Fuel homeostasis and locomotor behavior: role of leptin and melanocortin pathways View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-02

AUTHORS

G. Ceccarini, M. Maffei, P. Vitti, F. Santini

ABSTRACT

BACKGROUND: While it is now accepted that genes and their products affect food intake, the concept that locomotor behavior or the propensity for physical activity is controlled by neuro hum oral regulators is frequently underappreciated. In mammals, complex interactions have developed to allow the cross-talk between fuel homeostasis and physical activity. AIM: The aim of this review is to provide a synopsis of the influence of the leptin-melanocortin pathway, a well-studied pivotal player in body weight regulation, on locomotor behaviors. CONCLUSIONS: In rodents, reductions in leptin levels that physiologically occur following acute food deprivation or a reduction of the fat mass consequent to prolonged caloric restrictions are associated with a decrease in total locomotor activity and simultaneous increase in food-anticipatory activity, a locomotor behavior which reflects a foraging attitude. These actions can be prevented by leptin administration and are at least partially mediated by the neurons of the melanocortin pathway. In humans, twin studies have attributed to genetic factors approximately 50% of the variance of physical activity. An elevated number of the genes or loci which may affect physical activity are involved in body weight homeostasis. Polymorphisms of the melanocortin-4 and leptin receptors have repeatedly been associated with the level of physical activity. Unraveling the complexity of the regulation of locomotor behavior and the interconnections with the pathways involved in energy homeostasis may help explain the substantial individual variability in physical activities in humans and disentangle the harmful effects of sedentary lifestyle, which may be distinct from the detrimental effects of obesity. More... »

PAGES

125-131

References to SciGraph publications

  • 2000-09. Leptin suppresses semi-starvation induced hyperactivity in rats: implications for anorexia nervosa in MOLECULAR PSYCHIATRY
  • 1994-12. Positional cloning of the mouse obese gene and its human homologue in NATURE
  • 2005-04. Melanocortin-4 receptor gene and physical activity in the Québec Family Study in INTERNATIONAL JOURNAL OF OBESITY
  • 2007-12. Central dysregulations in the control of energy homeostasis and endocrine alterations in anorexia and bulimia nervosa in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • 2003-07. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor in NATURE NEUROSCIENCE
  • 2012-07. Genetics of Physical Activity and Physical Inactivity in Humans in BEHAVIOR GENETICS
  • 1998-05. Artificial Selection for Increased Wheel-Running Behavior in House Mice in BEHAVIOR GENETICS
  • 2002-11. Lessons in obesity from transgenic animals in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • 2000-09. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass in NATURE GENETICS
  • 2002-12. The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism in INTERNATIONAL JOURNAL OF OBESITY
  • 2012-06. The effect of three-month pre-season preparatory period and short-term exercise on plasma leptin, adiponectin, visfatin, and ghrelin levels in young female handball and basketball players in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • 2013-06. Plasma leptin and energy expenditure during prolonged, moderate intensity, treadmill exercise in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • 1998-10. Leptin and the regulation of body weight in mammals in NATURE
  • 2014-02. Pre-treatment circulating leptin/ghrelin ratio as a non-invasive marker to identify patients likely to regain the lost weight after an energy restriction treatment in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • 2005-05. Anatomy and regulation of the central melanocortin system in NATURE NEUROSCIENCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40618-014-0225-z

    DOI

    http://dx.doi.org/10.1007/s40618-014-0225-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015150812

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25501840


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