Spontaneous Reporting on Adverse Events by Consumers in the United States: An Analysis of the Food and Drug Administration Adverse ... View Full Text


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Article Info

DATE

2018-05-03

AUTHORS

Tadashi Toki, Shunsuke Ono

ABSTRACT

BACKGROUND: Voluntary reports on adverse events (AEs) submitted by consumers have been facilitated through the MedWatch program in the United States (US), but few studies have described the characteristics of voluntary reports. OBJECTIVE: The aim of this study was to reveal the characteristics of current voluntary reports on AEs reported by consumers and healthcare professionals. METHODS: We performed analysis on voluntary reports of AEs in the US Food and Drug Administration AE Reporting System (FAERS) database submitted in 2016. We compared reports by consumers with those by healthcare professionals. RESULTS: The number of voluntary reports by consumers has increased since 2013 in the US. Reports by consumers were different from ones by health professionals in several important aspects such as demographics and outcomes of patients, AEs, and suspect drugs. The proportion of reports on female patients and on disability as a patient outcome were higher in reports by consumers than in those by healthcare professionals. Consumers more frequently reported concomitant drugs compared with healthcare professionals. Time to report varied among the occupations and depending on seriousness of outcomes. CONCLUSIONS: Our analysis of voluntary AE reports in the US FAERS database has shown that voluntary reports tended to include AEs related to subjective symptoms, as in some previous studies on patient reporting in the EU. Voluntary reports by consumers seemed to be different from ones by healthcare professionals in important aspects including demographics and reporting behaviors. These findings suggest that the heterogeneities should be addressed appropriately in using spontaneous reports. More... »

PAGES

117-128

References to SciGraph publications

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  • 2013-03-09. Effect of Pharmacist Involvement on Patient Reporting of Adverse Drug Reactions: First Italian Study in DRUG SAFETY
  • 2014-09-26. Stimulated Reporting: The Impact of US Food and Drug Administration-Issued Alerts on the Adverse Event Reporting System (FAERS) in DRUG SAFETY
  • 2017-04-12. The Quality of Clinical Information in Adverse Drug Reaction Reports by Patients and Healthcare Professionals: A Retrospective Comparative Analysis in DRUG SAFETY
  • 2013-12-17. vigiGrade: A Tool to Identify Well-Documented Individual Case Reports and Highlight Systematic Data Quality Issues in DRUG SAFETY
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  • 2017-04-17. Patient Reporting in the EU: Analysis of EudraVigilance Data in DRUG SAFETY
  • 2016-09-15. A Survey of Adverse Event Reporting Practices Among US Healthcare Professionals in DRUG SAFETY
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  • 2011-05. How Patient Reporters Identify Adverse Drug Reactions in DRUG SAFETY
  • 2001-12. Do Women Have More Adverse Drug Reactions? in AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
  • 2017-06-07. An Algorithm to Identify Generic Drugs in the FDA Adverse Event Reporting System in DRUG SAFETY
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40801-018-0134-0

    DOI

    http://dx.doi.org/10.1007/s40801-018-0134-0

    DIMENSIONS

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    PUBMED

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