Statins are not a risk factor for liver damage associated with intravenous glucocorticoid pulse therapy for Graves’ orbitopathy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-11

AUTHORS

E. Sabini, E. Sisti, B. Coco, M. Leo, I. Ionni, F. Menconi, M. A. Profilo, B. Mazzi, R. Rocchi, F. Latrofa, P. Vitti, M. Brunetto, C. Marcocci, M. Marinò

ABSTRACT

OBJECTIVE: Acute liver damage (ALD) is associated with high-dose intravenous (iv) glucocorticoid (GC) (ivGC) pulse therapy in ~1 % of patients for Graves' orbitopathy (GO). It has been proposed that statins may increase the risk of ALD. Here we investigated the frequency of ALD according to the assumption of statins in a large retrospective cohort study. METHODS: We studied 1076 consecutive patients with GO given ivGC. ALD was defined as an increase in alanine aminotransferase ≥300 U/l. RESULTS: At the time of ivGC, 62 patients were taking statins and 1014 were not. The frequency of ALD has been reported to be 1.2 cases/100,000 statins users and 1300/100,000 in GO patients given ivGC. Thus, the expected frequency of ALD in patients given both statins and ivGC is 1560/100,000. Transferring these data to our series, one would have expected at least 0.96 cases of ALD (~one case), in the 62 patients given both ivGC and statins. However, no cases of ALD were observed in patients given statins, and the previously reported 14 cases of ALD in this series were seen in patients who were not taking statins. CONCLUSIONS: The lack of observation of cases of ALD in patients given ivGC and statins is quite reassuring. Although caution should be applied to any patient candidate to ivGC treatment and this should be particularly accurate in patients given statins, our findings somehow justify the use of ivGC in patients under statins, although further studies in larger cohorts are needed to confirm our conclusions. More... »

PAGES

1323-1327

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40618-016-0518-5

DOI

http://dx.doi.org/10.1007/s40618-016-0518-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031294540

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27465669


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucocorticoids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Graves Ophthalmopathy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydroxymethylglutaryl-CoA Reductase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sabini", 
        "givenName": "E.", 
        "id": "sg:person.012157705311.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012157705311.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sisti", 
        "givenName": "E.", 
        "id": "sg:person.01055331703.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055331703.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Hepatology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coco", 
        "givenName": "B.", 
        "id": "sg:person.01126315001.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126315001.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leo", 
        "givenName": "M.", 
        "id": "sg:person.0616435417.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616435417.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ionni", 
        "givenName": "I.", 
        "id": "sg:person.015633672701.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015633672701.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Menconi", 
        "givenName": "F.", 
        "id": "sg:person.01175375751.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175375751.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Profilo", 
        "givenName": "M. A.", 
        "id": "sg:person.0626137617.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626137617.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mazzi", 
        "givenName": "B.", 
        "id": "sg:person.0742704576.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742704576.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rocchi", 
        "givenName": "R.", 
        "id": "sg:person.01167520476.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167520476.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Latrofa", 
        "givenName": "F.", 
        "id": "sg:person.0660241732.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660241732.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vitti", 
        "givenName": "P.", 
        "id": "sg:person.0777360014.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777360014.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Hepatology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brunetto", 
        "givenName": "M.", 
        "id": "sg:person.0652305341.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652305341.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marcocci", 
        "givenName": "C.", 
        "id": "sg:person.01003046263.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003046263.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marin\u00f2", 
        "givenName": "M.", 
        "id": "sg:person.016021203562.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016021203562.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrd1901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005336052", 
          "https://doi.org/10.1038/nrd1901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd1901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005336052", 
          "https://doi.org/10.1038/nrd1901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrendo.2013.193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006242316", 
          "https://doi.org/10.1038/nrendo.2013.193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1478-3231.2004.0970.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010865951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13300-016-0167-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016194759", 
          "https://doi.org/10.1007/s13300-016-0167-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40618-014-0097-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016789120", 
          "https://doi.org/10.1007/s40618-014-0097-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40618-015-0241-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017441988", 
          "https://doi.org/10.1007/s40618-015-0241-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje-14-0712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021458264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03345386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021828143", 
          "https://doi.org/10.1007/bf03345386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.21059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028055530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.21059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028055530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpg.2011.08.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031560620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40618-014-0227-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033379838", 
          "https://doi.org/10.1007/s40618-014-0227-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200004273421707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034355315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje-11-0779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046172232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0953-6205(02)00089-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046308212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047664639", 
          "https://doi.org/10.1038/nri1839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047664639", 
          "https://doi.org/10.1038/nri1839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12020-016-0928-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048477264", 
          "https://doi.org/10.1007/s12020-016-0928-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0107294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048868579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2011.07.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051292814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/1050725041692927", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059204671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/105072504774193276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059204782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2006.0267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059319707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2015.0061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059322016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.115.306471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063343763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.115.306471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063343763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2010-1962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064292423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2014-4463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064295646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-126-2-199701150-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073701129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2000.10.521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074672519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078900619", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-11", 
    "datePublishedReg": "2016-11-01", 
    "description": "OBJECTIVE: Acute liver damage (ALD) is associated with high-dose intravenous (iv) glucocorticoid (GC) (ivGC) pulse therapy in ~1\u00a0% of patients for Graves' orbitopathy (GO). It has been proposed that statins may increase the risk of ALD. Here we investigated the frequency of ALD according to the assumption of statins in a large retrospective cohort study.\nMETHODS: We studied 1076 consecutive patients with GO given ivGC. ALD was defined as an increase in alanine aminotransferase \u2265300\u00a0U/l.\nRESULTS: At the time of ivGC, 62 patients were taking statins and 1014 were not. The frequency of ALD has been reported to be 1.2 cases/100,000 statins users and 1300/100,000 in GO patients given ivGC. Thus, the expected frequency of ALD in patients given both statins and ivGC is 1560/100,000. Transferring these data to our series, one would have expected at least 0.96 cases of ALD (~one case), in the 62 patients given both ivGC and statins. However, no cases of ALD were observed in patients given statins, and the previously reported 14 cases of ALD in this series were seen in patients who were not taking statins.\nCONCLUSIONS: The lack of observation of cases of ALD in patients given ivGC and statins is quite reassuring. Although caution should be applied to any patient candidate to ivGC treatment and this should be particularly accurate in patients given statins, our findings somehow justify the use of ivGC in patients under statins, although further studies in larger cohorts are needed to confirm our conclusions.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s40618-016-0518-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1088396", 
        "issn": [
          "0391-4097", 
          "1720-8386"
        ], 
        "name": "Journal of Endocrinological Investigation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "39"
      }
    ], 
    "name": "Statins are not a risk factor for liver damage associated with intravenous glucocorticoid pulse therapy for Graves\u2019 orbitopathy", 
    "pagination": "1323-1327", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9514e68ed64b1d10188a276f777b23ab4b224177d709e8c30577b9f8e349fb4a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27465669"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7806594"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s40618-016-0518-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031294540"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s40618-016-0518-5", 
      "https://app.dimensions.ai/details/publication/pub.1031294540"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70040_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs40618-016-0518-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40618-016-0518-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40618-016-0518-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40618-016-0518-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40618-016-0518-5'


 

This table displays all metadata directly associated to this object as RDF triples.

341 TRIPLES      21 PREDICATES      73 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s40618-016-0518-5 schema:about N004e7137e417413ebc95308697030314
2 N29b800e061bf446caf6a7ae70b0359cf
3 N36e8e697d2e1486ead3986f1673f17d8
4 N3ed55c3a0b9946bd851e80eebf4717eb
5 N4c5d8048d2a24459bc027ac68f59407e
6 N50a2983b07be4145b8cd8eb198b0abf6
7 N52feb64e86d84d119a62522d140546a8
8 N5fe962463eaf4b8095393ddbadc7d489
9 N6689fb0a78db45e5acc1f67f2ea89726
10 N7798c25962404c929081a3f14009a695
11 N7aca4391739346299c5dae8e64041260
12 N89cab933689e46529ebc9fc08eb482aa
13 Ncabc102d94b544a99e65ac19e3ba7de3
14 Ndce7f2de85594d739154392bb1776b0d
15 Ne293ce9626444892a0148d64c2b593d8
16 Nec6bb39ee2c8472a964f558fd390355b
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author N179b7186f78b4ee19a7e8672810247e5
20 schema:citation sg:pub.10.1007/bf03345386
21 sg:pub.10.1007/s12020-016-0928-3
22 sg:pub.10.1007/s13300-016-0167-x
23 sg:pub.10.1007/s40618-014-0097-2
24 sg:pub.10.1007/s40618-014-0227-x
25 sg:pub.10.1007/s40618-015-0241-7
26 sg:pub.10.1038/nrd1901
27 sg:pub.10.1038/nrendo.2013.193
28 sg:pub.10.1038/nri1839
29 https://app.dimensions.ai/details/publication/pub.1078900619
30 https://doi.org/10.1002/hep.21059
31 https://doi.org/10.1016/j.bpg.2011.08.003
32 https://doi.org/10.1016/j.jhep.2011.07.023
33 https://doi.org/10.1016/s0953-6205(02)00089-4
34 https://doi.org/10.1056/nejm200004273421707
35 https://doi.org/10.1089/1050725041692927
36 https://doi.org/10.1089/105072504774193276
37 https://doi.org/10.1089/thy.2000.10.521
38 https://doi.org/10.1089/thy.2006.0267
39 https://doi.org/10.1089/thy.2015.0061
40 https://doi.org/10.1111/j.1478-3231.2004.0970.x
41 https://doi.org/10.1161/circresaha.115.306471
42 https://doi.org/10.1210/jc.2010-1962
43 https://doi.org/10.1210/jc.2014-4463
44 https://doi.org/10.1371/journal.pone.0107294
45 https://doi.org/10.1530/eje-11-0779
46 https://doi.org/10.1530/eje-14-0712
47 https://doi.org/10.7326/0003-4819-126-2-199701150-00008
48 schema:datePublished 2016-11
49 schema:datePublishedReg 2016-11-01
50 schema:description OBJECTIVE: Acute liver damage (ALD) is associated with high-dose intravenous (iv) glucocorticoid (GC) (ivGC) pulse therapy in ~1 % of patients for Graves' orbitopathy (GO). It has been proposed that statins may increase the risk of ALD. Here we investigated the frequency of ALD according to the assumption of statins in a large retrospective cohort study. METHODS: We studied 1076 consecutive patients with GO given ivGC. ALD was defined as an increase in alanine aminotransferase ≥300 U/l. RESULTS: At the time of ivGC, 62 patients were taking statins and 1014 were not. The frequency of ALD has been reported to be 1.2 cases/100,000 statins users and 1300/100,000 in GO patients given ivGC. Thus, the expected frequency of ALD in patients given both statins and ivGC is 1560/100,000. Transferring these data to our series, one would have expected at least 0.96 cases of ALD (~one case), in the 62 patients given both ivGC and statins. However, no cases of ALD were observed in patients given statins, and the previously reported 14 cases of ALD in this series were seen in patients who were not taking statins. CONCLUSIONS: The lack of observation of cases of ALD in patients given ivGC and statins is quite reassuring. Although caution should be applied to any patient candidate to ivGC treatment and this should be particularly accurate in patients given statins, our findings somehow justify the use of ivGC in patients under statins, although further studies in larger cohorts are needed to confirm our conclusions.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree false
54 schema:isPartOf N6593c998e0f249d29c5da02e1d01643f
55 Nc434a35c022844b89d0b57a848333d9a
56 sg:journal.1088396
57 schema:name Statins are not a risk factor for liver damage associated with intravenous glucocorticoid pulse therapy for Graves’ orbitopathy
58 schema:pagination 1323-1327
59 schema:productId N06a76835f28449f9bde2eccde7d2df53
60 N54619d9deced4ba89391a0f49ced01b0
61 N6d75f9d6b11047db8a9398e53e387ef4
62 Nf3a8df649a6f4c2f9c271e011616f59e
63 Nfa2bed62c42a444da9977a351fe4968b
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031294540
65 https://doi.org/10.1007/s40618-016-0518-5
66 schema:sdDatePublished 2019-04-11T12:38
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher Nfb38c794bc3d49ed88df0683237e54fc
69 schema:url https://link.springer.com/10.1007%2Fs40618-016-0518-5
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N004e7137e417413ebc95308697030314 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Adult
75 rdf:type schema:DefinedTerm
76 N06a76835f28449f9bde2eccde7d2df53 schema:name nlm_unique_id
77 schema:value 7806594
78 rdf:type schema:PropertyValue
79 N092a83d011cb4a12ae75c2128355b324 schema:name Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
80 rdf:type schema:Organization
81 N1467ae6b322f46b58e24ad6ded56cdf2 rdf:first sg:person.016021203562.07
82 rdf:rest rdf:nil
83 N179b7186f78b4ee19a7e8672810247e5 rdf:first sg:person.012157705311.60
84 rdf:rest Nbbbeabea24944fd888995e8ab3222af6
85 N29b800e061bf446caf6a7ae70b0359cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Young Adult
87 rdf:type schema:DefinedTerm
88 N36e8e697d2e1486ead3986f1673f17d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Biomarkers
90 rdf:type schema:DefinedTerm
91 N3ed55c3a0b9946bd851e80eebf4717eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Adolescent
93 rdf:type schema:DefinedTerm
94 N40899692f818487fac399ebb4b6523f2 rdf:first sg:person.0616435417.26
95 rdf:rest Nb4bb47d99fee49d2a6432aa3d6e27b42
96 N4c5d8048d2a24459bc027ac68f59407e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Aged
98 rdf:type schema:DefinedTerm
99 N4f72e5be8fda42ad9bb4ad4f8ed0bc13 schema:name Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
100 rdf:type schema:Organization
101 N4ffb2a726cdd4569b48d9df96f71fe73 schema:name Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
102 rdf:type schema:Organization
103 N50a2983b07be4145b8cd8eb198b0abf6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Risk Factors
105 rdf:type schema:DefinedTerm
106 N52feb64e86d84d119a62522d140546a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Graves Ophthalmopathy
108 rdf:type schema:DefinedTerm
109 N54619d9deced4ba89391a0f49ced01b0 schema:name dimensions_id
110 schema:value pub.1031294540
111 rdf:type schema:PropertyValue
112 N578c2b3ff4244b1aa3ec3e5672c3a8eb rdf:first sg:person.0660241732.86
113 rdf:rest Ne3c0714e5961483899f13e8379c384ef
114 N5fe962463eaf4b8095393ddbadc7d489 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Hydroxymethylglutaryl-CoA Reductase Inhibitors
116 rdf:type schema:DefinedTerm
117 N6593c998e0f249d29c5da02e1d01643f schema:volumeNumber 39
118 rdf:type schema:PublicationVolume
119 N6689fb0a78db45e5acc1f67f2ea89726 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Male
121 rdf:type schema:DefinedTerm
122 N6d75f9d6b11047db8a9398e53e387ef4 schema:name readcube_id
123 schema:value 9514e68ed64b1d10188a276f777b23ab4b224177d709e8c30577b9f8e349fb4a
124 rdf:type schema:PropertyValue
125 N6e034ce2d24e4eea80cdf4be7e157c06 rdf:first sg:person.0652305341.69
126 rdf:rest Nce950459438c4bb7a3c8825d4986ec63
127 N7289a6862eb243888aff28cace528ea6 schema:name Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
128 rdf:type schema:Organization
129 N775c0a3d7adb4490aec47449b4278abf schema:name Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
130 rdf:type schema:Organization
131 N777fae97953b46b1840853c8b3c0964d rdf:first sg:person.01175375751.25
132 rdf:rest Nff71ddd036cd4543a18fcc418a2c4b07
133 N7798c25962404c929081a3f14009a695 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Retrospective Studies
135 rdf:type schema:DefinedTerm
136 N79b687c6bf04429f916056a7ee78037b schema:name Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
137 rdf:type schema:Organization
138 N7aca4391739346299c5dae8e64041260 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Female
140 rdf:type schema:DefinedTerm
141 N89cab933689e46529ebc9fc08eb482aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Administration, Intravenous
143 rdf:type schema:DefinedTerm
144 N8ef2fafcf4624da38ca356379344a07c rdf:first sg:person.01126315001.71
145 rdf:rest N40899692f818487fac399ebb4b6523f2
146 N92f05e78035e4494a08c34f9e5bf5f22 rdf:first sg:person.01167520476.55
147 rdf:rest N578c2b3ff4244b1aa3ec3e5672c3a8eb
148 N9e096ddee8c249f1a7c084d09fda2fae schema:name Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
149 rdf:type schema:Organization
150 Nb4bb47d99fee49d2a6432aa3d6e27b42 rdf:first sg:person.015633672701.14
151 rdf:rest N777fae97953b46b1840853c8b3c0964d
152 Nbb5888dd16b142918897b5882e7298aa schema:name Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
153 rdf:type schema:Organization
154 Nbbbeabea24944fd888995e8ab3222af6 rdf:first sg:person.01055331703.24
155 rdf:rest N8ef2fafcf4624da38ca356379344a07c
156 Nc35166c3b3ed4966bb241b27fba49dc2 schema:name Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
157 rdf:type schema:Organization
158 Nc434a35c022844b89d0b57a848333d9a schema:issueNumber 11
159 rdf:type schema:PublicationIssue
160 Ncaa7863ab88b42f189a9d71e9838a90f schema:name Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
161 rdf:type schema:Organization
162 Ncabc102d94b544a99e65ac19e3ba7de3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Humans
164 rdf:type schema:DefinedTerm
165 Ncc9767bbcfc54860bcc914e9ea3b592c schema:name Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
166 rdf:type schema:Organization
167 Nce950459438c4bb7a3c8825d4986ec63 rdf:first sg:person.01003046263.82
168 rdf:rest N1467ae6b322f46b58e24ad6ded56cdf2
169 Nd4a2f1a84b33408e96d09580433d44d2 schema:name Hepatology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
170 rdf:type schema:Organization
171 Ndce7f2de85594d739154392bb1776b0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Middle Aged
173 rdf:type schema:DefinedTerm
174 Ne293ce9626444892a0148d64c2b593d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Glucocorticoids
176 rdf:type schema:DefinedTerm
177 Ne3c0714e5961483899f13e8379c384ef rdf:first sg:person.0777360014.47
178 rdf:rest N6e034ce2d24e4eea80cdf4be7e157c06
179 Nec6bb39ee2c8472a964f558fd390355b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Liver Diseases
181 rdf:type schema:DefinedTerm
182 Nf3a8df649a6f4c2f9c271e011616f59e schema:name pubmed_id
183 schema:value 27465669
184 rdf:type schema:PropertyValue
185 Nf7ac805df9bc4d199c474f6dc079654e schema:name Hepatology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
186 rdf:type schema:Organization
187 Nf8444b23d0ff4ef2b1426ce9778d4394 schema:name Endocrinology Unit I, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
188 rdf:type schema:Organization
189 Nfa2bed62c42a444da9977a351fe4968b schema:name doi
190 schema:value 10.1007/s40618-016-0518-5
191 rdf:type schema:PropertyValue
192 Nfb38c794bc3d49ed88df0683237e54fc schema:name Springer Nature - SN SciGraph project
193 rdf:type schema:Organization
194 Nfb4affa7b07148db848ab77bbe915ede rdf:first sg:person.0742704576.10
195 rdf:rest N92f05e78035e4494a08c34f9e5bf5f22
196 Nff71ddd036cd4543a18fcc418a2c4b07 rdf:first sg:person.0626137617.03
197 rdf:rest Nfb4affa7b07148db848ab77bbe915ede
198 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
199 schema:name Medical and Health Sciences
200 rdf:type schema:DefinedTerm
201 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
202 schema:name Clinical Sciences
203 rdf:type schema:DefinedTerm
204 sg:journal.1088396 schema:issn 0391-4097
205 1720-8386
206 schema:name Journal of Endocrinological Investigation
207 rdf:type schema:Periodical
208 sg:person.01003046263.82 schema:affiliation Ncc9767bbcfc54860bcc914e9ea3b592c
209 schema:familyName Marcocci
210 schema:givenName C.
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003046263.82
212 rdf:type schema:Person
213 sg:person.01055331703.24 schema:affiliation N9e096ddee8c249f1a7c084d09fda2fae
214 schema:familyName Sisti
215 schema:givenName E.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055331703.24
217 rdf:type schema:Person
218 sg:person.01126315001.71 schema:affiliation Nd4a2f1a84b33408e96d09580433d44d2
219 schema:familyName Coco
220 schema:givenName B.
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126315001.71
222 rdf:type schema:Person
223 sg:person.01167520476.55 schema:affiliation Ncaa7863ab88b42f189a9d71e9838a90f
224 schema:familyName Rocchi
225 schema:givenName R.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167520476.55
227 rdf:type schema:Person
228 sg:person.01175375751.25 schema:affiliation Nf8444b23d0ff4ef2b1426ce9778d4394
229 schema:familyName Menconi
230 schema:givenName F.
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175375751.25
232 rdf:type schema:Person
233 sg:person.012157705311.60 schema:affiliation N79b687c6bf04429f916056a7ee78037b
234 schema:familyName Sabini
235 schema:givenName E.
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012157705311.60
237 rdf:type schema:Person
238 sg:person.015633672701.14 schema:affiliation Nbb5888dd16b142918897b5882e7298aa
239 schema:familyName Ionni
240 schema:givenName I.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015633672701.14
242 rdf:type schema:Person
243 sg:person.016021203562.07 schema:affiliation N092a83d011cb4a12ae75c2128355b324
244 schema:familyName Marinò
245 schema:givenName M.
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016021203562.07
247 rdf:type schema:Person
248 sg:person.0616435417.26 schema:affiliation N775c0a3d7adb4490aec47449b4278abf
249 schema:familyName Leo
250 schema:givenName M.
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616435417.26
252 rdf:type schema:Person
253 sg:person.0626137617.03 schema:affiliation Nc35166c3b3ed4966bb241b27fba49dc2
254 schema:familyName Profilo
255 schema:givenName M. A.
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626137617.03
257 rdf:type schema:Person
258 sg:person.0652305341.69 schema:affiliation Nf7ac805df9bc4d199c474f6dc079654e
259 schema:familyName Brunetto
260 schema:givenName M.
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652305341.69
262 rdf:type schema:Person
263 sg:person.0660241732.86 schema:affiliation N7289a6862eb243888aff28cace528ea6
264 schema:familyName Latrofa
265 schema:givenName F.
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660241732.86
267 rdf:type schema:Person
268 sg:person.0742704576.10 schema:affiliation N4ffb2a726cdd4569b48d9df96f71fe73
269 schema:familyName Mazzi
270 schema:givenName B.
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742704576.10
272 rdf:type schema:Person
273 sg:person.0777360014.47 schema:affiliation N4f72e5be8fda42ad9bb4ad4f8ed0bc13
274 schema:familyName Vitti
275 schema:givenName P.
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777360014.47
277 rdf:type schema:Person
278 sg:pub.10.1007/bf03345386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021828143
279 https://doi.org/10.1007/bf03345386
280 rdf:type schema:CreativeWork
281 sg:pub.10.1007/s12020-016-0928-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048477264
282 https://doi.org/10.1007/s12020-016-0928-3
283 rdf:type schema:CreativeWork
284 sg:pub.10.1007/s13300-016-0167-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016194759
285 https://doi.org/10.1007/s13300-016-0167-x
286 rdf:type schema:CreativeWork
287 sg:pub.10.1007/s40618-014-0097-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016789120
288 https://doi.org/10.1007/s40618-014-0097-2
289 rdf:type schema:CreativeWork
290 sg:pub.10.1007/s40618-014-0227-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033379838
291 https://doi.org/10.1007/s40618-014-0227-x
292 rdf:type schema:CreativeWork
293 sg:pub.10.1007/s40618-015-0241-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017441988
294 https://doi.org/10.1007/s40618-015-0241-7
295 rdf:type schema:CreativeWork
296 sg:pub.10.1038/nrd1901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005336052
297 https://doi.org/10.1038/nrd1901
298 rdf:type schema:CreativeWork
299 sg:pub.10.1038/nrendo.2013.193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006242316
300 https://doi.org/10.1038/nrendo.2013.193
301 rdf:type schema:CreativeWork
302 sg:pub.10.1038/nri1839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047664639
303 https://doi.org/10.1038/nri1839
304 rdf:type schema:CreativeWork
305 https://app.dimensions.ai/details/publication/pub.1078900619 schema:CreativeWork
306 https://doi.org/10.1002/hep.21059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028055530
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.bpg.2011.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031560620
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.jhep.2011.07.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051292814
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/s0953-6205(02)00089-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046308212
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1056/nejm200004273421707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034355315
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1089/1050725041692927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059204671
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1089/105072504774193276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059204782
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1089/thy.2000.10.521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074672519
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1089/thy.2006.0267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059319707
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1089/thy.2015.0061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059322016
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1111/j.1478-3231.2004.0970.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010865951
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1161/circresaha.115.306471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063343763
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1210/jc.2010-1962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064292423
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1210/jc.2014-4463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064295646
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1371/journal.pone.0107294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048868579
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1530/eje-11-0779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046172232
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1530/eje-14-0712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021458264
339 rdf:type schema:CreativeWork
340 https://doi.org/10.7326/0003-4819-126-2-199701150-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073701129
341 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...