A decade in female reproduction: an endocrine view of the past and into the future View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12

AUTHORS

Djuro Macut, Danijela Vojnović Milutinović, Aleksandra Rašić-Marković, Jelena Nestorov, Jelica Bjekić-Macut, Olivera Stanojlović

ABSTRACT

Over the last decade, huge achievements have been made in the fields of neurophysiology, molecular endocrinology, and biochemistry, as well as in the successful translation of clinical research into diseases into clinical practice. As regards female reproduction, most of the advances made in this area were achieved in gonadal axis regulation, regulation of behavior through sex steroids, reproductive genetics, preservation of ovarian reproductive function, steroid profiling, and metabolic and overall reproductive outcomes. The coming years are expected to bring further understanding of the relationships between nutrition, energy metabolism, and reproductive function and to succeed in identifying new genetic markers linked to adverse metabolic and unfavorable cardiovascular outcomes in women. From our perspective, future research in the field of female reproduction should be directed toward doing research into genetic reproductive abnormalities and neuroendocrine diseases, pathophysiology, long-term health outcomes for oligo/amenorrhea, hyperandrogenism, and ovulatory dysfunction. It is additionally expected that a better understanding will be gained of the endocrinology of the placenta and of pregnancy, the role of the microbiome in female reproduction, the role of insulin sensitizers, anti-obesity and anti-diabetic drugs, and various advances in the prevention of ovarian damage caused by various oncology therapies, while new therapeutic options for the treatment of infertility, including kisspeptin, will be developed. More... »

PAGES

497-505

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s42000-018-0073-x

    DOI

    http://dx.doi.org/10.1007/s42000-018-0073-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1109827512

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30421155


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