Lebertransplantation: Indikationen und Abklärung View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-10-24

AUTHORS

Armin Finkenstedt, Maria Effenberger, Heinz Zoller

ABSTRACT

Liver transplantation is indicated in a variety of acute, chronic or oncologic liver diseases if transplantation improves the quality of life and/or the survival of the patients. The decisive factor for the success of liver transplantation is to choose the right time to start the transplant evaluation. In patients with liver cirrhosis, transplant evaluation should start when the MELD (Model for End-Stage Liver Disease) score exceeds 15 or if clinical signs of decompensated liver disease as ascites, sarcopenia or encephalopathy occur. In patients with acute on chronic liver failure, transplant evaluation should start immediately due to a very high short-term mortality. In contrast to patients with acute liver failure, “high urgency” listing is not available for acute on chronic liver failure patients. Hepatocellular carcinoma and other malignant liver diseases can be potentially cured by liver transplantation in selected patients without extrahepatic tumor spread. In all cases, an extensive diagnostic work-up to exclude severe cardiopulmonary and uncontrolled infectious or malignant comorbidities is required for listing for liver transplantation. Once on the waiting list, regular follow-up is necessary to re-evaluate the indication for transplantation, to detect new contraindications and to perform MELD updates required for organ allocation. This review discusses in detail indications for liver transplantation, the evaluation process and the required follow-up examinations once on the waiting list. More... »

PAGES

112-120

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s41971-018-0038-6

DOI

http://dx.doi.org/10.1007/s41971-018-0038-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107818027


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