An update on the medical treatment of Graves’ hyperthyroidism View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-11

AUTHORS

Michele Marinò, Francesco Latrofa, Francesca Menconi, Luca Chiovato, Paolo Vitti

ABSTRACT

Medical treatment of Graves' hyperthyroidism is based on the use of thionamides; namely, methimazole and propylthiouracil. In the past, methimazole was preferred by European endocrinologists, whereas propylthiouracil was the first choice for the majority of their North American colleagues. However, because of the recent definition of a better side-effect profile, methimazole is nowadays the first choice world while. Although thionamides are quite effective for the short-term control of Graves' hyperthyroidism, a relatively high proportion of patients relapses after thionamide withdrawal. Other possible medical treatments, include iodine and compounds containing iodine, perchlorate, lithium (as an adjuvant in patients undergoing radioiodine therapy), β-adrenergic antagonists, glucocorticoids, and some new molecules still under investigation. Management of Graves' hyperthyroidism using thionamides as well as the other available medical treatments is here reviewed in detail, with a special mention of situations such as pregnancy and lactation, as well as neonatal and fetal thyrotoxicosis. More... »

PAGES

1041-1048

References to SciGraph publications

  • 2013-06. Prevalence and natural history of Graves’ orbitopathy in the XXI century in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • 2013-07. Chronic idiopathic urticaria and Graves’ disease in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • 1981-10. Spontaneous hypothyroidism after antithyroid treatment of hyperthyroid Graves’ disease in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • 2012-12. Short-term effects of combined treatment with potassium bromide and methimazole in patients with Graves’ disease in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40618-014-0136-z

    DOI

    http://dx.doi.org/10.1007/s40618-014-0136-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018545499

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25185644


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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40618-014-0136-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40618-014-0136-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40618-014-0136-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40618-014-0136-z'


     

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