In Vitro Study of the Effect of Breathing Pattern on Aerosol Delivery During High-Flow Nasal Therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-02-06

AUTHORS

Gavin Bennett, Mary Joyce, Louise Sweeney, Ronan MacLoughlin

ABSTRACT

INTRODUCTION: The use of concurrent aerosol delivery during high-flow nasal therapy (HFNT) may be exploited to facilitate delivery of a variety of prescribed medications for inhalation. The study assessed the effect of tidal volume, breath rate, and inspiratory:expiratory (I:E) ratio on the quantity of aerosol captured at the level of the trachea during simulated HFNT. METHODS: Testing was completed according to a factorial statistical design of experiments (DOE) approach. Tracheal dose was characterized with a vibrating mesh nebulizer (Aerogen Solo, Aerogen Ltd) using simulated adult, small child, and infant HFNT models. Furthermore, aerosol delivery was evaluated across a range of adult patient profiles with clinically representative test setups. RESULTS: Aerosol delivery increased with a large tidal volume, a rapid breath rate, and a long inspiratory time. Tidal volume, breath rate, and I:E ratio each had a significant effect on tracheal dose across simulated adult, small child, and infant breathing. CONCLUSION: The main trends that were identified in the statistical DOE predicted aerosol delivery across adult patient breathing profiles, in terms of tidal volume, breath rate, and I:E ratio. Therefore, patients with distressed breathing profiles may be expected to receive a larger aerosol dose than those with normal breathing rates. FUNDING: Aerogen Limited. More... »

PAGES

43-54

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s41030-019-0086-x

DOI

http://dx.doi.org/10.1007/s41030-019-0086-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111949847

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32026423


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Aerogen Limited, IDA Business Park, Dangan, Galway, Ireland", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Aerogen Limited, IDA Business Park, Dangan, Galway, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bennett", 
        "givenName": "Gavin", 
        "id": "sg:person.013433031026.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013433031026.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aerogen Limited, IDA Business Park, Dangan, Galway, Ireland", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Aerogen Limited, IDA Business Park, Dangan, Galway, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Joyce", 
        "givenName": "Mary", 
        "id": "sg:person.014230411426.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014230411426.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aerogen Limited, IDA Business Park, Dangan, Galway, Ireland", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Aerogen Limited, IDA Business Park, Dangan, Galway, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sweeney", 
        "givenName": "Louise", 
        "id": "sg:person.010270510570.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010270510570.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aerogen Limited, IDA Business Park, Dangan, Galway, Ireland", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Aerogen Limited, IDA Business Park, Dangan, Galway, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "MacLoughlin", 
        "givenName": "Ronan", 
        "id": "sg:person.01352307607.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352307607.81"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/jp.2013.120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010374373", 
          "https://doi.org/10.1038/jp.2013.120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-004-2255-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009781146", 
          "https://doi.org/10.1007/s00134-004-2255-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-010-1753-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009265274", 
          "https://doi.org/10.1007/s00134-010-1753-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s41030-018-0054-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103474270", 
          "https://doi.org/10.1007/s41030-018-0054-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc12890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011944601", 
          "https://doi.org/10.1186/cc12890"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02-06", 
    "datePublishedReg": "2019-02-06", 
    "description": "INTRODUCTION: The use of concurrent aerosol delivery during high-flow nasal therapy (HFNT) may be exploited to facilitate delivery of a variety of prescribed medications for inhalation. The study assessed the effect of tidal volume, breath rate, and inspiratory:expiratory (I:E) ratio on the quantity of aerosol captured at the level of the trachea during simulated HFNT.\nMETHODS: Testing was completed according to a factorial statistical design of experiments (DOE) approach. Tracheal dose was characterized with a vibrating mesh nebulizer (Aerogen Solo, Aerogen Ltd) using simulated adult, small child, and infant HFNT models. Furthermore, aerosol delivery was evaluated across a range of adult patient profiles with clinically representative test setups.\nRESULTS: Aerosol delivery increased with a large tidal volume, a rapid breath rate, and a long inspiratory time. Tidal volume, breath rate, and I:E ratio each had a significant effect on tracheal dose across simulated adult, small child, and infant breathing.\nCONCLUSION: The main trends that were identified in the statistical DOE predicted aerosol delivery across adult patient breathing profiles, in terms of tidal volume, breath rate, and I:E ratio. Therefore, patients with distressed breathing profiles may be expected to receive a larger aerosol dose than those with normal breathing rates.\nFUNDING: Aerogen Limited.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s41030-019-0086-x", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1136859", 
        "issn": [
          "2364-1754", 
          "2364-1746"
        ], 
        "name": "Pulmonary Therapy", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "keywords": [
      "high-flow nasal therapy", 
      "tidal volume", 
      "nasal therapy", 
      "aerosol delivery", 
      "small children", 
      "long inspiratory time", 
      "large tidal volumes", 
      "breathing profiles", 
      "breath rate", 
      "normal breathing rates", 
      "aerosol dose", 
      "inspiratory time", 
      "expiratory ratio", 
      "patient profiles", 
      "breathing pattern", 
      "mesh nebulizer", 
      "infant breathing", 
      "dose", 
      "breathing rate", 
      "therapy", 
      "vitro study", 
      "quantity of aerosol", 
      "delivery", 
      "adults", 
      "children", 
      "medications", 
      "patients", 
      "inhalation", 
      "trachea", 
      "breathing", 
      "significant effect", 
      "rate", 
      "volume", 
      "effect", 
      "study", 
      "profile", 
      "nebulizer", 
      "ratio", 
      "levels", 
      "testing", 
      "use", 
      "patterns", 
      "factorial statistical design", 
      "time", 
      "trends", 
      "DOE", 
      "variety", 
      "aerosols", 
      "model", 
      "approach", 
      "range", 
      "terms", 
      "design", 
      "statistical design", 
      "quantity", 
      "Limited", 
      "statistical DOE", 
      "setup", 
      "experiment approach", 
      "main trends", 
      "test setup", 
      "concurrent aerosol delivery", 
      "simulated HFNT", 
      "Tracheal dose", 
      "infant HFNT models", 
      "HFNT models", 
      "adult patient profiles", 
      "representative test setups", 
      "rapid breath rate", 
      "adult patient breathing profiles", 
      "patient breathing profiles", 
      "distressed breathing profiles", 
      "larger aerosol dose", 
      "Aerogen Limited"
    ], 
    "name": "In Vitro Study of the Effect of Breathing Pattern on Aerosol Delivery During High-Flow Nasal Therapy", 
    "pagination": "43-54", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111949847"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s41030-019-0086-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "32026423"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s41030-019-0086-x", 
      "https://app.dimensions.ai/details/publication/pub.1111949847"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_796.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s41030-019-0086-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s41030-019-0086-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s41030-019-0086-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s41030-019-0086-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s41030-019-0086-x'


 

This table displays all metadata directly associated to this object as RDF triples.

177 TRIPLES      22 PREDICATES      105 URIs      92 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s41030-019-0086-x schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author Nef5a843894504924b27dcf99237c72d5
4 schema:citation sg:pub.10.1007/s00134-004-2255-z
5 sg:pub.10.1007/s00134-010-1753-4
6 sg:pub.10.1007/s41030-018-0054-x
7 sg:pub.10.1038/jp.2013.120
8 sg:pub.10.1186/cc12890
9 schema:datePublished 2019-02-06
10 schema:datePublishedReg 2019-02-06
11 schema:description INTRODUCTION: The use of concurrent aerosol delivery during high-flow nasal therapy (HFNT) may be exploited to facilitate delivery of a variety of prescribed medications for inhalation. The study assessed the effect of tidal volume, breath rate, and inspiratory:expiratory (I:E) ratio on the quantity of aerosol captured at the level of the trachea during simulated HFNT. METHODS: Testing was completed according to a factorial statistical design of experiments (DOE) approach. Tracheal dose was characterized with a vibrating mesh nebulizer (Aerogen Solo, Aerogen Ltd) using simulated adult, small child, and infant HFNT models. Furthermore, aerosol delivery was evaluated across a range of adult patient profiles with clinically representative test setups. RESULTS: Aerosol delivery increased with a large tidal volume, a rapid breath rate, and a long inspiratory time. Tidal volume, breath rate, and I:E ratio each had a significant effect on tracheal dose across simulated adult, small child, and infant breathing. CONCLUSION: The main trends that were identified in the statistical DOE predicted aerosol delivery across adult patient breathing profiles, in terms of tidal volume, breath rate, and I:E ratio. Therefore, patients with distressed breathing profiles may be expected to receive a larger aerosol dose than those with normal breathing rates. FUNDING: Aerogen Limited.
12 schema:genre article
13 schema:inLanguage en
14 schema:isAccessibleForFree true
15 schema:isPartOf N153486df71b345f198c3f130a8d94628
16 Nbe9b023e234341a69ced92cd3209a46a
17 sg:journal.1136859
18 schema:keywords Aerogen Limited
19 DOE
20 HFNT models
21 Limited
22 Tracheal dose
23 adult patient breathing profiles
24 adult patient profiles
25 adults
26 aerosol delivery
27 aerosol dose
28 aerosols
29 approach
30 breath rate
31 breathing
32 breathing pattern
33 breathing profiles
34 breathing rate
35 children
36 concurrent aerosol delivery
37 delivery
38 design
39 distressed breathing profiles
40 dose
41 effect
42 experiment approach
43 expiratory ratio
44 factorial statistical design
45 high-flow nasal therapy
46 infant HFNT models
47 infant breathing
48 inhalation
49 inspiratory time
50 large tidal volumes
51 larger aerosol dose
52 levels
53 long inspiratory time
54 main trends
55 medications
56 mesh nebulizer
57 model
58 nasal therapy
59 nebulizer
60 normal breathing rates
61 patient breathing profiles
62 patient profiles
63 patients
64 patterns
65 profile
66 quantity
67 quantity of aerosol
68 range
69 rapid breath rate
70 rate
71 ratio
72 representative test setups
73 setup
74 significant effect
75 simulated HFNT
76 small children
77 statistical DOE
78 statistical design
79 study
80 terms
81 test setup
82 testing
83 therapy
84 tidal volume
85 time
86 trachea
87 trends
88 use
89 variety
90 vitro study
91 volume
92 schema:name In Vitro Study of the Effect of Breathing Pattern on Aerosol Delivery During High-Flow Nasal Therapy
93 schema:pagination 43-54
94 schema:productId N04146951443c4cbaad4eb329b644b4ed
95 N142d3b970723485494186f5654ade4b3
96 N235707ca12c34e1282f3cb87c63c66fe
97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111949847
98 https://doi.org/10.1007/s41030-019-0086-x
99 schema:sdDatePublished 2021-12-01T19:44
100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
101 schema:sdPublisher N2684d3d0273142a9a61e9692cccb12e3
102 schema:url https://doi.org/10.1007/s41030-019-0086-x
103 sgo:license sg:explorer/license/
104 sgo:sdDataset articles
105 rdf:type schema:ScholarlyArticle
106 N04146951443c4cbaad4eb329b644b4ed schema:name dimensions_id
107 schema:value pub.1111949847
108 rdf:type schema:PropertyValue
109 N142d3b970723485494186f5654ade4b3 schema:name pubmed_id
110 schema:value 32026423
111 rdf:type schema:PropertyValue
112 N153486df71b345f198c3f130a8d94628 schema:volumeNumber 5
113 rdf:type schema:PublicationVolume
114 N235707ca12c34e1282f3cb87c63c66fe schema:name doi
115 schema:value 10.1007/s41030-019-0086-x
116 rdf:type schema:PropertyValue
117 N2684d3d0273142a9a61e9692cccb12e3 schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 N2a1ab543cfe3402bb36032f742539277 rdf:first sg:person.014230411426.92
120 rdf:rest N44221968c66445a5b8ad19d3c39f5134
121 N44221968c66445a5b8ad19d3c39f5134 rdf:first sg:person.010270510570.53
122 rdf:rest Neaef60ccb7e74612b3a8f41449278c06
123 Nbe9b023e234341a69ced92cd3209a46a schema:issueNumber 1
124 rdf:type schema:PublicationIssue
125 Neaef60ccb7e74612b3a8f41449278c06 rdf:first sg:person.01352307607.81
126 rdf:rest rdf:nil
127 Nef5a843894504924b27dcf99237c72d5 rdf:first sg:person.013433031026.29
128 rdf:rest N2a1ab543cfe3402bb36032f742539277
129 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
130 schema:name Medical and Health Sciences
131 rdf:type schema:DefinedTerm
132 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
133 schema:name Cardiorespiratory Medicine and Haematology
134 rdf:type schema:DefinedTerm
135 sg:journal.1136859 schema:issn 2364-1746
136 2364-1754
137 schema:name Pulmonary Therapy
138 schema:publisher Springer Nature
139 rdf:type schema:Periodical
140 sg:person.010270510570.53 schema:affiliation grid-institutes:None
141 schema:familyName Sweeney
142 schema:givenName Louise
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010270510570.53
144 rdf:type schema:Person
145 sg:person.013433031026.29 schema:affiliation grid-institutes:None
146 schema:familyName Bennett
147 schema:givenName Gavin
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013433031026.29
149 rdf:type schema:Person
150 sg:person.01352307607.81 schema:affiliation grid-institutes:None
151 schema:familyName MacLoughlin
152 schema:givenName Ronan
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352307607.81
154 rdf:type schema:Person
155 sg:person.014230411426.92 schema:affiliation grid-institutes:None
156 schema:familyName Joyce
157 schema:givenName Mary
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014230411426.92
159 rdf:type schema:Person
160 sg:pub.10.1007/s00134-004-2255-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1009781146
161 https://doi.org/10.1007/s00134-004-2255-z
162 rdf:type schema:CreativeWork
163 sg:pub.10.1007/s00134-010-1753-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009265274
164 https://doi.org/10.1007/s00134-010-1753-4
165 rdf:type schema:CreativeWork
166 sg:pub.10.1007/s41030-018-0054-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1103474270
167 https://doi.org/10.1007/s41030-018-0054-x
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/jp.2013.120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010374373
170 https://doi.org/10.1038/jp.2013.120
171 rdf:type schema:CreativeWork
172 sg:pub.10.1186/cc12890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011944601
173 https://doi.org/10.1186/cc12890
174 rdf:type schema:CreativeWork
175 grid-institutes:None schema:alternateName Aerogen Limited, IDA Business Park, Dangan, Galway, Ireland
176 schema:name Aerogen Limited, IDA Business Park, Dangan, Galway, Ireland
177 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...