Ontology type: schema:ScholarlyArticle Open Access: True
2021-10-08
AUTHORSJia-Jin Chen, George Kuo, Pei-Chun Fan, Tao-Han Lee, Chieh-Li Yen, Cheng-Chia Lee, Ya-Chung Tian, Chih-Hsiang Chang
ABSTRACTBACKGROUNDS: Neutrophil-to-lymphocyte ratio (NLR), a surrogate marker of systemic response to physiological stress, is used for prognosis prediction in many diseases. However, the usefulness of this marker for predicting acute kidney injury (AKI) progression is unclear. METHODS: This retrospective study was based on the Chang Gung Research Database. Patients admitted to the intensive care unit with a diagnosis of stage 1 or 2 AKI were identified. The primary outcome was a composite of progression to stage 3 AKI, requirement of renal replacement therapy, or 14-day in-hospital mortality. The association between NLR and the primary outcome was examined using a logistic regression model and multivariable analysis. The nonlinearity and cutoff points of this relationship were determined using a restricted cubic spline model. RESULTS: A total of 10,441 patients were enrolled. NLR level at the time of stage 1-2 AKI diagnosis was a marker of adverse outcomes. After adjustment for confounders, NLR was independently associated with the composite outcome of AKI progression, renal replacement therapy, or mortality. The restricted cubic spline model revealed a J-shaped curve, with the lowest odds ratio for an NLR between 7 and 38. Subgroup analysis revealed linear and J-shaped relationships between NLR and the primary outcome in patients admitted to the intensive care unit for medical reasons and for cardiovascular surgery, respectively. CONCLUSIONS: NLR is an independent marker of AKI progression and in-hospital mortality. Because it is readily available in daily practice, it might be used for risk stratification in the AKI population. More... »
PAGES1-10
http://scigraph.springernature.com/pub.10.1007/s40620-021-01162-3
DOIhttp://dx.doi.org/10.1007/s40620-021-01162-3
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1141724499
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/34623629
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Nephrology, Chang Gung Memorial Hospital, Linkou, Taiwan",
"id": "http://www.grid.ac/institutes/grid.413801.f",
"name": [
"Department of Nephrology, Chang Gung Memorial Hospital, Linkou, Taiwan"
],
"type": "Organization"
},
"familyName": "Chen",
"givenName": "Jia-Jin",
"id": "sg:person.015551423005.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015551423005.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Nephrology, Chang Gung Memorial Hospital, Linkou, Taiwan",
"id": "http://www.grid.ac/institutes/grid.413801.f",
"name": [
"Department of Nephrology, Chang Gung Memorial Hospital, Linkou, Taiwan"
],
"type": "Organization"
},
"familyName": "Kuo",
"givenName": "George",
"id": "sg:person.013061302321.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013061302321.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Taipei, Taiwan",
"id": "http://www.grid.ac/institutes/grid.454211.7",
"name": [
"Department of Nephrology, Chang Gung Memorial Hospital, Linkou, Taiwan",
"Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Taipei, Taiwan"
],
"type": "Organization"
},
"familyName": "Fan",
"givenName": "Pei-Chun",
"id": "sg:person.01326076307.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326076307.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Nephrology, Chang Gung Memorial Hospital, Linkou, Taiwan",
"id": "http://www.grid.ac/institutes/grid.413801.f",
"name": [
"Department of Nephrology, Chang Gung Memorial Hospital, Linkou, Taiwan"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Tao-Han",
"id": "sg:person.016472636330.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016472636330.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Nephrology, Chang Gung Memorial Hospital, Linkou, Taiwan",
"id": "http://www.grid.ac/institutes/grid.413801.f",
"name": [
"Department of Nephrology, Chang Gung Memorial Hospital, Linkou, Taiwan"
],
"type": "Organization"
},
"familyName": "Yen",
"givenName": "Chieh-Li",
"id": "sg:person.01116311506.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116311506.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Taipei, Taiwan",
"id": "http://www.grid.ac/institutes/grid.454211.7",
"name": [
"Department of Nephrology, Chang Gung Memorial Hospital, Linkou, Taiwan",
"Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Taipei, Taiwan"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Cheng-Chia",
"id": "sg:person.011016563503.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011016563503.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Taipei, Taiwan",
"id": "http://www.grid.ac/institutes/grid.454211.7",
"name": [
"Department of Nephrology, Chang Gung Memorial Hospital, Linkou, Taiwan",
"Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Taipei, Taiwan"
],
"type": "Organization"
},
"familyName": "Tian",
"givenName": "Ya-Chung",
"id": "sg:person.01066477051.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066477051.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Taipei, Taiwan",
"id": "http://www.grid.ac/institutes/grid.454211.7",
"name": [
"Department of Nephrology, Chang Gung Memorial Hospital, Linkou, Taiwan",
"Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Taipei, Taiwan"
],
"type": "Organization"
},
"familyName": "Chang",
"givenName": "Chih-Hsiang",
"id": "sg:person.013547520153.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013547520153.88"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1186/s12967-019-1808-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1112779569",
"https://doi.org/10.1186/s12967-019-1808-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13054-017-1821-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091506242",
"https://doi.org/10.1186/s13054-017-1821-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13054-016-1212-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014361205",
"https://doi.org/10.1186/s13054-016-1212-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13054-017-1660-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084252001",
"https://doi.org/10.1186/s13054-017-1660-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41598-017-10516-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091456794",
"https://doi.org/10.1038/s41598-017-10516-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13054-016-1218-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028103400",
"https://doi.org/10.1186/s13054-016-1218-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-015-4869-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017623891",
"https://doi.org/10.1245/s10434-015-4869-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00134-018-5126-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1101535489",
"https://doi.org/10.1007/s00134-018-5126-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/cc13015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019086002",
"https://doi.org/10.1186/cc13015"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13054-014-0731-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050725326",
"https://doi.org/10.1186/s13054-014-0731-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13054-020-02912-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1127447725",
"https://doi.org/10.1186/s13054-020-02912-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11739-017-1715-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090921553",
"https://doi.org/10.1007/s11739-017-1715-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s40620-017-0461-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1093059575",
"https://doi.org/10.1007/s40620-017-0461-3"
],
"type": "CreativeWork"
}
],
"datePublished": "2021-10-08",
"datePublishedReg": "2021-10-08",
"description": "BACKGROUNDS: Neutrophil-to-lymphocyte ratio (NLR), a surrogate marker of systemic response to physiological stress, is used for prognosis prediction in many diseases. However, the usefulness of this marker for predicting acute kidney injury (AKI) progression is unclear.\nMETHODS: This retrospective study was based on the Chang Gung Research Database. Patients admitted to the intensive care unit with a diagnosis of stage 1 or 2 AKI were identified. The primary outcome was a composite of progression to stage 3 AKI, requirement of renal replacement therapy, or 14-day in-hospital mortality. The association between NLR and the primary outcome was examined using a logistic regression model and multivariable analysis. The nonlinearity and cutoff points of this relationship were determined using a restricted cubic spline model.\nRESULTS: A total of 10,441 patients were enrolled. NLR level at the time of stage 1-2 AKI diagnosis was a marker of adverse outcomes. After adjustment for confounders, NLR was independently associated with the composite outcome of AKI progression, renal replacement therapy, or mortality. The restricted cubic spline model revealed a J-shaped curve, with the lowest odds ratio for an NLR between 7 and 38. Subgroup analysis revealed linear and J-shaped relationships between NLR and the primary outcome in patients admitted to the intensive care unit for medical reasons and for cardiovascular surgery, respectively.\nCONCLUSIONS: NLR is an independent marker of AKI progression and in-hospital mortality. Because it is readily available in daily practice, it might be used for risk stratification in the AKI population.",
"genre": "article",
"id": "sg:pub.10.1007/s40620-021-01162-3",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1100597",
"issn": [
"1121-8428",
"1724-6059"
],
"name": "Journal of Nephrology",
"publisher": "Springer Nature",
"type": "Periodical"
}
],
"keywords": [
"acute kidney injury progression",
"kidney injury progression",
"renal replacement therapy",
"intensive care unit",
"primary outcome",
"cubic spline model",
"AKI progression",
"hospital mortality",
"lymphocyte ratio",
"care unit",
"replacement therapy",
"injury progression",
"Chang Gung Research Database",
"composite of progression",
"lower odds ratio",
"multi-institutional study",
"stage 1",
"logistic regression models",
"AKI diagnosis",
"AKI population",
"NLR levels",
"composite outcome",
"risk stratification",
"retrospective study",
"multivariable analysis",
"adverse outcomes",
"subgroup analysis",
"surrogate marker",
"ill population",
"odds ratio",
"cardiovascular surgery",
"independent marker",
"Research Database",
"medical reasons",
"prognosis prediction",
"cutoff point",
"NLR",
"systemic response",
"patients",
"mortality",
"progression",
"daily practice",
"outcomes",
"AKI",
"therapy",
"neutrophils",
"markers",
"diagnosis",
"regression models",
"spline model",
"physiological stress",
"surgery",
"confounders",
"population",
"disease",
"total",
"study",
"association",
"stratification",
"response",
"adjustment",
"ratio",
"levels",
"relationship",
"database",
"units",
"usefulness",
"analysis",
"practice",
"stress",
"reasons",
"model",
"time",
"curves",
"point",
"requirements",
"prediction",
"linear",
"composites",
"nonlinearity",
"Gung Research Database"
],
"name": "Neutrophil-to-lymphocyte ratio is a marker for acute kidney injury progression and mortality in critically ill populations: a population-based, multi-institutional study",
"pagination": "1-10",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1141724499"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s40620-021-01162-3"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"34623629"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s40620-021-01162-3",
"https://app.dimensions.ai/details/publication/pub.1141724499"
],
"sdDataset": "articles",
"sdDatePublished": "2022-01-01T19:03",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_905.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s40620-021-01162-3"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40620-021-01162-3'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40620-021-01162-3'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40620-021-01162-3'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40620-021-01162-3'
This table displays all metadata directly associated to this object as RDF triples.
242 TRIPLES
22 PREDICATES
118 URIs
97 LITERALS
5 BLANK NODES