Stiffness heterogeneity-induced double-edged sword behaviors of carcinoma-associated fibroblasts in antitumor therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-06

AUTHORS

Jiantao Feng, Shivani Sharma, Elizabeth Rao, Xiang Li, Qiang Zhang, Fulong Liao, Jie He, Dong Han, Jianyu Rao

ABSTRACT

Carcinoma-associated fibroblasts (CAFs) function as a double-edged sword in tumor progression. However, factors affecting the transition between tumor promotion and inhibition remain to be investigated. Here, we found that the transition was determined by stiffness heterogeneity of the tumor stroma in which tumor cells and CAFs were grown. When tumor cells were grown on a rigid plastic substrate, supernatants from CAFs inhibited the cytotoxic effects of 5-fluorouracil. In contrast, when tumor cells were grown on a soft substrate (5.3 kPa), supernatants from CAFs grown on a soft substrate increased the cytotoxicity of 5-fluorouracil. The diverse effects of CAFs were mediated by mechanotransduction factors, including stroma stiffness-induced cytokine expression in CAFs and signal transduction associated with stress fiber formation of CAFs. Moreover, we found that the cytokine expression in CAFs was regulated by nuclear Yes-associated protein, which changed according to cell stiffness, as characterized by atomic force microscopy. Overall, these findings suggested that modulating the mechanotransduction of the stroma together with CAFs might be important for increasing the efficacy of chemotherapy. More... »

PAGES

873-884

References to SciGraph publications

  • 2018-05. Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration in ANNALS OF BIOMEDICAL ENGINEERING
  • 2016-09. The biology and function of fibroblasts in cancer in NATURE REVIEWS CANCER
  • 2009-01. A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer in NATURE MEDICINE
  • 2014-12. The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance in CANCER CELL INTERNATIONAL
  • 2017-12. T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity in NATURE COMMUNICATIONS
  • 2015-05. Tuning the growth of metal-organic framework nanocrystals by using polyoxometalates as coordination modulators in SCIENCE CHINA MATERIALS
  • 2013-11. Microenvironmental regulation of tumor progression and metastasis in NATURE MEDICINE
  • 2017-07-14. Microenvironmental regulation of tumour angiogenesis in NATURE REVIEWS CANCER
  • 2013-10. Cancer drug resistance: an evolving paradigm in NATURE REVIEWS CANCER
  • 2018-04. Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects in SCIENCE CHINA MATERIALS
  • 2015-09. Big opportunities for small molecules in immuno-oncology in NATURE REVIEWS DRUG DISCOVERY
  • 2007-12. Nanomechanical analysis of cells from cancer patients in NATURE NANOTECHNOLOGY
  • 2018-04. Flow behavior of liquid metal in the connected fascial space: Intervaginal space injection in the rat wrist and mice with tumor in NANO RESEARCH
  • 2011-06. Role of YAP/TAZ in mechanotransduction in NATURE
  • 2018-11. Macrophages loaded CpG and GNR-PEI for combination of tumor photothermal therapy and immunotherapy in SCIENCE CHINA MATERIALS
  • 2013-06. Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts in NATURE CELL BIOLOGY
  • 2015-09. Sympathetic nervous system regulation of the tumour microenvironment in NATURE REVIEWS CANCER
  • 2017-10-13. Engineering and physical sciences in oncology: challenges and opportunities in NATURE REVIEWS CANCER
  • 2017-12. Force loading explains spatial sensing of ligands by cells in NATURE
  • 2015-11. Cell growth density modulates cancer cell vascular invasion via Hippo pathway activity and CXCR2 signaling in ONCOGENE
  • 2016-11. Understanding of the major reactions in solution synthesis of functional nanomaterials in SCIENCE CHINA MATERIALS
  • 2012-11. The nanomechanical signature of breast cancer in NATURE NANOTECHNOLOGY
  • 2011-10. The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine in NATURE MEDICINE
  • 2017-12. YAP modulates TGF-β1-induced simultaneous apoptosis and EMT through upregulation of the EGF receptor in SCIENTIFIC REPORTS
  • 2012-07. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion in NATURE
  • 2012-07. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors in NATURE
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    http://scigraph.springernature.com/pub.10.1007/s40843-018-9383-3

    DOI

    http://dx.doi.org/10.1007/s40843-018-9383-3

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