OSA Endotypes: What Are They and What Are Their Potential Clinical Implications? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09

AUTHORS

Christopher N. Schmickl, Robert L. Owens, Bradley A. Edwards, Atul Malhotra

ABSTRACT

To review critically the different mechanisms, or endotypes, causing obstructive sleep apnea (OSA) in individual patients, and their potential implications for management. Currently, at least four underlying mechanisms that contribute to OSA have been identified, namely a compromised upper airway anatomy, a poor pharyngeal muscle responsiveness, respiratory control instability (high loop gain), and a low arousal threshold (wake up too easily); the relative contributions of these four traits in an individual form their endotype. Endotypes provide therapeutic targets that may facilitate development of novel therapies, can predict treatment response to non-CPAP therapies, and may explain clinical phenotypes. Endotyping is currently restricted to specialized research laboratories, but newer methods relying on standard polysomnography may soon allow routine assessment of endotypes as part of clinical practice. Endotyping promises to transform the current one-size fits-all OSA management into an individualized precision medicine approach in the future. More... »

PAGES

231-242

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40675-018-0121-8

DOI

http://dx.doi.org/10.1007/s40675-018-0121-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105261715


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