vulnerability of neurons to aging and neurodegeneration. In this mini-review, we aim to describe the potential of vitamin D (cholecalciferol) as a neurosteroid based on our findings and conclusions. More... »

PAGES

17-21

Journal

TITLE

Hormones

ISSUE

1

VOLUME

18

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s42000-018-0087-4

DOI

http://dx.doi.org/10.1007/s42000-018-0087-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110227347

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30484097


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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s42000-018-0087-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s42000-018-0087-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s42000-018-0087-4'


 

This table displays all metadata directly associated to this object as RDF triples.

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