Photostable and Biocompatible Fluorescent Silicon Nanoparticles for Imaging-Guided Co-Delivery of siRNA and Doxorubicin to Drug-Resistant Cancer Cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Daoxia Guo, Xiaoyuan Ji, Fei Peng, Yiling Zhong, Binbin Chu, Yuanyuan Su, Yao He

ABSTRACT

A novel all-in-one fluorescent nanomedicine platform based on silicon nanoparticles (SiNPs) was developed for imaging-guided co-delivery of short interfering RNA (siRNA) and doxorubicin (DOX).The intracellular time-dependent release behaviors of siRNA and DOX were visually monitored by tracking the strong and stable fluorescence of SiNPs.The SiNPs-based nanocarriers displayed pronounced therapeutic efficiency on drug-resistant breast cancer cells. A novel all-in-one fluorescent nanomedicine platform based on silicon nanoparticles (SiNPs) was developed for imaging-guided co-delivery of short interfering RNA (siRNA) and doxorubicin (DOX). The intracellular time-dependent release behaviors of siRNA and DOX were visually monitored by tracking the strong and stable fluorescence of SiNPs. The SiNPs-based nanocarriers displayed pronounced therapeutic efficiency on drug-resistant breast cancer cells. The development of effective and safe vehicles to deliver small interfering RNA (siRNA) and chemotherapeutics remains a major challenge in RNA interference-based combination therapy with chemotherapeutics, which has emerged as a powerful platform to treat drug-resistant cancer cells. Herein, we describe the development of novel all-in-one fluorescent silicon nanoparticles (SiNPs)-based nanomedicine platform for imaging-guided co-delivery of siRNA and doxorubicin (DOX). This approach enhanced therapeutic efficacy in multidrug-resistant breast cancer cells (i.e., MCF-7/ADR cells). Typically, the SiNP-based nanocarriers enhanced the stability of siRNA in a biological environment (i.e., medium or RNase A) and imparted the responsive release behavior of siRNA, resulting in approximately 80% down-regulation of P-glycoprotein expression. Co-delivery of P-glycoprotein siRNA and DOX led to > 35-fold decrease in the half maximal inhibitory concentration of DOX in comparison with free DOX, indicating the pronounced therapeutic efficiency of the resultant nanocomposites for drug-resistant breast cancer cells. The intracellular time-dependent release behaviors of siRNA and DOX were revealed through tracking the strong and stable fluorescence of SiNPs. These data provide valuable information for designing effective RNA interference-based co-delivery carriers. More... »

PAGES

27

References to SciGraph publications

  • 2015-12. Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer in NATURE REVIEWS CANCER
  • 2019-03. Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness in NATURE NANOTECHNOLOGY
  • 1998-02. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans in NATURE
  • 2006-09. Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2001-05. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells in NATURE
  • 2012-07. NIH Image to ImageJ: 25 years of image analysis in NATURE METHODS
  • 2015-12. Clinical experiences with systemically administered siRNA-based therapeutics in cancer in NATURE REVIEWS DRUG DISCOVERY
  • 2013-11. Delivery materials for siRNA therapeutics in NATURE MATERIALS
  • 2010-04-15. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles in NATURE
  • 2013-12. Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin in NATURE COMMUNICATIONS
  • 2013-10. Cancer drug resistance: an evolving paradigm in NATURE REVIEWS CANCER
  • 2019-12. Defect engineered bioactive transition metals dichalcogenides quantum dots in NATURE COMMUNICATIONS
  • 2017-03-10. In vivo gastrointestinal drug-release monitoring through second near-infrared window fluorescent bioimaging with orally delivered microcarriers in NATURE COMMUNICATIONS
  • 2017-02. Highly efficient gene silencing and bioimaging based on fluorescent carbon dots in vitro and in vivo in NANO RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40820-019-0257-1

    DOI

    http://dx.doi.org/10.1007/s40820-019-0257-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112991394


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Soochow University", 
              "id": "https://www.grid.ac/institutes/grid.263761.7", 
              "name": [
                "Laboratory of Nanoscale Biochemical Analysis, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, 215123, Suzhou, Jiangsu, People\u2019s Republic of China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guo", 
            "givenName": "Daoxia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Soochow University", 
              "id": "https://www.grid.ac/institutes/grid.263761.7", 
              "name": [
                "Laboratory of Nanoscale Biochemical Analysis, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, 215123, Suzhou, Jiangsu, People\u2019s Republic of China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ji", 
            "givenName": "Xiaoyuan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Soochow University", 
              "id": "https://www.grid.ac/institutes/grid.263761.7", 
              "name": [
                "Laboratory of Nanoscale Biochemical Analysis, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, 215123, Suzhou, Jiangsu, People\u2019s Republic of China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peng", 
            "givenName": "Fei", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Soochow University", 
              "id": "https://www.grid.ac/institutes/grid.263761.7", 
              "name": [
                "Laboratory of Nanoscale Biochemical Analysis, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, 215123, Suzhou, Jiangsu, People\u2019s Republic of China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhong", 
            "givenName": "Yiling", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Soochow University", 
              "id": "https://www.grid.ac/institutes/grid.263761.7", 
              "name": [
                "Laboratory of Nanoscale Biochemical Analysis, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, 215123, Suzhou, Jiangsu, People\u2019s Republic of China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chu", 
            "givenName": "Binbin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Soochow University", 
              "id": "https://www.grid.ac/institutes/grid.263761.7", 
              "name": [
                "Laboratory of Nanoscale Biochemical Analysis, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, 215123, Suzhou, Jiangsu, People\u2019s Republic of China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Su", 
            "givenName": "Yuanyuan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Soochow University", 
              "id": "https://www.grid.ac/institutes/grid.263761.7", 
              "name": [
                "Laboratory of Nanoscale Biochemical Analysis, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, 215123, Suzhou, Jiangsu, People\u2019s Republic of China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "He", 
            "givenName": "Yao", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ncomms2655", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001267654", 
              "https://doi.org/10.1038/ncomms2655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmat3765", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001818681", 
              "https://doi.org/10.1038/nmat3765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.addr.2015.10.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002458634"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.addr.2013.07.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004115780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/adma.201601173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004144720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1605841113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005425786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.201407272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010528070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/adma.201505524", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013882994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja4098862", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018661636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35888", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018713804", 
              "https://doi.org/10.1038/35888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35888", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018713804", 
              "https://doi.org/10.1038/35888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/med.20244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019113908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c4cs00486h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019123520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd4685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019185606", 
              "https://doi.org/10.1038/nrd4685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1303958110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020059973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/smll.201601669", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020975868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acsnano.5b01954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025288514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026519625", 
              "https://doi.org/10.1038/nrc3599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/adma.201403848", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026777282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ar400221g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027189329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb1142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027343778", 
              "https://doi.org/10.1038/nsmb1142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb1142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027343778", 
              "https://doi.org/10.1038/nsmb1142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35078107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028423924", 
              "https://doi.org/10.1038/35078107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35078107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028423924", 
              "https://doi.org/10.1038/35078107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035817137", 
              "https://doi.org/10.1038/nmeth.2089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.201100884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035821656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08956", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035909146", 
              "https://doi.org/10.1038/nature08956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08956", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035909146", 
              "https://doi.org/10.1038/nature08956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/nn4035316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037388269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12274-016-1309-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039671811", 
              "https://doi.org/10.1007/s12274-016-1309-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12274-016-1309-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039671811", 
              "https://doi.org/10.1007/s12274-016-1309-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7150/thno.8263", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045142739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc4016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046543135", 
              "https://doi.org/10.1038/nrc4016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.analchem.5b00853", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055078371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.analchem.6b02488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055080252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.chemrev.5b00116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055085145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acsnano.5b00683", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055136895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jacs.6b02486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055875325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/138920011794520017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069175951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acsnano.6b07806", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084125149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acsnano.6b07806", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084125149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms14702", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084128930", 
              "https://doi.org/10.1038/ncomms14702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c7cs00479f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100898687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c7cs00479f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100898687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c7cs00479f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100898687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acsami.8b10527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106391454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acsami.8b10527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106391454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-018-07835-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110955606", 
              "https://doi.org/10.1038/s41467-018-07835-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-018-07835-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110955606", 
              "https://doi.org/10.1038/s41467-018-07835-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-018-07835-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110955606", 
              "https://doi.org/10.1038/s41467-018-07835-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-018-07835-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110955606", 
              "https://doi.org/10.1038/s41467-018-07835-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41565-018-0356-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111670104", 
              "https://doi.org/10.1038/s41565-018-0356-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41565-018-0356-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111670104", 
              "https://doi.org/10.1038/s41565-018-0356-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41565-018-0356-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111670104", 
              "https://doi.org/10.1038/s41565-018-0356-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41565-018-0356-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111670104", 
              "https://doi.org/10.1038/s41565-018-0356-z"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-03", 
        "datePublishedReg": "2019-03-01", 
        "description": "A novel all-in-one fluorescent nanomedicine platform based on silicon nanoparticles (SiNPs) was developed for imaging-guided co-delivery of short interfering RNA (siRNA) and doxorubicin (DOX).The intracellular time-dependent release behaviors of siRNA and DOX were visually monitored by tracking the strong and stable fluorescence of SiNPs.The SiNPs-based nanocarriers displayed pronounced therapeutic efficiency on drug-resistant breast cancer cells. A novel all-in-one fluorescent nanomedicine platform based on silicon nanoparticles (SiNPs) was developed for imaging-guided co-delivery of short interfering RNA (siRNA) and doxorubicin (DOX). The intracellular time-dependent release behaviors of siRNA and DOX were visually monitored by tracking the strong and stable fluorescence of SiNPs. The SiNPs-based nanocarriers displayed pronounced therapeutic efficiency on drug-resistant breast cancer cells. The development of effective and safe vehicles to deliver small interfering RNA (siRNA) and chemotherapeutics remains a major challenge in RNA interference-based combination therapy with chemotherapeutics, which has emerged as a powerful platform to treat drug-resistant cancer cells. Herein, we describe the development of novel all-in-one fluorescent silicon nanoparticles (SiNPs)-based nanomedicine platform for imaging-guided co-delivery of siRNA and doxorubicin (DOX). This approach enhanced therapeutic efficacy in multidrug-resistant breast cancer cells (i.e., MCF-7/ADR cells). Typically, the SiNP-based nanocarriers enhanced the stability of siRNA in a biological environment (i.e., medium or RNase A) and imparted the responsive release behavior of siRNA, resulting in approximately 80% down-regulation of P-glycoprotein expression. Co-delivery of P-glycoprotein siRNA and DOX led to > 35-fold decrease in the half maximal inhibitory concentration of DOX in comparison with free DOX, indicating the pronounced therapeutic efficiency of the resultant nanocomposites for drug-resistant breast cancer cells. The intracellular time-dependent release behaviors of siRNA and DOX were revealed through tracking the strong and stable fluorescence of SiNPs. These data provide valuable information for designing effective RNA interference-based co-delivery carriers.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s40820-019-0257-1", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1136349", 
            "issn": [
              "2311-6706", 
              "2150-5551"
            ], 
            "name": "Nano-Micro Letters", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "11"
          }
        ], 
        "name": "Photostable and Biocompatible Fluorescent Silicon Nanoparticles for Imaging-Guided Co-Delivery of siRNA and Doxorubicin to Drug-Resistant Cancer Cells", 
        "pagination": "27", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "eb620dcff7a1294eee4da4b2bdbf1959c9197c02499836dd39039072b96d65c6"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s40820-019-0257-1"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112991394"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s40820-019-0257-1", 
          "https://app.dimensions.ai/details/publication/pub.1112991394"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:57", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130817_00000006.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs40820-019-0257-1"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40820-019-0257-1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40820-019-0257-1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40820-019-0257-1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40820-019-0257-1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    230 TRIPLES      21 PREDICATES      67 URIs      19 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s40820-019-0257-1 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N31c3ba6b70334635a5abce60492f3552
    4 schema:citation sg:pub.10.1007/s12274-016-1309-1
    5 sg:pub.10.1038/35078107
    6 sg:pub.10.1038/35888
    7 sg:pub.10.1038/nature08956
    8 sg:pub.10.1038/ncomms14702
    9 sg:pub.10.1038/ncomms2655
    10 sg:pub.10.1038/nmat3765
    11 sg:pub.10.1038/nmeth.2089
    12 sg:pub.10.1038/nrc3599
    13 sg:pub.10.1038/nrc4016
    14 sg:pub.10.1038/nrd4685
    15 sg:pub.10.1038/nsmb1142
    16 sg:pub.10.1038/s41467-018-07835-1
    17 sg:pub.10.1038/s41565-018-0356-z
    18 https://doi.org/10.1002/adma.201403848
    19 https://doi.org/10.1002/adma.201505524
    20 https://doi.org/10.1002/adma.201601173
    21 https://doi.org/10.1002/anie.201100884
    22 https://doi.org/10.1002/anie.201407272
    23 https://doi.org/10.1002/med.20244
    24 https://doi.org/10.1002/smll.201601669
    25 https://doi.org/10.1016/j.addr.2013.07.012
    26 https://doi.org/10.1016/j.addr.2015.10.023
    27 https://doi.org/10.1021/acs.analchem.5b00853
    28 https://doi.org/10.1021/acs.analchem.6b02488
    29 https://doi.org/10.1021/acs.chemrev.5b00116
    30 https://doi.org/10.1021/acsami.8b10527
    31 https://doi.org/10.1021/acsnano.5b00683
    32 https://doi.org/10.1021/acsnano.5b01954
    33 https://doi.org/10.1021/acsnano.6b07806
    34 https://doi.org/10.1021/ar400221g
    35 https://doi.org/10.1021/ja4098862
    36 https://doi.org/10.1021/jacs.6b02486
    37 https://doi.org/10.1021/nn4035316
    38 https://doi.org/10.1039/c4cs00486h
    39 https://doi.org/10.1039/c7cs00479f
    40 https://doi.org/10.1073/pnas.1303958110
    41 https://doi.org/10.1073/pnas.1605841113
    42 https://doi.org/10.2174/138920011794520017
    43 https://doi.org/10.7150/thno.8263
    44 schema:datePublished 2019-03
    45 schema:datePublishedReg 2019-03-01
    46 schema:description A novel all-in-one fluorescent nanomedicine platform based on silicon nanoparticles (SiNPs) was developed for imaging-guided co-delivery of short interfering RNA (siRNA) and doxorubicin (DOX).The intracellular time-dependent release behaviors of siRNA and DOX were visually monitored by tracking the strong and stable fluorescence of SiNPs.The SiNPs-based nanocarriers displayed pronounced therapeutic efficiency on drug-resistant breast cancer cells. A novel all-in-one fluorescent nanomedicine platform based on silicon nanoparticles (SiNPs) was developed for imaging-guided co-delivery of short interfering RNA (siRNA) and doxorubicin (DOX). The intracellular time-dependent release behaviors of siRNA and DOX were visually monitored by tracking the strong and stable fluorescence of SiNPs. The SiNPs-based nanocarriers displayed pronounced therapeutic efficiency on drug-resistant breast cancer cells. The development of effective and safe vehicles to deliver small interfering RNA (siRNA) and chemotherapeutics remains a major challenge in RNA interference-based combination therapy with chemotherapeutics, which has emerged as a powerful platform to treat drug-resistant cancer cells. Herein, we describe the development of novel all-in-one fluorescent silicon nanoparticles (SiNPs)-based nanomedicine platform for imaging-guided co-delivery of siRNA and doxorubicin (DOX). This approach enhanced therapeutic efficacy in multidrug-resistant breast cancer cells (i.e., MCF-7/ADR cells). Typically, the SiNP-based nanocarriers enhanced the stability of siRNA in a biological environment (i.e., medium or RNase A) and imparted the responsive release behavior of siRNA, resulting in approximately 80% down-regulation of P-glycoprotein expression. Co-delivery of P-glycoprotein siRNA and DOX led to > 35-fold decrease in the half maximal inhibitory concentration of DOX in comparison with free DOX, indicating the pronounced therapeutic efficiency of the resultant nanocomposites for drug-resistant breast cancer cells. The intracellular time-dependent release behaviors of siRNA and DOX were revealed through tracking the strong and stable fluorescence of SiNPs. These data provide valuable information for designing effective RNA interference-based co-delivery carriers.
    47 schema:genre research_article
    48 schema:inLanguage en
    49 schema:isAccessibleForFree false
    50 schema:isPartOf N806ebd91aa974ae0879662ede638f4ad
    51 N9c811eac27704a90937223e7563f8503
    52 sg:journal.1136349
    53 schema:name Photostable and Biocompatible Fluorescent Silicon Nanoparticles for Imaging-Guided Co-Delivery of siRNA and Doxorubicin to Drug-Resistant Cancer Cells
    54 schema:pagination 27
    55 schema:productId N6587dd574bb141df9466a97adba59a78
    56 N7c4b5cd87efd4b85ae4fd82ff667b986
    57 Nec45acb9f288460da73879bdc515de3a
    58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112991394
    59 https://doi.org/10.1007/s40820-019-0257-1
    60 schema:sdDatePublished 2019-04-11T13:57
    61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    62 schema:sdPublisher Nc4d597f357f042389d326553688a779b
    63 schema:url https://link.springer.com/10.1007%2Fs40820-019-0257-1
    64 sgo:license sg:explorer/license/
    65 sgo:sdDataset articles
    66 rdf:type schema:ScholarlyArticle
    67 N003e4718166045c0813c73c1c333463a rdf:first N132b88f1318d4d2294f2a2371d251a6b
    68 rdf:rest Nc7b66e244a5f447ca930ed303de3ceea
    69 N030bc24adb83448186546e8b4cf30b01 schema:affiliation https://www.grid.ac/institutes/grid.263761.7
    70 schema:familyName Peng
    71 schema:givenName Fei
    72 rdf:type schema:Person
    73 N0e879d8f67e040599e5c8b087edc2c82 rdf:first Na1b71656ccce46c08f65a4b93b779879
    74 rdf:rest Na34816554e134443b49c921b8a7fb5ee
    75 N132b88f1318d4d2294f2a2371d251a6b schema:affiliation https://www.grid.ac/institutes/grid.263761.7
    76 schema:familyName Ji
    77 schema:givenName Xiaoyuan
    78 rdf:type schema:Person
    79 N23cb1a98c1df46fe8846848525bb0474 schema:affiliation https://www.grid.ac/institutes/grid.263761.7
    80 schema:familyName Su
    81 schema:givenName Yuanyuan
    82 rdf:type schema:Person
    83 N31c3ba6b70334635a5abce60492f3552 rdf:first N97df752fc3b441d58c2723c9f858c663
    84 rdf:rest N003e4718166045c0813c73c1c333463a
    85 N43e8bf74bf744801910ae271805cc965 rdf:first N23cb1a98c1df46fe8846848525bb0474
    86 rdf:rest N82c5cc1dd2c84b3796a1c658e9eb558a
    87 N6587dd574bb141df9466a97adba59a78 schema:name dimensions_id
    88 schema:value pub.1112991394
    89 rdf:type schema:PropertyValue
    90 N7c4b5cd87efd4b85ae4fd82ff667b986 schema:name doi
    91 schema:value 10.1007/s40820-019-0257-1
    92 rdf:type schema:PropertyValue
    93 N806ebd91aa974ae0879662ede638f4ad schema:issueNumber 1
    94 rdf:type schema:PublicationIssue
    95 N82c5cc1dd2c84b3796a1c658e9eb558a rdf:first Nad9be69e6c684abdb78d9cd4b13eb13a
    96 rdf:rest rdf:nil
    97 N97df752fc3b441d58c2723c9f858c663 schema:affiliation https://www.grid.ac/institutes/grid.263761.7
    98 schema:familyName Guo
    99 schema:givenName Daoxia
    100 rdf:type schema:Person
    101 N9c811eac27704a90937223e7563f8503 schema:volumeNumber 11
    102 rdf:type schema:PublicationVolume
    103 Na1b71656ccce46c08f65a4b93b779879 schema:affiliation https://www.grid.ac/institutes/grid.263761.7
    104 schema:familyName Zhong
    105 schema:givenName Yiling
    106 rdf:type schema:Person
    107 Na34816554e134443b49c921b8a7fb5ee rdf:first Ne453897f67f942f8b7677bb3b2b55f45
    108 rdf:rest N43e8bf74bf744801910ae271805cc965
    109 Nad9be69e6c684abdb78d9cd4b13eb13a schema:affiliation https://www.grid.ac/institutes/grid.263761.7
    110 schema:familyName He
    111 schema:givenName Yao
    112 rdf:type schema:Person
    113 Nc4d597f357f042389d326553688a779b schema:name Springer Nature - SN SciGraph project
    114 rdf:type schema:Organization
    115 Nc7b66e244a5f447ca930ed303de3ceea rdf:first N030bc24adb83448186546e8b4cf30b01
    116 rdf:rest N0e879d8f67e040599e5c8b087edc2c82
    117 Ne453897f67f942f8b7677bb3b2b55f45 schema:affiliation https://www.grid.ac/institutes/grid.263761.7
    118 schema:familyName Chu
    119 schema:givenName Binbin
    120 rdf:type schema:Person
    121 Nec45acb9f288460da73879bdc515de3a schema:name readcube_id
    122 schema:value eb620dcff7a1294eee4da4b2bdbf1959c9197c02499836dd39039072b96d65c6
    123 rdf:type schema:PropertyValue
    124 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    125 schema:name Medical and Health Sciences
    126 rdf:type schema:DefinedTerm
    127 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    128 schema:name Oncology and Carcinogenesis
    129 rdf:type schema:DefinedTerm
    130 sg:journal.1136349 schema:issn 2150-5551
    131 2311-6706
    132 schema:name Nano-Micro Letters
    133 rdf:type schema:Periodical
    134 sg:pub.10.1007/s12274-016-1309-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039671811
    135 https://doi.org/10.1007/s12274-016-1309-1
    136 rdf:type schema:CreativeWork
    137 sg:pub.10.1038/35078107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028423924
    138 https://doi.org/10.1038/35078107
    139 rdf:type schema:CreativeWork
    140 sg:pub.10.1038/35888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018713804
    141 https://doi.org/10.1038/35888
    142 rdf:type schema:CreativeWork
    143 sg:pub.10.1038/nature08956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035909146
    144 https://doi.org/10.1038/nature08956
    145 rdf:type schema:CreativeWork
    146 sg:pub.10.1038/ncomms14702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084128930
    147 https://doi.org/10.1038/ncomms14702
    148 rdf:type schema:CreativeWork
    149 sg:pub.10.1038/ncomms2655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001267654
    150 https://doi.org/10.1038/ncomms2655
    151 rdf:type schema:CreativeWork
    152 sg:pub.10.1038/nmat3765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001818681
    153 https://doi.org/10.1038/nmat3765
    154 rdf:type schema:CreativeWork
    155 sg:pub.10.1038/nmeth.2089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035817137
    156 https://doi.org/10.1038/nmeth.2089
    157 rdf:type schema:CreativeWork
    158 sg:pub.10.1038/nrc3599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026519625
    159 https://doi.org/10.1038/nrc3599
    160 rdf:type schema:CreativeWork
    161 sg:pub.10.1038/nrc4016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046543135
    162 https://doi.org/10.1038/nrc4016
    163 rdf:type schema:CreativeWork
    164 sg:pub.10.1038/nrd4685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019185606
    165 https://doi.org/10.1038/nrd4685
    166 rdf:type schema:CreativeWork
    167 sg:pub.10.1038/nsmb1142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027343778
    168 https://doi.org/10.1038/nsmb1142
    169 rdf:type schema:CreativeWork
    170 sg:pub.10.1038/s41467-018-07835-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110955606
    171 https://doi.org/10.1038/s41467-018-07835-1
    172 rdf:type schema:CreativeWork
    173 sg:pub.10.1038/s41565-018-0356-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1111670104
    174 https://doi.org/10.1038/s41565-018-0356-z
    175 rdf:type schema:CreativeWork
    176 https://doi.org/10.1002/adma.201403848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026777282
    177 rdf:type schema:CreativeWork
    178 https://doi.org/10.1002/adma.201505524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013882994
    179 rdf:type schema:CreativeWork
    180 https://doi.org/10.1002/adma.201601173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004144720
    181 rdf:type schema:CreativeWork
    182 https://doi.org/10.1002/anie.201100884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035821656
    183 rdf:type schema:CreativeWork
    184 https://doi.org/10.1002/anie.201407272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010528070
    185 rdf:type schema:CreativeWork
    186 https://doi.org/10.1002/med.20244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019113908
    187 rdf:type schema:CreativeWork
    188 https://doi.org/10.1002/smll.201601669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020975868
    189 rdf:type schema:CreativeWork
    190 https://doi.org/10.1016/j.addr.2013.07.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004115780
    191 rdf:type schema:CreativeWork
    192 https://doi.org/10.1016/j.addr.2015.10.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002458634
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1021/acs.analchem.5b00853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055078371
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1021/acs.analchem.6b02488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055080252
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1021/acs.chemrev.5b00116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055085145
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1021/acsami.8b10527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106391454
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1021/acsnano.5b00683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055136895
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1021/acsnano.5b01954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025288514
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1021/acsnano.6b07806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084125149
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1021/ar400221g schema:sameAs https://app.dimensions.ai/details/publication/pub.1027189329
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1021/ja4098862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018661636
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1021/jacs.6b02486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055875325
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1021/nn4035316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037388269
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1039/c4cs00486h schema:sameAs https://app.dimensions.ai/details/publication/pub.1019123520
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1039/c7cs00479f schema:sameAs https://app.dimensions.ai/details/publication/pub.1100898687
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1073/pnas.1303958110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020059973
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1073/pnas.1605841113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005425786
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.2174/138920011794520017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069175951
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.7150/thno.8263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045142739
    227 rdf:type schema:CreativeWork
    228 https://www.grid.ac/institutes/grid.263761.7 schema:alternateName Soochow University
    229 schema:name Laboratory of Nanoscale Biochemical Analysis, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, 215123, Suzhou, Jiangsu, People’s Republic of China
    230 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...