Iodine intake and chronic autoimmune thyroiditis: a comparative study between coastal and mainland regions in Greece View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12

AUTHORS

Τ. Giassa, I. Mamali, Ε. Gaki, G. Kaltsas, G. Kouraklis, Κ. Β. Markou, T. Karatzas

ABSTRACT

INTRODUCTION: The purpose of this study was to evaluate the relationship between iodine intake and autoimmune thyroiditis in Chios, an island located in the North East Aegean Sea, in comparison to mainland regions in South Western Greece (SWG). MATERIALS AND METHODS: Urine iodine concentration (UIC), thyroid function (serum TSH, thyroid autoantibodies: anti-TPO and anti-Tg), and thyroid U/S were assessed in 200 subjects (150 females and 50 males) from Chios and 322 subjects (255 females and 67 males) from several mainland regions in SWG. All participants were recruited from outpatient clinics and were diagnosed as euthyroid. RESULTS: Median UIC in Chios was significantly higher compared to SWG (136.1 vs. 104.5 μg/L, p < 0.001), indicating that both regions are iodine sufficient according to World Health Organization (WHO) criteria. The prevalence of thyroid autoimmunity was 66.5% in Chios and 27% in SWG, significantly higher in females (46.7%) than in males (26.5%). Furthermore, individuals with increased levels of thyroid autoantibodies either anti-TPO or anti-Tg (TAbs) showed increased median UIC levels compared to those / subjects / patients with normal levels (126.7 vs. 108.95 μg/L, p < 0.001). Serum TSH mean values (mIU/L) were greater in females (mean = 2.1 ± 1.41) compared to males (mean = 1.82 ± 1.26) (p = 0.04) and decreased with age. CONCLUSIONS: In conclusion, in the present study, we clearly indicate that increased thyroid autoimmunity is positively associated with increased iodine intake, as well as with the female gender. Moreover, iodine intake and thyroid autoimmunity appear to be significantly higher in a coastal region (Chios) than in mainland Greece (SWG). Additional environmental factors, apart from iodine, should be investigated in future studies. Mean TSH values were increased in females and decreased with age. The latter is probably due to the presence of autonomous goiter in older Greek populations, as a result of long-term status of iodine deficiency in the past. More... »

PAGES

565-571

References to SciGraph publications

  • 2018-04. In vivo uptake of iodine from a Fucus serratus Linnaeus seaweed bath: does volatile iodine contribute? in ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
  • 2011-10. Cutting Edge: The Etiology of Autoimmune Thyroid Diseases in CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s42000-018-0057-x

    DOI

    http://dx.doi.org/10.1007/s42000-018-0057-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107300450

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30267376


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