Real-world results of direct-acting antivirals use for the treatment of chronic hepatitis C in old patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Mohamed El Kassas, Reem El Sheemy, Mohamed Alboraie, Mohamed El Badry, Mohamed Naguib Wifi, Naglaa Youssef, Sameera Ezzat, Marwa Tahoon, Lobna Abdelsalam, Sara M. Abdelhakam, Zainab Ali-Eldin

ABSTRACT

What are the real-world efficacy and safety of direct-acting antivirals (DAAs) in old chronic HCV population? The overall sustained virological response rate was 98.9%. Higher albumin, higher platelet count, lower bilirubin and lower stage of fibrosis were among predictors of favorable response. Different DAAs regimens were safe and effective in old patients with chronic HCV. Old people with chronic hepatitis C (HCV) were considered a difficult-to-treat category with more frequent adverse events until recently. Interferon-free direct-acting antivirals (DAAs) improved treatment adherence and quality of life of old patients. In this study, we aimed at reporting the real-world efficacy and safety of DAAs, in addition to predictors of sustained virological response (SVR) in old chronic HCV population. This is a prospective observational intention-to-treat analysis that included old chronic hepatitis C genotype-4 patients (> 65 years) treated in a single specialized viral hepatitis treatment center in Egypt. Treatment regimens were allocated according to national guidelines for treatment of hepatitis C. Primary outcome was undetectable HCV-RNA at 12-week post-treatment by PCR. Secondary outcomes were identification of predictors of SVR and assessment of safety related issues. Our study included 864 patients (64% females) with mean age of 67.7 ± 2.8 years. Overall SVR rate was 98.9% while SVR rates for sofosbuvir/daclatasvir/ribavirin, paritaprevir/ombitasvir/ritonavir/ribavirin, sofosbuvir/daclatasvir, sofosbuvir/ledipasvir/ribavirin, sofosbuvir/simeprevir/daclatasvir/ribavirin, sofosbuvir/simeprevir, interferon/sofosbuvir/ribavirin and sofosbuvir/ribavirin were 100%, 100%, 100%, 100%, 100%, 99.3%, 98% and 94.2%, respectively. DAAs were well tolerated. None of the patients discontinued the treatment due to adverse effects. Higher albumin, higher platelet count, lower bilirubin and lower stage of fibrosis were among predictors of favourable response. Different DAAs regimens were safe and effective in old Egyptian patients with chronic HCV. More... »

PAGES

295-302

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s41999-019-00167-3

DOI

http://dx.doi.org/10.1007/s41999-019-00167-3

DIMENSIONS

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31 schema:description What are the real-world efficacy and safety of direct-acting antivirals (DAAs) in old chronic HCV population? The overall sustained virological response rate was 98.9%. Higher albumin, higher platelet count, lower bilirubin and lower stage of fibrosis were among predictors of favorable response. Different DAAs regimens were safe and effective in old patients with chronic HCV. Old people with chronic hepatitis C (HCV) were considered a difficult-to-treat category with more frequent adverse events until recently. Interferon-free direct-acting antivirals (DAAs) improved treatment adherence and quality of life of old patients. In this study, we aimed at reporting the real-world efficacy and safety of DAAs, in addition to predictors of sustained virological response (SVR) in old chronic HCV population. This is a prospective observational intention-to-treat analysis that included old chronic hepatitis C genotype-4 patients (> 65 years) treated in a single specialized viral hepatitis treatment center in Egypt. Treatment regimens were allocated according to national guidelines for treatment of hepatitis C. Primary outcome was undetectable HCV-RNA at 12-week post-treatment by PCR. Secondary outcomes were identification of predictors of SVR and assessment of safety related issues. Our study included 864 patients (64% females) with mean age of 67.7 ± 2.8 years. Overall SVR rate was 98.9% while SVR rates for sofosbuvir/daclatasvir/ribavirin, paritaprevir/ombitasvir/ritonavir/ribavirin, sofosbuvir/daclatasvir, sofosbuvir/ledipasvir/ribavirin, sofosbuvir/simeprevir/daclatasvir/ribavirin, sofosbuvir/simeprevir, interferon/sofosbuvir/ribavirin and sofosbuvir/ribavirin were 100%, 100%, 100%, 100%, 100%, 99.3%, 98% and 94.2%, respectively. DAAs were well tolerated. None of the patients discontinued the treatment due to adverse effects. Higher albumin, higher platelet count, lower bilirubin and lower stage of fibrosis were among predictors of favourable response. Different DAAs regimens were safe and effective in old Egyptian patients with chronic HCV.
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