Stellenwert von Vedolizumab als Erstlinienbiologikum bei chronisch-entzündlichen Darmerkrankungen (CED) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-01-08

AUTHORS

Andreas Blesl, Christoph Högenauer, Robert Koch, Clemens Dejaco, Harald Vogelsang, Josef Stimakovits, Harry Fuchssteiner, Thomas Haas, Wolfgang Petritsch

ABSTRACT

Vedolizumab (Entyvio®) is a gut-selective monoclonal IgG1 antibody approved for the treatment of ulcerative colitis and Crohn’s disease. Compared to TNF-α inhibitors, vedolizumab offers comparable response rates in patients with inflammatory bowel disease. In general, vedolizumab has a more favourable side effect profile for serious adverse events and infections, is likely to have a better safety profile in older age and can be safely used if contraindications for TNF-α inhibitors like a class III and IV congestive heart failure are present. In Austria, reimbursement is currently limited to TNF-α inhibitor failure, intolerance or patients with contraindications for these drugs. Vedolizumab as first-line biologic therapy for ulcerative colitis or Crohn’s disease will currently not be reimbursed in Austria. More... »

PAGES

10-17

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s41971-018-0043-9

DOI

http://dx.doi.org/10.1007/s41971-018-0043-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111268272


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