Bone Regeneration by Homeopathic Symphytum officinale View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-10-19

AUTHORS

Shahla Vaezi, Hamideh Moalemzadeh Haghighi, Sara Amel Farzad, Sepideh Arabzadeh, Fatemeh Kalalinia

ABSTRACT

PurposeCell therapy has been proposed as an effective treatment method for bone regeneration using stem cells and osteogenic inducting mediators. In the present study, the ability of homeopathic remedy Symphytum officinale to induce osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rat BM-MSCs) was studiedMethodsMSCs were isolated from the rat’s bone morrow. Cytotoxic effect of Symphytum on the MSCs was evaluated by MTT assay. The osteogenic induction ability of Symphytum has been assessed by alizarin red staining (ALZ) and quantitative alkaline phosphatase (ALP) activity assays and compared with the osteogenic standard medium.ResultsMTT assay results illustrated that Symphytum 200 C had a high cytotoxicity (to about 75.2 ± 3.12), so that lower potencies were used for the next experiments. Symphytum 6 C had the most color intensity in ALZ and ALP staining assays. Also, quantitative analyses of ALP activity revealed that Symphytum 6 C caused the most increase in the ALP activity up to 4.04 ± 0.34 and 7.86 ± 1.38 on day 7 and 21, respectively.ConclusionsAccording to this finding, Symphytum could enhance osteogenic differentiation of MSCs and can be considered as a safe, low cost, and highly effective drug for bone regeneration.Lay SummaryCell therapy has been proposed as an effective treatment method for bone regeneration using stem cells and osteogenic inducting mediators. In the present study, the ability of homeopathic remedy Symphytum officinale to induce osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rat BM-MSCs) was studied. The results illustrated that Symphytum 6 C had the most osteogenic induction effect compare with osteogenic standard medium. According to this finding, Symphytum officinale as a natural compound can significantly induce osteogenic differentiation of rat BM-MSCs. So, it could be considered as a safe and more cost-effective therapeutic agent for clinical treatment of bone disorders.Graphical Abstract More... »

PAGES

548-555

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40883-020-00181-z

DOI

http://dx.doi.org/10.1007/s40883-020-00181-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1131891006


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1004", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Biotechnology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biology, Faculty of Basic Science, Islamic Azad University, Damghan Branch, Damghan, Iran", 
          "id": "http://www.grid.ac/institutes/grid.508789.b", 
          "name": [
            "Department of Biology, Faculty of Basic Science, Islamic Azad University, Damghan Branch, Damghan, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vaezi", 
        "givenName": "Shahla", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran", 
          "id": "http://www.grid.ac/institutes/grid.411583.a", 
          "name": [
            "Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haghighi", 
        "givenName": "Hamideh Moalemzadeh", 
        "id": "sg:person.07456701023.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07456701023.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran", 
          "id": "http://www.grid.ac/institutes/grid.411583.a", 
          "name": [
            "Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Farzad", 
        "givenName": "Sara Amel", 
        "id": "sg:person.01105023447.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105023447.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran, P. O. Box 91775-1365, Mashhad, Iran", 
          "id": "http://www.grid.ac/institutes/grid.411583.a", 
          "name": [
            "Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran, P. O. Box 91775-1365, Mashhad, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arabzadeh", 
        "givenName": "Sepideh", 
        "id": "sg:person.0646034670.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646034670.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran, P. O. Box 91775-1365, Mashhad, Iran", 
          "id": "http://www.grid.ac/institutes/grid.411583.a", 
          "name": [
            "Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran, P. O. Box 91775-1365, Mashhad, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kalalinia", 
        "givenName": "Fatemeh", 
        "id": "sg:person.01354672317.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354672317.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10561-017-9652-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091220758", 
          "https://doi.org/10.1007/s10561-017-9652-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar2116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032169750", 
          "https://doi.org/10.1186/ar2116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02850297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026822138", 
          "https://doi.org/10.1007/bf02850297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10354-007-0474-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027631128", 
          "https://doi.org/10.1007/s10354-007-0474-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1026048907739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008454319", 
          "https://doi.org/10.1023/a:1026048907739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00870", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040325841", 
          "https://doi.org/10.1038/nature00870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1749-799x-5-37", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042007506", 
          "https://doi.org/10.1186/1749-799x-5-37"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00225804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004864562", 
          "https://doi.org/10.1007/bf00225804"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-10-19", 
    "datePublishedReg": "2020-10-19", 
    "description": "PurposeCell therapy has been proposed as an effective treatment method for bone regeneration using stem cells and osteogenic inducting mediators. In the present study, the ability of homeopathic remedy Symphytum officinale to induce osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rat BM-MSCs) was studiedMethodsMSCs were isolated from the rat\u2019s bone morrow. Cytotoxic effect of Symphytum on the MSCs was evaluated by MTT assay. The osteogenic induction ability of Symphytum has been assessed by alizarin red staining (ALZ) and quantitative alkaline phosphatase (ALP) activity assays and compared with the osteogenic standard medium.ResultsMTT assay results illustrated that Symphytum 200 C had a high cytotoxicity (to about 75.2\u2009\u00b1\u20093.12), so that lower potencies were used for the next experiments. Symphytum 6 C had the most color intensity in ALZ and ALP staining assays. Also, quantitative analyses of ALP activity revealed that Symphytum 6 C caused the most increase in the ALP activity up to 4.04\u2009\u00b1\u20090.34 and 7.86\u2009\u00b1\u20091.38 on day 7 and 21, respectively.ConclusionsAccording to this finding, Symphytum could enhance osteogenic differentiation of MSCs and can be considered as a safe, low cost, and highly effective drug for bone regeneration.Lay SummaryCell therapy has been proposed as an effective treatment method for bone regeneration using stem cells and osteogenic inducting mediators. In the present study, the ability of homeopathic remedy Symphytum officinale to induce osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rat BM-MSCs) was studied. The results illustrated that Symphytum 6 C had the most osteogenic induction effect compare with osteogenic standard medium. According to this finding, Symphytum officinale as a natural compound can significantly induce osteogenic differentiation of rat BM-MSCs. So, it could be considered as a safe and more cost-effective therapeutic agent for clinical treatment of bone disorders.Graphical Abstract", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s40883-020-00181-z", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1052574", 
        "issn": [
          "2364-4133", 
          "2364-4141"
        ], 
        "name": "Regenerative Engineering and Translational Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "keywords": [
      "bone marrow-derived mesenchymal stem cells", 
      "marrow-derived mesenchymal stem cells", 
      "effective treatment method", 
      "bone morrow", 
      "alizarin red staining", 
      "mesenchymal stem cells", 
      "rat bone marrow-derived mesenchymal stem cells", 
      "stem cells", 
      "rat BM-MSCs", 
      "treatment methods", 
      "osteogenic differentiation", 
      "bone regeneration", 
      "present study", 
      "bone disorders", 
      "BM-MSCs", 
      "effective drugs", 
      "day 7", 
      "ALP activity", 
      "clinical treatment", 
      "therapeutic agents", 
      "lower potency", 
      "cytotoxic effects", 
      "MTT assay", 
      "osteogenic induction ability", 
      "red staining", 
      "staining assays", 
      "therapy", 
      "osteogenic induction effect", 
      "Symphytum officinale", 
      "alkaline phosphatase (ALP) activity assay", 
      "natural compounds", 
      "higher cytotoxicity", 
      "standard medium", 
      "cells", 
      "mediators", 
      "assays", 
      "differentiation", 
      "activity assays", 
      "ResultsMTT", 
      "phosphatase activity assays", 
      "findings", 
      "MSCs", 
      "officinale", 
      "drugs", 
      "disorders", 
      "regeneration", 
      "staining", 
      "induction ability", 
      "treatment", 
      "next experiment", 
      "activity", 
      "potency", 
      "study", 
      "induction effect", 
      "cytotoxicity", 
      "most increase", 
      "effect", 
      "ability", 
      "agents", 
      "Symphytum", 
      "quantitative analysis", 
      "increase", 
      "results", 
      "method", 
      "analysis", 
      "medium", 
      "compounds", 
      "color intensity", 
      "intensity", 
      "cost", 
      "low cost", 
      "Morrow", 
      "experiments"
    ], 
    "name": "Bone Regeneration by Homeopathic Symphytum officinale", 
    "pagination": "548-555", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1131891006"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s40883-020-00181-z"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s40883-020-00181-z", 
      "https://app.dimensions.ai/details/publication/pub.1131891006"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_839.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s40883-020-00181-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40883-020-00181-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40883-020-00181-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40883-020-00181-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40883-020-00181-z'


 

This table displays all metadata directly associated to this object as RDF triples.

205 TRIPLES      22 PREDICATES      108 URIs      90 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s40883-020-00181-z schema:about anzsrc-for:10
2 anzsrc-for:1004
3 anzsrc-for:11
4 anzsrc-for:1103
5 schema:author N3f9a0928eb6146be8057eee91c49b3e4
6 schema:citation sg:pub.10.1007/bf00225804
7 sg:pub.10.1007/bf02850297
8 sg:pub.10.1007/s10354-007-0474-y
9 sg:pub.10.1007/s10561-017-9652-3
10 sg:pub.10.1023/a:1026048907739
11 sg:pub.10.1038/nature00870
12 sg:pub.10.1186/1749-799x-5-37
13 sg:pub.10.1186/ar2116
14 schema:datePublished 2020-10-19
15 schema:datePublishedReg 2020-10-19
16 schema:description PurposeCell therapy has been proposed as an effective treatment method for bone regeneration using stem cells and osteogenic inducting mediators. In the present study, the ability of homeopathic remedy Symphytum officinale to induce osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rat BM-MSCs) was studiedMethodsMSCs were isolated from the rat’s bone morrow. Cytotoxic effect of Symphytum on the MSCs was evaluated by MTT assay. The osteogenic induction ability of Symphytum has been assessed by alizarin red staining (ALZ) and quantitative alkaline phosphatase (ALP) activity assays and compared with the osteogenic standard medium.ResultsMTT assay results illustrated that Symphytum 200 C had a high cytotoxicity (to about 75.2 ± 3.12), so that lower potencies were used for the next experiments. Symphytum 6 C had the most color intensity in ALZ and ALP staining assays. Also, quantitative analyses of ALP activity revealed that Symphytum 6 C caused the most increase in the ALP activity up to 4.04 ± 0.34 and 7.86 ± 1.38 on day 7 and 21, respectively.ConclusionsAccording to this finding, Symphytum could enhance osteogenic differentiation of MSCs and can be considered as a safe, low cost, and highly effective drug for bone regeneration.Lay SummaryCell therapy has been proposed as an effective treatment method for bone regeneration using stem cells and osteogenic inducting mediators. In the present study, the ability of homeopathic remedy Symphytum officinale to induce osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rat BM-MSCs) was studied. The results illustrated that Symphytum 6 C had the most osteogenic induction effect compare with osteogenic standard medium. According to this finding, Symphytum officinale as a natural compound can significantly induce osteogenic differentiation of rat BM-MSCs. So, it could be considered as a safe and more cost-effective therapeutic agent for clinical treatment of bone disorders.Graphical Abstract
17 schema:genre article
18 schema:inLanguage en
19 schema:isAccessibleForFree false
20 schema:isPartOf N3a30017dcf174bd3ba4e04f9684dfe17
21 Ne6f2516b57734823af842385cc584df6
22 sg:journal.1052574
23 schema:keywords ALP activity
24 BM-MSCs
25 MSCs
26 MTT assay
27 Morrow
28 ResultsMTT
29 Symphytum
30 Symphytum officinale
31 ability
32 activity
33 activity assays
34 agents
35 alizarin red staining
36 alkaline phosphatase (ALP) activity assay
37 analysis
38 assays
39 bone disorders
40 bone marrow-derived mesenchymal stem cells
41 bone morrow
42 bone regeneration
43 cells
44 clinical treatment
45 color intensity
46 compounds
47 cost
48 cytotoxic effects
49 cytotoxicity
50 day 7
51 differentiation
52 disorders
53 drugs
54 effect
55 effective drugs
56 effective treatment method
57 experiments
58 findings
59 higher cytotoxicity
60 increase
61 induction ability
62 induction effect
63 intensity
64 low cost
65 lower potency
66 marrow-derived mesenchymal stem cells
67 mediators
68 medium
69 mesenchymal stem cells
70 method
71 most increase
72 natural compounds
73 next experiment
74 officinale
75 osteogenic differentiation
76 osteogenic induction ability
77 osteogenic induction effect
78 phosphatase activity assays
79 potency
80 present study
81 quantitative analysis
82 rat BM-MSCs
83 rat bone marrow-derived mesenchymal stem cells
84 red staining
85 regeneration
86 results
87 staining
88 staining assays
89 standard medium
90 stem cells
91 study
92 therapeutic agents
93 therapy
94 treatment
95 treatment methods
96 schema:name Bone Regeneration by Homeopathic Symphytum officinale
97 schema:pagination 548-555
98 schema:productId N0421903e276a47fb8570df9572b9efa7
99 Nffafa21a26f84d51908a3e909a093f1f
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1131891006
101 https://doi.org/10.1007/s40883-020-00181-z
102 schema:sdDatePublished 2022-05-20T07:37
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher N5bb75b81d677494cbb477722cea93ec7
105 schema:url https://doi.org/10.1007/s40883-020-00181-z
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N0421903e276a47fb8570df9572b9efa7 schema:name doi
110 schema:value 10.1007/s40883-020-00181-z
111 rdf:type schema:PropertyValue
112 N29944bbd296740ecbe10905b17021a12 rdf:first sg:person.0646034670.44
113 rdf:rest N36b9d2fff2254e64928753b88a94b0b1
114 N36b9d2fff2254e64928753b88a94b0b1 rdf:first sg:person.01354672317.51
115 rdf:rest rdf:nil
116 N3a30017dcf174bd3ba4e04f9684dfe17 schema:issueNumber 4
117 rdf:type schema:PublicationIssue
118 N3f9a0928eb6146be8057eee91c49b3e4 rdf:first N5e809299a3c84acaba8a7a7b89c8dd27
119 rdf:rest Ncdb7938426bc4c93a479c024304b3431
120 N5bb75b81d677494cbb477722cea93ec7 schema:name Springer Nature - SN SciGraph project
121 rdf:type schema:Organization
122 N5e809299a3c84acaba8a7a7b89c8dd27 schema:affiliation grid-institutes:grid.508789.b
123 schema:familyName Vaezi
124 schema:givenName Shahla
125 rdf:type schema:Person
126 Ncdb7938426bc4c93a479c024304b3431 rdf:first sg:person.07456701023.31
127 rdf:rest Nfef7fc1448744a42996f964412535039
128 Ne6f2516b57734823af842385cc584df6 schema:volumeNumber 7
129 rdf:type schema:PublicationVolume
130 Nfef7fc1448744a42996f964412535039 rdf:first sg:person.01105023447.30
131 rdf:rest N29944bbd296740ecbe10905b17021a12
132 Nffafa21a26f84d51908a3e909a093f1f schema:name dimensions_id
133 schema:value pub.1131891006
134 rdf:type schema:PropertyValue
135 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
136 schema:name Technology
137 rdf:type schema:DefinedTerm
138 anzsrc-for:1004 schema:inDefinedTermSet anzsrc-for:
139 schema:name Medical Biotechnology
140 rdf:type schema:DefinedTerm
141 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
142 schema:name Medical and Health Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
145 schema:name Clinical Sciences
146 rdf:type schema:DefinedTerm
147 sg:journal.1052574 schema:issn 2364-4133
148 2364-4141
149 schema:name Regenerative Engineering and Translational Medicine
150 schema:publisher Springer Nature
151 rdf:type schema:Periodical
152 sg:person.01105023447.30 schema:affiliation grid-institutes:grid.411583.a
153 schema:familyName Farzad
154 schema:givenName Sara Amel
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105023447.30
156 rdf:type schema:Person
157 sg:person.01354672317.51 schema:affiliation grid-institutes:grid.411583.a
158 schema:familyName Kalalinia
159 schema:givenName Fatemeh
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354672317.51
161 rdf:type schema:Person
162 sg:person.0646034670.44 schema:affiliation grid-institutes:grid.411583.a
163 schema:familyName Arabzadeh
164 schema:givenName Sepideh
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646034670.44
166 rdf:type schema:Person
167 sg:person.07456701023.31 schema:affiliation grid-institutes:grid.411583.a
168 schema:familyName Haghighi
169 schema:givenName Hamideh Moalemzadeh
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07456701023.31
171 rdf:type schema:Person
172 sg:pub.10.1007/bf00225804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004864562
173 https://doi.org/10.1007/bf00225804
174 rdf:type schema:CreativeWork
175 sg:pub.10.1007/bf02850297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026822138
176 https://doi.org/10.1007/bf02850297
177 rdf:type schema:CreativeWork
178 sg:pub.10.1007/s10354-007-0474-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1027631128
179 https://doi.org/10.1007/s10354-007-0474-y
180 rdf:type schema:CreativeWork
181 sg:pub.10.1007/s10561-017-9652-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091220758
182 https://doi.org/10.1007/s10561-017-9652-3
183 rdf:type schema:CreativeWork
184 sg:pub.10.1023/a:1026048907739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008454319
185 https://doi.org/10.1023/a:1026048907739
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/nature00870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040325841
188 https://doi.org/10.1038/nature00870
189 rdf:type schema:CreativeWork
190 sg:pub.10.1186/1749-799x-5-37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042007506
191 https://doi.org/10.1186/1749-799x-5-37
192 rdf:type schema:CreativeWork
193 sg:pub.10.1186/ar2116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032169750
194 https://doi.org/10.1186/ar2116
195 rdf:type schema:CreativeWork
196 grid-institutes:grid.411583.a schema:alternateName Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran, P. O. Box 91775-1365, Mashhad, Iran
197 Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran
198 Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
199 schema:name Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran, P. O. Box 91775-1365, Mashhad, Iran
200 Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran
201 Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
202 rdf:type schema:Organization
203 grid-institutes:grid.508789.b schema:alternateName Department of Biology, Faculty of Basic Science, Islamic Azad University, Damghan Branch, Damghan, Iran
204 schema:name Department of Biology, Faculty of Basic Science, Islamic Azad University, Damghan Branch, Damghan, Iran
205 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...