Transsphenoidal surgery for pituitary adenomas: early results from a single center View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12

AUTHORS

I. Karamouzis, M. Caputo, C. Mele, A. Nuzzo, M. Zavattaro, P. Car, G. Panzarasa, F. Prodam, P. Marzullo, Gianluca Aimaretti

ABSTRACT

OBJECTIVE: To evaluate early results of transsphenoidal surgery for pituitary adenomas. DESIGN: Retrospective evaluation of 90 consecutive patients undergoing endoscopic pituitary adenoma surgery (2007-2016) at "Maggiore della Carità" Hospital in Novara, Italy. Age at diagnosis, sex, symptoms at presentation, hormonal and radiological data, complications of surgery, and short-term follow-up information were collected. RESULTS: The majority of patients were male (M/F: 1.5/1, mean age at diagnosis 62.1 ± 1.5 years mean ± SEM). Most patients (91.1%) presented with a macroadenoma (27.4 mm ± 1.1 mm mean ± SEM), while 77.8% were non-functioning pituitary adenomas. Clinical presentations related to mass effect were visual impairment (74.0%) and/or hypopituitarism (55.1%). The main surgery complication was insipidus diabetes (12.2%), followed by cerebral hemorrhage (4.4%), cerebrospinal fluid (CSF) leaks (4.4%), syndrome of inappropriate antidiuresis (SIAD) (2.2%), and epistaxis (2.2%); only one patient died because of stroke. Risk of complications was not associated with tumor size (OR = 0.588, 95% CI 0.967-1.081, p = 0.443). Visual function improved in 70.6% of patients, while recovery of normal pituitary function occurred in 48.1%. Early neuroimaging studies demonstrated no residual tumor in 27.6% of patients. Invasion of cavernous sinus (OR = 3.293, 95% CI 0.897-16.738, p = 0.05) and maximum tumor diameter (OR = 6.857, 95% CI 1.039-1.309, p < 0.01) were associated with an unfavorable surgical outcome. CONCLUSIONS: Transsphenoidal endoscopic surgery for pituitary adenomas is safe and is frequently followed by improvement in visual symptoms, whereas recovery of pituitary function is less common. In our patients, complete surgical removal of adenomas is comparable to that of other series, but further investigations will be necessary to clarify the long-term risk of tumor recurrence. More... »

PAGES

551-556

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s42000-018-0082-9

DOI

http://dx.doi.org/10.1007/s42000-018-0082-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110371421

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30515666


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Outcome Assessment (Health Care)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pituitary Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Postoperative Complications", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sphenoid Bone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transanal Endoscopic Surgery", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Eastern Piedmont Amadeo Avogadro", 
          "id": "https://www.grid.ac/institutes/grid.16563.37", 
          "name": [
            "Endocrinology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karamouzis", 
        "givenName": "I.", 
        "id": "sg:person.0766574213.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766574213.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Eastern Piedmont Amadeo Avogadro", 
          "id": "https://www.grid.ac/institutes/grid.16563.37", 
          "name": [
            "Endocrinology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caputo", 
        "givenName": "M.", 
        "id": "sg:person.01367443677.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367443677.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Eastern Piedmont Amadeo Avogadro", 
          "id": "https://www.grid.ac/institutes/grid.16563.37", 
          "name": [
            "Endocrinology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mele", 
        "givenName": "C.", 
        "id": "sg:person.01205003217.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205003217.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Eastern Piedmont Amadeo Avogadro", 
          "id": "https://www.grid.ac/institutes/grid.16563.37", 
          "name": [
            "Endocrinology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nuzzo", 
        "givenName": "A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Eastern Piedmont Amadeo Avogadro", 
          "id": "https://www.grid.ac/institutes/grid.16563.37", 
          "name": [
            "Endocrinology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zavattaro", 
        "givenName": "M.", 
        "id": "sg:person.01036130012.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036130012.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliero Universitaria Maggiore della Carita", 
          "id": "https://www.grid.ac/institutes/grid.412824.9", 
          "name": [
            "Neurosurgery, AOU \u201cMaggiore della Carit\u00e0\u201d Hospital, Novara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Car", 
        "givenName": "P.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliero Universitaria Maggiore della Carita", 
          "id": "https://www.grid.ac/institutes/grid.412824.9", 
          "name": [
            "Neurosurgery, AOU \u201cMaggiore della Carit\u00e0\u201d Hospital, Novara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Panzarasa", 
        "givenName": "G.", 
        "id": "sg:person.016130321403.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016130321403.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Eastern Piedmont Amadeo Avogadro", 
          "id": "https://www.grid.ac/institutes/grid.16563.37", 
          "name": [
            "Endocrinology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Prodam", 
        "givenName": "F.", 
        "id": "sg:person.01170211670.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170211670.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Eastern Piedmont Amadeo Avogadro", 
          "id": "https://www.grid.ac/institutes/grid.16563.37", 
          "name": [
            "Endocrinology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marzullo", 
        "givenName": "P.", 
        "id": "sg:person.01067622763.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067622763.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Eastern Piedmont Amadeo Avogadro", 
          "id": "https://www.grid.ac/institutes/grid.16563.37", 
          "name": [
            "Endocrinology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aimaretti", 
        "givenName": "Gianluca", 
        "id": "sg:person.01353610472.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353610472.61"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1227/00006123-198706000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000034759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ecl.2014.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007919715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2265.2003.01784.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008461058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19960801)78:3<502::aid-cncr18>3.0.co;2-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011164978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje.0.1460179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016724128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje.0.1460179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016724128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje.0.1460179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016724128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000147976.06937.1d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020883292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2265.2000.01153.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021111061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(07)60673-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023581004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03350330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025193683", 
          "https://doi.org/10.1007/bf03350330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2016-2118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027282762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-7091-6084-8_7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027300881", 
          "https://doi.org/10.1007/978-3-7091-6084-8_7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-7091-6084-8_7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027300881", 
          "https://doi.org/10.1007/978-3-7091-6084-8_7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000095534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042549257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2004-820914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057432083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2008-1052019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057544539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006123-199702000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060246345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2003-030461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064286864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2005-2552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064288951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2011-0179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064292692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem-62-6-1173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064314282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.84.10.6019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064322175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/00006123-199310000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064432730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/00006123-199310000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064432730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000325862.83961.12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064436570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns/2008/108/3/0525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns/2008/108/3/0525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns/2008/108/3/0525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns/2008/108/3/0525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns/2008/108/3/0525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns/2008/108/3/0525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1997.87.1.0044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071098467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1997.87.1.0044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071098467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1997.87.1.0044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071098467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2002.97.2.0293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071100412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2002.97.2.0293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071100412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2002.97.2.0293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071100412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.beem.2017.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083919304"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "OBJECTIVE: To evaluate early results of transsphenoidal surgery for pituitary adenomas.\nDESIGN: Retrospective evaluation of 90 consecutive patients undergoing endoscopic pituitary adenoma surgery (2007-2016) at \"Maggiore della Carit\u00e0\" Hospital in Novara, Italy. Age at diagnosis, sex, symptoms at presentation, hormonal and radiological data, complications of surgery, and short-term follow-up information were collected.\nRESULTS: The majority of patients were male (M/F: 1.5/1, mean age at diagnosis 62.1\u2009\u00b1\u20091.5\u00a0years mean \u00b1 SEM). Most patients (91.1%) presented with a macroadenoma (27.4\u00a0mm\u2009\u00b1\u20091.1\u00a0mm mean \u00b1 SEM), while 77.8% were non-functioning pituitary adenomas. Clinical presentations related to mass effect were visual impairment (74.0%) and/or hypopituitarism (55.1%). The main surgery complication was insipidus diabetes (12.2%), followed by cerebral hemorrhage (4.4%), cerebrospinal fluid (CSF) leaks (4.4%), syndrome of inappropriate antidiuresis (SIAD) (2.2%), and epistaxis (2.2%); only one patient died because of stroke. Risk of complications was not associated with tumor size (OR\u2009=\u20090.588, 95% CI 0.967-1.081, p\u2009=\u20090.443). Visual function improved in 70.6% of patients, while recovery of normal pituitary function occurred in 48.1%. Early neuroimaging studies demonstrated no residual tumor in 27.6% of patients. Invasion of cavernous sinus (OR\u2009=\u20093.293, 95% CI 0.897-16.738, p\u2009=\u20090.05) and maximum tumor diameter (OR\u2009=\u20096.857, 95% CI 1.039-1.309, p\u2009<\u20090.01) were associated with an unfavorable surgical outcome.\nCONCLUSIONS: Transsphenoidal endoscopic surgery for pituitary adenomas is safe and is frequently followed by improvement in visual symptoms, whereas recovery of pituitary function is less common. In our patients, complete surgical removal of adenomas is comparable to that of other series, but further investigations will be necessary to clarify the long-term risk of tumor recurrence.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s42000-018-0082-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1030758", 
        "issn": [
          "1109-3099", 
          "2520-8721"
        ], 
        "name": "Hormones", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Transsphenoidal surgery for pituitary adenomas: early results from a single center", 
    "pagination": "551-556", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1d989b793f2ba5208f5c8e17f99e129eabeaa5a6478d7ca7385bb255209f3b02"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30515666"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101142469"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s42000-018-0082-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110371421"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s42000-018-0082-9", 
      "https://app.dimensions.ai/details/publication/pub.1110371421"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000364_0000000364/records_72868_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs42000-018-0082-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s42000-018-0082-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s42000-018-0082-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s42000-018-0082-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s42000-018-0082-9'


 

This table displays all metadata directly associated to this object as RDF triples.

261 TRIPLES      21 PREDICATES      67 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s42000-018-0082-9 schema:about N2776e7f364e6424c93954b6469820356
2 N33db42f1157f49ecb3c8866843039bb5
3 N3951bee9a15d4baaaeab8bebb594d532
4 N5400665a2bf0426883f52429d13c960c
5 N569583f811b5410897f122dda4d97146
6 N66e75469a96f4df5ac902b2f3b14843b
7 N700de44cdf484d0aa5c995ea23b0092d
8 N8a41a1b66c7e4b7885845663087e9026
9 N9284ab7bdd68480f8f81ac5d471ca005
10 Nba51a81cb04942b090756874eaeaf8be
11 Nd33eedb3f62d4c4eb54a98da6623e7a8
12 Ne470b01c34c6453da18c2c8e7f966174
13 anzsrc-for:11
14 anzsrc-for:1103
15 schema:author N64f1ac45ef744d14b6d330572ed0dac1
16 schema:citation sg:pub.10.1007/978-3-7091-6084-8_7
17 sg:pub.10.1007/bf03350330
18 https://doi.org/10.1002/(sici)1097-0142(19960801)78:3<502::aid-cncr18>3.0.co;2-2
19 https://doi.org/10.1016/j.beem.2017.02.001
20 https://doi.org/10.1016/j.ecl.2014.10.010
21 https://doi.org/10.1016/s0140-6736(07)60673-4
22 https://doi.org/10.1046/j.1365-2265.2000.01153.x
23 https://doi.org/10.1046/j.1365-2265.2003.01784.x
24 https://doi.org/10.1055/s-2004-820914
25 https://doi.org/10.1055/s-2008-1052019
26 https://doi.org/10.1097/00006123-199702000-00001
27 https://doi.org/10.1159/000095534
28 https://doi.org/10.1210/jc.2003-030461
29 https://doi.org/10.1210/jc.2005-2552
30 https://doi.org/10.1210/jc.2011-0179
31 https://doi.org/10.1210/jc.2016-2118
32 https://doi.org/10.1210/jcem-62-6-1173
33 https://doi.org/10.1210/jcem.84.10.6019
34 https://doi.org/10.1227/00006123-198706000-00017
35 https://doi.org/10.1227/00006123-199310000-00008
36 https://doi.org/10.1227/01.neu.0000147976.06937.1d
37 https://doi.org/10.1227/01.neu.0000325862.83961.12
38 https://doi.org/10.1530/eje.0.1460179
39 https://doi.org/10.3171/jns.1997.87.1.0044
40 https://doi.org/10.3171/jns.2002.97.2.0293
41 https://doi.org/10.3171/jns/2008/108/3/0525
42 schema:datePublished 2018-12
43 schema:datePublishedReg 2018-12-01
44 schema:description OBJECTIVE: To evaluate early results of transsphenoidal surgery for pituitary adenomas. DESIGN: Retrospective evaluation of 90 consecutive patients undergoing endoscopic pituitary adenoma surgery (2007-2016) at "Maggiore della Carità" Hospital in Novara, Italy. Age at diagnosis, sex, symptoms at presentation, hormonal and radiological data, complications of surgery, and short-term follow-up information were collected. RESULTS: The majority of patients were male (M/F: 1.5/1, mean age at diagnosis 62.1 ± 1.5 years mean ± SEM). Most patients (91.1%) presented with a macroadenoma (27.4 mm ± 1.1 mm mean ± SEM), while 77.8% were non-functioning pituitary adenomas. Clinical presentations related to mass effect were visual impairment (74.0%) and/or hypopituitarism (55.1%). The main surgery complication was insipidus diabetes (12.2%), followed by cerebral hemorrhage (4.4%), cerebrospinal fluid (CSF) leaks (4.4%), syndrome of inappropriate antidiuresis (SIAD) (2.2%), and epistaxis (2.2%); only one patient died because of stroke. Risk of complications was not associated with tumor size (OR = 0.588, 95% CI 0.967-1.081, p = 0.443). Visual function improved in 70.6% of patients, while recovery of normal pituitary function occurred in 48.1%. Early neuroimaging studies demonstrated no residual tumor in 27.6% of patients. Invasion of cavernous sinus (OR = 3.293, 95% CI 0.897-16.738, p = 0.05) and maximum tumor diameter (OR = 6.857, 95% CI 1.039-1.309, p < 0.01) were associated with an unfavorable surgical outcome. CONCLUSIONS: Transsphenoidal endoscopic surgery for pituitary adenomas is safe and is frequently followed by improvement in visual symptoms, whereas recovery of pituitary function is less common. In our patients, complete surgical removal of adenomas is comparable to that of other series, but further investigations will be necessary to clarify the long-term risk of tumor recurrence.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree false
48 schema:isPartOf N0117c7f2953047b8bc3fa8d7b1027a78
49 N51191488436142129a50789618cf5b70
50 sg:journal.1030758
51 schema:name Transsphenoidal surgery for pituitary adenomas: early results from a single center
52 schema:pagination 551-556
53 schema:productId N1252cbec34264a2e92ddeb13d806b988
54 N2b4bc2f92bf247bdbc7188e9931535c1
55 N8e3eca37d324466cbcd3445c17aa259c
56 Ncf45f2b0a4c9428884f60f38ac7453b0
57 Ne5d9e282ba2746e3997eaecde4028462
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110371421
59 https://doi.org/10.1007/s42000-018-0082-9
60 schema:sdDatePublished 2019-04-11T12:55
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N42c29309b0ea4273b45b3cfbd5782b44
63 schema:url https://link.springer.com/10.1007%2Fs42000-018-0082-9
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N0117c7f2953047b8bc3fa8d7b1027a78 schema:volumeNumber 17
68 rdf:type schema:PublicationVolume
69 N1252cbec34264a2e92ddeb13d806b988 schema:name doi
70 schema:value 10.1007/s42000-018-0082-9
71 rdf:type schema:PropertyValue
72 N1529a365c2f84640a8929a891d7e87c5 rdf:first sg:person.016130321403.28
73 rdf:rest N86cd0f8d76be4c00b1647583ac45c19e
74 N2776e7f364e6424c93954b6469820356 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Middle Aged
76 rdf:type schema:DefinedTerm
77 N2b4bc2f92bf247bdbc7188e9931535c1 schema:name dimensions_id
78 schema:value pub.1110371421
79 rdf:type schema:PropertyValue
80 N33db42f1157f49ecb3c8866843039bb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Transanal Endoscopic Surgery
82 rdf:type schema:DefinedTerm
83 N3951bee9a15d4baaaeab8bebb594d532 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Male
85 rdf:type schema:DefinedTerm
86 N3c66622de94c4d28a3372b0d812658ea rdf:first Nb42b45910cff4545b354c3675e97307e
87 rdf:rest N1529a365c2f84640a8929a891d7e87c5
88 N3d8b32ca02e54c9e953c1ca591a53073 schema:affiliation https://www.grid.ac/institutes/grid.16563.37
89 schema:familyName Nuzzo
90 schema:givenName A.
91 rdf:type schema:Person
92 N42c29309b0ea4273b45b3cfbd5782b44 schema:name Springer Nature - SN SciGraph project
93 rdf:type schema:Organization
94 N4fa4f6e8a43046fc940f70e5acc104cb rdf:first sg:person.01036130012.46
95 rdf:rest N3c66622de94c4d28a3372b0d812658ea
96 N51191488436142129a50789618cf5b70 schema:issueNumber 4
97 rdf:type schema:PublicationIssue
98 N5400665a2bf0426883f52429d13c960c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Adenoma
100 rdf:type schema:DefinedTerm
101 N569583f811b5410897f122dda4d97146 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Female
103 rdf:type schema:DefinedTerm
104 N64f1ac45ef744d14b6d330572ed0dac1 rdf:first sg:person.0766574213.26
105 rdf:rest N94678dd99a014cca99094640d1ccb21e
106 N66e75469a96f4df5ac902b2f3b14843b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Humans
108 rdf:type schema:DefinedTerm
109 N700de44cdf484d0aa5c995ea23b0092d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Aged
111 rdf:type schema:DefinedTerm
112 N76114e5ff05e4b0a954fbd1012b25591 rdf:first sg:person.01205003217.58
113 rdf:rest Nf0090387a65a4a16ad5b2d7863770675
114 N780768d2a48c40618a170b489b109755 rdf:first sg:person.01067622763.33
115 rdf:rest Nc2b7a0c2e36a4eaf89874b19f43196ba
116 N86cd0f8d76be4c00b1647583ac45c19e rdf:first sg:person.01170211670.20
117 rdf:rest N780768d2a48c40618a170b489b109755
118 N8a41a1b66c7e4b7885845663087e9026 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Pituitary Neoplasms
120 rdf:type schema:DefinedTerm
121 N8e3eca37d324466cbcd3445c17aa259c schema:name readcube_id
122 schema:value 1d989b793f2ba5208f5c8e17f99e129eabeaa5a6478d7ca7385bb255209f3b02
123 rdf:type schema:PropertyValue
124 N9284ab7bdd68480f8f81ac5d471ca005 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Outcome Assessment (Health Care)
126 rdf:type schema:DefinedTerm
127 N94678dd99a014cca99094640d1ccb21e rdf:first sg:person.01367443677.87
128 rdf:rest N76114e5ff05e4b0a954fbd1012b25591
129 Nb42b45910cff4545b354c3675e97307e schema:affiliation https://www.grid.ac/institutes/grid.412824.9
130 schema:familyName Car
131 schema:givenName P.
132 rdf:type schema:Person
133 Nba51a81cb04942b090756874eaeaf8be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Retrospective Studies
135 rdf:type schema:DefinedTerm
136 Nc2b7a0c2e36a4eaf89874b19f43196ba rdf:first sg:person.01353610472.61
137 rdf:rest rdf:nil
138 Ncf45f2b0a4c9428884f60f38ac7453b0 schema:name nlm_unique_id
139 schema:value 101142469
140 rdf:type schema:PropertyValue
141 Nd33eedb3f62d4c4eb54a98da6623e7a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Sphenoid Bone
143 rdf:type schema:DefinedTerm
144 Ne470b01c34c6453da18c2c8e7f966174 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Postoperative Complications
146 rdf:type schema:DefinedTerm
147 Ne5d9e282ba2746e3997eaecde4028462 schema:name pubmed_id
148 schema:value 30515666
149 rdf:type schema:PropertyValue
150 Nf0090387a65a4a16ad5b2d7863770675 rdf:first N3d8b32ca02e54c9e953c1ca591a53073
151 rdf:rest N4fa4f6e8a43046fc940f70e5acc104cb
152 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
153 schema:name Medical and Health Sciences
154 rdf:type schema:DefinedTerm
155 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
156 schema:name Clinical Sciences
157 rdf:type schema:DefinedTerm
158 sg:journal.1030758 schema:issn 1109-3099
159 2520-8721
160 schema:name Hormones
161 rdf:type schema:Periodical
162 sg:person.01036130012.46 schema:affiliation https://www.grid.ac/institutes/grid.16563.37
163 schema:familyName Zavattaro
164 schema:givenName M.
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036130012.46
166 rdf:type schema:Person
167 sg:person.01067622763.33 schema:affiliation https://www.grid.ac/institutes/grid.16563.37
168 schema:familyName Marzullo
169 schema:givenName P.
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067622763.33
171 rdf:type schema:Person
172 sg:person.01170211670.20 schema:affiliation https://www.grid.ac/institutes/grid.16563.37
173 schema:familyName Prodam
174 schema:givenName F.
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170211670.20
176 rdf:type schema:Person
177 sg:person.01205003217.58 schema:affiliation https://www.grid.ac/institutes/grid.16563.37
178 schema:familyName Mele
179 schema:givenName C.
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205003217.58
181 rdf:type schema:Person
182 sg:person.01353610472.61 schema:affiliation https://www.grid.ac/institutes/grid.16563.37
183 schema:familyName Aimaretti
184 schema:givenName Gianluca
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353610472.61
186 rdf:type schema:Person
187 sg:person.01367443677.87 schema:affiliation https://www.grid.ac/institutes/grid.16563.37
188 schema:familyName Caputo
189 schema:givenName M.
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367443677.87
191 rdf:type schema:Person
192 sg:person.016130321403.28 schema:affiliation https://www.grid.ac/institutes/grid.412824.9
193 schema:familyName Panzarasa
194 schema:givenName G.
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016130321403.28
196 rdf:type schema:Person
197 sg:person.0766574213.26 schema:affiliation https://www.grid.ac/institutes/grid.16563.37
198 schema:familyName Karamouzis
199 schema:givenName I.
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766574213.26
201 rdf:type schema:Person
202 sg:pub.10.1007/978-3-7091-6084-8_7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027300881
203 https://doi.org/10.1007/978-3-7091-6084-8_7
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/bf03350330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025193683
206 https://doi.org/10.1007/bf03350330
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1002/(sici)1097-0142(19960801)78:3<502::aid-cncr18>3.0.co;2-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011164978
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.beem.2017.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083919304
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.ecl.2014.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007919715
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/s0140-6736(07)60673-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023581004
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1046/j.1365-2265.2000.01153.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021111061
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1046/j.1365-2265.2003.01784.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008461058
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1055/s-2004-820914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057432083
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1055/s-2008-1052019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057544539
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1097/00006123-199702000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060246345
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1159/000095534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042549257
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1210/jc.2003-030461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064286864
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1210/jc.2005-2552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064288951
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1210/jc.2011-0179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064292692
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1210/jc.2016-2118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027282762
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1210/jcem-62-6-1173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064314282
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1210/jcem.84.10.6019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064322175
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1227/00006123-198706000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000034759
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1227/00006123-199310000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064432730
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1227/01.neu.0000147976.06937.1d schema:sameAs https://app.dimensions.ai/details/publication/pub.1020883292
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1227/01.neu.0000325862.83961.12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064436570
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1530/eje.0.1460179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016724128
249 rdf:type schema:CreativeWork
250 https://doi.org/10.3171/jns.1997.87.1.0044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071098467
251 rdf:type schema:CreativeWork
252 https://doi.org/10.3171/jns.2002.97.2.0293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071100412
253 rdf:type schema:CreativeWork
254 https://doi.org/10.3171/jns/2008/108/3/0525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071083589
255 rdf:type schema:CreativeWork
256 https://www.grid.ac/institutes/grid.16563.37 schema:alternateName University of Eastern Piedmont Amadeo Avogadro
257 schema:name Endocrinology, Department of Translational Medicine, Università del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy
258 rdf:type schema:Organization
259 https://www.grid.ac/institutes/grid.412824.9 schema:alternateName Azienda Ospedaliero Universitaria Maggiore della Carita
260 schema:name Neurosurgery, AOU “Maggiore della Carità” Hospital, Novara, Italy
261 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...