Normal CSF orexin levels in the patients with hypersomnolence following HPV vaccination View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Aya Imanishi, Takashi Kanbayashi, Yohei Sagawa, Takaki Taniguchi, Akari Usumoto, Kotaro Yuge, Nozomu Kotorii, Tomomi Kinoshita, Toshiaki Hirai, Yuki Omori, Kazuhisa Yoshizawa, Tetsuo Shimizu

ABSTRACT

Public concern has been growing over severe adverse events caused by human papillomavirus (HPV) vaccination. Some patients also exhibited sleep disorders. We investigated their symptoms, clinical examinations and cerebrospinal fluid orexin (hypocretin) levels. The subjects were 6 patients with hypersomnolence after HPV vaccination. Since all of them had normal orexin levels, hypersomnolence was not caused by orexin deficiency. Although each case did not meet the diagnostic criteria of narcolepsy type 2 and idiopathic hypersomnia adequately, one case had frequent multiple SOREMPs and the other had shortened sleep latency. They might be affected with symptoms of hypersomnolence disorders after their vaccination. More... »

PAGES

259-261

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s41105-019-00210-7

DOI

http://dx.doi.org/10.1007/s41105-019-00210-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111390220


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157 schema:name Department of Neuropsychiatry, Kurume University School of Medicine, Kurume, Japan
158 Department of Pediatrics, Kurume University School of Medicine, Kurume, Japan
159 rdf:type schema:Organization
 




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