Obstructive Sleep Apnea and Metabolic Risk: an Update View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-06

AUTHORS

Lunara S. Freitas, Sofia F. Furlan, Luciano F. Drager

ABSTRACT

This short review is aimed at presenting the most recent literature linking obstructive sleep apnea (OSA) with metabolic risk. In the last decades, substantial evidence derived from experimental, translational, and clinical studies has supported the possibility that OSA predisposes to cardiovascular diseases via activation and propagation of multiple pathophysiological pathways. While initial studies focused on the hemodynamic effects of OSA, further studies indicated that the components of OSA (especially intermittent hypoxia) also promote metabolic deregulation, including insulin resistance, impaired lipoprotein clearance, and dyslipidemia. This review indicates that the precise effects of chronic intermittent hypoxia and the relative impact of sleep fragmentation on glucose and lipid metabolism still require further studies as well as the impact of effective OSA treatment. Personalized medicine devoting to explore potential biomarkers that predicts metabolic risk may help to prevent cardiovascular disease in patients with OSA. More... »

PAGES

170-177

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40675-018-0118-3

DOI

http://dx.doi.org/10.1007/s40675-018-0118-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103482108


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