High serum osteopontin levels are associated with prevalent fractures and worse lipid profile in post-menopausal women with type 2 diabetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-06-18

AUTHORS

T. Filardi, V. Carnevale, R. Massoud, C. Russo, L. Nieddu, F. Tavaglione, I. Turinese, A. Lenzi, E. Romagnoli, S. Morano

ABSTRACT

PurposePatients with type 2 diabetes (T2DM) have increased fracture risk. Osteopontin (OPN) is a protein involved in bone remodeling and inflammation. The aim of this study was to evaluate the association of OPN with fracture prevalence and with metabolic parameters in post-menopausal women with T2DM.MethodsSixty-four post-menopausal women with T2DM (age 67.0 ± 7.8 years, diabetes duration 8.9 ± 6.7 years), enrolled in a previous study, were followed up (3.6 ± 0.9 years). Previous fragility fractures were recorded. The FRAX score (without BMD) was calculated and biochemical parameters (plasma glucose, HbA1c, lipid profile and renal function) were assessed. Serum 25OH-vitamin D, calcium, PTH and OPN were evaluated at baseline. The association between OPN and fracture prevalence at baseline was evaluated by a logistic model.ResultsOPN levels were higher in patients with previous fractures (n.25) than in patients without previous fractures at baseline (n.39) (p = 0.006). The odds of having fractures at baseline increased by 6.7 (1.9–31.4, 95% CI, p = 0.007) for each increase of 1 ng/ml in OPN levels, after adjustment for vitamin D and HbA1c levels. Fracture incidence was 4.7%. Higher OPN associated with a decrease in HDL-cholesterol (p = 0.048), after adjustment for age, basal HDL-cholesterol, basal and follow-up HbA1c and follow-up duration. 25OH-vitamin D associated with an increase in FRAX-estimated probability of hip fracture at follow-up (p = 0.029), after adjustment for age, 25OH-vitamin D and time.ConclusionsIn post-menopausal women with T2DM, OPN might be a useful marker of fracture and worse lipid profile. More... »

PAGES

295-301

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40618-018-0914-0

DOI

http://dx.doi.org/10.1007/s40618-018-0914-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104906634

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29916137


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