Inhaler Devices for Delivery of LABA/LAMA Fixed-Dose Combinations in Patients with COPD View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-03-13

AUTHORS

Anthony D’Urzo, Kenneth R. Chapman, James F. Donohue, Peter Kardos, M. Reza Maleki-Yazdi, David Price

ABSTRACT

Inhaled fixed-dose combinations (FDCs) of a long-acting β-agonist (LABA) and a long-acting muscarinic antagonist (LAMA) have become the cornerstone for the maintenance treatment of symptomatic COPD patients. In this regard, global COPD treatment guidelines have recognized the importance of inhaler devices as integral contributors to the effectiveness of LABA/LAMA FDCs and recommend regular assessment of inhaler device use by the patients in order to improve long-term clinical outcomes. Optimal disease control is also highly dependent upon patient preferences and adherence to inhaler devices. This review objectively examines and compares the major inhaler devices used to deliver different LABA/LAMA FDCs, discusses the inhaler device characteristics that determine drug deposition in the airways, real-life preference for inhaler devices, and handling of inhaler devices that impact the results of the long-term management of COPD. The introduction of new LABA/LAMA FDCs, new inhaler devices, and more clinical studies have created confusion among physicians in choosing the optimal inhaled therapy for COPD patients; in this context, this review attempts to provide an evidence-based framework for informed decision-making with a particular focus on the inhaler devices.Funding. The preparation of this manuscript was funded by Novartis Pharma AG. More... »

PAGES

23-41

References to SciGraph publications

  • 2009-11-28. Inhaler choice and inhalation technique: key factors for asthma control in NPJ PRIMARY CARE RESPIRATORY MEDICINE
  • 2015-04-30. Preference, satisfaction and critical errors with Genuair and Breezhaler inhalers in patients with COPD: a randomised, cross-over, multicentre study in NPJ PRIMARY CARE RESPIRATORY MEDICINE
  • 2012-01-05. Beyond lung function in COPD management: effectiveness of LABA/LAMA combination therapy on patient-centred outcomes in NPJ PRIMARY CARE RESPIRATORY MEDICINE
  • 2013-12-20. Advances in Metered Dose Inhaler Technology: Hardware Development in AAPS PHARMSCITECH
  • 2018-06-14. Comparison of peak inspiratory flow rate via the Breezhaler®, Ellipta® and HandiHaler® dry powder inhalers in patients with moderate to very severe COPD: a randomized cross-over trial in BMC PULMONARY MEDICINE
  • 2016-11-24. A randomised open-label cross-over study of inhaler errors, preference and time to achieve correct inhaler use in patients with COPD or asthma: comparison of ELLIPTA with other inhaler devices in NPJ PRIMARY CARE RESPIRATORY MEDICINE
  • 2017-06-27. Improving the Efficiency of Respiratory Drug Delivery: A Review of Current Treatment Trends and Future Strategies for Asthma and Chronic Obstructive Pulmonary Disease in PULMONARY THERAPY
  • 2017-04-13. Effectiveness and success factors of educational inhaler technique interventions in asthma & COPD patients: a systematic review in NPJ PRIMARY CARE RESPIRATORY MEDICINE
  • 2013-10-16. The History and Performance of the Breezhaler Device in INDACATEROL
  • 2018-01-16. Critical inhaler errors in asthma and COPD: a systematic review of impact on health outcomes in RESPIRATORY RESEARCH
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    URI

    http://scigraph.springernature.com/pub.10.1007/s41030-019-0090-1

    DOI

    http://dx.doi.org/10.1007/s41030-019-0090-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112764916

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32026426


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