Analysis of the association between plasma PCSK9 and Lp(a) in Han Chinese View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-02-19

AUTHORS

S.-H. Yang, S. Li, Y. Zhang, R.-X. Xu, C.-G. Zhu, Y.-L. Guo, N.-Q. Wu, P. Qing, Y. Gao, C.-J. Cui, Q. Dong, J. Sun, J.-J. Li

ABSTRACT

PurposeIt has been reported that proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors can significantly reduce lipoprotein(a) [Lp(a)], and the mechanism for Lp(a) reduction remains unclear. Recently an interesting clinical research with a small sample showed a positive correlation between plasma PCSK9 and Lp(a) levels in diabetes. Here we aimed to use a relatively large sample to investigate whether such an association exists in Han Chinese.MethodsA total of 783 inpatients were consecutively enrolled and composed of 172 patients with type 2 diabetes mellitus (T2DM) and 611 non-T2DM subjects. Plasma PCSK9 level was measured by ELISA, and its association with Lp(a) was assayed by Spearman’s correlation and multiple regression. Clinical and biochemical parameters were determined in all subjects studied.ResultsNo significant differences in PCSK9 and Lp(a) levels were found between T2DM and non-T2DM patients. PCSK9 level was not related to Lp(a) level either in T2DM or non-T2DM group in bivariate correlation and multiple linear regression analysis. Additionally, no association between the levels of PCSK9 and Lp(a) was found in well, poorly controlled T2DM patients or in T2DM patients with or without coronary artery disease (CAD). Besides, no difference was found among the PCSK9 values across tertiles of Lp(a) level.ConclusionWe found no association of plasma PCSK9 levels with Lp(a) level in Han Chinese with or without T2DM, suggesting that Lp(a) reduction by PCSK9 inhibitors may not be achieved simply through PCSK9 pathway at least in Chinese. More... »

PAGES

875-883

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40618-016-0433-9

DOI

http://dx.doi.org/10.1007/s40618-016-0433-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052469678

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26894681


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23 schema:description PurposeIt has been reported that proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors can significantly reduce lipoprotein(a) [Lp(a)], and the mechanism for Lp(a) reduction remains unclear. Recently an interesting clinical research with a small sample showed a positive correlation between plasma PCSK9 and Lp(a) levels in diabetes. Here we aimed to use a relatively large sample to investigate whether such an association exists in Han Chinese.MethodsA total of 783 inpatients were consecutively enrolled and composed of 172 patients with type 2 diabetes mellitus (T2DM) and 611 non-T2DM subjects. Plasma PCSK9 level was measured by ELISA, and its association with Lp(a) was assayed by Spearman’s correlation and multiple regression. Clinical and biochemical parameters were determined in all subjects studied.ResultsNo significant differences in PCSK9 and Lp(a) levels were found between T2DM and non-T2DM patients. PCSK9 level was not related to Lp(a) level either in T2DM or non-T2DM group in bivariate correlation and multiple linear regression analysis. Additionally, no association between the levels of PCSK9 and Lp(a) was found in well, poorly controlled T2DM patients or in T2DM patients with or without coronary artery disease (CAD). Besides, no difference was found among the PCSK9 values across tertiles of Lp(a) level.ConclusionWe found no association of plasma PCSK9 levels with Lp(a) level in Han Chinese with or without T2DM, suggesting that Lp(a) reduction by PCSK9 inhibitors may not be achieved simply through PCSK9 pathway at least in Chinese.
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30 ConclusionWe
31 ELISA
32 Han Chinese
33 PCSK9
34 PCSK9 inhibitors
35 PCSK9 levels
36 PCSK9 pathway
37 PCSK9 values
38 PurposeIt
39 ResultsNo significant differences
40 Spearman correlation
41 T2DM
42 T2DM patients
43 analysis
44 artery disease
45 association
46 biochemical parameters
47 bivariate correlations
48 clinical research
49 coronary artery disease
50 correlation
51 diabetes
52 diabetes mellitus
53 differences
54 disease
55 group
56 inhibitors
57 inpatients
58 large sample
59 levels
60 levels of PCSK9
61 linear regression analysis
62 mechanism
63 mellitus
64 multiple linear regression analysis
65 multiple regression
66 non-T2DM group
67 non-T2DM patients
68 non-T2DM subjects
69 parameters
70 pathway
71 patients
72 plasma PCSK9
73 plasma PCSK9 levels
74 positive correlation
75 proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors
76 reduction
77 regression
78 regression analysis
79 research
80 samples
81 significant differences
82 small samples
83 subjects
84 subtilisin/kexin type 9 inhibitors
85 tertile
86 total
87 type 2 diabetes mellitus
88 values
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